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  1. Tuberculosis (TB) is still one of the leading causes of death worldwide. Genetic studies have pointed to the relevance of the NOD2 and CD14 polymorphic alleles in association with the risk of diseases caused by M...

    Authors: Juan M. Cubillos-Angulo, Catarina D. Fernandes, Davi N. Araújo, Cristinna A. Carmo, María B. Arriaga and Bruno B. Andrade

    Citation: Systematic Reviews 2021 10:174

    Content type: Research

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  2. Current clinical guidelines recommend conservative management including non-pharmacologic therapy prior to considering surgery for knee OA. There is a paucity of clinical trials investigating the use of biomec...

    Authors: Michael J. Callaghan, Elizabeth Palmer and Terence O’Neill

    Citation: Systematic Reviews 2021 10:173

    Content type: Research

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  3. Utilization of post-abortion family planning is very critical to reduce high levels of unintended pregnancy, which is the root cause of induced abortion. In Eastern Africa, it is estimated that as many as 95% ...

    Authors: Asmamaw Demis Bizuneh and Getnet Gedefaw Azeze

    Citation: Systematic Reviews 2021 10:172

    Content type: Research

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  4. Major depression significantly impairs quality of life, increases the risk of suicide, and poses tremendous economic burden on individuals and societies. Duloxetine, a serotonin norepinephrine reuptake inhibit...

    Authors: Faiza Siddiqui, Marija Barbateskovic, Sophie Juul, Kiran Kumar Katakam, Klaus Munkholm, Christian Gluud and Janus Christian Jakobsen

    Citation: Systematic Reviews 2021 10:171

    Content type: Protocol

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  5. Substantial literature has highlighted the importance of patient-reported outcome and experience measures (PROMs and PREMs, respectively) to collect clinically relevant information to better understand and add...

    Authors: Angela C. Wolff, Andrea Dresselhuis, Samar Hejazi, Duncan Dixon, Deborah Gibson, A. Fuchsia Howard, Sarah Liva, Barbara Astle, Sheryl Reimer-Kirkham, Vanessa K. Noonan and Lisa Edwards

    Citation: Systematic Reviews 2021 10:169

    Content type: Protocol

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  6. Cancer diagnosis in childhood or adolescence impacts significantly on school attendance, experience and educational outcomes. While there is longstanding recognition in clinical practice that these effects spa...

    Authors: Gemma Bryan, Paula Kelly, Heather Chesters, Jayne Franklin, Helen Griffiths, Loveday Langton, Luke Langton, Claire E. Wakefield and Faith Gibson

    Citation: Systematic Reviews 2021 10:167

    Content type: Protocol

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  7. Sleep disturbances constitute a common complication in pediatric cancer patients and survivors and are frequently severe enough to warrant treatment. Suboptimal sleep has been associated with decreased emotion...

    Authors: Peter L. Stavinoha, Ineke M. Olsthoorn, Maria C. Swartz, Sara Nowakowski, Stephanie J. Wells, Rachel S. Hicklen, Irtiza Sheikh and Hannah J. Jang

    Citation: Systematic Reviews 2021 10:166

    Content type: Protocol

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  8. People with intellectual disabilities have been historically excluded from decision-making processes. Previous literature indicates that increasing social participation may be an effective way to address this ...

    Authors: Andrés Aparicio, Paulina Arango, Rosario Espinoza, Vicente Villate and Marcela Tenorio

    Citation: Systematic Reviews 2021 10:165

    Content type: Protocol

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  9. Health systems are often fragmented in low- and middle-income countries (LMICs). This can increase inefficiencies and restrict progress towards universal health coverage. The objective of the systematic review...

    Authors: Marina Siqueira, Maíra Coube, Christopher Millett, Rudi Rocha and Thomas Hone

    Citation: Systematic Reviews 2021 10:164

    Content type: Protocol

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  10. Hyperhidrosis is a chronic skin condition that impairs the patient’s quality of life (QoL). There are several patient-reported outcome measures (PROMs) for patients affected by hyperhidrosis available; however...

