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  1. Mobility, one of the basic daily activities, helps in carrying out routine work, which contributes to people’s well-being. A lack of friendly and accessible infrastructure may act as a barrier, which limits ol...

    Authors: Divya Sussana Patil, Uday Narayan Yadav, Sobin George, Marco Helbich, Dick Ettema and Ajay Bailey

    Citation: Systematic Reviews 2020 9:196

    Content type: Protocol

    Published on:

  2. Hypertension is a disease with significant clinical and socio-economic consequences. The reduction in cardiovascular mortality and morbidity in patients treated for hypertension is directly related to the magn...

    Authors: Elena Filipova, Stela Dineva, Katya Uzunova, Velichka Pavlova, Krassimir Kalinov and Toni Vekov

    Citation: Systematic Reviews 2020 9:195

    Content type: Systematic review update

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  3. Several cardiovascular pathologies cause heart failure. Heart failure with reduced ejection fraction (HFrEF) is deteriorated by neurohormonal activation, so neurohormonal antagonists are recommended in HFrEF p...

    Authors: Rama Krishna Guggilla, Pawel Mateusz Sowa, Jacek Jamiolkowski, Siamala Sinnadurai, Adnan Amin and Karol Adam Kaminski

    Citation: Systematic Reviews 2020 9:194

    Content type: Protocol

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  4. Arteriovenous (AV) hemodialysis access creation is recommended by international guidelines as the preferred method of hemodialysis access. However, most AV access sites will require revision to maintain patenc...

    Authors: Mark Rockley, Sudhir Nagpal, Ashish Gupta and Derek J. Roberts

    Citation: Systematic Reviews 2020 9:193

    Content type: Protocol

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  5. Antenatal care is one of the continua of reproductive health care, and inadequate antenatal care utilization results in an adverse feto-maternal outcome. Pregnancy intention is an essential factor that plays a...

    Authors: Tadesse Tolossa, Ebisa Turi, Getahun Fetensa, Ginenus Fekadu and Fassikaw Kebede

    Citation: Systematic Reviews 2020 9:191

    Content type: Research

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  6. With the legalization of cannabis in Canada, there is an increase trend in use. Cannabis has been known to have several health implications, one of which is the development of cannabis use disorder (CUD). CUD ...

    Authors: Alannah Hillmer, Caroul Chawar, Stephanie Sanger, Alessia D’Elia, Mehreen Butt, Raveena Kapoor, Flavio Kapczinski, Guillaume Pare, Lehana Thabane and Zainab Samaan

    Citation: Systematic Reviews 2020 9:190

    Content type: Protocol

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  7. Metastasectomy is performed on a select cohort of patients with advanced and/or recurrent bone and soft tissue sarcomas because of the potential for long term relapse free and overall survival associated with ...

    Authors: Ying Wang, Megan Delisle, Denise Smith and Amirrtha Srikanthan

    Citation: Systematic Reviews 2020 9:189

    Content type: Protocol

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  8. Hospitalized newborn infants may require analgesia and sedation either for the management of procedural pain, during or after surgery, and other painful conditions. The benefits and harms of opioids administer...

    Authors: Mari Kinoshita, Katarzyna Stempel, Israel Junior Borges do Nascimento, Dhashini Naidu Vejayaram, Elisabeth Norman and Matteo Bruschettini

    Citation: Systematic Reviews 2020 9:183

    Content type: Protocol

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  9. Mesenchymal stem cells (MSCs) are multipotent cells that demonstrate therapeutic potential for the treatment of acute and chronic inflammatory-mediated conditions. Especially for acute conditions, it is critic...

    Authors: Chintan Dave, Andrea McRae, Emily Doxtator, Shirley H. J. Mei, Katrina Sullivan, Dianna Wolfe, Josee Champagne and Lauralyn McIntyre

    Citation: Systematic Reviews 2020 9:188

    Content type: Protocol

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  10. Recent surveys of Canadian cannabis users reflect increasing consumption rates, some of whom may have diabetes. However, healthcare providers have limited information resources on the effects of recreational c...

