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  1. Protocol

    Effects of transcutaneous electrical nerve stimulation (TENS) on proinflammatory cytokines: protocol for systematic review

    Pain reduction can be achieved by lowering proinflammatory cytokine levels in the blood. Transcutaneous electrical nerve stimulation (TENS) is a non-invasive physiotherapeutic resource for pain management, but...

    Tábata Cristina do Carmo Almeida, Francisco Winter dos Santos Figueiredo, Valter Cordeiro Barbosa Filho, Luiz Carlos de Abreu, Fernando Luiz Affonso Fonseca and Fernando Adami

    Systematic Reviews 2017 6:139

    Published on: 11 July 2017

  2. Protocol

    Delay discounting differences in brain activation, connectivity, and structure in individuals with addiction: a systematic review protocol

    Delayed reward discounting (DRD), the degree to which future rewards are discounted relative to immediate rewards, is used as an index of impulsive decision-making and has been associated with a number of prob...

    Max M. Owens, Michael T. Amlung, Steven R. H. Beach, Lawrence H. Sweet and James MacKillop

    Systematic Reviews 2017 6:138

    Published on: 11 July 2017

  3. Protocol

    Anorexia nervosa and cancer: a protocol for a systematic review and meta-analysis of observational studies

    Anorexia nervosa is characterized by a severe restriction of caloric intake, low body weight, fear of gaining weight or of becoming fat, and disturbance of body image. Pathogenesis of the disorder may include ...

    Ferrán Catalá-López, Brian Hutton, Jane A. Driver, Manuel Ridao, José M. Valderas, Ricard Gènova-Maleras, Jaume Forés-Martos, Adolfo Alonso-Arroyo, Diego Macías Saint-Gerons, Eduard Vieta, Alfonso Valencia and Rafael Tabarés-Seisdedos

    Systematic Reviews 2017 6:137

    Published on: 11 July 2017

  4. Research

    Evidence for a comprehensive approach to Aboriginal tobacco control to maintain the decline in smoking: an overview of reviews among Indigenous peoples

    Tobacco smoking is a leading cause of disease and premature mortality among Aboriginal and Torres Strait Islander (Indigenous) Australians. While the daily smoking prevalence among Indigenous Australians has d...

    Catherine Chamberlain, Susan Perlen, Sue Brennan, Lucie Rychetnik, David Thomas, Raglan Maddox, Noore Alam, Emily Banks, Andrew Wilson and Sandra Eades

    Systematic Reviews 2017 6:135

    Published on: 10 July 2017

  5. Protocol

    The effect and safety of postmenopausal hormone therapy and selective estrogen receptor modulators on kidney outcomes in women: a protocol for systematic review and meta-analysis

    The prevalence of menopause in women with or at risk of chronic kidney disease is increasing globally. Although international guidelines on menopause recommend the use of postmenopausal hormone therapy with or...

    Sandra M. Dumanski, Sharanya Ramesh, Matthew T. James, Amy Metcalfe, Kara Nerenberg, Ellen W. Seely, Helen Lee Robertson and Sofia B. Ahmed

    Systematic Reviews 2017 6:134

    Published on: 7 July 2017

  6. Protocol

    Protocol for a systematic review of N-of-1 trial protocol guidelines and protocol reporting guidelines

    N-of-1 trials are multiple cross-over trials done in individual participants, generating individual treatment effect information. While reporting guidelines for the CONSORT Extension for N-of-1 trials (CENT) a...

    Antony J. Porcino, Salima Punja, An-Wen Chan, Richard Kravitz, Aaron Orkin, Philippe Ravaud, Christopher H. Schmid and Sunita Vohra

    Systematic Reviews 2017 6:132

    Published on: 6 July 2017

  7. Protocol

    Management of frailty: a protocol of a network meta-analysis of randomized controlled trials

    Frailty is a common syndrome affecting 5–17% of community-dwelling older adults. Various interventions are used to prevent or treat frailty. Given the diversity of singular and multi-faceted frailty interventi...

    Ahmed M. Negm, Courtney C. Kennedy, Lehana Thabane, Areti-Angeliki Veroniki, Jonathan D. Adachi, Julie Richardson, Ian D. Cameron, Aidan Giangregorio and Alexandra Papaioannou

    Systematic Reviews 2017 6:130

    Published on: 5 July 2017

  8. Protocol

    Developing a framework for a novel multi-disciplinary, multi-agency intervention(s), to improve medication management in community-dwelling older people on complex medication regimens (MEMORABLE)––a realist synthesis

    Medication-related adverse events have been estimated to be responsible for 5700 deaths and cost the UK £750 million annually. This burden falls disproportionately on older people. Outcomes from interventions ...

    Ian Maidment, Andrew Booth, Judy Mullan, Jane McKeown, Sylvia Bailey and Geoffrey Wong

    Systematic Reviews 2017 6:125

    Published on: 3 July 2017

  9. Research

    Telephone consultations for general practice: a systematic review

    The use of information technology, including internet- and telephone-based resources, is becoming an alternative and supporting method of providing many forms of services in a healthcare and health management ...