    Authors: Michaela Gabes, Helge Knüttel and Christian J. Apfelbacher

    Citation: Systematic Reviews 2021 10:163

    Content type: Protocol

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  11. Building a dataset of individual participant data (IPD) for meta-analysis represents considerable research investment as well as collaboration across multiple institutions and researchers. Making arrangements ...

    Authors: Nancy Medley, Anna Cuthbert, Richard Crew, Lesley Stewart, Catrin Tudur Smith and Zarko Alfirevic

    Citation: Systematic Reviews 2021 10:162

    Content type: Commentary

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  12. Due to the diversity of studies in animal models reporting that molecular mechanisms are involved in the teratogenic effect of the Zika virus (ZIKV), the objective of the present study is to evaluate the metho...

    Authors: Gabriela Elis Wachholz, Julia do Amaral Gomes, Juliano André Boquett, Fernanda Sales Luiz Vianna, Lavínia Schuler-Faccini and Lucas Rosa Fraga

    Citation: Systematic Reviews 2021 10:160

    Content type: Protocol

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  13. The prevalence of epilepsy in pregnant women is estimated at 0.3-1%. Anti-epileptic drug (AED) exposure in-utero has been associated with various adverse health outcomes in neonates, including adverse birth we...

    Authors: Alekhya Lavu, Christine Vaccaro, Walid Shouman, Silvia Alessi Severini and Sherif Eltonsy

    Citation: Systematic Reviews 2021 10:159

    Content type: Protocol

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  14. The overuse of prescribed antimicrobials, concurrent use of traditional medicine, and prescribed antimicrobials have led to antimicrobial resistance. The absence of collaboration between traditional health pra...

    Authors: Aganze Gloire-Aimé Mushebenge, Mukanda Gedeon Kadima, Tivani Mashamba-Thompson and Manimbulu Nlooto

    Citation: Systematic Reviews 2021 10:158

    Content type: Protocol

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  15. Dzherelo (Immunoxel) is one of the few approved immunomodulators that has been shown to produce positive treatment outcomes in patients with tuberculosis (TB). The aim of this review was to assess the effectiv...

    Authors: Marcel Kitenge, Bessie Phiri, Sara M. Pheeha, Modupe Ogunrombi and Peter S. Nyasulu

    Citation: Systematic Reviews 2021 10:157

    Content type: Research

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  16. Current text mining tools supporting abstract screening in systematic reviews are not widely used, in part because they lack sensitivity and precision. We set out to develop an accessible, semi-automated “work...

    Authors: Ba’ Pham, Jelena Jovanovic, Ebrahim Bagheri, Jesmin Antony, Huda Ashoor, Tam T. Nguyen, Patricia Rios, Reid Robson, Sonia M. Thomas, Jennifer Watt, Sharon E. Straus and Andrea C. Tricco

    Citation: Systematic Reviews 2021 10:156

    Content type: Research

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  17. Serological testing based on different antibody types are an alternative method being used to diagnose SARS-CoV-2 and has the potential of having higher diagnostic accuracy compared to the current gold standar...

    Authors: Arthur Vengesai, Herald Midzi, Maritha Kasambala, Hamlet Mutandadzi, Tariro L. Mduluza-Jokonya, Simbarashe Rusakaniko, Francisca Mutapi, Thajasvarie Naicker and Takafira Mduluza

    Citation: Systematic Reviews 2021 10:155

    Content type: Research

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  18. Major depressive disorder is one of the most common, burdensome, and costly psychiatric disorders worldwide. Antidepressants are frequently used to treat major depressive disorder. It has been shown repeatedly...

    Authors: Sophie Juul, Faiza Siddiqui, Marija Barbateskovic, Caroline Kamp Jørgensen, Michael Pascal Hengartner, Irving Kirsch, Christian Gluud and Janus Christian Jakobsen

    Citation: Systematic Reviews 2021 10:154

    Content type: Protocol

    Published on:

  19. Ageing is a global and universal process that results in physiological, psychological and behavioural changes. Due to the changing needs of the individual and the circumstances of the family, long-term care of...