    Authors: Caroline J. Porr, Patricia Rios, Harpreet S. Bajaj, Aoife M. Egan, Celine Huot, Ryan Batten, Lisa Bishop, Devonne Ryan, Erin Davis, Nazia Darvesh, Arifur Rahman, Shabnam Asghari, Lily Acheampong and Andrea C. Tricco

    Citation: Systematic Reviews 2020 9:187

    Content type: Research

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  11. According to the United Nation High Commissioner for Refugee Global Trends report in 2019, on average, there are 2.7 refugees per 1000 national population in high-income countries, where girls and women attrib...

    Authors: Sarah DeSa, Akalewold T. Gebremeskel and Sanni Yaya

    Citation: Systematic Reviews 2020 9:186

    Content type: Protocol

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  12. Systematic reviews of medical devices are particularly challenging as the quality of evidence tends to be more limited than evidence on pharmaceutical products. This article describes the methods used to ident...

    Authors: Ros Wade, Sahar Sharif-Hurst, Melissa Harden, Matthew Walton, Lindsay Claxton, Robert Hodgson and Alison Eastwood

    Citation: Systematic Reviews 2020 9:184

    Content type: Research

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  13. Acute low back pain is associated with pain and disability, but symptoms are often self-healing. The effectiveness of exercise therapy for acute low back pain remains uncertain with conflicting evidence from s...

    Authors: Marc Karlsson, Anna Bergenheim, Maria E. H. Larsson, Lena Nordeman, Maurits van Tulder and Susanne Bernhardsson

    Citation: Systematic Reviews 2020 9:182

    Content type: Research

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  14. Diet during infancy and early childhood can have implications on child growth, health, and developmental trajectories. Yet, poor dietary habits are common in young children, who often consume diets that are no...

    Authors: Jacklyn Jackson, Luke Wolfenden, Alice Grady, Melanie Lum, Alecia Leonard, Sam McCrabb, Alix Hall, Nicole Pearson, Courtney Barnes and Sze Lin Yoong

    Citation: Systematic Reviews 2020 9:181

    Content type: Protocol

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  15. Signals of adverse drug reactions (ADRs) form the basis of some regulatory risk-minimization actions in pharmacovigilance. Reviews of limited scope have highlighted that such signals are mostly supported by re...

    Authors: Daniele Sartori, Jeffrey K. Aronson and Igho J. Onakpoya

    Citation: Systematic Reviews 2020 9:180

    Content type: Protocol

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  16. A comprehensive overview of treatments of common fractures is missing, although it would be important for shared decision-making in clinical practice. The aim was to determine benefits and harms of surgical co...

    Authors: Søren T. Skou, Carsten B. Juhl, Kristoffer B. Hare, L. Stefan Lohmander and Ewa M. Roos

    Citation: Systematic Reviews 2020 9:179

    Content type: Research

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  17. Indigenous communities are often portrayed from a deficit-based lens; however, Indigenous communities have self-determined perspectives of health and well-being that are strength based. The objective of this s...

    Authors: K. Thiessen, M. Haworth-Brockman, R. Stout, P. Moffitt, J. Gelowitz, J. Schneider and L. Demczuk

    Citation: Systematic Reviews 2020 9:177

    Content type: Protocol

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  18. Vitamin D deficiency can play a role in extraskeletal functions that are involved with a set of risk factors associated with metabolic syndrome (MetS). The purpose of this review is to investigate the impact o...

    Authors: Séphora Louyse Silva Aquino, Aline Tuane Oliveira Cunha, Josivan Gomes Lima, Karine Cavalcanti Maurício Sena-Evangelista, Antonio Gouveia Oliveira, Ricardo Ney Cobucci and Lucia Fatima Campos Pedrosa

    Citation: Systematic Reviews 2020 9:176

    Content type: Protocol

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  19. Use of electroencephalography (EEG) is currently recommended by the American Clinical Neurophysiology Society for a wide range of indications, including diagnosis of nonconvulsive status epilepticus and evalua...

