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  1. Content type: Protocol

    Neuropathic pain affects 7–10% of people, but responds poorly to pharmacotherapy, indicating a need for better treatments. Mechanistic research on neuropathic pain frequently uses human surrogate models of the...

    Authors: Victoria J. Madden, Gillian J. Bedwell, Prince C. Chikezie, Andrew S. C. Rice and Peter R. Kamerman

    Citation: Systematic Reviews 2019 8:208

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  2. Content type: Research

    Chronic hepatitis B (CHB) infection poses a significant burden to public health worldwide. Most cases are clinically silent until late in the disease course. The main goal of current therapy is to improve surv...

    Authors: William W. L. Wong, Petros Pechivanoglou, Josephine Wong, Joanna M. Bielecki, Alex Haines, Aysegul Erman, Yasmin Saeed, Arcturus Phoon, Mina Tadrous, Mona Younis, Noha Z. Rayad, Valeria Rac, Harry L. A. Janssen and Murray D. Krahn

    Citation: Systematic Reviews 2019 8:207

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  3. Content type: Protocol

    Due to the worldwide rise in cancer incidence, and therefore the rise in the need for antineoplastic chemotherapy, it is important for both healthcare professionals and patients alike that the side effects of ...

    Authors: Ruan Nilton Rodrigues Melo, Stephanie Carolina Francisco, Caroline de Castro Moura, Kirsty Loudon, Namie Okino Sawada, Érika de Cássia Lopes Chaves, Tânia Couto Machado Chianca, Denismar Alves Nogueira, Si Jia Zhu and Ana Cláudia Mesquita Garcia

    Citation: Systematic Reviews 2019 8:206

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  4. Content type: Protocol

    About 5.8 million maternal deaths, neonatal deaths and stillbirths occur every year with 99% of them taking place in low- and middle-income countries. Two thirds of them could be prevented through cost-effecti...

    Authors: Rejina Gurung, Nabila Zaka, Shyam Sundar Budhathoki, Avinash K. Sunny, Jeevan Thapa, Hong Zhou and Ashish KC

    Citation: Systematic Reviews 2019 8:205

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  5. Content type: Protocol

    Cataract is the leading cause of blindness and low vision worldwide. Presently, cataract surgery is the only treatment for cataract and is very effective in restoring sight. In cataract surgery, the natural le...

    Authors: Shalu Jain, Kavitha Rajshekar, Anjana Aggarwal, Akshay Chauhan and Vijay Kumar Gauba

    Citation: Systematic Reviews 2019 8:204

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  6. Content type: Protocol

    Evidence shows that the implementation of optimal post-arrest care significantly increases survival and functional outcomes among patients who experience an out-of-hospital cardiac arrest (OHCA). However, diff...

    Authors: Morgan Slater, Victoria M. Sparrow-Downes, Precilla Veigas, Joanna M. Bielecki and Valeria E. Rac

    Citation: Systematic Reviews 2019 8:203

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  7. Content type: Protocol

    The way pain is remembered and reported can affect medical decisions taken by patients and health-care professionals. Memory of pain has been investigated extensively for the past few decades; however, the res...

    Authors: Wacław M. Adamczyk, Dominika Farley, Karolina Wiercioch-Kuzianik, Elżbieta A. Bajcar, Ewa Buglewicz, Jakub Nastaj, Aleksandra Gruszka and Przemysław Bąbel

    Citation: Systematic Reviews 2019 8:201

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  8. Content type: Research

    Obesity is a cardiovascular disease risk factor. Conventional weight loss (CWL) programmes focus on weight loss, however ‘health, not weight loss, focused’ (HNWL) programmes concentrate on improved health and ...

    Authors: Nazanin Khasteganan, Deborah Lycett, Gill Furze and Andy P. Turner

    Citation: Systematic Reviews 2019 8:200

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  9. Content type: Protocol

    Whiplash is a common traumatic cervical injury which is most often a consequence of rear-end motor vehicle accidents. It has been estimated that up to 50% of the whiplash patients suffer from chronic symptoms,...

