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  1. Content type: Research

    The importance of sex and gender considerations in research is being increasingly recognized. Evidence indicates that sex and gender can influence intervention effectiveness. We assessed the extent to which se...

    Authors: Jennifer Petkovic, Jessica Trawin, Omar Dewidar, Manosila Yoganathan, Peter Tugwell and Vivian Welch

    Citation: Systematic Reviews 2018 7:113

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  2. Content type: Research

    We estimated the effectiveness of serial B-type natriuretic peptide (BNP) blood testing to guide up-titration of medication compared with symptom-guided up-titration of medication in patients with heart failur...

    Authors: Maria Pufulete, Rachel Maishman, Lucy Dabner, Julian P. T. Higgins, Chris A. Rogers, Mark Dayer, John MacLeod, Sarah Purdy, William Hollingworth, Morten Schou, Manuel Anguita-Sanchez, Patric Karlström, Michael Kleiner Shochat, Theresa McDonagh, Angus K. Nightingale and Barnaby C. Reeves

    Citation: Systematic Reviews 2018 7:112

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  3. Content type: Methodology

    The evaluation of imprecision is a key dimension of the grading of the confidence in the estimate. Grading of Recommendations Assessment, Development and Evaluation (GRADE) gives recommendations on how to down...

    Authors: Greta Castellini, Matteo Bruschettini, Silvia Gianola, Christian Gluud and Lorenzo Moja

    Citation: Systematic Reviews 2018 7:110

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  4. Content type: Research

    Clinical research investigating effective intervention strategies for adolescents to improve health behaviors has shifted to the application of motivational interviewing (MI). Evidence indicates that MI is an ...

    Authors: Christina Mutschler, Erica Naccarato, Jen Rouse, Caitlin Davey and Kelly McShane

    Citation: Systematic Reviews 2018 7:109

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  5. Content type: Protocol

    Malaria remains one of the leading causes of morbidity and mortality in most low- and middle-income countries. Chloroquine is a previously cheap and effective antimalarial agent whose loss to resistance result...

    Authors: Moses Ocan, Dickens Akena, Sam Nsobya, Moses R. Kamya, Richard Senono, Alison Annet Kinengyere and Ekwaro A. Obuku

    Citation: Systematic Reviews 2018 7:108

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  6. Content type: Protocol

    Rates of cannabis use are highest during emerging adulthood (age 18–25), with the prevalence of near daily and daily increasing among this age group. Emerging adults are clinically challenging in terms of harm...

    Authors: Jillian Halladay, Tashia Petker, Allan Fein, Catharine Munn and James MacKillop

    Citation: Systematic Reviews 2018 7:106

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  7. Content type: Protocol

    Daily iron-folic acid supplementation reduces anemia and various adverse obstetric outcomes such as preterm delivery, low birthweight, hemorrhage, and perinatal and maternal morbidity and mortality. However, i...

    Authors: Mohammed Akibu, Tesfalidet Tekelab, Abdella Amano, Merga Besho, Stephanie Grutzmacher, Mesfin Tadese and Tesfa Dejenie Habtewold

    Citation: Systematic Reviews 2018 7:107

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  8. Content type: Protocol

    Metformin is one of the most commonly used drugs for type 2 diabetes mellitus (T2DM). Despite its efficacy and safety, metformin is frequently associated with highly variable glycemic responses, which is hypot...

    Authors: Edith Pascale Mofo Mato, Magellan Guewo-Fokeng, M. Faadiel Essop and Peter Mark Oroma Owira

    Citation: Systematic Reviews 2018 7:105

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  9. Content type: Protocol

    A recent paradigm shift within the intensive care discipline has led to implementation of protocols to drive early recovery from the intensive care unit (ICU). These protocols belong to a large knowledge, tran...

    Authors: David Wyler, Michael Esterlis, Brittany Burns Dennis, Andrew Ng and Abhijit Lele

    Citation: Systematic Reviews 2018 7:104

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  10. Content type: Research

    Gastrointestinal cancer patients are susceptible to significant postoperative morbidity. The aim of this systematic review was to examine the effects of preoperative exercise therapy (PET) on patients undergoi...

