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  1. Knowledge translation (KT) is an important means of improving the health service quality. Most research on the effectiveness of KT strategies has focused on individual strategies, i.e., those directly targetin...

    Authors: Karine Latulippe, Annie LeBlanc, Marie-Pierre Gagnon, Katia Boivin, Pascale Lavoie, Joëlle Dufour, Emmanuelle Paquette Raynard, Eve Richard and Marie-Ève Lamontagne

    Citation: Systematic Reviews 2021 10:255

    Content type: Protocol

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  2. Mild traumatic brain injury (mTBI) is an increasing public health problem that can lead to persistent symptoms that have several functional consequences. Understanding the prognosis of a condition is an import...

    Authors: Julien Déry, Élaine De Guise, Ève-Line Bussières and Marie-Eve Lamontagne

    Citation: Systematic Reviews 2021 10:254

    Content type: Protocol

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  3. The upper respiratory tract of children is colonized by various microbial species during the healthy state, whereas the lungs are believed to be sterile. In children with respiratory infections, micro-organism...

    Authors: Richa Rao, Jeanne M. Dsouza and Joseph L. Mathew

    Citation: Systematic Reviews 2021 10:253

    Content type: Protocol

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  4. Dementia prevalence is increasing globally and yet evidence suggest that gaps exist in dementia-specific knowledge among health and social care practitioners. Technological modes of educational delivery may be...

    Authors: Kevin Muirhead, Leah Macaden, Keith Smyth, Colin Chandler, Charlotte Clarke, Rob Polson and Chris O’Malley

    Citation: Systematic Reviews 2021 10:252

    Content type: Research

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  5. Adults with learning disabilities have an increased disposition to unhealthy lifestyle behaviours which often occur simultaneously. Existing studies focus on complex interventions targeting unhealthy diet, phy...

    Authors: Dikshyanta Rana, Sophie Westrop, Evi Germeni, Arlene McGarty, Louisa Ells, Phillippa Lally, Michael McEwan, Craig Melville, Leanne Harris and Olivia Wu

    Citation: Systematic Reviews 2021 10:251

    Content type: Protocol

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  6. Serious mental illnesses (SMI) such as schizophrenia and bipolar disorder first develop between ages 14 and 25. Once diagnosed, young peoples’ health can deteriorate, and it is therefore vital to detect this e...

    Authors: Lindsay H. Dewa, Arturas Kalniunas, Stephen Orleans-Foli, Sofia Pappa and Paul Aylin

    Citation: Systematic Reviews 2021 10:250

    Content type: Research

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  7. Mesenchymal stromal cells (MSCs) have significant immunomodulatory and tissue repair capabilities, mediated partly by conditioned media or through secreted extracellular vesicles (MSC-EVs). Infection with SARS...

    Authors: Aidan M. Kirkham, Madeline Monaghan, Adrian J. M. Bailey, Risa Shorr, Manoj M. Lalu, Dean A. Fergusson and David S. Allan

    Citation: Systematic Reviews 2021 10:249

    Content type: Protocol

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  8. The number of individuals with a visual impairment in the UK was estimated a few years ago to be around 1.8 million. People can be visually impaired from birth, childhood, early adulthood or later in life. Tho...

    Authors: Sally J. Giles, Maria Panagioti, Lisa Riste, Sudeh Cheraghi-Sohi, Penny Lewis, Isabel Adeyemi, Karen Davies, Rebecca Morris, Denham Phipps, Christine Dickenson, Darren Ashcroft and Caroline Sanders

    Citation: Systematic Reviews 2021 10:248

    Content type: Protocol

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  9. Anorexia nervosa (AN) is associated with structural brain abnormalities. Studies have reported less cerebral tissue and more cerebrospinal fluid (CSF) in individuals with AN relative to healthy controls, altho...

    Authors: Melissa J Dreier, Avery L. Van De Water, Danielle L. Kahn, Kendra R. Becker, Kamryn T. Eddy, Jennifer J. Thomas, Laura M. Holsen, Elizabeth A. Lawson, Madhusmita Misra, Amanda E. Lyall and Lauren Breithaupt

    Citation: Systematic Reviews 2021 10:247

    Content type: Protocol

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  10. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) extension statement for network meta-analysis (NMA) published in 2015 promotes comprehensive reporting in published systematic re...