    Authors: Shaurya Taran, Wael Ahmed, Esther Bui, Lara Prisco, Cecil D. Hahn and Victoria A. McCredie

    Citation: Systematic Reviews 2020 9:175

    Content type: Protocol

    Published on:

  20. Malaria is one of the major contributing risk factors for poor development of children living in low- and middle-income countries (LMICs). However, little is known about the specific domains of cognition and b...

    Authors: Andrew Sentoogo Ssemata, Jacquelline Ann Nakitende, Simon Kizito, Elizabeth C. Whipple, Paul Bangirana, Noeline Nakasujja, Chandy C. John and Megan S. McHenry

    Citation: Systematic Reviews 2020 9:174

    Content type: Protocol

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  21. Healthcare workers (HCWs) are at particular risk during pandemics and epidemics of highly virulent diseases with significant morbidity and case fatality rate. These diseases include severe acute respiratory sy...

    Authors: Ana Licina, Andrew Silvers and Rhonda L. Stuart

    Citation: Systematic Reviews 2020 9:173

    Content type: Systematic review update

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  22. Home-based hospitalization (HBH) offers an alternative delivery model to hospital care. There has been a remarkable increase in pilot initiatives and deployment of this model to optimize services offered to a ...

    Authors: Christiane Pereira Martins Casteli, Gisèle Irène Claudine Mbemba, Serge Dumont, Clémence Dallaire, Lucille Juneau, Elisabeth Martin, Marie-Claude Laferrière and Marie-Pierre Gagnon

    Citation: Systematic Reviews 2020 9:172

    Content type: Research

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  23. With the rapid development of technologies for type 1 diabetes, economic evaluations are integral in guiding cost-effective clinical and policy decisions. We therefore aimed to review and synthesise the curren...

    Authors: Anthony Pease, Ella Zomer, Danny Liew, Clement Lo, Arul Earnest and Sophia Zoungas

    Citation: Systematic Reviews 2020 9:171

    Content type: Research

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  24. The World Health Organization declared on March 11, 2020, that the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) has escalated from epidemic into pandemic. As the initial outbreak ...

    Authors: Yuxi Li, Juan Li, Dongling Zhong, Yue Zhang, Yonggang Zhang, Yan Guo, Mike Clarke and Rongjiang Jin

    Citation: Systematic Reviews 2020 9:170

    Content type: Protocol

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  25. Psychological stress is a prevalent factor in inflammatory bowel disease (IBD) with detrimental effects on patients’ quality of life and possibly disease course. Although the aetiology of symptom exacerbation ...

    Authors: Mariyana Schoultz, Michelle Beattie, Trish Gorely and Janni Leung

    Citation: Systematic Reviews 2020 9:169

    Content type: Research

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  26. Behavioural weight management programmes are effective in assisting people with overweight or obesity to lose excess body weight. Yet, many still struggle to attain their weight loss goals in such programmes. ...

    Authors: Meigan Thomson, Anne Martin, Jennifer Logue, Valerie Wells and Sharon A. Simpson

    Citation: Systematic Reviews 2020 9:168

    Content type: Protocol

    Published on:

  27. Medical cannabis (MC) is currently being used as an adjunct to opiates given its analgesic effects and potential to reduce opiate addiction. This review assessed if MC used in combination with opioids to treat...

    Authors: Babasola O. Okusanya, Ibitola O. Asaolu, John E. Ehiri, Linda Jepkoech Kimaru, Abidemi Okechukwu and Cecilia Rosales

    Citation: Systematic Reviews 2020 9:167

    Content type: Research

    Published on:

  28. Professional identity development is an area of contemporary interest within medical education. It can be defined as ‘the foundational process one experiences during the transformation from lay person to physi...

    Authors: Megan El Brown, Paul Whybrow, Gavin Kirwan and Gabrielle M. Finn

    Citation: Systematic Reviews 2020 9:166

    Content type: Protocol

    Published on:

  29. Caregivers of women with breast cancer in low-and-middle-income countries experience significant physical and economic burdens. The review aimed to map the evidence of studies that had reported on the experien...