    Authors: Sarah A. Vermillion, Alston James, Robert D. Dorrell, Peter Brubaker, Shannon L. Mihalko, Adrienne R. Hill and Clancy J. Clark

    Citation: Systematic Reviews 2018 7:103

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  11. Content type: Protocol

    The Sustainable Development Goals (SDGs) emphasize the need for strengthening the capacity of all developing countries in the early warning, risk reduction and management of national as well as global health r...

    Authors: Neusa Fernanda Torres, Buyisile Chibi, Lyn E. Middleton, Vernon P. Solomon and Tivani Mashamba-Thompson

    Citation: Systematic Reviews 2018 7:102

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  12. Content type: Protocol

    Patient-Oriented Research (POR) is a Canadian initiative for health research that refers to research processes informed by full and active patient involvement in all aspects of the research. Ideally, POR resul...

    Authors: Anastasia A. Mallidou, Noreen Frisch, Mary M. Doyle-Waters, Martha L. P. MacLeod, John Ward and Pat Atherton

    Citation: Systematic Reviews 2018 7:101

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  13. Content type: Protocol

    When patients have been on opioid therapy for more than 90 days, more than half of them continue using opioids years later. Knowing that long-term opioid consumption could lead to harmful side effects includin...

    Authors: M. Gabrielle Pagé, Irina Kudrina, Hervé Tchala Vignon Zomahoun, Daniela Ziegler, Pierre Beaulieu, Céline Charbonneau, Jennifer Cogan, Raoul Daoust, Marc O. Martel, Andrée Néron, Philippe Richebé and Hance Clarke

    Citation: Systematic Reviews 2018 7:97

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  14. Content type: Research

    There is considerable interest in the impact of increased flavan-3-ol intake on cardiovascular disease (CVD) and diabetes outcomes. Through evidence mapping, we determined the extent of the evidence base to in...

    Authors: Gowri Raman, Marissa Shams-White, Esther E. Avendano, Fan Chen, Janet A. Novotny and Aedin Cassidy

    Citation: Systematic Reviews 2018 7:100

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  15. Content type: Protocol

    Systematic review (SR) guidelines recommend extending literature search to gray literature in order to identify all available data related to the review topic. We aim to conduct an overview of SRs on populatio...

    Authors: Karima Chaabna, Sohaila Cheema, Amit Abraham, Hekmat Alrouh, Ravinder Mamtani and Javaid I. Sheikh

    Citation: Systematic Reviews 2018 7:94

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  16. Content type: Protocol

    Diabetes mellitus (DM) in women of childbearing age may affect the fetus, thereby accelerating the intergenerational risk of DM. The Middle East and North Africa (MENA) region is experiencing a growing epidemi...

    Authors: Rami H. Al-Rifai and Faisal Aziz

    Citation: Systematic Reviews 2018 7:96

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  17. Content type: Protocol

    Glucose abnormalities in cystic fibrosis (CF) are common, but there is limited evidence to guide their dietary management. Progressive impaired glucose tolerance eventually leads to cystic fibrosis-related dia...

    Authors: Laura Birch, Fiona E. Lithander, Simon Langton Hewer, Katie Harriman, Julian Hamilton-Shield and Rachel Perry

    Citation: Systematic Reviews 2018 7:98

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  18. Content type: Protocol

    Pediatric epilepsy, including treatment-resistant forms, has a major effect on the quality of life, morbidity, and mortality of affected children. Interest has been growing in the use of medical cannabis as a ...

    Authors: Jesse Elliott, Deirdre DeJean, Tammy Clifford, Doug Coyle, Beth Potter, Becky Skidmore, Christine Alexander, Alexander E. Repetski, Bláthnaid McCoy and George A. Wells

    Citation: Systematic Reviews 2018 7:95

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  19. Content type: Protocol

    ‘Pain rewarded’ is a hypothesis wherein acute pain sufferers are exposed to reinforcers and punishers from their environment that shape their behaviour, i.e. pain responses. Such a point of view has been taken...

