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  1. Content type: Protocol

    The worldwide incidence and prevalence of diabetes mellitus (DM) are increasing. DM has a high social and economic burden due to its complications and associated disorders. Peripheral arterial disease (PAD) is...

    Authors: Carolina Dutra Queiroz Flumignan, Fábio Cabral Freitas Amaral, Ronald Luiz Gomes Flumignan, Vladimir Tonello Vasconcelos, Gabriela Araújo Attie, Raul Muffato Daolio, Henrique Jorge Guedes-Neto, Jorge Eduardo de Amorim, José Carlos Costa Baptista-Silva and Luis Carlos Uta Nakano

    Citation: Systematic Reviews 2018 7:228

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  2. Content type: Research

    Within increasingly constrained school timetables, interventions that integrate academic and health education to reduce substance use and violence may hold promise as a category of intervention that can positi...

    Authors: Tara Tancred, Sara Paparini, G. J. Melendez-Torres, Adam Fletcher, James Thomas, Rona Campbell and Chris Bonell

    Citation: Systematic Reviews 2018 7:227

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  3. Content type: Protocol

    Each year, infection with Plasmodium causes millions of clinical cases of malaria and hundreds of thousands of deaths. Resistance to different antimalarial medications continues to develop and spread, threatening...

    Authors: Rebekah Burrow, Thomas R. Fanshawe and Georgina S. Humphreys

    Citation: Systematic Reviews 2018 7:221

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  4. Content type: Protocol

    Acute myocardial infarction (MI) remains one of the leading causes of death worldwide with no curative therapy available. Stem cell therapies have been gaining interest as a means to repair the cardiac tissue ...

    Authors: Kashif Khan, Karina Gasbarrino, Ibtisam Mahmoud, Georges Makhoul, Bin Yu, Line Dufresne, Stella S. Daskalopoulou, Adel Schwertani and Renzo Cecere

    Citation: Systematic Reviews 2018 7:225

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  5. Content type: Protocol

    Depression and non-communicable diseases (NCDs) account for a growing burden on health systems in low- and middle-income countries (LMICs). Depression is generally associated with the outcomes of NCDs and is a...

    Authors: Michael Udedi, Brian Pence, Felix Kauye and Adamson S. Muula

    Citation: Systematic Reviews 2018 7:223

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  6. Content type: Protocol

    Peripheral neuropathies are a common complication in patients with diabetes. Changes in nerve function and central pain processing can be quantified by assessing pain thresholds and pain modulation mechanisms.

    Authors: Eva Sierra-Silvestre, Leanne Bisset and Michel W. Coppieters

    Citation: Systematic Reviews 2018 7:222

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  7. Content type: Protocol

    A growing number of postdoctoral scholars are following diverse career paths that require broad skill sets to ensure success. Yet, most postdoctoral professional learning and development initiatives are intend...

    Authors: Lorelli Nowell, K. Alix Hayden, Carol Berenson, Natasha Kenny, Nancy Chick and Carolyn Emery

    Citation: Systematic Reviews 2018 7:224

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  8. Content type: Protocol

    Key populations who bear a disproportionate burden of HIV, including female sex workers, men who have sex with men, people who use drugs, transgender people, and incarcerated populations, have been understudie...

    Authors: Amrita Rao, Sheree Schwartz, Keith Sabin, Tisha Wheeler, Jinkou Zhao, James Hargreaves and Stefan Baral

    Citation: Systematic Reviews 2018 7:220

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  9. Content type: Protocol

    Fetal growth restriction (FGR) is a complication of pregnancy associated with major neonatal morbidity and commonly diagnosed at birth based on birth weight below the 5th or the 10th centile. There is no conse...

    Authors: Cédric Gasse, Kim Paquette, Suzanne Demers, Stéphanie Roberge, Emmanuel Bujold and Amélie Boutin

    Citation: Systematic Reviews 2018 7:219

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  10. Content type: Protocol

    Research partnership approaches, in which researchers and stakeholders work together collaboratively on a research project, are an important component of research, knowledge translation, and implementation. De...

