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  1. Systematic review is an indispensable tool for optimal evidence collection and evaluation in evidence-based medicine. However, the explosive increase of the original literatures makes it difficult to accomplis...

    Authors: Yuelun Zhang, Siyu Liang, Yunying Feng, Qing Wang, Feng Sun, Shi Chen, Yiying Yang, Xin He, Huijuan Zhu and Hui Pan

    Citation: Systematic Reviews 2022 11:11

    Content type: Protocol

    Published on:

  2. Complementary and Alternative Medicine (CAM) has gained popularity among the general population, but its acceptance and use among medical specialists have been inconclusive. This systematic review aimed to ide...

    Authors: Phanupong Phutrakool and Krit Pongpirul

    Citation: Systematic Reviews 2022 11:10

    Content type: Research

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  3. In recent decades, the literature on Social Network Analysis and health has experienced a significant increase. Disease transmission, health behavior, organizational networks, social capital, and social suppor...

    Authors: Rosario Fernández-Peña, María-Antonia Ovalle-Perandones, Pilar Marqués-Sánchez, Carmen Ortego-Maté and Nestor Serrano-Fuentes

    Citation: Systematic Reviews 2022 11:9

    Content type: Protocol

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  4. Prospective registration aims to reduce bias in the conduct and reporting of research and to increase transparency. In addition, prospective registration of systematic reviews is argued to help preventing unin...

    Authors: Dawid Pieper and Tanja Rombey

    Citation: Systematic Reviews 2022 11:8

    Content type: Commentary

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  5. People with depression often present with concurrent cognitive impairment. Computerized cognitive training (CCT) is a safe and efficacious strategy to maintain or enhance cognitive performance in a range of cl...

    Authors: Amit Lampit, Nathalie H. Launder, Ruth Minkov, Alice Rollini, Christopher G. Davey, Carsten Finke, Nicola T. Lautenschlager and Hanna Malmberg Gavelin

    Citation: Systematic Reviews 2022 11:6

    Content type: Protocol

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  6. Infection is a common problem and a major cause of morbidity and mortality for patients in intensive care units (ICUs). According to published meta-analyses, oral care has been found to reduce the risk of noso...

    Authors: Xiaoxia Tang, Yunxia Shen, Xuejiao Pan, Jianglong Liao, Yanfei Xu, Wen Luo, Xiaolin Zhang, Chun’e Li, Qing Wan, Xin Cai, Xiaomei Zhang, Tao Wang and Guilan Zhang

    Citation: Systematic Reviews 2022 11:5

    Content type: Protocol

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  7. Despite the fact that nephron-sparing treatment is considered preferable from a surgical perspective patients’ quality of life (QoL) following different types of nephron-sparing treatments remains unclear.

    Authors: Theresa Junker, Louise Duus, Benjamin S. B. Rasmussen, Nessn Azawi, Lars Lund, Ole Graumann and Birgitte Nørgaard

    Citation: Systematic Reviews 2022 11:4

    Content type: Research

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  8. The aim of the present study was to provide an overview of gingival crevicular fluid (GCF) bone turnover markers (BTMs) concerning the physiology of orthodontic tooth movement (OTM) and assess their potential ...

    Authors: L. Kakali, I. Giantikidis, I. Sifakakis, E. Kalimeri, I. Karamani, E. Mavrogonatou and D. Kloukos

    Citation: Systematic Reviews 2022 11:3

    Content type: Systematic review update

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  9. Early prostate cancer (PCa) treatment interventions may leave men with debilitating sexual side effects, especially when not diagnosed or present at initial follow-up treatment. Men are often embarrassed to di...

    Authors: Pierre Röscher, Ronisha Sathiram, Joanne E. Milios and Jacqueline M. van Wyk

    Citation: Systematic Reviews 2022 11:2

    Content type: Research

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  10. Individuals with obesity are at higher risk of experiencing complications during their pregnancy and may also experience infertility, requiring assisted reproductive technologies (ART) to conceive. The current...

    Authors: Kameela Alibhai, Isabella Churchill, Tannys Vause and Heather Anne Lochnan

    Citation: Systematic Reviews 2022 11:1

    Content type: Protocol

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  11. In December 2019, a novel coronavirus, severe acute respiratory syndrome coronavirus 2 was identified as the cause of an acute respiratory disease, coronavirus disease 2019 (COVID-19). Given the lack of valida...

