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  1. Methodology

    A proposed framework for developing quality assessment tools

    Assessment of the quality of included studies is an essential component of any systematic review. A formal quality assessment is facilitated by using a structured tool. There are currently no guidelines availa...

    Penny Whiting, Robert Wolff, Susan Mallett, Iveta Simera and Jelena Savović

    Systematic Reviews 2017 6:204

    Published on: 17 October 2017

  2. Protocol

    Costs related to cardiac arrest management: a systematic review protocol

    Each year, about 500,000 people suffer a cardiac arrest (either out-of-hospital or in-hospital) in the USA. Although significant improvements in survival have occurred through the implementation of complex hig...

    Guillaume Geri, Joshua Gilgan, Carolyn Ziegler, Wanrudee Isaranuwatchai and Laurie J. Morrison

    Systematic Reviews 2017 6:205

    Published on: 17 October 2017

  3. Letter

    SEED: a tool for disseminating systematic review data into Wikipedia

    Wikipedia, the free-content online encyclopaedia, contains many heavily accessed pages relating to healthcare. Cochrane systematic reviews contain much high-grade evidence but dissemination into Wikipedia has ...

    Lena Schmidt, Johannes Friedel and Clive E. Adams

    Systematic Reviews 2017 6:206

    Published on: 17 October 2017

  4. Research

    High-flow oxygen via nasal cannulae in patients with acute hypoxemic respiratory failure: a systematic review and meta-analysis

    We performed a systematic review and meta-analysis to evaluate the efficacy and safety of high-flow oxygen via nasal cannulae (HFNC) compared to non-invasive ventilation (NIV) and/or standard oxygen in patient...

    Murdoch Leeies, Eric Flynn, Alexis F. Turgeon, Bojan Paunovic, Hal Loewen, Rasheda Rabbani, Ahmed M. Abou-Setta, Niall D. Ferguson and Ryan Zarychanski

    Systematic Reviews 2017 6:202

    Published on: 16 October 2017

  5. Protocol

    Ventriculoperitoneal shunt insertion for hydrocephalus in human immunodeficiency virus-infected adults: a systematic review and meta-analysis protocol

    Hydrocephalus is a recognised complication of human immunodeficiency virus (HIV)-related opportunistic infections. Symptomatic raised cerebrospinal fluid pressure can be treated with ventriculoperitoneal shunt...

    James J. M. Loan, Ncedile Mankahla, Graeme Meintjes and A. Graham Fieggen

    Systematic Reviews 2017 6:201

    Published on: 16 October 2017

  6. Protocol

    Predictors of multidisciplinary rehabilitation outcomes in patients with chronic musculoskeletal pain: protocol for a systematic review and meta-analysis

    Chronic musculoskeletal pain is a major public health problem. Early prediction for optimal treatment results has received growing attention, but there is presently a lack of evidence regarding what informatio...

    Elena Tseli, Wilhelmus Johannes Andreas Grooten, Britt-Marie Stålnacke, Katja Boersma, Paul Enthoven, Björn Gerdle and Björn Olov Äng

    Systematic Reviews 2017 6:199

    Published on: 11 October 2017

  7. Research

    Recommendations for reporting of systematic reviews and meta-analyses of diagnostic test accuracy: a systematic review

    This study is to perform a systematic review of existing guidance on quality of reporting and methodology for systematic reviews of diagnostic test accuracy (DTA) in order to compile a list of potential items ...

    Trevor A. McGrath, Mostafa Alabousi, Becky Skidmore, Daniël A. Korevaar, Patrick M. M. Bossuyt, David Moher, Brett Thombs and Matthew D. F. McInnes

    Systematic Reviews 2017 6:194

    Published on: 10 October 2017

  8. Protocol

    Herceptin® (trastuzumab) in HER2-positive early breast cancer: protocol for a systematic review and cumulative network meta-analysis

    Human epidermal growth factor receptor 2-positive (HER2+) breast cancer is an aggressive disease that makes up about 20% of all invasive breast cancers. HER2+ breast cancer is associated with poor prognosis an...

    Florence R. Wilson, Megan E. Coombes, Quinlan Wylie, Mariya Yurchenko, Christine Brezden-Masley, Brian Hutton, Becky Skidmore and Chris Cameron

    Systematic Reviews 2017 6:196

    Published on: 10 October 2017

  9. Research

    Effect of intra-pregnancy nonsurgical periodontal therapy on inflammatory biomarkers and adverse pregnancy outcomes: a systematic review with meta-analysis

    The aim of this systematic review with meta-analysis was to analyze the effects of intra-pregnancy nonsurgical periodontal therapy on periodontal inflammatory biomarkers and adverse pregnancy outcomes.

    Helbert Eustáquio Cardoso da Silva, Cristine Miron Stefani, Nilce de Santos Melo, Adriano de Almeida de Lima, Cassiano Kuchenbecker Rösing, André Luís Porporatti and Graziela De Luca Canto

    Systematic Reviews 2017 6:197

    Published on: 10 October 2017

  10. Protocol

    Syphilis in the Americas: a protocol for a systematic review of syphilis prevalence and incidence in four high-risk groups, 1980–2016

    Syphilis infection has recently resurfaced as a significant public health problem. Although there has been a tremendous amount of research on the epidemiology of syphilis, there has been limited work done to s...