    Authors: Aidin Abedi, C. A. C. Prinsen, Ishan Shah, Zorica Buser and Jeffrey C. Wang

    Citation: Systematic Reviews 2019 8:199

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  10. Content type: Protocol

    Psychological violence is estimated to be the most common form of intimate partner violence (IPV). Despite this, research on the independent effect of psychological violence on mental health is scarce. Moreove...

    Authors: Sarah Dokkedahl, Robin Niels Kok, Siobhan Murphy, Trine Rønde Kristensen, Ditte Bech-Hansen and Ask Elklit

    Citation: Systematic Reviews 2019 8:198

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  11. Content type: Protocol

    One of the most challenging health problems is liver disease, which can be caused by medications, toxic substances, and excessive consumption of alcohol. Liver problems can be also caused by infections, autoim...

    Authors: Willy Tambwe Muzumbukilwa, Mukanda Gedeon Kadima, Manimbulu Nlooto and Peter Mark Oroma Owira

    Citation: Systematic Reviews 2019 8:197

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  12. Content type: Protocol

    Non-specific low back pain (LBP) is the leading cause of disability worldwide. Acute LBP usually has a good prognosis, with rapid improvement within the first 6 weeks. However, the majority of patients develop...

    Authors: Silvia Gianola, Greta Castellini, Anita Andreano, Davide Corbetta, Pamela Frigerio, Valentina Pecoraro, Valentina Redaelli, Andrea Tettamanti, Andrea Turolla, Lorenzo Moja and Maria Grazia Valsecchi

    Citation: Systematic Reviews 2019 8:196

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  13. Content type: Protocol

    Isotonic crystalloid fluid bolus therapy is used in critically ill children to restore or maintain hemodynamic stability. However, the ideal choice of crystalloid remains to be determined. The most easily avai...

    Authors: Anab Rebecca Lehr, Soha Rached-d’Astous, Melissa Parker, Lauralyn McIntyre, Margaret Sampson, Jemila Hamid and Kusum Menon

    Citation: Systematic Reviews 2019 8:195

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  14. Content type: Protocol

    Strategies to improve the effectiveness and quality of health and care have predominantly emphasised the implementation of new research and evidence into service organisation and delivery. A parallel, but less...

    Authors: Christopher Burton, Lynne Williams, Tracey Bucknall, Stephen Edwards, Denise Fisher, Beth Hall, Gill Harris, Peter Jones, Matthew Makin, Anne McBride, Rachel Meacock, John Parkinson, Jo Rycroft-Malone and Justin Waring

    Citation: Systematic Reviews 2019 8:194

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  15. Content type: Protocol

    Human resource for health (HRH) challenges jeopardise the South African health system, undermining the efforts made to curb the burden of disease. There is a demand for a category of health workers, which will...

    Authors: Euphemia Mbali Mhlongo and Elizabeth Lutge

    Citation: Systematic Reviews 2019 8:193

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  16. Content type: Protocol

    Pedestrians’ unsafe crossing behavior exposes them at risk of trauma and death and puts a tremendous burden on the health care system. The theory of planned behavior (TPB) is one of the leading theoretical mod...

    Authors: Mahdi Moshki, Abdoljavad Khajavi, Fatemeh Sadeghi-Ghyassi, Homayoun Sadeghi-Bazargani and Saeid Pour-Doulati

    Citation: Systematic Reviews 2019 8:192

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  17. Content type: Protocol

    Experiencing a lower limb amputation (LLA) or spinal cord injury (SCI) is a life-changing event, affecting physical and systemic function as well as having psychological and social impacts. However, the severi...

    Authors: Matthew Young, Carly McKay, Sean Williams, Peter Rouse and James L. J. Bilzon

    Citation: Systematic Reviews 2019 8:191

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  18. Content type: Research

    Human papillomavirus (HPV) infection causes cervical cancer. More than 80% of those diagnosed with cervical cancer live in low- and middle-income countries (LMICs). The World Health Organization recommends vac...