    Authors: Wacław M. Adamczyk, Kerstin Luedtke, Ewa Buglewicz and Przemysław Bąbel

    Citation: Systematic Reviews 2018 7:93

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  20. Content type: Protocol

    As general population life expectancy has increased, the need to investigate the quality of life has arisen, especially because it is important that people have a healthy long life and with good quality. Studi...

    Authors: Janete Capel Hernandes, Viviane Cruvinel Di Castro, Mauro Elias Mendonça and Celmo Celeno Porto

    Citation: Systematic Reviews 2018 7:92

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  21. Content type: Protocol

    Neoadjuvant chemotherapy (NACT), a standard of care for locally advanced breast cancer patients, is widely used for early breast cancer patients also. The varying role of regimens used as NACT needs to be inve...

    Authors: Mona Pathak, Sada Nand Dwivedi, S. V. S. Deo, Bhaskar Thakur, Vishnubhatla Sreenivas and G. K. Rath

    Citation: Systematic Reviews 2018 7:89

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  22. Content type: Protocol

    Individuals with substance use and addictive disorders often display greater risk-taking behaviour, higher impulsivity, and altered reward processing compared to individuals without these disorders. While it i...

    Authors: Katherine R. Naish, Lana Vedelago, James MacKillop and Michael Amlung

    Citation: Systematic Reviews 2018 7:90

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  23. Content type: Protocol

    Dementia is a globally prevalent disease that requires ongoing and increasing levels of care, often provided in the first instance by informal caregivers. Supporting transitions in informal caregiving in demen...

    Authors: Marianne Cranwell, Anna Gavine, Linda McSwiggan and Timothy B. Kelly

    Citation: Systematic Reviews 2018 7:91

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  24. Content type: Protocol

    Menu labelling is continuing to gather public and legislative support as one of the potential environmental strategies for addressing the obesity pandemic. However, issues relating to implementation have been ...

    Authors: Claire Kerins, Jennifer McSharry, Catherine Hayes, Ivan J. Perry, Fiona Geaney and Colette Kelly

    Citation: Systematic Reviews 2018 7:88

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  25. Content type: Editorial

    The journal recently celebrated its fifth anniversary. Like systematic reviews themselves, the journal is thriving and publishing a variety of protocols, reviews, and methods papers. We have also had success i...

    Authors: David Moher, Lesley A. Stewart and Paul Shekelle

    Citation: Systematic Reviews 2018 7:87

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  26. Content type: Protocol

    Meningococcal disease (MD) is notoriously difficult to diagnose in the early stages of the illness and presents similarly to many self-limiting viral infections. This mandates a cautious approach to diagnosis ...

    Authors: Thomas Waterfield, Derek Fairley, Fiona Lynn, Bronagh Blackwood and Michael D. Shields

    Citation: Systematic Reviews 2018 7:86

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  27. Content type: Research

    Self-management support interventions may potentially delay kidney function decline and associated complications in patients with comorbid diabetes and chronic kidney disease. However, the effectiveness of the...

    Authors: Edward Zimbudzi, Clement Lo, Marie L. Misso, Sanjeeva Ranasinha, Peter G. Kerr, Helena J. Teede and Sophia Zoungas

    Citation: Systematic Reviews 2018 7:84

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  28. Content type: Protocol

    Systematic reviews (SRs) of randomised controlled trials (RCTs) can provide the best evidence to inform decision-making, but their methodological and reporting quality varies. Tools exist to guide the critical...

    Authors: Allison Gates, Michelle Gates, Gonçalo Duarte, Maria Cary, Monika Becker, Barbara Prediger, Ben Vandermeer, Ricardo M. Fernandes, Dawid Pieper and Lisa Hartling

    Citation: Systematic Reviews 2018 7:85

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  29. Content type: Protocol

    Non-infectious uveitis represents a sub-type of intraocular inflammation often associated with disorders of immune dysregulation. If untreated, the intraocular inflammation may progress to severe visual impair...