    Authors: Areti Angeliki Veroniki, Sofia Tsokani, Stella Zevgiti, Irene Pagkalidou, Katerina-Maria Kontouli, Pinar Ambarcioglu, Nikos Pandis, Carole Lunny, Adriani Nikolakopoulou, Theodoros Papakonstantinou, Anna Chaimani, Sharon E. Straus, Brian Hutton, Andrea C. Tricco, Dimitris Mavridis and Georgia Salanti

    Citation: Systematic Reviews 2021 10:246

    Content type: Research

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  11. In many units around the world, microsurgical free-tissue transfer represents the gold standard for reconstruction of significant soft tissue defects following cancer, trauma or infection. However, many recons...

    Authors: Henry T. de Berker, Urška Čebron, Daniel Bradley, Vinod Patel, Meklit Berhane, Fernando Almas, Gary Walton, Mekonen Eshete, Mark McGurk, Dominique Martin and Calum Honeyman

    Citation: Systematic Reviews 2021 10:245

    Content type: Protocol

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  12. The use of process evaluations is a growing area of interest in research groups working on complex interventions. This methodology tries to understand how the intervention was implemented to inform policy and ...

    Authors: María Lazo-Porras, Hueiming Liu, J. Jaime Miranda, Graham Moore, Mafalda Burri, François Chappuis, Pablo Perel and David Beran

    Citation: Systematic Reviews 2021 10:244

    Content type: Protocol

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  13. Conflicting findings and the analysis of unpublished and retracted data have led to controversy on the safety of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in people with COVID-...

    Authors: Malindu E. Fernando, Aaron Drovandi and Jonathan Golledge

    Citation: Systematic Reviews 2021 10:243

    Content type: Research

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  14. Antimicrobial resistance (AMR) is accelerated by the widespread and often indiscriminate use of antimicrobials in humans, animals, and the environment. In 2015, the World Health Organization recognised AMR as ...

    Authors: Aparna Ananthakrishnan, Chris Painter and Yot Teerawattananon

    Citation: Systematic Reviews 2021 10:242

    Content type: Protocol

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  15. Back pain is a widespread health problem that accounts for substantial disability and high costs. The workplace is considered to critically affect the occurrence and persistence of back pain and therefore offe...

    Authors: Angelika Eisele-Metzger, Daria S. Schoser, Kathrin Grummich, Guido Schwarzer, Lukas Schwingshackl, Bianca Biallas, Christiane Wilke, Joerg J. Meerpohl and Cordula Braun

    Citation: Systematic Reviews 2021 10:241

    Content type: Protocol

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  16. Relative to their counterparts in the general population, young people who leave, or transition out of, out-of-home (OOHC) arrangements commonly experience poorer outcomes across a range of indicators, includi...

    Authors: David J. A. Taylor, Aron Shlonsky, Bianca Albers, Sangita Chakraborty, Jane Lewis, Phillip Mendes, Geraldine Macdonald and Kevin Williams

    Citation: Systematic Reviews 2021 10:240

    Content type: Protocol

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  17. Adolescence and young adulthood is a risk period for the emergence of mental disorders. There is strong evidence that psychotherapeutic interventions are effective for most mental disorders. However, very litt...

    Authors: Eleni Vousoura, Vera Gergov, Bogdan Tudor Tulbure, Nigel Camilleri, Andrea Saliba, LuisJoaquin Garcia-Lopez, Ioana R. Podina, Tamara Prevendar, Henriette Löffler-Stastka, Giuseppe Augusto Chiarenza, Martin Debbané, Silvana Markovska-Simoska, Branka Milic, Sandra Torres, Randi Ulberg and Stig Poulsen

    Citation: Systematic Reviews 2021 10:239

    Content type: Protocol

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  18. While one in three women around the world are estimated to have experienced intimate partner or sexual violence, these rates are often exacerbated during conflict and humanitarian crisis. This systematic revie...