    Authors: Femke Hoekstra, Kelly J. Mrklas, Kathryn M. Sibley, Tram Nguyen, Mathew Vis-Dunbar, Christine J. Neilson, Leah K. Crockett, Heather L. Gainforth and Ian D. Graham

    Citation: Systematic Reviews 2018 7:217

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  11. Content type: Research

    With over 230 million surgical procedures performed annually worldwide, better application of evidence in anesthesia and perioperative medicine may reduce widespread variation in clinical practice and improve ...

    Authors: Sylvain Boet, Nicole Etherington, David Nicola, Andrew Beck, Susan Bragg, Ian D. Carrigan, Sarah Larrigan, Cassandra T. Mendonca, Isaac Miao, Tatyana Postonogova, Benjamin Walker, José De Wit, Karim Mohamed, Nadia Balaa, Manoj Mathew Lalu, Daniel I McIsaac…

    Citation: Systematic Reviews 2018 7:218

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  12. Content type: Protocol

    Blood cultures are an integral part of the diagnosis of bacteremia in unwell patients. The treatment of bacteremia involves the rapid and accurate identification of the causative agent grown from the blood cul...

    Authors: J. A. Hughes, C. J. Cabilan, Julian Williams, Mercedes Ray and Fiona Coyer

    Citation: Systematic Reviews 2018 7:216

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  13. Content type: Protocol

    The 20–70% participation of diabetes patients in lifestyle interventions (LSI) worldwide seems to be rather sub-optimal, in spite of all intents of such interventions to delay further progress of the disease. ...

    Authors: Charalabos-Markos Dintsios, Nadja Chernyak, Benjamin Grehl and Andrea Icks

    Citation: Systematic Reviews 2018 7:214

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  14. Content type: Research

    Currently, there is a lack of guidelines for the use of short-acting bronchodilators (SABD) in people admitted to hospital for acute exacerbation of chronic obstructive pulmonary disease (AECOPD), despite rout...

    Authors: Zoe A. Kopsaftis, Nur S. Sulaiman, Oliver D. Mountain, Kristin V. Carson-Chahhoud, Paddy A. Phillips and Brian J. Smith

    Citation: Systematic Reviews 2018 7:213

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  15. Content type: Protocol

    Studies suggest that the Patient-Centred Medical Home (PCMH) model of primary care is more effective than standard care for improving clinical outcomes in patients with chronic diseases (non-communicable disea...

    Authors: James Rufus John, Shima Ghassempour, Federico Girosi and Evan Atlantis

    Citation: Systematic Reviews 2018 7:215

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  16. Content type: Research

    The objective of the review was to synthesize evidence of barriers and facilitators to the integration of mental health services into PHC from existing literature. The structure of the review was guided by the...

    Authors: Edith K. Wakida, Zohray M. Talib, Dickens Akena, Elialilia S. Okello, Alison Kinengyere, Arnold Mindra and Celestino Obua

    Citation: Systematic Reviews 2018 7:211

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  17. Content type: Protocol

    Bariatric surgery results in substantial medical and economic benefits; however, independent studies typically report high patient preoperative attrition rates. Studies have identified individual characteristi...

    Authors: Tamasin Taylor, Ofa Dewes, Nalei Taufa, Wendy Wrapson and Richard Siegert

    Citation: Systematic Reviews 2018 7:212

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  18. Content type: Research

    There is increasing recognition that it is good practice to involve stakeholders (meaning patients, the public, health professionals and others) in systematic reviews, but limited evidence about how best to do...

    Authors: Alex Pollock, Pauline Campbell, Caroline Struthers, Anneliese Synnot, Jack Nunn, Sophie Hill, Heather Goodare, Jacqui Morris, Chris Watts and Richard Morley

    Citation: Systematic Reviews 2018 7:208

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  19. Content type: Protocol

    People living with dementia (PLWD) are admitted to hospital twice as often as those without dementia, for ambulatory care sensitive conditions (ACSC) that could have been managed in ambulatory and primary care...

