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  1. The global prevalence of people living with dementia is expected to increase exponentially and yet evidence suggests gaps in dementia-specific knowledge amongst practitioners. Evidence-based learning approache...

    Authors: Kevin Muirhead, Leah Macaden, Charlotte Clarke, Keith Smyth, Rob Polson and Chris O’Malley

    Citation: Systematic Reviews 2019 8:316

    Content type: Protocol

    Published on:

  2. There is a widespread belief that information technologies will improve diagnosis, treatment and care. Evidence about their effectiveness in health care is, however, mixed. It is not clear why this is the case...

    Authors: Justin Keen, Joanne Greenhalgh, Rebecca Randell, Peter Gardner, Justin Waring, Roberta Longo, Jon Fistein, Maysam Abdulwahid, Natalie King and Judy Wright

    Citation: Systematic Reviews 2019 8:307

    Content type: Protocol

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  3. Sepsis is a major cause of morbidity and mortality among neonates and infants. Antibiotics are a central part of the first line treatment for sepsis in neonatal intensive care units worldwide. However, the evi...

    Authors: Steven Kwasi Korang, Sanam Safi, Christian Gluud, Ulrik Lausten-Thomsen and Janus C. Jakobsen

    Citation: Systematic Reviews 2019 8:306

    Content type: Protocol

    Published on:

  4. Practitioner-level implementation interventions such as audit and feedback, communities of practice, and local opinion leaders have shown potential to change nurses’ behaviour in clinical practice and improve ...

    Authors: Guillaume Fontaine, Sylvie Cossette, Marc-André Maheu-Cadotte, Marie-France Deschênes, Geneviève Rouleau, Andréane Lavallée, Catherine Pépin, Ariane Ballard, Gabrielle Chicoine, Alexandra Lapierre, Patrick Lavoie, Jérémie Blondin and Tanya Mailhot

    Citation: Systematic Reviews 2019 8:305

    Content type: Protocol

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  5. Antibiotic resistance is a global public health threat. Water from human activities is collected at wastewater treatment plants where processes often do not sufficiently neutralize antibiotic resistant bacteri...

    Authors: Daloha Rodríguez-Molina, Petra Mang, Heike Schmitt, Mariana Carmen Chifiriuc, Katja Radon and Laura Wengenroth

    Citation: Systematic Reviews 2019 8:304

    Content type: Protocol

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  6. Physical inactivity is the fourth leading risk factor for global mortality. Reducing sedentary behaviour and increasing physical activity are efficacious for improving many physical and mental health condition...

    Authors: Jean-Pierre Laake and Joanna Fleming

    Citation: Systematic Reviews 2019 8:303

    Content type: Protocol

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  7. Chinese herbal medicines (CHMs) are the major interventions of traditional Chinese medicine (TCM), which are typically administered as either single herbs or formulas. The Cochrane systematic reviews (SRs) of ...

    Authors: Xuan Zhang, Qi-Ying Aixinjueluo, Si-Yao Li, Lisa-L Song, Chung-Tai Lau, Ran Tan and Zhao-Xiang Bian

    Citation: Systematic Reviews 2019 8:302

    Content type: Research

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  8. In the U.S., Hispanic women experience a disproportionate rate of obesity and obesity-related chronic diseases. At the same time, Hispanic women remain considerably underrepresented in behavioral weight loss i...

    Authors: Kristin E. Morrill, Melissa Lopez-Pentecost, Guadalupe Ballesteros, Jeanne L. Pfander, Melanie D. Hingle, Yann C. Klimentidis, Cynthia A. Thomson and David O. Garcia

    Citation: Systematic Reviews 2019 8:301

    Content type: Protocol

    Published on:

  9. Fathers are under-represented in research and programs addressing early childhood health and development. Recruiting fathers into these interventions can be hampered for multiple reasons, including recruitment...