    Authors: Maureen Murphy, Mary Ellsberg, Aminat Balogun and Claudia Garcia-Moreno

    Citation: Systematic Reviews 2021 10:238

    Content type: Protocol

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  19. In pediatric palliative care (PPC), there is a need to involve the child’s voice in situations regarding their symptoms and care needs. Patient-reported outcome measures (PROMs) can be tools to systematically ...

    Authors: Heidi Holmen, Anette Winger, Simen A. Steindal, Charlotte Castor, Lisbeth Gravdal Kvarme, Kirsti Riiser, Kari L. Mariussen and Anja Lee

    Citation: Systematic Reviews 2021 10:237

    Content type: Protocol

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  20. Systematic reviews and meta-analyses are critical in health-related decision-making, and are considered the gold standard in research synthesis methods. However, with new trials being regularly published and w...

    Authors: Julieta Sabates, Sylvie Belleville, Mary Castellani, Tzvi Dwolatzky, Benjamin M. Hampstead, Amit Lampit, Sharon Simon, Kaarin Anstey, Belinda Goodenough, Serafino Mancuso, Davis Marques, Richard Sinnott and Alex Bahar-Fuchs

    Citation: Systematic Reviews 2021 10:236

    Content type: Methodology

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  21. “Assessing risk of bias in human environmental epidemiology studies using three tools: different conclusions from different tools,” a recent publication in this journal, applied the study evaluation approach d...

    Authors: Elizabeth G. Radke, Barbara S. Glenn and Andrew D. Kraft

    Citation: Systematic Reviews 2021 10:235

    Content type: Letter

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  22. Several comorbidity indices have been created to estimate and adjust for the burden of comorbidity. The objective of this systematic review was to evaluate and compare the ability of different comorbidity indi...

    Authors: Per Hviid Gundtoft, Mari Jørstad, Julie Ladeby Erichsen, Hagen Schmal and Bjarke Viberg

    Citation: Systematic Reviews 2021 10:234

    Content type: Research

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  23. Many randomized controlled trials fail to reach their target sample size. When coupled with the omission and underrepresentation of disadvantaged groups in randomized controlled trials, many trials fail to obt...

    Authors: Abigail LaPlante, Renata W. Yen, Talia Isaacs, Joanna Crocker, Zsofia Demjen, Danielle Schubbe, Alice M. Kennedy, Jaclyn Engel, Nancy O’Brien, Carla Richters and Marie-Anne Durand

    Citation: Systematic Reviews 2021 10:233

    Content type: Protocol

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  24. Suicide is a leading cause of death in children and youth, with suicidal thoughts and suicide attempts (referred to as non-fatal suicidal behaviors (NFSB)) being among its strongest predictors. Positive parent...

    Authors: Florence Perquier, Sarah Hetrick, Terri Rodak, Xin Jing, Wei Wang, Katherine T. Cost, Peter Szatmari and Madison Aitken

    Citation: Systematic Reviews 2021 10:232

    Content type: Protocol

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  25. Sarcomas are a rare and heterogeneous group of tumors originating from mesenchymal or connective tissue. They represent less than 1% of all adult cancers. The etiology and epidemiology of sarcomas remain under...

    Authors: D. Edwards, A. Voronina, K. Attwood and A. Grand’Maison

    Citation: Systematic Reviews 2021 10:231

    Content type: Systematic review update

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  26. Although measures have been put in place, musculoskeletal injuries are noticeable high among the nursing fraternity with low back pain (LBP) being the most prevalent. It is evident that healthcare professional...

    Authors: Kagiso Kgakge, Mbuzeleni Hlongwa and Themba Ginindza

    Citation: Systematic Reviews 2021 10:229

    Content type: Protocol

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  27. Parents can be psychologically impacted when their children are diagnosed with eye diseases, such as blindness, strabismus, and eye cancer. Stress can reduce the quality of parental care and may be linked to t...

    Authors: Julio Cesar Souza-Silva, Cleusa Alves Martins, Marco Túlio Antônio Garciazapata and Maria Alves Barbosa

    Citation: Systematic Reviews 2021 10:228

    Content type: Protocol

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  28. Major depressive disorder is a common psychiatric disorder causing great burden on patients and societies. Tricyclic antidepressants are frequently used worldwide to treat patients with major depressive disord...