    Authors: Jane V. Tehan, Anita Panayiotou, Helen Baxter, Paul Yates, Joanne Tropea and Frances Batchelor

    Citation: Systematic Reviews 2018 7:209

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  20. Content type: Protocol

    Although documentation of harm towards children and young people has existed for centuries, it was not until the 1960s that it became a specific focus for health professionals. Since that time, the importance ...

    Authors: Jan Pringle, Ross Whitehead, Dona Milne, Eileen Scott and John McAteer

    Citation: Systematic Reviews 2018 7:207

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  21. Content type: Protocol

    In the long term, smoking cessation can decrease the risk of cancer, stroke, and heart attacks and improve overall survival. The aim of the proposed umbrella review is to summarize existing systematic reviews ...

    Authors: Alemu S. Melka, Catherine L. Chojenta, Elizabeth G. Holliday and Deborah J. Loxton

    Citation: Systematic Reviews 2018 7:210

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  22. Content type: Protocol

    Internet-based interventions are emerging as an alternative way of delivering accessible healthcare for various conditions including hearing and balance disorders. A comprehensive review regarding the evidence...

    Authors: Eldré W. Beukes, Vinaya Manchaiah, David M. Baguley, Peter M. Allen and Gerhard Andersson

    Citation: Systematic Reviews 2018 7:205

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  23. Content type: Protocol

    Older adults are more likely to access the emergency department, which suffers from overcrowding and congestion, for conditions that could potentially be treated in other settings. Older adults living in long-...

    Authors: Shannon Leduc, Peter Kelly, Venkatesh Thiruganasambandamoorthy, George Wells and Christian Vaillancourt

    Citation: Systematic Reviews 2018 7:206

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  24. Content type: Protocol

    In low- and middle-income countries (LMICs), the burden of non-communicable diseases (NCDs) is growing against an existing burden of other diseases such as HIV/AIDS. Integrated models of care can help address ...

    Authors: Jeannine Uwimana Nicol, Anke Rohwer, Taryn Young, Charlotte M Bavuma and Joerg J Meerpohl

    Citation: Systematic Reviews 2018 7:203

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  25. Content type: Research

    Treatment with anti-tuberculosis drugs may cause patients to experience serious adverse effects. Genetic factors, such as polymorphisms of CYP genes, may increase the likelihood of a patient experiencing such adv...

    Authors: Marty Richardson, Jamie Kirkham, Kerry Dwan, Derek J. Sloan, Geraint Davies and Andrea L. Jorgensen

    Citation: Systematic Reviews 2018 7:204

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  26. Content type: Protocol

    Musculoskeletal injuries (strains/sprains, contusions, dislocations, and fractures) are the most common injury sustained in a road traffic crash. They can have a long-term impact upon the ability to engage in ...

    Authors: Elise M. Gane, Charlotte L. Brakenridge, Esther J. Smits and Venerina Johnston

    Citation: Systematic Reviews 2018 7:202

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  27. Content type: Methodology

    Researchers performing systematic reviews (SRs) must carefully consider the relevance of thousands of citations retrieved from bibliographic database searches, the majority of which will be excluded later on c...

    Authors: Wichor M. Bramer, Dean Giustini, Jos Kleijnen and Oscar H. Franco

    Citation: Systematic Reviews 2018 7:200

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  28. Content type: Systematic review update

    There is scanty or inconclusive evidence on which cervical cancer screening tool is effective and suitable for human immunodeficiency virus (HIV)-seropositive women. The aim of this review was to assess, synth...

    Authors: Witness Mapanga, Brendan Girdler-Brown, Shingairai A. Feresu, Tsungai Chipato and Elvira Singh

    Citation: Systematic Reviews 2018 7:198

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  29. Content type: Research

    Universal health coverage (UHC) is a key area in post-2015 global agenda which has been incorporated as target for achieving health-related Sustainable Development Goals (SDGs). A global framework has been dev...