    Authors: Elizabeth M. Keys, Jill M. Norris, Emily E. Cameron, Katherine S. Bright, Lianne M. Tomfohr-Madsen and Karen M. Benzies

    Citation: Systematic Reviews 2019 8:300

    Content type: Protocol

    Published on:

  10. Opioid agonist maintenance treatment (OAMT) is a first-line treatment for heroin dependence, but its effectiveness has been assessed primarily through clinical outcomes with a limited attention to patient pers...

    Authors: Ivan Solà, Joan Trujols, Elisa Ribalta, Saul Alcaraz, Gemma Robleda, Clara Selva Olid and José Pérez de los Cobos

    Citation: Systematic Reviews 2019 8:299

    Content type: Protocol

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  11. The present protocol was designed for a systematic review and meta-analysis aimed at determining the association of telomere length with substance use disorders with the exclusion of nicotine addiction, and to...

    Authors: Fernando Navarro-Mateu, María Rubio-Aparicio, Pedro Cayuela, Francisco-Javier Álvarez, Agustín Roca-Vega, María Dolores Chirlaque, María Luisa Cayuela, Mathilde Husky, Salvador Martínez and Julio Sánchez-Meca

    Citation: Systematic Reviews 2019 8:298

    Content type: Protocol

    Published on:

  12. Prevention of antenatal and postnatal depression is crucial, given its high prevalence and severe consequences. Although several systematic reviews and meta-analyses have examined the effects of psychological ...

    Authors: Naonori Yasuma, Zui Narita, Natsu Sasaki, Erika Obikane, Junpei Sekiya, Takuma Inagawa, Aiichiro Nakajima, Yuji Yamada, Ryuichi Yamazaki, Asami Matsunaga, Tomomi Saito, Kazuhiro Watanabe, Kotaro Imamura, Norito Kawakami and Daisuke Nishi

    Citation: Systematic Reviews 2019 8:297

    Content type: Protocol

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  13. Active school travel by bike may provide appropriate means to promote physical activity through commuting to and from school, expanding the mobility during leisure time, and integrating a lifelong positive beh...

    Authors: Dorothea M. I. Schönbach, Teatske M. Altenburg, Mai J. M. Chinapaw, Adilson Marques and Yolanda Demetriou

    Citation: Systematic Reviews 2019 8:296

    Content type: Protocol

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  14. A healthy and productive health workforce is central to a well-functioning health system. However, health workers are at high risk of poor psychological wellbeing due to their particularly strenuous work deman...

    Authors: Julia Lohmann, Denny John and Aso Dzay

    Citation: Systematic Reviews 2019 8:294

    Content type: Protocol

    Published on:

  15. Exosomes may have critical roles in the maternal-embryo cross-talk for the recognition and maintenance of pregnancy during maternal aging. Exosomes have the capability to carry developmental signaling molecule...

    Authors: Halimeh Mobarak, Reza Rahbarghazi, Francesca Lolicato, Mohammad Heidarpour, Fariba Pashazadeh, Mohammad Nouri and Mahdi Mahdipour

    Citation: Systematic Reviews 2019 8:293

    Content type: Protocol

    Published on:

  16. The implementation of trauma systems in many high-income countries over the last 50 years has led to important reductions in injury mortality and disability in many healthcare jurisdictions. Injury organizatio...

    Authors: Brice Batomen, Lynne Moore, Mabel Carabali, Pier-Alexandre Tardif, Howard Champion and Arijit Nandi

    Citation: Systematic Reviews 2019 8:292

    Content type: Protocol

    Published on:

  17. Nutritional therapy practice guidelines are designed to improve nutritional practices and thus the delivery of nutritional therapy in critically ill patients. However, they are not implemented despite the stro...

    Authors: Nomaxabiso M. Mooi and Busisiwe P. Ncama

    Citation: Systematic Reviews 2019 8:291

    Content type: Protocol

    Published on:

  18. Childhood adiposity has increased dramatically in the last few decades and is an important predictor of adulthood chronic disease. Later eating rhythm, termed night eating (NE), is increasingly prevalent in ad...

