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Featured article: Comparing GRADE and Trial Sequential Analysis in the assessment of imprecision in Cochrane systematic reviews

Greta Castellini and colleagues evaluated the reporting of imprecision in accordance to the GRADE system in 100 Cochrane reviews and found that only 13% stated the criteria they applied to assess imprecision. The authors re-analyzed imprecision for the reviews using the GRADE Handbook and the Trial Sequential Analysis Manual and highlight that initiatives to improve adherence to the GRADE Handbook are warranted, with TSA potentially assisting in such development.

Articles

  1. Content type: Protocol

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    Authors: Andrea C. Tricco, Julia E. Moore, Nicole Beben, Ross C. Brownson, David A. Chambers, Lisa R. Dolovich, Annemarie Edwards, Lee Fairclough, Paul P. Glasziou, Ian D. Graham, Brenda R. Hemmelgarn, Bev Holmes, Wanrudee Isaranuwatchai, Chantelle C. Lachance, France Legare, Jessie McGowan…

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Edited by Dr Joanne E McKenzie

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Aims and scope

Systematic Reviews encompasses all aspects of the design, conduct and reporting of systematic reviews. The journal publishes high quality systematic review products including systematic review protocols, systematic reviews related to a very broad definition of health, rapid reviews, updates of already completed systematic reviews, and methods research related to the science of systematic reviews, such as decision modeling. The journal also aims to ensure that the results of all well-conducted systematic reviews are published, regardless of their outcome.

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Conducting a systematic review of animal studies?

Systematic Reviews considers protocols and results papers of systematic reviews of animal studies relevant for human health. You can now also prospectively register these reviews on PROSPERO.

Thank you to our peer reviewers

The editors and staff of Systematic Reviews would like to warmly thank our peer reviewers whose comments have helped to shape the journal.

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Call for papers: Automation in systematic reviews

We are pleased to announce that Systematic Reviews is accepting submissions for a new thematic series on automation in the systematic review process.

Guest Edited by Professor Joseph Lau (Brown University, USA), this series will include articles about innovative uses of computer technologies in producing systematic reviews.

David Moher

About the Editors

Dr David Moher, Editor-in-Chief

Dr Moher is a senior scientist at the Clinical Epidemiology Program, Ottawa Hospital Research Institute, and Associate Professor, Department of Epidemiology and Community Medicine, University of Ottawa. Dr Moher has been involved in systematic reviews for more than 20 years and has made contributions to the conduct and reporting of systematic reviews. Dr Moher is associated with many journals, is a member of the advisory board for the International Congress on Peer Review and Biomedical Publication, and a member of the EQUATOR Network's steering group.

Paul Shekelle

Dr Paul Shekelle, Editor-in-Chief

Dr Shekelle is a Staff Physician at the West Los Angeles Veterans Affairs Medical Center and has served as the Director of the Southern California Evidence-based Practice Center for the RAND Corporation since 1997. He is also a Professor of Medicine at the University of California, Los Angeles (UCLA) School of Medicine. He is widely recognized in the field of guidelines, quality measurement, and evidence-based medicine. Dr Shekelle has extensive experience in the health care arena and was previously the methodologist for the Agency for Health Care Policy and Research (now the Agency for Healthcare Research and Quality [AHRQ]) Low-Back Guidelines Panel, and he has participated in a number of other guideline development activities. He is currently the chair of the Clinical Guidelines Committee of the American College of Physicians.

Lesley Stewart

Prof Lesley Stewart, Editor-in-Chief

Prof Stewart is Director of the Centre for Reviews and Dissemination (CRD) at the University of York and is a National Institute for Health Research (NIHR) Senior Investigator. Prof Stewart has been involved in evidence synthesis in healthcare since the late 1980's, previously running the Medical Research Council Clinical Trials Unit meta-analysis research program. Together with colleagues in Cambridge and Oxford, she helped establish the methodology and framework for individual patient data (IPD) reviews and was a founding member of the Cochrane Collaboration. Her research interests include the avoidance of bias and development of IPD methods and approaches to systematic review. Recently, she has instigated the development of PROSPERO an international register for the prospective registration of systematic reviews.

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