    Martin J Downes, Merehau C Mervin, Joshua M Byrnes and Paul A Scuffham

    Systematic Reviews 2017 6:128

    Published on: 3 July 2017

  10. Research

    The effects of chronic and acute physical activity on working memory performance in healthy participants: a systematic review with meta-analysis of randomized controlled trials

    Understanding how physical activity (PA) influences cognitive function in populations with cognitive impairments, such as dementia, is an increasingly studied topic yielding numerous published systematic revie...

    Azeem Rathore and Barbara Lom

    Systematic Reviews 2017 6:124

    Published on: 30 June 2017

  11. Protocol

    What determines the effects and costs of breast cancer screening? A protocol of a systematic review of reviews

    Multiple reviews demonstrated high variability in effectiveness and cost-effectiveness outcomes among studies on breast cancer screening (BCS) programmes. No study to our knowledge has summarized the current e...

    O. Mandrik, O. I. Ekwunife, N. Zielonke, F. Meheus, J. L. Severens, S. K. Lhachimi and R. Murillo

    Systematic Reviews 2017 6:122

    Published on: 28 June 2017

  12. Protocol

    The association between child and adolescent emotional disorder and poor attendance at school: a systematic review protocol

    Anxiety and depression are common in young people and are associated with a range of adverse outcomes. Research has suggested a relationship between emotional disorder and poor school attendance, and thus poor...

    Katie Finning, Darren Moore, Obioha C. Ukoumunne, Emilia Danielsson-Waters and Tamsin Ford

    Systematic Reviews 2017 6:121

    Published on: 28 June 2017

  13. Protocol

    An assessment of the factors affecting the commercialization of cell-based therapeutics: a systematic review protocol

    Cellular-based therapies represent a platform technology within the rapidly expanding field of regenerative medicine and are distinct from conventional therapeutics—offering a unique approach to managing what ...

    David Pettitt, Zeeshaan Arshad, Benjamin Davies, James Smith, Anna French, Doug Cole, Kim Bure, Sue Dopson, David DiGiusto, Jeff Karp, Brock Reeve, Richard Barker, Georg Holländer and David Brindley

    Systematic Reviews 2017 6:120

    Published on: 26 June 2017

  14. Protocol

    Stress ulcer prophylaxis versus placebo or no prophylaxis in adult hospitalised acutely ill patients—protocol for a systematic review with meta-analysis and trial sequential analysis

    Stress ulcer prophylaxis is considered standard of care in many critically ill patients in the intensive care unit (ICU). However, the quality of evidence supporting this has recently been questioned, and clin...

    Søren Marker, Anders Perner, Jørn Wetterslev, Marija Barbateskovic, Janus Christian Jakobsen, Mette Krag, Anders Granholm, Carl Thomas Anthon and Morten Hylander Møller

    Systematic Reviews 2017 6:118

    Published on: 24 June 2017

  15. Protocol

    An investigation of the impact of using different methods for network meta-analysis: a protocol for an empirical evaluation

    Network meta-analysis, a method to synthesise evidence from multiple treatments, has increased in popularity in the past decade. Two broad approaches are available to synthesise data across networks, namely, a...

    Amalia (Emily) Karahalios, Georgia Salanti, Simon L. Turner, G. Peter Herbison, Ian R. White, Areti Angeliki Veroniki, Adriani Nikolakopoulou and Joanne E. Mckenzie

    Systematic Reviews 2017 6:119

    Published on: 24 June 2017

  16. Research

    Identifying approaches for assessing methodological and reporting quality of systematic reviews: a descriptive study

    The methodological quality and completeness of reporting of the systematic reviews (SRs) is fundamental to optimal implementation of evidence-based health care and the reduction of research waste. Methods exis...

    Kusala Pussegoda, Lucy Turner, Chantelle Garritty, Alain Mayhew, Becky Skidmore, Adrienne Stevens, Isabelle Boutron, Rafael Sarkis-Onofre, Lise M. Bjerre, Asbjørn Hróbjartsson, Douglas G. Altman and David Moher

    Systematic Reviews 2017 6:117

    Published on: 19 June 2017

  17. Protocol

    Effects of perioperative statin use on cardiovascular complications in patients submitted to non-cardiac surgery: protocol for a systematic review, meta-analysis, and trial sequential analysis

    Preliminary evidence suggests statins may reduce major perioperative vascular events. However, evidence is limited to observational studies, underpowered trials, and non-comprehensive systematic reviews. This ...

    Erica Aranha Suzumura, Rodrigo Antonini Ribeiro, Leticia Kawano-Dourado, Pedro Gabriel de Barros e Silva, Claudia Oliveira, Mabel Fernandes Figueiró, Alexandre Biasi Cavalcanti, Renato D. Lopes and Otavio Berwanger

    Systematic Reviews 2017 6:116

    Published on: 19 June 2017

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