    Authors: Hakan Safaralilo Foss, Ann Oldervoll, Atle Fretheim, Claire Glenton and Simon Lewin

    Citation: Systematic Reviews 2019 8:190

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  19. Content type: Protocol

    South Asia has one of the largest proportions of undernourished children in the world, especially stunting, wasting, and underweight as well as micronutrient deficiencies such as the deficiency of iron, vitami...

    Authors: Nidhi Wali, Kingsley Agho and Andre M. N. Renzaho

    Citation: Systematic Reviews 2019 8:189

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  20. Content type: Protocol

    In postural stability evaluation, the dual-task concept is often adopted in order to create a more challenging situation. The dual-task consists of performing simultaneously two tasks, a primary static or dyna...

    Authors: Luca Petrigna, Ewan Thomas, Ambra Gentile, Antonio Paoli, Simona Pajaujiene, Antonio Palma and Antonino Bianco

    Citation: Systematic Reviews 2019 8:188

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  21. Content type: Protocol

    Improving upper limb (UL) motor recovery after stroke represents a major clinical and scientific goal. We aim to complete three systematic reviews to estimate the (1) association between time to start of UL th...

    Authors: Kathryn S. Hayward, Sharon F. Kramer, Vincent Thijs, Julie Ratcliffe, Nick S. Ward, Leonid Churilov, Laura Jolliffe, Dale Corbett, Geoffrey Cloud, Tina Kaffenberger, Amy Brodtmann, Julie Bernhardt and Natasha A. Lannin

    Citation: Systematic Reviews 2019 8:187

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  22. Content type: Protocol

    Opiate agonist therapy (OAT) prescribing rates by family physicians are low in the context of community-based, comprehensive primary care. Understanding the factors that support and/or inhibit OAT prescribing ...

    Authors: Lara L. Nixon, Jazmin C. Marlinga, K. Alix Hayden and Kelly J. Mrklas

    Citation: Systematic Reviews 2019 8:186

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  23. Content type: Protocol

    There has been an identified need for greater patient and family member involvement in healthcare. This is particularly relevant in an intensive care unit (ICU), as the family provides a key communicative and ...

    Authors: Andreas Xyrichis, Simon Fletcher, Sally Brearley, Julia Philippou, Ed Purssell, Marius Terblanche, Anne Marie Rafferty and Scott Reeves

    Citation: Systematic Reviews 2019 8:185

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  24. Content type: Research

    Infant mental health has emerged as a unique area of practice and research distinguished from child and youth sub-specialties by its advocacy for a relational practice framework with an emphasis on parents/car...

    Authors: Alan McLuckie, Ashley L. Landers, Janet A. Curran, Robin Cann, Domenica H. Carrese, Alicia Nolan, Kim Corrigan and Normand J. Carrey

    Citation: Systematic Reviews 2019 8:183

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  25. Content type: Protocol

    Nursing care quality varies between hospitals, and even between departments within the same institution. Suboptimal care can have deleterious consequences for patients such as lengthened hospital stay, nosocom...

    Authors: Joachim Rapin, Joanie Pellet, Cedric Mabire, Sylvie Gendron and Carl-Ardy Dubois

    Citation: Systematic Reviews 2019 8:182

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  26. Content type: Protocol

    Defined as a headache lasting at least 15 days per month, chronic headache is reported by 3% of the general population, and a substantial proportion of them are refractory to current therapies. Occipital nerve...

    Authors: Sylvine Carrondo Cottin, Nevair Gallani, Léo Cantin and Michel Prud’Homme

    Citation: Systematic Reviews 2019 8:181

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  27. Content type: Protocol

    An increasing number of studies have investigated the clinical epidemiology and outcomes of ventilator-associated pneumonia (VAP) in intensive care units. However, these findings have not been clearly defined ...