    Authors: Thanansayan Dhivagaran, Umaima Abbas, Fahad Butt, Luckshann Arunasalam and Oswin Chang

    Citation: Systematic Reviews 2021 10:317

    Content type: Protocol

    Published on:

  12. Whether due to aging, disability, injury, or other circumstances, an increasing number of Canadians experience functional limitations that reduce their ability to participate in activities of daily life. While...

    Authors: Brad W. R. Roberts, Abdulrahman Al Bochi, Mark Weiler, Yashoda Sharma, Cesar Marquez-Chin, Steven Pong, Jessica Babineau, Waqas Sajid, Tilak Dutta and Albert H. Vette

    Citation: Systematic Reviews 2021 10:316

    Content type: Protocol

    Published on:

  13. The comparative safety and efficacy between anti-vascular endothelial growth factor agents (anti-VEGFs) and between combined therapies for patients with neovascular age-related macular degeneration (nAMD) is u...

    Authors: Andrea C. Tricco, Sonia M. Thomas, Erin Lillie, Areti Angeliki Veroniki, Jemila S. Hamid, Ba’ Pham, Taehoon Lee, Arnav Agarwal, Jane P. Sharpe, Alistair Scott, Rachel Warren, Ronak Brahmbhatt, Erin Macdonald, Ghayath Janoudi, Rajeev H. Muni, Carolina L. M. Francisconi…

    Citation: Systematic Reviews 2021 10:315

    Content type: Research

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  14. Dyspnea with bilateral pulmonary edema is common among patients in emergency departments (EDs) or intensive care units (ICUs). For the initial management of patients with this condition, cardiopulmonary edema ...

    Authors: Takero Terayama, Takuya Taniguchi, Ryosuke Imai, Keisuke Anan, Takuo Yoshida, Koichi Ando, Satoshi Okamori and Yohei Okada

    Citation: Systematic Reviews 2021 10:314

    Content type: Protocol

    Published on:

  15. The Extension for Community Healthcare Outcomes (ECHO) Model of continuing tele-education is an innovative guided-practice model aiming at amplifying healthcare professionals’ competencies in the management of...

    Authors: Gabrielle Chicoine, José Côté, Jacinthe Pepin, Guillaume Fontaine, Marc-André Maheu-Cadotte, Quan Nha Hong, Geneviève Rouleau, Daniela Ziegler and Didier Jutras-Aswad

    Citation: Systematic Reviews 2021 10:313

    Content type: Protocol

    Published on:

  16. Swallowing impairment (dysphagia) following brain injury can lead to life-threatening complications such as dehydration, aspiration pneumonia and acute choking episodes. In adult therapeutic practice, there is...

    Authors: Rhiannon Halfpenny, Alexandra Stewart, Paula Kelly, Eleanor Conway and Christina Smith

    Citation: Systematic Reviews 2021 10:312

    Content type: Protocol

    Published on:

  17. Urban health is a field of research and practice that has attracted the interest of various disciplines. While it is encouraged for diverse disciplines to contribute to a multidisciplinary field of study such ...

    Authors: Jinhee Kim, Ben Harris-Roxas, Evelyne de Leeuw, David Lilley, Alana Crimeen and Peter Sainsbury

    Citation: Systematic Reviews 2021 10:311

    Content type: Protocol

    Published on:

  18. Although systematic reviews are considered as central components in evidence-based practice, they currently face an important challenge to keep up with the exponential publication rate of clinical trials. Afte...

    Authors: S. Elbers, H. Wittink, U. Kaiser, J. Kleijnen, J. Pool, A. Köke and R. Smeets

    Citation: Systematic Reviews 2021 10:309

    Content type: Commentary

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  19. Solitary pulmonary nodule (SPN) is a common finding in routine clinical practice when performing chest imaging tests. The vast majority of these nodules are benign, and only a small proportion are malignant. T...

    Authors: Marina Senent-Valero, Julián Librero and María Pastor-Valero

    Citation: Systematic Reviews 2021 10:308

    Content type: Research

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  20. Home visiting services for older adults have been offered for decades to maintain and promote health and independent functioning, thus enhancing quality of life. Previous systematic reviews have provided a mix...

