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  1. Stroke is a leading cause of death and disability worldwide. Identifying the aetiology of ischaemic stroke is essential in order to initiate appropriate and timely secondary prevention measures to reduce the r...

    Authors: Emma P. Bray, Naoimh E. McMahon, Munirah Bangee, A. Hakam Al-Khalidi, Valerio Benedetto, Umesh Chauhan, Andrew J. Clegg, Rachel F. Georgiou, Josephine Gibson, Deirdre A. Lane, Gregory Y. H. Lip, Elizabeth Lightbody, Alakendu Sekhar, Kausik Chatterjee and Caroline L. Watkins

    Citation: Systematic Reviews 2019 8:331

    Content type: Protocol

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  2. Hypertension, type 2 diabetes mellitus and cardiovascular disease are among the leading causes of mortality globally. Exercise is one of the commonly recommended interventions/preventions for hypertension, typ...

    Authors: Anupa Rijal, Emil Eik Nielsen, Bianca Hemmingsen, Dinesh Neupane, Peter Haulund Gæde, Michael Hecht Olsen and Janus Christian Jakobsen

    Citation: Systematic Reviews 2019 8:330

    Content type: Protocol

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  3. Pyrazinamide (PZA) is a key component of current and future regimens for tuberculosis (TB). Inclusion of PZA at higher doses and for longer durations may improve efficacy outcomes but must be balanced against ...

    Authors: James D. Millard, Elizabeth A. Mackay, Laura J. Bonnett and Geraint R. Davies

    Citation: Systematic Reviews 2019 8:329

    Content type: Protocol

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  4. Research shows that there are inadequate interventions in resource-limited settings that could enable women of reproductive age to access and use health services in those settings. The main objective of this s...

    Authors: Joyce T. Shatilwe and Tivani P. Mashamba-Thompson

    Citation: Systematic Reviews 2019 8:328

    Content type: Protocol

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  5. Over the past decades, there has been an increase in overweight and obesity in women of childbearing age, as well as the general population. Overweight and obesity are related to a later, increased risk of typ...

    Authors: Pernille Kjaergaard Christiansen, Mette Maria Skjøth, Mette Juel Rothmann, Christina Anne Vinter, Ronald Francis Lamont and Eva Draborg

    Citation: Systematic Reviews 2019 8:327

    Content type: Research

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  6. The use of substances is a growing concern in Ethiopia, and their impacts on younger generation have been a concern of different professionals. Even though students are at high-risk of substance abuse, there i...

    Authors: Hirbo Shore Roba, Addisu Shunu Beyene, Asnake Ararsa Irenso and Berhe Gebremichael

    Citation: Systematic Reviews 2019 8:326

    Content type: Research

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  7. Living systematic reviews (LSRs) offer an approach to keeping high-quality evidence synthesis continually up to date, so the most recent, relevant and reliable evidence can be used to inform policy and practic...

    Authors: Tanya Millard, Anneliese Synnot, Julian Elliott, Sally Green, Steve McDonald and Tari Turner

    Citation: Systematic Reviews 2019 8:325

    Content type: Research

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  8. Fatigue is a common symptom in cancer patients that can persist beyond the curative treatment phase. This systematic review evaluated the effectiveness of psychological interventions for cancer-related fatigue...

    Authors: T. K. Corbett, A. Groarke, D. Devane, E. Carr, J. C. Walsh and B. E. McGuire

    Citation: Systematic Reviews 2019 8:324

    Content type: Research

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  9. Severe acute malnutrition affects more than 20 million children. Africa is pointed out as a region where the problem is highly prevalent. There were individual studies on the recovery rate and its determinants...

    Authors: Kassahun Gebeyehu Yazew, Chanyalew Worku Kassahun, Amare Wondim Ewnetie, Habtamu Kerebih Mekonen and Endalamaw Salilew Abagez

    Citation: Systematic Reviews 2019 8:323

    Content type: Systematic review update

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  10. Over the past decade, mesenchymal stromal cells have been increasingly investigated for their therapeutic potential in several different illnesses. However, cell therapy can be limited by potentially serious a...