    Authors: Caroline Kamp Jørgensen, Sophie Juul, Faiza Siddiqui, Marija Barbateskovic, Klaus Munkholm, Michael Pascal Hengartner, Irving Kirsch, Christian Gluud and Janus Christian Jakobsen

    Citation: Systematic Reviews 2021 10:227

    Content type: Protocol

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  29. The General Movements Assessment is a non-invasive and cost-effective tool with demonstrated reliability for identifying infants at risk for cerebral palsy. Early detection of cerebral palsy allows for the imp...

    Authors: Judy Seesahai, Maureen Luther, Paige Terrien Church, Patricia Maddalena, Elizabeth Asztalos, Thomas Rotter and Rudaina Banihani

    Citation: Systematic Reviews 2021 10:226

    Content type: Research

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  30. The acute respiratory distress syndrome (ARDS) has high morbidity and mortality. Positive end-expiratory pressure (PEEP) is commonly used in patients with ARDS but the best method to select the optimal PEEP le...

    Authors: Manuel Tisminetzky, Jose Dianti, Bruno L. Ferreyro, Federico Angriman, Lorenzo Del Sorbo, Sachin Sud, Daniel Talmor, Eddy Fan, Niall D. Ferguson, Ary Serpa Neto, Neill K. J. Adhikari and Ewan C. Goligher

    Citation: Systematic Reviews 2021 10:225

    Content type: Protocol

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  31. Research suggests that childhood psychological maltreatment (i.e., emotional abuse and emotional neglect) is associated with mental health problems that persist into adulthood, for example anxiety, depression,...

    Authors: Zhuoni Xiao, Mina Murat Baldwin, Franziska Meinck, Ingrid Obsuth and Aja Louise Murray

    Citation: Systematic Reviews 2021 10:224

    Content type: Protocol

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  32. Hospitals operate under constant pressure to contain costs and improve the quality of care. The literature suggests that there is an association between health care providers’ financial performance and the qua...

    Authors: Katarzyna Dubas-Jakóbczyk, Ewa Kocot, Marzena Tambor and Wilm Quentin

    Citation: Systematic Reviews 2021 10:221

    Content type: Protocol

    Published on:

  33. Hypertension has become an important public health concern in the developing world owing to rising prevalence and its adverse impact on ailing health systems. Despite being a modifiable risk factor for cardiov...

    Authors: Fidelis Atibila, Gill ten Hoor, Emmanuel Timmy Donkoh, Abdul Iddrisu Wahab and Gerjo Kok

    Citation: Systematic Reviews 2021 10:220

    Content type: Research

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  34. N95 respiratory protection masks are used by healthcare professionals to prevent contamination from infectious microorganisms transmitted by droplets or aerosols.

    Authors: Livia Fernandes Probst, Ana Tereza Gomes Guerrero, Andréia Insabralde de Queiroz Cardoso, Antonio Jose Grande, Mariana Garcia Croda, James Venturini, Maria Cristina de Camargo Fonseca, Anamaria Mello Miranda Paniago, Jorge Otávio Maia Barreto and Sandra Maria do Vale Leone de Oliveira

    Citation: Systematic Reviews 2021 10:219

    Content type: Research

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  35. Celiac disease (CD) is one of the most common gluten-related disorders. Although the only effective treatment is a strict gluten-free diet, doubts remain as to whether healthcare professionals take this restri...

    Authors: Irene Lizano-Díez, Eduardo L. Mariño and Pilar Modamio

    Citation: Systematic Reviews 2021 10:218

    Content type: Systematic review update

    Published on:

  36. Although oral opioid agonist therapies (OATs), buprenorphine and methadone, are effective first-line treatments, OAT remains largely underutilized due to low retention rates and wide variation across programs....

    Authors: Jan Klimas, Michee-Ana Hamilton, Lauren Gorfinkel, Ahmed Adam, Walter Cullen and Evan Wood

    Citation: Systematic Reviews 2021 10:216

    Content type: Research

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  37. Men are less likely to participate in health promotion. One approach to reach men is the concept of men’s sheds. This community-based health promotion concept brings older men together to engage in joint activ...