    Authors: Yea Lu Tay, Nurul Salwana Abu Bakar, Ruzimah Tumiran, Noor Hasidah Ab Rahman, Noor Areefa Ameera Mohd Ma’amor, Weng Keong Yau and Zalilah Abdullah

    Citation: Systematic Reviews 2021 10:307

    Content type: Protocol

    Published on:

  21. There are limited data on the clinical benefits of adding surgical resection in patients with recurrent or metastatic gastrointestinal stromal tumors (GISTs). This protocol outlines the planned scope and metho...

    Authors: Zhaolun Cai, Chunyu Xin, Zhiyuan Jiang, Chunyu Liu, Chaoyong Shen, Guozhen Zhao, Yuan Yin, Xiaonan Yin, Zhou Zhao, Mingchun Mu and Bo Zhang

    Citation: Systematic Reviews 2021 10:306

    Content type: Protocol

    Published on:

  22. Early onset fetal growth restriction secondary to placental insufficiency can lead to severe maternal and neonatal morbidity and mortality. Pre-clinical studies and a few small randomised clinical trials have ...

    Authors: Jessica Liauw, Katie Groom, Wessel Ganzevoort, Christian Gluud, Christopher J. D. McKinlay, Andrew Sharp, Laura Mackay, Chirag Kariya, Ken Lim, Peter von Dadelszen, Jacqueline Limpens and Janus C. Jakobsen

    Citation: Systematic Reviews 2021 10:305

    Content type: Protocol

    Published on:

  23. Several resources have been developed (e.g., reporting guidelines) to promote high-standard practices in health research. However, there was no continuous and systematic assessment of recommended practices in ...

    Authors: Nórton Luís Oliveira, Cíntia Ehlers Botton, Angélica Trevisan De Nardi and Daniel Umpierre

    Citation: Systematic Reviews 2021 10:304

    Content type: Research

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  24. Autism spectrum disorder (ASD) is a neurodevelopmental disorder defined by persistent deficits in social functioning and the presence of restricted and repetitive behaviours (RRBs). RRBs refer to four subtypes...

    Authors: Tegan Sellick, Alexandra Ure and Katrina Williams

    Citation: Systematic Reviews 2021 10:303

    Content type: Protocol

    Published on:

  25. The prevalence of type 2 diabetes mellitus (T2DM) is growing in China. Depression is a significant complication of T2DM, leading to poor management of T2DM. Thus, early detection and treatment of depression in...

    Authors: Xiaobo Liu, Chao Dong, Hong Jiang, Dongling Zhong, Yuxi Li, Huiling Zhang, Jun Zhang, Jin Fan, Juan Li, Li Guan and Rongjiang Jin

    Citation: Systematic Reviews 2021 10:302

    Content type: Protocol

    Published on:

  26. The global prevalence of diabetes is nearly 9%, with an upward trend in type 2 diabetes mellitus (T2DM) and gestational diabetes (GDM). Although evidence shows that vulnerable groups are affected disproportion...

    Authors: Jessica Breuing, Christine Joisten, Annika Lena Neuhaus, Simone Heß, Lena Kusche, Fabiola Haas, Mark Spiller and Dawid Pieper

    Citation: Systematic Reviews 2021 10:301

    Content type: Research

    Published on:

  27. To the best of our knowledge, a scoping review of the published literature investigating the determinants of adult stroke survivors’ reintegration to normal living has not been conducted. This scoping review a...

    Authors: Michael Opeoluwa Ogunlana, Pragashnie Govender, Olufemi Oyeleye Oyewole and Ifeoma Blessing Nwosu

    Citation: Systematic Reviews 2021 10:300

    Content type: Protocol

    Published on:

  28. The COVID-19 pandemic has devastated the global community with nearly 4.9 million deaths as of October 2021. While organ transplant (OT) recipients (OTr) may be at increased risk for severe COVID-19 due to the...

    Authors: Alexis H. Lerner, Elizabeth J. Klein, Anna Hardesty, Orestis A. Panagiotou, Chelsea Misquith and Dimitrios Farmakiotis

    Citation: Systematic Reviews 2021 10:299

    Content type: Protocol

    Published on:

  29. The North American opioid crisis is driven by opioid-related mortality and morbidity, including opioid use-associated infections (OUAIs), resulting in a substantial burden for society. Users of legal and illeg...