    Authors: Letasha Kalideen, Pragashnie Govender, Jacqueline Marina van Wyk and Desmond Kuupiel

    Citation: Systematic Reviews 2021 10:153

    Content type: Protocol

    Published on:

  20. Preterm birth (PTB) is estimated to affect 14.9 million babies globally every year. Global rates of PTB continue to increase from 9.8 to 10.6% over a 15-year period from 2000 to 2014. Vaginal progesterone is c...

    Authors: Kimberley P. Williams, Liam McAuliffe, Rosanna Diacci, Anne-Marie Aubin, Ashad Issah, Carol Wang, Jason Phung and Craig E. Pennell

    Citation: Systematic Reviews 2021 10:152

    Content type: Protocol

    Published on:

  21. Corneal transplantation is the most frequently performed transplantation in the UK. Despite this, the therapeutic value of matching human leukocyte antigen (HLA) subtypes for transplanted corneas remains contr...

    Authors: Gagandeep Singh Sachdeva, Joshua Piollo Cabada, Syed Saad Karim, Dmitry Lakvin Kahandawa, Kevin Anil Thomas, Anusha Kumar, Robert J. Barry and Gibran Farook Butt

    Citation: Systematic Reviews 2021 10:150

    Content type: Protocol

    Published on:

  22. Osteoarthritis is the most common degenerative joint disease. It is associated with significant socioeconomic burden and poor quality of life, mainly due to knee osteoarthritis (KOA), and related total knee ar...

    Authors: Jingyu Zhong, Liping Si, Guangcheng Zhang, Jiayu Huo, Yue Xing, Yangfan Hu, Huan Zhang and Weiwu Yao

    Citation: Systematic Reviews 2021 10:149

    Content type: Protocol

    Published on:

  23. Venous leg ulcers (VLUs) are chronic wounds characterized by slow healing and high recurrence. Information on prevalence and incidence is essential for ascertaining the burden of VLU on the health care system ...

    Authors: S. Probst, C. D. Weller, P. Bobbink, C. Saini, M. Pugliese, Monika Buehrer Skinner and G. Gethin

    Citation: Systematic Reviews 2021 10:148

    Content type: Protocol

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  24. Adolescent multiple risk behaviour (MRB) continues to be a global health issue. Most interventions have focused on the proximal causes of adolescent MRB such as peer or family influence, rather than targeting ...

    Authors: Laura Tinner, Deborah Caldwell and Rona Campbell

    Citation: Systematic Reviews 2021 10:147

    Content type: Protocol

    Published on:

    The Correction to this article has been published in Systematic Reviews 2021 10:168

  25. An intestinal ostomy is an artificial bowel opening created on the skin. Procedure-related mortality is extremely rare. However, the presence of an ostomy may be associated with significant morbidity. Complica...

    Authors: Charlotte Mareike Kugler, Jessica Breuing, Tanja Rombey, Simone Hess, Peter Ambe, Erich Grohmann and Dawid Pieper

    Citation: Systematic Reviews 2021 10:146

    Content type: Protocol

    Published on:

  26. The use of minimally and non-invasive monitoring systems (including continuous glucose monitoring) has increased rapidly over recent years. Up to now, it remains unclear how accurate devices can detect hypogly...

    Authors: Nicole Lindner, Aya Kuwabara and Tim Holt

    Citation: Systematic Reviews 2021 10:145

    Content type: Research

    Published on:

  27. Nephrotic syndrome is the most common kidney disease in children worldwide. Our aim was to critically appraise the quality of recent Clinical Practice Guidelines (CPGs) for idiopathic steroid-sensitive nephrot...