    Authors: Mengxuan Zou, Kate Northstone, Rachel Perry, Laura Johnson and Sam Leary

    Citation: Systematic Reviews 2019 8:290

    Content type: Protocol

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  19. Since the deinstitutionalization policy, in psychiatric hospitals, the care of patients with schizophrenia was left to their families which has been imposing a heavy burden on them. Family caregiver burden cou...

    Authors: Zahra Tamizi, Masoud Fallahi-Khoshknab, Asghar Dalvandi, Farahnaz Mohammadi-Shahboulaghi, Eesa Mohammadi and Enayatollah Bakhshi

    Citation: Systematic Reviews 2019 8:289

    Content type: Protocol

    Published on:

  20. Obesity and its consequences are worldwide epidemic problem; therefore, studies with strategies and mechanisms that favor weight loss to improve outcomes in health are necessary. Effects of mushrooms on body w...

    Authors: Denise Grotto, Isabella Ferreira Camargo, Katia Kodaira, Lauren Giustti Mazzei, Juliana Castro, Raquel Andrade Leite Vieira, Cristiane de Cásia Bergamaschi and Luciane Cruz Lopes

    Citation: Systematic Reviews 2019 8:288

    Content type: Protocol

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  21. Inflammation in anterior uveitis is characterised by breakdown of the blood-ocular barrier, which allows leakage of blood constituents of higher molecular weight into the aqueous humour. In routine clinical ca...

    Authors: Thomas W. McNally, Xiaoxuan Liu, Sophie Beese, Pearse A. Keane, David J. Moore and Alastair K. Denniston

    Citation: Systematic Reviews 2019 8:287

    Content type: Protocol

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  22. Despite advances in resuscitation care, mortality rates following cardiac arrest (CA) remain high. Between one-quarter (in-hospital CA) and two-thirds (out of hospital CA) of patients admitted comatose to inte...

    Authors: Alex Monk and Shashank Patil

    Citation: Systematic Reviews 2019 8:286

    Content type: Protocol

    Published on:

  23. Despite existing best practice care recommendations for addressing tobacco smoking, alcohol consumption and weight management in preconception and antenatal care, such recommendations are often not implemented...

    Authors: Emma Doherty, Melanie Kingsland, Luke Wolfenden, John Wiggers, Julia Dray, Jenna Hollis, Elizabeth J. Elliott, Justine B. Daly, Kylie A. Bailey, John Attia, Mandy Hunter, Ian Symonds, Belinda Tully, Danika Tremain and Rebecca K. Hodder

    Citation: Systematic Reviews 2019 8:285

    Content type: Protocol

    Published on:

  24. Obsessive-compulsive disorder (OCD) is a chronic mental health disorder characterized by recurring obsessions and compulsions affecting 1–3% of children and adolescents. Current treatment options are limited b...

    Authors: Lucía Babiano-Espinosa, Lidewij H. Wolters, Bernhard Weidle, Vivian op de Beek, Sindre A. Pedersen, Scott Compton and Norbert Skokauskas

    Citation: Systematic Reviews 2019 8:284

    Content type: Research

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  25. Oropharyngeal dysphagia or swallowing difficulties are common in acute care and critical care, affecting 47% of hospitalised frail elderly, 50% of acute stroke patients and approximately 62% of critically ill ...

    Authors: Sallyanne Duncan, Jennifer Mc Gaughey, Richard Fallis, Daniel F. McAuley, Margaret Walshe and Bronagh Blackwood

    Citation: Systematic Reviews 2019 8:283

    Content type: Protocol

    Published on:

  26. The relative scale adjusts for baseline variability and therefore may lead to findings that can be generalized more widely. It is routinely used for the analysis of binary outcomes but only rarely for continuo...

    Authors: Harri Hemilä and Jan O. Friedrich

    Citation: Systematic Reviews 2019 8:282

    Content type: Methodology

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  27. This systematic review was conducted to inform the Canadian Task Force on Preventive Health Care recommendations on screening for thyroid dysfunction (TD). The review sought to answer key questions on the bene...

    Authors: Francesca Reyes Domingo, Marc T. Avey and Marion Doull

    Citation: Systematic Reviews 2019 8:260

    Content type: Research

    Published on:

  28. This review aimed to assess the existing evidence regarding the clinical effectiveness and safety of pharmacological and non-pharmacological interventions in adults with insomnia and identify where research or...