    Authors: Alvin Tieu, Mitchell Slobodian, Dean A. Fergusson, Joshua Montroy, Dylan Burger, Duncan J. Stewart, Risa Shorr, David S. Allan and Manoj M. Lalu

    Citation: Systematic Reviews 2019 8:322

    Content type: Protocol

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  11. Trastuzumab is a monoclonal antibody for patients with HER2 (human epidermal growth factor receptor 2)-positive breast cancer, which is added to regular treatment and reduces mortality. Originally, trastuzumab...

    Authors: Miriam Van den Nest, Anna Glechner, Maria Gold and Gerald Gartlehner

    Citation: Systematic Reviews 2019 8:321

    Content type: Research

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  12. There has been increased interest in the role of cannabis for treating medical conditions. The availability of different cannabis-based products can make the side effects of exposure unpredictable. We sought t...

    Authors: Misty Pratt, Adrienne Stevens, Micere Thuku, Claire Butler, Becky Skidmore, L. Susan Wieland, Mark Clemons, Salmaan Kanji and Brian Hutton

    Citation: Systematic Reviews 2019 8:320

    Content type: Research

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  13. The World Health Organization describes the perpetuation of human rights violations against people with mental health problems as a global emergency. Despite this observation, recent studies suggest that coerc...

    Authors: Pierre Pariseau-Legault, Sandrine Vallée-Ouimet, Marie-Hélène Goulet and Jean-Daniel Jacob

    Citation: Systematic Reviews 2019 8:318

    Content type: Protocol

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  14. The growing number of medical literature and textual data in online repositories led to an exponential increase in the workload of researchers involved in citation screening for systematic reviews. This work a...

    Authors: Corrado Lanera, Paola Berchialla, Abhinav Sharma, Clara Minto, Dario Gregori and Ileana Baldi

    Citation: Systematic Reviews 2019 8:317

    Content type: Methodology

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  15. The global prevalence of people living with dementia is expected to increase exponentially and yet evidence suggests gaps in dementia-specific knowledge amongst practitioners. Evidence-based learning approache...

    Authors: Kevin Muirhead, Leah Macaden, Charlotte Clarke, Keith Smyth, Rob Polson and Chris O’Malley

    Citation: Systematic Reviews 2019 8:316

    Content type: Protocol

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  16. Emergency and disaster are on the rise in the world. One of the most important components of disaster risk management is the early warning system. Studies have shown divergent models of warning systems with di...

    Authors: Hamid Reza Khankeh, Seyed Hossein Hosseini, Mehrdad Farrokhi, Mohammad Ali Hosseini and Nasir Amanat

    Citation: Systematic Reviews 2019 8:315

    Content type: Protocol

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  17. To meet global targets for the treatment of HIV, high-prevalence countries are launching or expanding differentiated models of service delivery (DSD) for antiretroviral therapy (ART). Ongoing studies report on...

    Authors: Lawrence Long, Salome Kuchukhidze, Sophie Pascoe, Brooke Nichols, Refiloe Cele, Caroline Govathson, Amy Huber, David Flynn and Sydney Rosen

    Citation: Systematic Reviews 2019 8:314

    Content type: Protocol

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  18. Smoking remains a major public health concern. School-based social networks influence uptake of smoking among peers. During the past two decades, the UK macro-systemic context within which schools are nested a...

    Authors: H. J. Littlecott, J. Hawkins, M. Mann, G. J. Melendez-Torres, F. Dobbie and G. Moore

    Citation: Systematic Reviews 2019 8:313

    Content type: Protocol

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  19. Intimate partner violence among young women continues to be a worldwide concern. Globally, a considerable number of studies reported numerous factors that influence intimate partner violence among the young. T...

    Authors: Maria Suzana B. Maguele and Nelisiwe Khuzwayo

    Citation: Systematic Reviews 2019 8:312

    Content type: Protocol

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  20. Mechanically ventilated patients in the intensive care unit (ICU) experience profound communication impairment, placing them at risk for poor physical and psychological outcomes. Patient communication strategi...