    Authors: Grace Kusi, Adwoa Bemah Boamah Mensah, Kofi Boamah Mensah, Veronica Millicent Dzomeku, Felix Apiribu, Precious Adade Duodu, Bakinam Adamu, Pascal Agbadi and Kwadwo Osei Bonsu

    Citation: Systematic Reviews 2020 9:165

    Content type: Systematic review update

    Published on:

  30. Increasing numbers of critically ill patients experience a prolonged intensive care unit stay contributing to greater physical and psychological morbidity, strain on families and cost to health systems. Qualit...

    Authors: Laura Allum, Chloe Apps, Nicholas Hart, Natalie Pattison, Bronwen Connolly and Louise Rose

    Citation: Systematic Reviews 2020 9:164

    Content type: Protocol

    Published on:

  31. Exergaming is a fun, engaging, and interactive form of exercising that may help overcome some of the traditional exercise barriers and help improve adherence on the part of older adults, providing therapeutic ...

    Authors: T. B. F. Pacheco, C. S. P. de Medeiros, V. H. B. de Oliveira, E. R. Vieira and F. A. C. de Cavalcanti

    Citation: Systematic Reviews 2020 9:163

    Content type: Research

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  32. Decision-makers increasingly request rapid answers to clinical or public health questions. To save time, personnel, and financial resources, rapid reviews streamline the methodological steps of the systematic ...

    Authors: Lisa Affengruber, Gernot Wagner, Siw Waffenschmidt, Stefan K. Lhachimi, Barbara Nussbaumer-Streit, Kylie Thaler, Ursula Griebler, Irma Klerings and Gerald Gartlehner

    Citation: Systematic Reviews 2020 9:162

    Content type: Research

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  33. Over 4.2 million confirmed cases and more than 285,000 deaths, COVID-19 pandemic continues to harm significant number of people worldwide. Several studies have reported the impact of COVID-19 in general popula...

    Authors: Binny Thomas, Abdulrouf Pallivalapila, Wessam El Kassem, Asma Tarannum, Fatema Al Hail, Mohammed Rijims, Hussain Parappil, Arabo Ibrahim Bayo, Shamsa Ahmad, Zachariah Nazar, Derek Stewart and Moza Al Hail

    Citation: Systematic Reviews 2020 9:161

    Content type: Protocol

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  34. More than eight in ten of the world’s 1.65 million adolescents living with human immunodeficiency virus (ALHIV) live in sub-Saharan Africa (SSA). Suboptimal adherence to antiretroviral therapy (ART) and poor v...

    Authors: Melkamu Merid Mengesha, Dessalegn Ajema, Awugchew Teshome and Abera Kenay Tura

    Citation: Systematic Reviews 2020 9:160

    Content type: Protocol

    Published on:

  35. Early postoperative hyperglycemia (POHG) is common and associated with poor postoperative outcomes. Currently, there is no systematic review and meta-analysis that addresses the knowledge gap of the incidence ...

    Authors: Paddy Ssentongo, Joseph A. Lewcun, Anna E. Ssentongo and David I. Soybel

    Citation: Systematic Reviews 2020 9:158

    Content type: Protocol

    Published on:

  36. The purpose of this review is to evaluate the use and effectiveness of the local administration of tramadol in reducing post-operative pain during surgical interventions.

    Authors: Maria Beatrice Passavanti, Giacomo Piccinno, Aniello Alfieri, Sveva Di Franco, Pasquale Sansone, Giuseppe Mangoni, Vincenzo Pota, Caterina Aurilio, Maria Caterina Pace and Marco Fiore

    Citation: Systematic Reviews 2020 9:157

    Content type: Protocol

    Published on:

  37. There is limited evidence on whether screening for type 2 diabetes mellitus affects health outcomes. A recent systematic review of randomised clinical trials found only one trial that met their inclusion crite...