    Authors: Joshua Blair, Robert Barry, Philip I. Murray, David J. Moore and Alastair K. Denniston

    Citation: Systematic Reviews 2018 7:83

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  30. Content type: Research

    Early diagnosis of human immunodeficiency virus (HIV) is important because antiretroviral therapies are more effective if infected individuals are diagnosed early. Diagnosis of HIV relies on laboratory testing...

    Authors: Benhildah N. Rumbwere Dube, Tom P. Marshall, Ronan P. Ryan and Modupe Omonijo

    Citation: Systematic Reviews 2018 7:82

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  31. Content type: Research

    Anemia continued to become a major public health problem in developing nations including Ethiopia. Especially, school children are more vulnerable for anemia and consequences of anemia. Generating accurate epi...

    Authors: Robel Tezera, Zekariyas Sahile, Delelegn Yilma, Equilnet Misganaw and Ermiyas Mulu

    Citation: Systematic Reviews 2018 7:80

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  32. Content type: Protocol

    Of various chronic diseases, low back pain (LBP) is the most common and debilitating musculoskeletal condition among older adults aged 65 years or older. While more than 17 million older adults in the USA suff...

    Authors: Arnold Y. L. Wong, Katarina Sjögren Forss, Jenny Jakobsson, Veronika Schoeb, Christine Kumlien and Gunilla Borglin

    Citation: Systematic Reviews 2018 7:81

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  33. Content type: Protocol

    Conducting a health technology assessment (HTA) of public health interventions (PHIs) poses some challenges. PHIs are often complex interventions, which affect the number and degree of interactions of the aspe...

    Authors: Tim Mathes, Gerald Willms, Stephanie Polus, Constance Stegbauer, Melanie Messer, Corinna Klingler, Heidi Ehrenreich, Dea Niebuhr, Georg Marckmann, Ansgar Gerhardus and Dawid Pieper

    Citation: Systematic Reviews 2018 7:79

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  34. Content type: Protocol

    Needle-related procedures are the most important source of pain in children in hospital setting. Unmanaged pain could result in short- and long-term physiological, psychological, and emotional consequences. Al...

    Authors: Ariane Ballard, Christelle Khadra, Samara Adler, Evelyne Doyon-Trottier and Sylvie Le May

    Citation: Systematic Reviews 2018 7:78

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  35. Content type: Protocol

    Adult brachial plexus injuries (BPI) are becoming more common. The reconstruction and prognosis of pre-ganglionic injuries (root avulsions) are different to other types of BPI injury. Preoperative magnetic res...

    Authors: Ryckie G. Wade, Yemisi Takwoingi, Justin C. R. Wormald, John P. Ridgway, Steven Tanner, James J. Rankine and Grainne Bourke

    Citation: Systematic Reviews 2018 7:76

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  36. Content type: Commentary

    Systematic reviews (SR) are vital to health care, but have become complicated and time-consuming, due to the rapid expansion of evidence to be synthesised. Fortunately, many tasks of systematic reviews have th...

    Authors: Elaine Beller, Justin Clark, Guy Tsafnat, Clive Adams, Heinz Diehl, Hans Lund, Mourad Ouzzani, Kristina Thayer, James Thomas, Tari Turner, Jun Xia, Karen Robinson and Paul Glasziou

    Citation: Systematic Reviews 2018 7:77

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  37. Content type: Protocol

    There will be a lack of 18 million healthcare workers by 2030. Multiplying the number of well-trained healthcare workers through innovative ways such as eLearning is highly recommended in solving this shortage...

    Authors: Gloria C. Law, Christian Apfelbacher, Pawel P. Posadzki, Sandra Kemp and Lorainne Tudor Car

    Citation: Systematic Reviews 2018 7:75

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  38. Content type: Protocol

    Hearing loss is one of the leading causes of disability worldwide, with greater than 20% of Canadian adults having measurable hearing loss in at least one ear. Patients with hearing loss experience impaired qu...