    Authors: Irina Kudrina, Svetlana Puzhko, Kristian B. Filion, Genevieve Gore, Elena Paraskevopoulos, Sarah Windle, Marc O. Martel and Mark J. Eisenberg

    Citation: Systematic Reviews 2021 10:298

    Content type: Protocol

    Published on:

  30. Idiopathic pulmonary fibrosis (IPF) is one of the common types of interstitial lung disease having high prevalence and mortality worldwide. As a result of patient-centred hindering factors of adherence to cent...

    Authors: Revati Amin, K. Vaishali, G. Arun Maiya, Aswini Kumar Mohapatra, Uday Narayan Yadav and Shradha S. Parsekar

    Citation: Systematic Reviews 2021 10:297

    Content type: Protocol

    Published on:

  31. Peer-support programs are a useful social support strategy for populations trying to quit smoking who are willing to maintain smoking abstinence. This study is a protocol for a systematic review and meta-analy...

    Authors: Hyun-Ju Seo, Soo Young Kim, Dongah Park, Seung-Soo Sheen, Miyoung Choi, Bo-Hyoung Jang, Su Jung Lee and Youngju Cha

    Citation: Systematic Reviews 2021 10:296

    Content type: Protocol

    Published on:

  32. In many countries, children who are diagnosed with autism during the first 5 years of life are offered a range of early intervention options. These options vary considerably in the theoretical approaches and t...

    Authors: Katherine Pye, Hannah Jackson, Teresa Iacono and Alan Shiell

    Citation: Systematic Reviews 2021 10:295

    Content type: Protocol

    Published on:

  33. Despite the expectations regarding the effectiveness of chloroquine (CQ) and hydroxychloroquine (HCQ) for coronavirus disease (COVID-19) management, concerns about their adverse events have remained.

    Authors: Mayra Souza Botelho, Fernanda Bolfi, Renata Giacomini Occhiuto Ferreira Leite, Mauro Salles Ferreira Leite, Luisa Rocco Banzato, Luiza Teixeira Soares, Thaina Oliveira Felicio Olivatti, Amanda Sampaio Mangolim, Flávia Ramos Kazan Oliveira, Luciana Patrícia Fernandes Abbade, Joelcio Francisco Abbade, Ricardo Augusto Monteiro de Barros Almeida, Julia Simões Corrêa Galendi, Lehana Thabane and Vania dos Santos Nunes-Nogueira

    Citation: Systematic Reviews 2021 10:294

    Content type: Research

    Published on:

  34. Low levels of physical activity are common during the hospital stay and have been associated with negative health outcomes. Understanding barriers and enablers to physical activity during a hospital stay can i...

    Authors: Sven Jacobus Gertruda Geelen, Hanneke Corine van Dijk - Huisman, Robert Adriaan de Bie, Cindy Veenhof, Raoul Engelbert, Marike van der Schaaf and Antoine François Lenssen

    Citation: Systematic Reviews 2021 10:293

    Content type: Research

    Published on:

  35. Subclinical hypothyroidism is a thyroid disorder diagnosed from the laboratory blood test results of otherwise asymptomatic patients. It has been associated with poor cardiovascular outcomes, mortality and pro...

    Authors: Brenda S. Bauer, Amaya Azcoaga-Lorenzo, Utkarsh Agrawal and Colin McCowan

    Citation: Systematic Reviews 2021 10:290

    Content type: Protocol

    Published on:

  36. The coronavirus disease 19 (covid-19) pandemic has underscored the need to expedite clinical research, which may lead investigators to shift away from measuring patient-important outcomes (PIO), limiting resea...

    Authors: Mario A. Jimenez-Mora, Andrea Ramírez Varela, Jose F. Meneses-Echavez, Julia Bidonde, Adriana Angarita-Fonseca, Reed A. C. Siemieniuk, Dena Zeraatkar, Jessica J. Bartoszko, Romina Brignardello-Petersen, Kimia Honarmand, Bram Rochwerg, Gordon Guyatt and Juan José Yepes-Nuñez

    Citation: Systematic Reviews 2021 10:289

    Content type: Protocol

    Published on:

  37. Many prognostic models of diabetic microvascular complications have been developed, but their performances still varies. Therefore, we conducted a systematic review and meta-analysis to summarise the performan...