    Authors: Laura Istanboulian, Louise Rose, Yana Yunusova, Franklin Gorospe and Craig Dale

    Citation: Systematic Reviews 2019 8:311

    Content type: Protocol

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  21. Type 2 diabetes mellitus (T2DM) is a worldwide epidemic, and while its etiology is polygenic, the role of environmental contaminant exposure in T2DM pathogenesis is of increasing importance. However, the evide...

    Authors: Julia Hildebrand, Swarni Thakar, Tonya-Leah Watts, Laura Banfield, Lehana Thabane, Joseph Macri, Stephen Hill and M. Constantine Samaan

    Citation: Systematic Reviews 2019 8:309

    Content type: Protocol

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  22. Metabolic syndrome (MetS) is defined as an accumulation of risk factors that include chronic hypertension, dyslipidaemia, insulin resistance and obesity and leads to an increased risk for diabetes, cardiovascu...

    Authors: Philip Norris, Bianca Viljoen, Nicholas Ralph, Jeff Gow and Natalie Silvey

    Citation: Systematic Reviews 2019 8:308

    Content type: Protocol

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  23. There is a widespread belief that information technologies will improve diagnosis, treatment and care. Evidence about their effectiveness in health care is, however, mixed. It is not clear why this is the case...

    Authors: Justin Keen, Joanne Greenhalgh, Rebecca Randell, Peter Gardner, Justin Waring, Roberta Longo, Jon Fistein, Maysam Abdulwahid, Natalie King and Judy Wright

    Citation: Systematic Reviews 2019 8:307

    Content type: Protocol

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  24. Sepsis is a major cause of morbidity and mortality among neonates and infants. Antibiotics are a central part of the first line treatment for sepsis in neonatal intensive care units worldwide. However, the evi...

    Authors: Steven Kwasi Korang, Sanam Safi, Christian Gluud, Ulrik Lausten-Thomsen and Janus C. Jakobsen

    Citation: Systematic Reviews 2019 8:306

    Content type: Protocol

    Published on:

  25. Practitioner-level implementation interventions such as audit and feedback, communities of practice, and local opinion leaders have shown potential to change nurses’ behaviour in clinical practice and improve ...

    Authors: Guillaume Fontaine, Sylvie Cossette, Marc-André Maheu-Cadotte, Marie-France Deschênes, Geneviève Rouleau, Andréane Lavallée, Catherine Pépin, Ariane Ballard, Gabrielle Chicoine, Alexandra Lapierre, Patrick Lavoie, Jérémie Blondin and Tanya Mailhot

    Citation: Systematic Reviews 2019 8:305

    Content type: Protocol

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  26. Antibiotic resistance is a global public health threat. Water from human activities is collected at wastewater treatment plants where processes often do not sufficiently neutralize antibiotic resistant bacteri...

    Authors: Daloha Rodríguez-Molina, Petra Mang, Heike Schmitt, Mariana Carmen Chifiriuc, Katja Radon and Laura Wengenroth

    Citation: Systematic Reviews 2019 8:304

    Content type: Protocol

    Published on:

  27. Physical inactivity is the fourth leading risk factor for global mortality. Reducing sedentary behaviour and increasing physical activity are efficacious for improving many physical and mental health condition...

    Authors: Jean-Pierre Laake and Joanna Fleming

    Citation: Systematic Reviews 2019 8:303

    Content type: Protocol

    Published on:

  28. Chinese herbal medicines (CHMs) are the major interventions of traditional Chinese medicine (TCM), which are typically administered as either single herbs or formulas. The Cochrane systematic reviews (SRs) of ...

    Authors: Xuan Zhang, Qi-Ying Aixinjueluo, Si-Yao Li, Lisa-L Song, Chung-Tai Lau, Ran Tan and Zhao-Xiang Bian

    Citation: Systematic Reviews 2019 8:302

    Content type: Research

    Published on:

  29. In the U.S., Hispanic women experience a disproportionate rate of obesity and obesity-related chronic diseases. At the same time, Hispanic women remain considerably underrepresented in behavioral weight loss i...

    Authors: Kristin E. Morrill, Melissa Lopez-Pentecost, Guadalupe Ballesteros, Jeanne L. Pfander, Melanie D. Hingle, Yann C. Klimentidis, Cynthia A. Thomson and David O. Garcia

    Citation: Systematic Reviews 2019 8:301

    Content type: Protocol

    Published on:

  30. Fathers are under-represented in research and programs addressing early childhood health and development. Recruiting fathers into these interventions can be hampered for multiple reasons, including recruitment...