    Authors: John Mark M. Gutiérrez, Annabelle R. Borromeo, Allan L. Dueño, Emmanuel D. Paragas Jr, Rosanta O. Ellasus, Russel S. Abalos-Fabia, Jerry A. Abriam, Arnel E. Sonido, Monina A. Hernandez, Alain Jason A. Generale, Roberto C. Sombillo, Mary Grace C. Lacanaria, Mae M. Centeno, Jose Reinhard C. Laoingco and John Anthony A. Domantay

    Citation: Systematic Reviews 2019 8:180

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  28. Content type: Protocol

    Depression is a leading contributor to disability-adjusted life-years because of early onset and chronicity throughout the lifecycle. It is crucial to identify early predictors of depression among adolescents ...

    Authors: Gloria A. Pedersen, Zuzanna Zajkowska, Christian Kieling, Kamal Gautam, Valeria Mondelli, Helen L. Fisher, Johnna R. Swartz, Abiodun Adewuya, Rakesh Karmacharya and Brandon A. Kohrt

    Citation: Systematic Reviews 2019 8:179

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  29. Content type: Research

    The operation areas of clowns in the medical context are multifaceted. Clowning in children undergoing surgery has been shown to be able to lessen children’s anxiety. Hence, our aim was to assess the effective...

    Authors: Nadja Könsgen, Stephanie Polus, Tanja Rombey and Dawid Pieper

    Citation: Systematic Reviews 2019 8:178

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  30. Content type: Research

    School tobacco policies (STPs) that aim to achieve a tobacco-free environment require consistent enforcement by school staff. However, little is known about why staff choose whether or not to enforce STPs. The...

    Authors: Anu Linnansaari, Michael Schreuders, Anton E. Kunst, Arja Rimpelä and Pirjo Lindfors

    Citation: Systematic Reviews 2019 8:177

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  31. Content type: Protocol

    Health workers routinely carry out clinical behaviours, such as prescribing, test-ordering or hand-washing, which impact on patient diagnoses, care, treatment and recovery. Social norms are the implicit or exp...

    Authors: Sarah Cotterill, Rachael Powell, Sarah Rhodes, Benjamin Brown, Jane Roberts, Mei Yee Tang and Jack Wilkinson

    Citation: Systematic Reviews 2019 8:176

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  32. Content type: Protocol

    Schistosomiasis is one of the most prevalent parasitic diseases in low- and middle-income countries (LMICs), being regarded as a neglected tropical disease in sub-Saharan Africa. Praziquantel is the convention...

    Authors: Gloire-Aimé Aganze Mushebenge, Tivani Mashamba-Thompson and Manimbulu Nlooto

    Citation: Systematic Reviews 2019 8:175

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  33. Content type: Research

    Research articles tend to focus on positive findings in their abstract, especially if multiple outcomes have been studied. At the same time, search queries in databases are generally limited to the abstract, t...

    Authors: Bram Duyx, Gerard M. H. Swaen, Miriam J. E. Urlings, Lex M. Bouter and Maurice P. Zeegers

    Citation: Systematic Reviews 2019 8:174

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  34. Content type: Protocol

    Super diversity has become a twenty-first-century phenomena in the UK. The Five Year Forward View Plan for Mental Health commits to improving access to Perinatal Mental Health services for all new mothers. Exi...

    Authors: Harpreet Kaur Sihre, Anne-Marie Simons, Paramjit Gill, Antje Lindenmeyer and Qulsom Fazil

    Citation: Systematic Reviews 2019 8:173

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  35. Content type: Protocol

    Hearing loss in newborns and children is a public health concern, due to high prevalence and negative effects on their development. Early detection and intervention of childhood hearing loss may mitigate these...

    Authors: Bénédicte Vos, Dorie Noll, Marie Pigeon, Marlene Bagatto and Elizabeth M. Fitzpatrick

    Citation: Systematic Reviews 2019 8:172

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  36. Content type: Methodology

    Lung cancer (LC) is the most common cause of cancer death in the world and associated with significant economic burden. We conducted a review of published literature to identify prognostic factors associated w...