    Authors: Patricia Rios, Roberta Cardoso, Deanna Morra, Vera Nincic, Zahra Goodarzi, Bechara Farah, Sharada Harricharan, Charles M. Morin, Judith Leech, Sharon E. Straus and Andrea C. Tricco

    Citation: Systematic Reviews 2019 8:281

    Content type: Research

    Published on:

  29. Systematic reviews of health interventions are increasingly incorporating evidence outside of randomized controlled trials (RCT). While non-randomized study (NRS) types may be more prone to bias compared to RC...

    Authors: Kelly Farrah, Kelsey Young, Matthew C. Tunis and Linlu Zhao

    Citation: Systematic Reviews 2019 8:280

    Content type: Research

    Published on:

  30. We explored the performance of three machine learning tools designed to facilitate title and abstract screening in systematic reviews (SRs) when used to (a) eliminate irrelevant records (automated simulation) ...

    Authors: Allison Gates, Samantha Guitard, Jennifer Pillay, Sarah A. Elliott, Michele P. Dyson, Amanda S. Newton and Lisa Hartling

    Citation: Systematic Reviews 2019 8:278

    Content type: Research

    Published on:

  31. Web applications that employ natural language processing technologies to support systematic reviewers during abstract screening have become more common. The goal of our project was to conduct a case study to e...

    Authors: Gerald Gartlehner, Gernot Wagner, Linda Lux, Lisa Affengruber, Andreea Dobrescu, Angela Kaminski-Hartenthaler and Meera Viswanathan

    Citation: Systematic Reviews 2019 8:277

    Content type: Research

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  32. Compromised natural killer (NK) cell cytotoxic function is a well-documented and consistent feature of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Other outcomes evaluated in NK cells of ME/CF...

    Authors: Natalie Eaton-Fitch, Stanley du Preez, Hélène Cabanas, Donald Staines and Sonya Marshall-Gradisnik

    Citation: Systematic Reviews 2019 8:279

    Content type: Systematic review update

    Published on:

  33. Alcohol use disorder (AUD) is highly prevalent and accounts globally for 1.6% of disability-adjusted life years (DALYs) among females and 6.0% of DALYs among males. Effective treatments for AUDs are available ...

    Authors: Susan A. Rombouts, James Conigrave, Eva Louie, Paul Haber and Kirsten C. Morley

    Citation: Systematic Reviews 2019 8:275

    Content type: Protocol

    Published on:

  34. Obesity in childhood is associated with adverse health outcomes and complications throughout the life-span of a child. Available evidence suggests a dramatic increase in childhood obesity in sub-Saharan Africa...

    Authors: Frederick I. Danquah, Matilda Yeboah, Vitalis Bawontuo and Desmond Kuupiel

    Citation: Systematic Reviews 2019 8:274

    Content type: Protocol

    Published on:

  35. Peripheral nerve block is a single injection that inhibits the transmission of peripheral nerve impulses to the central nervous system. The inhibition of the nociceptive impulse may decrease the occurrence of ...

    Authors: Jennifer Héroux, Emilie Belley-Côté, Pablo Echavé, Marie-Josée Loignon, Pierre-Olivier Bessette, Nicolas Patenaude, Jean-Patrice Baillargeon and Frédérick D’Aragon

    Citation: Systematic Reviews 2019 8:273

    Content type: Protocol

    Published on:

  36. Pharmacy interventions are a subset of public health interventions and its research is usually performed within the scope of a trial. The economic evaluation of pharmacy interventions requires certain consider...

    Authors: Suzete Costa, Maria Cary, Dennis K. Helling, João Pereira and Céu Mateus

    Citation: Systematic Reviews 2019 8:272

    Content type: Research

    Published on:

  37. Gestational diabetes (GDM) is increasingly common and has significant implications during pregnancy and for the long-term health of the mother and offspring. However, it is a heterogeneous condition with inter...