    Authors: Khalid Abdulaziz Alhasan, Reem Al Khalifah, Majed Aloufi, Weiam Almaiman, Muddathir Hamad, Naif Abdulmajeed, Abdullah Al Salloum, Jameela A. Kari, Muneera AlJelaify, Rolan K. Bassrawi, Turki Al Hussain, Adi Alherbish, Abdulhadi Al Talhi, Mohamad-Hani Temsah, Sidharth Kumar Sethi, Rupesh Raina…

    Citation: Systematic Reviews 2021 10:144

    Content type: Research

    Published on:

  28. Coronavirus disease 2019 (COVID-19) has no confirmed specific treatments. However, there might be in vitro and early clinical data as well as evidence from severe acute respiratory syndrome and Middle Eastern ...

    Authors: Benjamin P. Geisler, Lara Zahabi, Adam Edward Lang, Naomi Eastwood, Elaine Tennant, Ljiljana Lukic, Elad Sharon, Hai-Hua Chuang, Chang-Berm Kang, Knakita Clayton-Johnson, Ahmed Aljaberi, Haining Yu, Chinh Bui, Tuan Le Mau, Wen-Cheng Li, Debbie Teodorescu…

    Citation: Systematic Reviews 2021 10:143

    Content type: Protocol

    Published on:

  29. Reducing child health inequalities is a global health priority and evidence suggests that optimal development of knowledge, skills and attributes in early childhood could reduce health risks across the life co...

    Authors: Michelle Black, Amy Barnes, Mark Strong and David Taylor-Robinson

    Citation: Systematic Reviews 2021 10:142

    Content type: Protocol

    Published on:

  30. Eczematous skin diseases, e.g., atopic dermatitis or contact dermatitis, are associated with a high disease burden, a significant impact on quality of life and a higher risk for anxiety and depression. Therefo...

    Authors: Marc Rocholl, Michaela Ludewig, Carola Brakemeier, Swen Malte John and Annika Wilke

    Citation: Systematic Reviews 2021 10:141

    Content type: Research

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  31. The world has changed dramatically since the beginning of 2020 due to COVID-19. As a result of the pandemic, many older adults are now experiencing an increased and unprecedented amount of psychological stress...

    Authors: Ryan Churchill, Indira Riadi, Lucy Kervin, Kelly Teo and Theodore Cosco

    Citation: Systematic Reviews 2021 10:140

    Content type: Protocol

    Published on:

  32. Patch angioplasty in conventional carotid endarterectomy is suggested to reduce the risk of restenosis and recurrent ipsilateral stroke compared with primary closure. A systematic review of randomized clinical...

    Authors: Martijn S. Marsman, Jørn Wetterslev, Abdelkarime Kh. Jahrome, Christian Gluud, Frans L. Moll, Frederik Keus and Giel G. Koning

    Citation: Systematic Reviews 2021 10:139

    Content type: Systematic review update

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  33. With the burden of prostate cancer, it has become imperative to exploit cost-effective ways to tackle this menace. Women have demonstrated their ability to recognize early cancer signs, and it is, therefore, r...

    Authors: Ebenezer Wiafe, Kofi Boamah Mensah, Adwoa Bemah Boamah Mensah, Varsha Bangalee and Frasia Oosthuizen

    Citation: Systematic Reviews 2021 10:138

    Content type: Research

    Published on:

  34. Female sex workers are extremely vulnerable and highly susceptible to being infected with human immunodeficiency virus. As a result, community-based targeted interventions have been recommended as one of the m...

    Authors: Lydia Atuhaire, Olatunji Adetokunboh, Constance Shumba and Peter S. Nyasulu

    Citation: Systematic Reviews 2021 10:137

    Content type: Research

    Published on:

  35. In nursing students, high stress levels can lead to burnout, anxiety, and depression. Our objective is to characterize the epidemiology of perceived stress, stressors, and coping strategies among nursing stude...

    Authors: Sonia Chaabane, Karima Chaabna, Sapna Bhagat, Amit Abraham, Sathyanarayanan Doraiswamy, Ravinder Mamtani and Sohaila Cheema

    Citation: Systematic Reviews 2021 10:136

    Content type: Research

    Published on:

  36. Despite prophylactic human papillomavirus (HPV) vaccination being a safe, effective and cost-effective public health intervention for the prevention of cervical cancer, the HPV vaccine is not actively recommen...