    Authors: Elizabeth M. Keys, Jill M. Norris, Emily E. Cameron, Katherine S. Bright, Lianne M. Tomfohr-Madsen and Karen M. Benzies

    Citation: Systematic Reviews 2019 8:300

    Content type: Protocol

    Published on:

  31. Opioid agonist maintenance treatment (OAMT) is a first-line treatment for heroin dependence, but its effectiveness has been assessed primarily through clinical outcomes with a limited attention to patient pers...

    Authors: Ivan Solà, Joan Trujols, Elisa Ribalta, Saul Alcaraz, Gemma Robleda, Clara Selva Olid and José Pérez de los Cobos

    Citation: Systematic Reviews 2019 8:299

    Content type: Protocol

    Published on:

  32. The present protocol was designed for a systematic review and meta-analysis aimed at determining the association of telomere length with substance use disorders with the exclusion of nicotine addiction, and to...

    Authors: Fernando Navarro-Mateu, María Rubio-Aparicio, Pedro Cayuela, Francisco-Javier Álvarez, Agustín Roca-Vega, María Dolores Chirlaque, María Luisa Cayuela, Mathilde Husky, Salvador Martínez and Julio Sánchez-Meca

    Citation: Systematic Reviews 2019 8:298

    Content type: Protocol

    Published on:

  33. Prevention of antenatal and postnatal depression is crucial, given its high prevalence and severe consequences. Although several systematic reviews and meta-analyses have examined the effects of psychological ...

    Authors: Naonori Yasuma, Zui Narita, Natsu Sasaki, Erika Obikane, Junpei Sekiya, Takuma Inagawa, Aiichiro Nakajima, Yuji Yamada, Ryuichi Yamazaki, Asami Matsunaga, Tomomi Saito, Kazuhiro Watanabe, Kotaro Imamura, Norito Kawakami and Daisuke Nishi

    Citation: Systematic Reviews 2019 8:297

    Content type: Protocol

    Published on:

  34. Active school travel by bike may provide appropriate means to promote physical activity through commuting to and from school, expanding the mobility during leisure time, and integrating a lifelong positive beh...

    Authors: Dorothea M. I. Schönbach, Teatske M. Altenburg, Mai J. M. Chinapaw, Adilson Marques and Yolanda Demetriou

    Citation: Systematic Reviews 2019 8:296

    Content type: Protocol

    Published on:

  35. A healthy and productive health workforce is central to a well-functioning health system. However, health workers are at high risk of poor psychological wellbeing due to their particularly strenuous work deman...

    Authors: Julia Lohmann, Denny John and Aso Dzay

    Citation: Systematic Reviews 2019 8:294

    Content type: Protocol

    Published on:

  36. Exosomes may have critical roles in the maternal-embryo cross-talk for the recognition and maintenance of pregnancy during maternal aging. Exosomes have the capability to carry developmental signaling molecule...

    Authors: Halimeh Mobarak, Reza Rahbarghazi, Francesca Lolicato, Mohammad Heidarpour, Fariba Pashazadeh, Mohammad Nouri and Mahdi Mahdipour

    Citation: Systematic Reviews 2019 8:293

    Content type: Protocol

    Published on:

  37. The implementation of trauma systems in many high-income countries over the last 50 years has led to important reductions in injury mortality and disability in many healthcare jurisdictions. Injury organizatio...

    Authors: Brice Batomen, Lynne Moore, Mabel Carabali, Pier-Alexandre Tardif, Howard Champion and Arijit Nandi

    Citation: Systematic Reviews 2019 8:292

    Content type: Protocol

    Published on:

  38. Nutritional therapy practice guidelines are designed to improve nutritional practices and thus the delivery of nutritional therapy in critically ill patients. However, they are not implemented despite the stro...