    Authors: Ruth Lewis, Maggie Hendry, Nafees Din, Marian A. Stanciu, Sadia Nafees, Annie Hendry, Zhi Hao Teoh, Thomas Lloyd, Rachel Parsonage, Richard D. Neal, Gareth Collier and Dyfed W. Huws

    Citation: Systematic Reviews 2019 8:171

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  37. Content type: Protocol

    Psychiatric disorders are highly prevalent and associated with great symptomatic, functional, and health economic burdens. Psychotherapy is among the recommended and used interventions for most psychiatric dis...

    Authors: Sophie Juul, Stig Poulsen, Susanne Lunn, Per Sørensen, Janus Christian Jakobsen and Sebastian Simonsen

    Citation: Systematic Reviews 2019 8:169

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  38. Content type: Protocol

    This systemic review aims to synthesise the current literature surrounding off-therapy surveillance imaging in children and young people with extra-cranial solid tumours, with a view to establishing if routine...

    Authors: Jessica E. Morgan, Melissa Harden and Robert S. Phillips

    Citation: Systematic Reviews 2019 8:168

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  39. Content type: Protocol

    Depression is a common comorbidity in type 2 diabetes. Studies have consistently shown that major depression is associated with decreased diabetic self-care behaviour. People with subthreshold depression exper...

    Authors: Monika Shrestha, Amal Al-Ghareeb, Fatimah Alenazi and Richard Gray

    Citation: Systematic Reviews 2019 8:167

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  40. Content type: Commentary

    Reporting standards in biomedical research have been shown to be suboptimal. The publication of the PRISMA statement has improved the completeness of reporting of systematic reviews, but several issues specifi...

    Authors: Trevor A. McGrath, David Moher and Matthew D. F. McInnes

    Citation: Systematic Reviews 2019 8:166

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  41. Content type: Protocol

    Seriously ill children suffer from numerous symptoms at the end of their lives, including pain, anxiety, and restricted communication. There are currently no comprehensive overviews of which health interventio...

    Authors: Veerle E. Piette, Joachim Cohen, Luc Deliens, Nele Pauwels, Jutte van der Werff ten Bosch and Kim Beernaert

    Citation: Systematic Reviews 2019 8:165

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  42. Content type: Protocol

    Physically aggressive behaviors are very common among older people living with cognitive impairment. These behaviors may have significant consequences for family and formal caregivers, as well as for the other...

    Authors: Anne Bourbonnais, Marie-Hélène Goulet, Philippe Landreville, Edith Ellefsen, Caroline Larue, Marie-Hélène Lalonde and Paul L. Gendreau

    Citation: Systematic Reviews 2019 8:164

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  43. Content type: Protocol

    Early diagnosis and treatment of tuberculosis (TB) have been shown to reduce the impact of TB illness particularly, among TB key populations such as people living with HIV/AIDS, prisoners, refugees, migrants, ...

    Authors: Desmond Kuupiel, Vitalis Bawontuo and Tivani P. Mashamba-Thompson

    Citation: Systematic Reviews 2019 8:162

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  44. Content type: Protocol

    Sexual dysfunction refers to a chain of psychiatric, individual, and couple’s experiences that manifests itself as a dysfunction in sexual desire, sexual arousal, orgasm, and pain during intercourse. The aim o...

    Authors: Mojdeh Banaei, Maryam Azizi, Azam Moridi, Sareh Dashti, Asiyeh Pormehr Yabandeh and Nasibeh Roozbeh

    Citation: Systematic Reviews 2019 8:161

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  45. Content type: Protocol

    Dementia is one of the greatest health and care priorities globally. Caring for persons with dementia is a challenge and often leads to negative psychological, physiological and financial consequences for info...

    Authors: Vimal Sriram, Crispin Jenkinson and Michele Peters

    Citation: Systematic Reviews 2019 8:158

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