    Authors: Shamil D. Cooray, Jacqueline A. Boyle, Georgia Soldatos, Lihini A. Wijeyaratne and Helena J. Teede

    Citation: Systematic Reviews 2019 8:270

    Content type: Protocol

    Published on:

  38. Chronic primary musculoskeletal pain (CPMP) is one subcategory of the new classification of chronic primary pain for the upcoming ICD-11, defined as chronic pain in the muscles, bones, joints, or tendons that ...

    Authors: Helen Koechlin, Ben Whalley, Nicky J. Welton and Cosima Locher

    Citation: Systematic Reviews 2019 8:269

    Content type: Protocol

    Published on:

  39. Investing in women’s health is an inevitable investment in our future. We systematically reviewed the available evidence and summarized the weighted prevalence of type 2 diabetes (T2DM) and pre-diabetes mellit...

    Authors: Rami H. Al-Rifai, Maria Majeed, Maryam A. Qambar, Ayesha Ibrahim, Khawla M. AlYammahi and Faisal Aziz

    Citation: Systematic Reviews 2019 8:268

    Content type: Research

    Published on:

  40. A considerable proportion of adults with low back pain (LBP) suffer from depressive symptoms or depression. Those with depressive symptoms or depression may be at risk of poorer LBP recovery and require more h...

    Authors: Jessica J. Wong, Andrea C. Tricco, Pierre Côté and Laura C. Rosella

    Citation: Systematic Reviews 2019 8:267

    Content type: Protocol

    Published on:

  41. Experimental designs for evaluating knowledge translation (KT) interventions can provide strong estimates of effectiveness but offer limited insight into how the intervention worked. Consequently, process evaluat...

    Authors: Shannon D. Scott, Thomas Rotter, Rachel Flynn, Hannah M. Brooks, Tabatha Plesuk, Katherine H. Bannar-Martin, Thane Chambers and Lisa Hartling

    Citation: Systematic Reviews 2019 8:266

    Content type: Research

    Published on:

  42. While Internet- and mobile-based interventions (IMIs) might possess the potential to increase access to evidence-based therapies for post-traumatic stress disorder (PTSD), comprehensive knowledge on active int...

    Authors: Lena Steubl, Cedric Sachser, Harald Baumeister and Matthias Domhardt

    Citation: Systematic Reviews 2019 8:265

    Content type: Protocol

    Published on:

  43. The relation between socioeconomic position (SEP) and obesity measured by body mass index (BMI) has been extensively reviewed, but there is less research on the association between SEP and body composition. Fa...

    Authors: Charis Bridger Staatz, Yvonne Kelly, Rebecca Lacey and Rebecca Hardy

    Citation: Systematic Reviews 2019 8:263

    Content type: Protocol

    Published on:

  44. Paediatric cancers account for a minor fraction of deaths and hence receive little attention from policymakers. In low-income countries, the absence of comprehensive national paediatric strategies results in a...

    Authors: Sehlisiwe R. Ndlovu, Desmond Kuupiel and Themba G. Ginindza

    Citation: Systematic Reviews 2019 8:262

    Content type: Protocol

    Published on:

  45. This systematic review aims to inform the development of a screening tool which pre-operatively predicts which children are likely to develop velopharyngeal insufficiency, one of the causes of poor speech outc...

    Authors: David Sainsbury, Caroline Williams, Catherine de Blacam, Joanne Mullen, Ambika Chadha, Yvonne Wren and Peter Hodgkinson

    Citation: Systematic Reviews 2019 8:261

    Content type: Protocol

    Published on:

  46. Optimal type 1 diabetes mellitus (T1D) care requires lifelong appropriate insulin treatment, which can be provided either by multiple daily injections (MDI) of insulin or by continuous subcutaneous insulin inf...

    Authors: Tiago Jeronimo Dos Santos, Juan de Mata Donado Campos, Cristina Alexandra Fraga Medin, Jesús Argente and Fernando Rodríguez-Artalejo

    Citation: Systematic Reviews 2019 8:259

    Content type: Protocol

    Published on:

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