    Authors: Nadera Ahmadzai, Shaun Kilty, Dianna Wolfe, Jamie Bonaparte, David Schramm, Elizabeth Fitzpatrick, Vincent Lin, Wei Cheng, Becky Skidmore, David Moher and Brian Hutton

    Citation: Systematic Reviews 2018 7:74

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  39. Content type: Research

    Organizational contextual features have been recognized as important determinants for implementing evidence-based practices across healthcare settings for over a decade. However, implementation scientists have...

    Authors: Shelly-Anne Li, Lianne Jeffs, Melanie Barwick and Bonnie Stevens

    Citation: Systematic Reviews 2018 7:72

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  40. Content type: Protocol

    Exertional lower body musculoskeletal injuries (ELBI) cost billions of dollars and compromise the readiness and job performance of military service and public safety workers (i.e., tactical populations). The p...

    Authors: Shawn D. Flanagan, Aaron M. Sinnott, Kellen T. Krajewski, Caleb D. Johnson, Shawn R. Eagle, Alice D. LaGoy, Meaghan E. Beckner, Anne Z. Beethe, Rose Turner, Mita Lovalekar, Courtenay Dunn-Lewis, Chris Connaboy and Bradley C. Nindl

    Citation: Systematic Reviews 2018 7:73

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  41. Content type: Research

    Pharmacist counselling is an important service that has been associated with improved outcomes. The primary aim of this review was to identify, describe, and determine the effectiveness of interventions for im...

    Authors: Sinaa Al Aqeel, Norah Abanmy, Hiba AlShaya and Albatoul Almeshari

    Citation: Systematic Reviews 2018 7:71

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  42. Content type: Research

    Health information is readily accessible but is of variable quality. General knowledge about how to assess whether claims about health interventions are trustworthy is not common, so people’s health decisions ...

    Authors: Leila Cusack, Chris B. Del Mar, Iain Chalmers, Elizabeth Gibson and Tammy C. Hoffmann

    Citation: Systematic Reviews 2018 7:68

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  43. Content type: Protocol

    Cryptosporidium is a protozoan parasite of humans and other animals worldwide and is one of the greatest contributors to human diarrhoeal illness. Transmission can occur indirectly via contaminated food or water,...

    Authors: Caoimhe McKerr, Sarah J. O’Brien, Rachel M. Chalmers, Roberto Vivancos and Robert M. Christley

    Citation: Systematic Reviews 2018 7:70

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  44. Content type: Protocol

    To investigate the use of physical activity monitors (PAMs) for the elderly, the scientific literature should be systematically reviewed and the effect quantified, as the evidence seems inconclusive.

    Authors: Rasmus Tolstrup Larsen, Jan Christensen, Carsten Bogh Juhl, Henning Boje Andersen and Henning Langberg

    Citation: Systematic Reviews 2018 7:69

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  45. Content type: Protocol

    People with a mental illness experience a higher morbidity and mortality from chronic diseases relative to the general population. A higher prevalence of risk behaviours, including tobacco smoking, poor nutrit...

    Authors: Caitlin Fehily, Kate Bartlem, John Wiggers, Luke Wolfenden, Timothy Regan, Julia Dray, Jacqueline Bailey and Jenny Bowman

    Citation: Systematic Reviews 2018 7:67

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  46. Content type: Protocol

    Implementation science is the study of strategies used to integrate evidence-based practices into real-world settings (Eccles and Mittman, Implement Sci. 1(1):1, 2006). Central to the identification of replica...

    Authors: Cara C. Lewis, Kayne D. Mettert, Caitlin N. Dorsey, Ruben G. Martinez, Bryan J. Weiner, Elspeth Nolen, Cameo Stanick, Heather Halko and Byron J. Powell

    Citation: Systematic Reviews 2018 7:66

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  47. Content type: Protocol

    Transportation interventions seek to decrease delay in reaching a health facility for emergency obstetric care and are, thus, believed to contribute to reductions in such adverse pregnancy and childbirth outco...

    Authors: John Ehiri, Halimatou Alaofè, Ibitola Asaolu, Joy Chebet, Ekpereonne Esu and Martin Meremikwu

    Citation: Systematic Reviews 2018 7:65

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