    Authors: Sigit Ari Saputro, Oraluck Pattanaprateep, Anuchate Pattanateepapon, Swekshya Karmacharya and Ammarin Thakkinstian

    Citation: Systematic Reviews 2021 10:288

    Content type: Research

    Published on:

  38. Though cervical cancer is largely preventable, it is still the second most common female cancer globally and the leading cause of cancer deaths among females in African. Though many efforts have been done to s...

    Authors: Ayele Semachew Kasa, Tadesse Dagget, Yeshiwork Beyene, Getnet Dessie, Aklilu Endalamaw, Yinager Workineh, Emiru Ayalew, Balew Zeleke, Sitotaw Kerie, Getasew Mulat and Worku Animaw

    Citation: Systematic Reviews 2021 10:287

    Content type: Research

    Published on:

  39. Approaches for rapid reviews that focus on streamlining systematic review methods are not always suitable for exploring complex policy questions, as developing and testing theories to explain these complexitie...

    Authors: Michael G. Wilson, Sandy Oliver, G. J. Melendez-Torres, John N. Lavis, Kerry Waddell and Kelly Dickson

    Citation: Systematic Reviews 2021 10:286

    Content type: Research

    Published on:

  40. Hemodynamic assessment in patients with pulmonary arterial hypertension (PAH) is essential for risk stratification and pharmacological management. However, the prognostic value of the hemodynamic changes after...

    Authors: Shih-Hsien Sung, Wan-Yu Yeh, Chern-En Chiang, Chi-Jung Huang, Wei-Ming Huang, Chen-Huan Chen and Hao-Min Cheng

    Citation: Systematic Reviews 2021 10:284

    Content type: Research

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  41. Burnout is a syndrome caused by chronic stress in the workplace that has not been successfully managed. Although prevalence of burnout is well documented in different fields, little is known about this syndrom...

    Authors: Sharareh Azedi Tehrani, Abbasali Keshtkar, Akilesh Ramasamy and Majid Fadaei

    Citation: Systematic Reviews 2021 10:283

    Content type: Protocol

    Published on:

  42. Non-traumatic coma is a common acute childhood presentation to healthcare facilities in Africa and is associated with high morbidity and mortality. Historically, the majority of cases were attributed to cerebr...

    Authors: Stephen T. J. Ray, Charlotte Fuller, Alexandra Boubour, Laura J. Bonnett, David G. Lalloo, Karl B. Seydel and Michael J. Griffiths

    Citation: Systematic Reviews 2021 10:282

    Content type: Protocol

    Published on:

  43. The primary objective of this study is twofold: (1) to examine the effect of COVID-19 safety measures, enacted to prevent transmission of SARS-nCOV-2, on total physical activity in the adult general population...

    Authors: Fabian Schwendinger, Denis Infanger, Elena Pocecco, Joséphine Gander, Timo Hinrichs and Arno Schmidt-Trucksäss

    Citation: Systematic Reviews 2021 10:281

    Content type: Protocol

    Published on:

  44. The aim of this study was to review the scientific evidence and describe the ocular treatment-emergent adverse events (TEAEs) related to pharmacological treatment in patients with multiple sclerosis.

    Authors: Juliana Muñoz-Ortiz, Juliana Reyes-Guanes, Estefanía Zapata-Bravo, Laura Mora-Muñoz, Juan Antonio Reyes-Hurtado, Luis Octavio Tierradentro-García, William Rojas-Carabali, Marcela Gómez-Suarez and Alejandra de-la-Torre

    Citation: Systematic Reviews 2021 10:280

    Content type: Systematic review update

    Published on:

  45. People with disabilities (PWDs) remain among the poorest and least empowered population. They experience limited access to basic services, especially in low- and middle-income countries (LMIC). The infringemen...

    Authors: Sithembiso Blose, Saul Cobbing and Verusia Chetty

    Citation: Systematic Reviews 2021 10:279

    Content type: Protocol

    Published on:

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