    Authors: K. M. Saif-Ur-Rahman, Iqbal Anwar, Md. Hasan, Shahed Hossain, Sohana Shafique, Fariha Haseen, Md. Khalequzzaman, Aminur Rahman and Shariful Islam

    Citation: Systematic Reviews 2018 7:196

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  30. Content type: Protocol

    Stroke rehabilitation aims to optimise function and reduce complications post-stroke. Rehabilitation to optimise physical function post-stroke has beneficial effects for survivors of mild to moderate stroke. H...

    Authors: Mark P. McGlinchey, Jimmy James, Christopher McKevitt, Abdel Douiri, Sarah McLachlan and Catherine M. Sackley

    Citation: Systematic Reviews 2018 7:197

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  31. Content type: Protocol

    Malaria control and prevention efforts continue to rely heavily on the use of medicines especially artemisinin agents. However, currently, the emergence of artemisinin resistance threatens this effort globally...

    Authors: Moses Ocan, Dickens Akena, Sam Nsobya, Moses R. Kamya, Richard Senono, Alison Annet Kinengyere and Ekwaro Obuku

    Citation: Systematic Reviews 2018 7:199

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  32. Content type: Research

    Pediatric type 2 diabetes mellitus (T2DM) is a relatively new disease with increasing incidence corresponding to the obesity epidemic among youth. It is important for clinicians to have access to high-quality ...

    Authors: Meha Bhatt, Ahmed Nahari, Pei-Wen Wang, Emily Kearsley, Nicole Falzone, Sondra Chen, Erin Fu, Yaanu Jeyakumar, Justyna Zukowski, Laura Banfield, Lehana Thabane and M. Constantine Samaan

    Citation: Systematic Reviews 2018 7:193

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  33. Content type: Research

    This review assesses the utility of applying an automated content analysis method to the field of mental health policy development. We considered the possibility of using the Wordscores algorithm to assess res...

    Authors: Kristel Alla, Florin Oprescu, Wayne D. Hall, Harvey A. Whiteford, Brian W. Head and Carla S. Meurk

    Citation: Systematic Reviews 2018 7:194

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  34. Content type: Protocol

    Momordica charantia Linnaeus (Cucurbitaceae) has been used traditionally as a nutritious food and as a herbal medicine for type 2 diabetes mellitus. However, human studies that investigated its glycemic control h...

    Authors: Emanuel L. Peter, Serawit Deyno, Andrew Mtewa, Félicien Mushagalusa Kasali, Prakash B. Nagendrappa, Duncan Sesaazi, Casim Umba Tolo and Patrick Engeu Ogwang

    Citation: Systematic Reviews 2018 7:192

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  35. Content type: Research

    Originator trastuzumab (Herceptin®; H) is an antibody-targeted therapy to treat patients with human epidermal growth factor receptor 2-positive (HER2+) early breast cancer (EBC). We investigated the overall su...

    Authors: Florence R. Wilson, Megan E. Coombes, Christine Brezden-Masley, Mariya Yurchenko, Quinlan Wylie, Reuben Douma, Abhishek Varu, Brian Hutton, Becky Skidmore and Chris Cameron

    Citation: Systematic Reviews 2018 7:191

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  36. Content type: Protocol

    Evidence from diverse areas of medicine (e.g., cardiovascular disease, diabetes) indicates that healthcare providers (HCPs) often do not adhere to clinical practice guidelines (CPGs) despite a clear indication...

    Authors: Joshua A. Rash, Norman Buckley, Jason W. Busse, Tavis S. Campbell, Kim Corace, Lynn Cooper, David Flusk, Alfonso Iorio, Kim L. Lavoie, Patricia A. Poulin and B. Skidmore

    Citation: Systematic Reviews 2018 7:189

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  37. Content type: Systematic review update

    Nearly 15% of pregnancies end in fatal perinatal obstetric complications including bleeding, infections, hypertension, obstructed labour and complications of abortion. Globally, an estimated 10.7 million women...

    Authors: Ayele Geleto, Catherine Chojenta, Abdulbasit Musa and Deborah Loxton

    Citation: Systematic Reviews 2018 7:183

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  38. Content type: Research

    Schools can play an important role in promoting health. However, many education policies and institutions are increasingly emphasising academic attainment targets, which appear to be diminishing the time avail...