    Authors: Matthew Palmer, Kota Katanoda, Eiko Saito, Cecilia Acuti Martellucci, Shiori Ostuki, Shuhei Nomura, Erika Ota, Julia M. L. Brotherton and Jane Hocking

    Citation: Systematic Reviews 2021 10:135

    Content type: Protocol

    Published on:

  37. Countries around the world have committed in policy to transforming their mental health services towards a recovery orientation. How has mental health recovery been implemented into services for adults, and wh...

    Authors: Myra Piat, Megan Wainwright, Eleni Sofouli, Brigitte Vachon, Tania Deslauriers, Cassandra Préfontaine and Francesca Frati

    Citation: Systematic Reviews 2021 10:134

    Content type: Research

    Published on:

  38. Indigenous young people worldwide are at greater risk of developing mental health concerns due to ongoing inequity and disadvantage. Digital mental health (dMH) interventions are identified as a potential appr...

    Authors: Josie Povey, Buaphrao Raphiphatthana, Michelle Torok, Tricia Nagel, Fiona Shand, Michelle Sweet, Anne Lowell, Patj Patj Janama Robert Mills and Kylie Dingwall

    Citation: Systematic Reviews 2021 10:133

    Content type: Protocol

    Published on:

  39. We aimed to synthesise data on issues related to stakeholder perceptions of consent for the use of secondary data. To better understand the current literature available, we conducted a systematic literature re...

    Authors: Elizabeth Hutchings, Max Loomes, Phyllis Butow and Frances M. Boyle

    Citation: Systematic Reviews 2021 10:132

    Content type: Research

    Published on:

  40. Preterm birth (PTB) is the leading cause of death in children under five years. Spontaneous preterm birth (SPTB) is the major cause of preterm delivery. The key risk factors for SPTB are women who have a short...

    Authors: Ashad Issah, Rosanna Diacci, Kimberley P. Williams, Anne-Marie Aubin, Liam McAuliffe, Jason Phung, Carol Wang, Panos Maouris and Craig E. Pennell

    Citation: Systematic Reviews 2021 10:130

    Content type: Protocol

    Published on:

  41. Physical restraint (PR) is a routine care measure in many hospital wards to ensure patient safety. However, it is associated with many different professional, legal, and ethical challenges. Some guidelines and...

    Authors: Azam Sharifi, Narges Arsalani, Masoud Fallahi-Khoshknab and Farahnaz Mohammadi-Shahbolaghi

    Citation: Systematic Reviews 2021 10:129

    Content type: Research

    Published on:

  42. There is growing interest in the use of routine patient-reported outcome measures (PROMs) to influence the care of individual patients with stroke. However, there are significant gaps in our understanding as t...

    Authors: A. Smith, J. Hewitt, T. J. Quinn and M. Robling

    Citation: Systematic Reviews 2021 10:128

    Content type: Protocol

    Published on:

  43. Massage is a popularly used complementary and alternative therapy. Previous randomised controlled trials have examined the effects of massage on children, and several systematic reviews have been conducted to ...

    Authors: Shu-Cheng Chen, Juan Yu, Sam Chun-Sum Yuen, Jason Chun-Sing Lam, Lorna Kwai-Ping Suen and Wing-Fai Yeung

    Citation: Systematic Reviews 2021 10:127

    Content type: Protocol

    Published on:

  44. Public safety personnel and frontline healthcare professionals are at increased risk of exposure to potentially psychologically traumatic events (PPTE) and developing posttraumatic stress injuries (PTSI, e.g.,...

    Authors: Paula M. Di Nota, Anees Bahji, Dianne Groll, R. Nicholas Carleton and Gregory S. Anderson

    Citation: Systematic Reviews 2021 10:126

    Content type: Research

    Published on:

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