    Authors: Nomaxabiso M. Mooi and Busisiwe P. Ncama

    Citation: Systematic Reviews 2019 8:291

    Content type: Protocol

    Published on:

  39. Childhood adiposity has increased dramatically in the last few decades and is an important predictor of adulthood chronic disease. Later eating rhythm, termed night eating (NE), is increasingly prevalent in ad...

    Authors: Mengxuan Zou, Kate Northstone, Rachel Perry, Laura Johnson and Sam Leary

    Citation: Systematic Reviews 2019 8:290

    Content type: Protocol

    Published on:

  40. Since the deinstitutionalization policy, in psychiatric hospitals, the care of patients with schizophrenia was left to their families which has been imposing a heavy burden on them. Family caregiver burden cou...

    Authors: Zahra Tamizi, Masoud Fallahi-Khoshknab, Asghar Dalvandi, Farahnaz Mohammadi-Shahboulaghi, Eesa Mohammadi and Enayatollah Bakhshi

    Citation: Systematic Reviews 2019 8:289

    Content type: Protocol

    Published on:

  41. Obesity and its consequences are worldwide epidemic problem; therefore, studies with strategies and mechanisms that favor weight loss to improve outcomes in health are necessary. Effects of mushrooms on body w...

    Authors: Denise Grotto, Isabella Ferreira Camargo, Katia Kodaira, Lauren Giustti Mazzei, Juliana Castro, Raquel Andrade Leite Vieira, Cristiane de Cásia Bergamaschi and Luciane Cruz Lopes

    Citation: Systematic Reviews 2019 8:288

    Content type: Protocol

    Published on:

  42. Inflammation in anterior uveitis is characterised by breakdown of the blood-ocular barrier, which allows leakage of blood constituents of higher molecular weight into the aqueous humour. In routine clinical ca...

    Authors: Thomas W. McNally, Xiaoxuan Liu, Sophie Beese, Pearse A. Keane, David J. Moore and Alastair K. Denniston

    Citation: Systematic Reviews 2019 8:287

    Content type: Protocol

    Published on:

  43. Despite advances in resuscitation care, mortality rates following cardiac arrest (CA) remain high. Between one-quarter (in-hospital CA) and two-thirds (out of hospital CA) of patients admitted comatose to inte...

    Authors: Alex Monk and Shashank Patil

    Citation: Systematic Reviews 2019 8:286

    Content type: Protocol

    Published on:

  44. Despite existing best practice care recommendations for addressing tobacco smoking, alcohol consumption and weight management in preconception and antenatal care, such recommendations are often not implemented...

    Authors: Emma Doherty, Melanie Kingsland, Luke Wolfenden, John Wiggers, Julia Dray, Jenna Hollis, Elizabeth J. Elliott, Justine B. Daly, Kylie A. Bailey, John Attia, Mandy Hunter, Ian Symonds, Belinda Tully, Danika Tremain and Rebecca K. Hodder

    Citation: Systematic Reviews 2019 8:285

    Content type: Protocol

    Published on:

  45. Obsessive-compulsive disorder (OCD) is a chronic mental health disorder characterized by recurring obsessions and compulsions affecting 1–3% of children and adolescents. Current treatment options are limited b...

    Authors: Lucía Babiano-Espinosa, Lidewij H. Wolters, Bernhard Weidle, Vivian op de Beek, Sindre A. Pedersen, Scott Compton and Norbert Skokauskas

    Citation: Systematic Reviews 2019 8:284

    Content type: Research

    Published on:

  46. Oropharyngeal dysphagia or swallowing difficulties are common in acute care and critical care, affecting 47% of hospitalised frail elderly, 50% of acute stroke patients and approximately 62% of critically ill ...

    Authors: Sallyanne Duncan, Jennifer Mc Gaughey, Richard Fallis, Daniel F. McAuley, Margaret Walshe and Bronagh Blackwood

    Citation: Systematic Reviews 2019 8:283

    Content type: Protocol

    Published on:

  47. The relative scale adjusts for baseline variability and therefore may lead to findings that can be generalized more widely. It is routinely used for the analysis of binary outcomes but only rarely for continuo...

    Authors: Harri Hemilä and Jan O. Friedrich

    Citation: Systematic Reviews 2019 8:282

    Content type: Methodology

    Published on:

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