    Authors: Tara Tancred, Sara Paparini, G. J. Melendez-Torres, James Thomas, Adam Fletcher, Rona Campbell and Chris Bonell

    Citation: Systematic Reviews 2018 7:190

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  39. Content type: Protocol

    A patent microvascular anastomosis is of paramount importance in free tissue transfer. Anastomotic coupler devices provide an alternative to technically demanding hand-sewn venous anastomosis. Various advantag...

    Authors: Timo Rodi, Alexander Geierlehner, Afshin Mosahebi, Grigorios Tanos and Justin Conrad Rosen Wormald

    Citation: Systematic Reviews 2018 7:186

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  40. Content type: Protocol

    Congenital diaphragmatic hernia is a rare and life-threatening anomaly that occurs during fetal development and results in an incomplete or incorrect formation of the diaphragm. Surgical therapy of the diaphra...

    Authors: Johannes Morche, Tim Mathes, Anja Jacobs, Barbara Pietsch, Lucas Wessel, Sabine Gruber, Edmund A. M. Neugebauer and Dawid Pieper

    Citation: Systematic Reviews 2018 7:185

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  41. Content type: Protocol

    Shoulder pain is a common problem in the general population and is responsible for prolonged periods of disability, loss of productivity, absence from work and inability to carry out household activities. Rota...

    Authors: Gemma Greenall, Andrew Carr, David Beard, Jonathan Rees, Amar Rangan, Naomi Merritt, Melina Dritsaki, Navraj S. Nagra, Mathew Baldwin, Sally Hopewell and Jonathan A. Cook

    Citation: Systematic Reviews 2018 7:187

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  42. Content type: Protocol

    Inflammatory bowel disease (IBD) is a debilitating chronic disease characterised by inflammation and ulceration of the gastrointestinal tract. It is associated with a range of debilitating symptoms and reduced...

    Authors: Sophie Elizabeth Beese, Isobel Marion Harris, David Moore and Janine Dretzke

    Citation: Systematic Reviews 2018 7:184

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  43. Content type: Research

    Visual impairment from diabetic retinopathy (DR) is an increasing global public health concern, which is preventable with screening and early treatment. Digital retinal imaging has become a preferred choice as...

    Authors: Mapa Mudiyanselage Prabhath Nishantha Piyasena, Gudlavalleti Venkata S. Murthy, Jennifer L. Y. Yip, Clare Gilbert, Tunde Peto, Iris Gordon, Suwin Hewage and Sureshkumar Kamalakannan

    Citation: Systematic Reviews 2018 7:182

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  44. Content type: Protocol

    There are growing professional expectations for nurses to engage in and develop competence in evidence-informed decision-making (EIDM) due to opportunities for improved client and community outcomes and provis...

    Authors: Emily Belita, Jennifer Yost, Janet E. Squires, Rebecca Ganann, Trish Burnett and Maureen Dobbins

    Citation: Systematic Reviews 2018 7:181

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  45. Content type: Protocol

    Parents of babies admitted to neonatal units experience an arduous emotional journey. Feelings of helplessness, fear, sadness, guilt, grief and anger are common. These feelings can lead to anxiety, depression ...

    Authors: Harriet Hunt, Rebecca Whear, Kate Boddy, Leanna Wakely, Alison Bethel, Christopher Morris, Rebecca Abbott, Susan Prosser, Andrew Collinson, Jennifer Kurinczuk and Jo Thompson-Coon

    Citation: Systematic Reviews 2018 7:179

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  46. Content type: Protocol

    Liver transplant recipients suffer many complications, but few intraoperative interventions supported by high-quality evidence have been found effective to reduce their incidence or severity. Fluid balance has...

    Authors: François Martin Carrier, Michaël Chassé, Han Ting Wang, Pierre Aslanian, Marc Bilodeau and Alexis F. Turgeon

    Citation: Systematic Reviews 2018 7:180

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