    Authors: Helen Mearns, Paul Kuodi Otiku, Mary Shelton, Tamara Kredo, Benjamin M. Kagina and Bey-Marrié Schmidt

    Citation: Systematic Reviews 2020 9:156

    Content type: Protocol

    Published on:

  38. This paper is the initial Position Statement of Evidence Synthesis International, a new partnership of organizations that produce, support and use evidence synthesis around the world. The paper (i) argues for ...

    Authors: David Gough, Phil Davies, Gro Jamtvedt, Etienne Langlois, Julia Littell, Tamara Lotfi, Edoardo Masset, Tracy Merlin, Andrew S. Pullin, Merel Ritskes-Hoitinga, John-Arne Røttingen, Emily Sena, Ruth Stewart, David Tovey, Howard White, Jennifer Yost…

    Citation: Systematic Reviews 2020 9:155

    Content type: Commentary

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  39. Prediction of long-term neurodevelopmental outcomes remains an elusive goal for neonatology. Clinical and socioeconomic markers have not proven to be adequately reliable. The limitation in prognostication incl...

    Authors: Judy Seesahai, Maureen Luther, Carmen Cindy Rhoden, Paige Terrien Church, Elizabeth Asztalos and Rudaina Banihani

    Citation: Systematic Reviews 2020 9:154

    Content type: Systematic review update

    Published on:

  40. Capacity to deliver outpatient care for patients with cardiac implantable electronic devices (CIEDs) may soon be outweighed by need. This systematic review aims to investigate the comparative effectiveness, sa...

    Authors: Shannon E. Kelly, Tammy J. Clifford, Doug Coyle, Janet Martin, Vivian Welch, Becky Skidmore, David Birnie, Ratika Parkash, Anthony S. L. Tang and George A. Wells

    Citation: Systematic Reviews 2020 9:153

    Content type: Protocol

    Published on:

  41. Hypertension is one of the public health challenges. Various risk factors are associated with hypertension, including social demographics, geographical location, health behaviours, and social stress. Intervent...

    Authors: Fateme Arabi Basharic, Ali Janati, Mohammad Zakaria Pezeshki, Rahim Khodayari-Zarnaq, Fatemeh Sadeghi-Ghyassi and Masoumeh Gholizadeh

    Citation: Systematic Reviews 2020 9:152

    Content type: Protocol

    Published on:

  42. Virtual care models are used to follow-up patients with cardiovascular implantable electronic devices (CIED), including pacemakers, implantable cardioverter defibrillators, and cardiac resynchronization therap...

    Authors: Shannon E. Kelly, Tammy J. Clifford, Becky Skidmore, David Birnie, Ratika Parkash and George A. Wells

    Citation: Systematic Reviews 2020 9:151

    Content type: Protocol

    Published on:

  43. This review will provide an overview of published data comparing transposition of the extensor indicis pollicis (EIP) tendon and palmaris longus (PL) tendon grafting in thumb extension reconstruction following...

    Authors: Abdulwares Meiwandi, Sarantos Kaptanis and Marios Papadakis

    Citation: Systematic Reviews 2020 9:149

    Content type: Protocol

    Published on:

  44. Velamentous cord insertion (VCI) is an umbilical cord attachment to the membranes surrounding the placenta instead of the central mass. VCI is strongly associated with vasa praevia (VP), where umbilical vessel...

    Authors: Amy Buchanan-Hughes, Anna Bobrowska, Cristina Visintin, George Attilakos and John Marshall

    Citation: Systematic Reviews 2020 9:147

    Content type: Research

    Published on:

  45. Pre- and post-partum depression is a common mood disorder with detrimental effects on both mother and child. The aim of the proposed review is to summarize evidence related to the effects of both pre- and post...

    Authors: Lea Takács, Vít Kandrnal, Šárka Kaňková, František Bartoš and Jiří Mudrák

    Citation: Systematic Reviews 2020 9:146

    Content type: Protocol

    Published on:

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