    Ken Kitayama, Eddy R. Segura, Jordan E. Lake, Amaya G. Perez-Brumer, Catherine E. Oldenburg, Bethany A. Myers, Paria Pourjavaheri, Chinomnso N. Okorie, Robinson L. Cabello and Jesse L. Clark

    Systematic Reviews 2017 6:195

    Published on: 10 October 2017

  11. Protocol

    Identifying effective components for mobile health behaviour change interventions for smoking cessation and service uptake: protocol of a systematic review and planned meta-analysis

    Mobile health (mHealth) interventions for smoking cessation have been shown to be associated with an increase in effectiveness. However, interventions using mobile phones to change people’s behaviour are often...

    Pritaporn Kingkaew, Liz Glidewell, Rebecca Walwyn, Hamish Fraser and Jeremy C. Wyatt

    Systematic Reviews 2017 6:193

    Published on: 6 October 2017

  12. Protocol

    Prevalence, awareness, and associated risk factors of hypertension in older adults in Africa: a systematic review and meta-analysis protocol

    The health of older persons has not been a major priority in many African countries. Hypertension is one of the common health problems of older persons. However, there is little information on the prevalence o...

    William K. Bosu, Justice M. K. Aheto, Eugenio Zucchelli and Siobhan Reilly

    Systematic Reviews 2017 6:192

    Published on: 4 October 2017

  13. Protocol

    Role of bispectral index monitoring and burst suppression in prognostication following out-of-hospital cardiac arrest: a systematic review protocol

    Out-of-hospital cardiac arrest (OHCA) is associated with significant mortality or may have a poor neurological outcome. Various community-training programmes have improved practices like bystander cardiopulmon...

    Leanne Eveson, Marcela Vizcaychipi and Shashank Patil

    Systematic Reviews 2017 6:191

    Published on: 25 September 2017

  14. Protocol

    The effect of psychological interventions on the prevention of chronic pain in adults: a systematic review protocol

    Numerous psychological risk and protective factors have been identified as contributing to or preventing the development of the prevalent issue of chronic pain. Systematic reviews of studies on psychological i...

    Mélanie Bérubé, Céline Gélinas, Manon Choinière, Nancy Feeley, Géraldine Martorella, Stefan Parent and David L. Streiner

    Systematic Reviews 2017 6:190

    Published on: 21 September 2017

  15. Protocol

    Risk of mortality among children, adolescents, and adults with autism spectrum disorder or attention deficit hyperactivity disorder and their first-degree relatives: a protocol for a systematic review and meta-analysis of observational studies

    Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are childhood onset neurodevelopmental disorders that may persist into adulthood. ASD and ADHD tend to run in families and may...

    Ferrán Catalá-López, Brian Hutton, Matthew J. Page, Manuel Ridao, Jane A. Driver, Adolfo Alonso-Arroyo, Jaume Forés-Martos, Diego Macías Saint-Gerons, Eduard Vieta, Alfonso Valencia and Rafael Tabarés-Seisdedos

    Systematic Reviews 2017 6:189

    Published on: 15 September 2017

  16. Protocol

    Interventions to control myopia progression in children: protocol for an overview of systematic reviews and meta-analyses

    Myopia is a common visual disorder with increasing prevalence among developed countries of the world. Myopia constitutes a substantial risk factor for several ocular conditions that can lead to blindness. The ...

    Efthymia Prousali, Asimina Mataftsi, Nikolaos Ziakas, Andreas Fontalis, Periklis Brazitikos and Anna-Bettina Haidich

    Systematic Reviews 2017 6:188

    Published on: 11 September 2017

  17. Editorial

    Overviews of systematic reviews: great promise, greater challenge

    The proliferation of systematic reviews and escalating demand from policy makers has driven a newer form of evidence synthesis—overviews of systematic reviews. Systematic Reviews are publishing a special thematic...

    Joanne E. McKenzie and Sue E. Brennan

    Systematic Reviews 2017 6:185

    Published on: 8 September 2017

  18. Protocol

    Comparative safety and efficacy of pharmacological and non-pharmacological interventions for the behavioral and psychological symptoms of dementia: protocol for a systematic review and network meta-analysis

    Behavioral and psychological symptoms of dementia (BPSD) are highly prevalent in patients with dementia. Both pharmacological and non-pharmacological strategies are commonly used to treat these symptoms, but t...

    Jennifer Watt, Zahra Goodarzi, Andrea C. Tricco, Areti-Angeliki Veroniki and Sharon E. Straus

    Systematic Reviews 2017 6:182

    Published on: 7 September 2017

  19. Protocol

    Strategies to improve the quality of life of persons post-stroke: protocol of a systematic review

    While many outcomes post-stroke (e.g., depression) have been previously investigated, there is no complete data on the impact of a variety of quality improvement strategies on the quality of life and physical ...

    Sarah E.P. Munce, Laure Perrier, Saeha Shin, Chamila Adhihetty, Kristen Pitzul, Michelle L.A. Nelson and Mark T. Bayley

    Systematic Reviews 2017 6:184

    Published on: 7 September 2017

  20. Protocol

    Social determinants of common metabolic risk factors (high blood pressure, high blood sugar, high body mass index and high waist-hip ratio) of major non-communicable diseases in South Asia region: a systematic review protocol

    Prevalence of non-communicable diseases has been increasing at a greater pace in developing countries and, in particular, the South Asia region. Various behavioral, social and environmental factors present in ...

    Sudesh Raj Sharma, Shiva Raj Mishra, Kusum Wagle, Rachel Page, Anna Matheson, Danielle Lambrick, James Faulkner, David Lounsbury and Abhinav Vaidya

    Systematic Reviews 2017 6:183

    Published on: 7 September 2017

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