    Authors: Birte Marie Albrecht, Linda Foettinger and Karin Bammann

    Citation: Systematic Reviews 2021 10:215

    Content type: Protocol

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  38. Antipsychotic drugs and especially the newer compounds are known to cause metabolic side effects. However, a comprehensive comparison of the different substances regarding their propensity to cause metabolic s...

    Authors: Johannes Schneider-Thoma, Angelika Kapfhammer, Dongfang Wang, Irene Bighelli, Spyridon Siafis, Hui Wu, Wulf-Peter Hansen, John M. Davis, Georgia Salanti and Stefan Leucht

    Citation: Systematic Reviews 2021 10:214

    Content type: Protocol

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  39. Considerable disparities exist on the use of adipose tissue-derived stem cells (ADSCs) for treatment of spinal cord injury (SCI). Hence, the current systematic review aimed to investigate the efficacy of ADSCs...

    Authors: Seyedeh Niloufar Rafiei Alavi, Arian Madani Neishaboori, Hasti Hossein, Arash Sarveazad and Mahmoud Yousefifard

    Citation: Systematic Reviews 2021 10:213

    Content type: Systematic review update

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  40. We aimed to perform a systematic review and meta-analysis of the association between obstructive sleep apnea (OSA) and cardiac as well as coronary impairment evaluated using imaging modalities. Finding of this...

    Authors: Mi Lu, Zhenjia Wang, Xiaojun Zhan and Yongxiang Wei

    Citation: Systematic Reviews 2021 10:212

    Content type: Systematic review update

    Published on:

  41. Chronic obstructive pulmonary disease (COPD) is a major cause of years of life lost globally. Acute exacerbations of COPD (AECOPD) drive disease progression, reduce quality of life and are a source of mortalit...

    Authors: Ruan Spies, Matthew Potter, Ruan Hollamby, Stefan van der Walt, Ameer Hohlfeld, Eleanor Ochodo and Richard N. van Zyl-Smit

    Citation: Systematic Reviews 2021 10:211

    Content type: Protocol

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  42. There is abundant evidence for sex differences in the diagnosis, implantation, and outcomes for cardiac resynchronization therapy (CRT) devices. Controversial data suggesting women are less likely to receive t...

    Authors: Omar Dewidar, David Birnie, Irina Podinic, Vivian Welch and George A. Wells

    Citation: Systematic Reviews 2021 10:210

    Content type: Protocol

    Published on:

  43. It is well recognised that access and receipt of appropriate guideline recommended treatment with systemic anti-cancer therapies for secondary breast cancer is a key determinant in overall survival. Where ther...

    Authors: Sally Anne Pearson, Sally Taylor, Antonia Marsden and Janelle Yorke

    Citation: Systematic Reviews 2021 10:209

    Content type: Protocol

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  44. There has been an exponential growth in the number of clinical research studies regarding exercise training in multiple sclerosis, and literature reviews and meta-analyses have documented the many benefits of ...

    Authors: Y. C. Learmonth, L. A. Pilutti, M. P. Herring, R. W. Motl, B. Chan and A. P. Metse

    Citation: Systematic Reviews 2021 10:208

    Content type: Protocol

    Published on:

  45. Children’s academic readiness has important implications for subsequent achievement and psychosocial functioning. A growing number of studies are utilizing randomized controlled trials (RCT) to examine whether...

    Authors: Heather Prime, Krysta Andrews, Andrea Gonzalez, Magdalena Janus, Andrea C. Tricco, Teresa Bennett and Leslie Atkinson

    Citation: Systematic Reviews 2021 10:207

    Content type: Protocol

    Published on:

  46. Ocular toxoplasmosis (OT) is the most common cause of posterior uveitis, which leads to visual impairment in a large proportion of patients. Antibiotics and corticosteroids lower the risk of permanent visual l...

    Authors: John E. Feliciano-Alfonso, Juliana Muñoz-Ortiz, María Alejandra Marín-Noriega, Andrés Vargas-Villanueva, Laura Triviño-Blanco, Natalia Carvajal-Saiz and Alejandra de-la-Torre

    Citation: Systematic Reviews 2021 10:206

    Content type: Systematic review update

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