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  1. Migraines are a chronic disease for millions worldwide and have been hypothesized to be hormonally mediated due to their higher prevalence in females and menstrual associations. Estrogen has been commonly impl...

    Authors: Nihaal Reddy, Miraj N. Desai, Anna Schoenbrunner, Steven Schneeberger and Jeffrey E. Janis

    Citation: Systematic Reviews 2021 10:72

    Content type: Research

    Published on:

  2. The term temporomandibular disorder (TMD) includes disorders of the temporomandibular joints (TMJ), masticatory muscles and adjacent tissues. Several studies have examined the effectiveness of manual therapy (...

    Authors: Giacomo Asquini, Alison Rushton, Laurent Pitance, Nicola Heneghan and Deborah Falla

    Citation: Systematic Reviews 2021 10:70

    Content type: Protocol

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  3. Midazolam is used for sedation before diagnostic and therapeutic medical procedures by several routes including oral, intravenous, intranasal and intramuscular. This is an update of a Cochrane review published...

    Authors: Aaron Conway, Kristina Chang, Sebastian Mafeld and Joanna Sutherland

    Citation: Systematic Reviews 2021 10:69

    Content type: Systematic review update

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  4. The care of the emergency department (ED) for a person after a suicide attempt can act as a protector against future suicidal behavior. For this reason, it is essential that the ED ensure an assistance that in...

    Authors: Ana Paula Coutinho da Silva, Margarida Rangel Henriques, Inês Areal Rothes, Tiago Zortea, José Carlos Santos and Pim Cuijpers

    Citation: Systematic Reviews 2021 10:68

    Content type: Protocol

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  5. Waiting lists are an ongoing issue for publicly funded community and hospital-based health services. Parents and caregivers are instrumental supports in the health and well-being of young and school-aged child...

    Authors: C. Bernie, M. Mitchell, K. Williams and T. May

    Citation: Systematic Reviews 2021 10:67

    Content type: Protocol

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  6. Stroke is the second leading cause of death worldwide, and 53.4% of stroke survivors suffer from post-stroke cognitive impairment. Post-stroke cognitive impairment can increase hospitalization rate and cost of...

    Authors: Qing Zhao, Xue Wang, Tao Wang, Adam A. Dmytriw, Xiao Zhang, Kun Yang, Jichang Luo, Xuesong Bai, Nan Jiang, Bin Yang, Yan Ma, Liqun Jiao and Yunyan Xie

    Citation: Systematic Reviews 2021 10:66

    Content type: Protocol

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  7. Length of stay (LOS) for inpatient psychiatric services is an important factor with serious drawbacks when it is extended more than needed. Impacts on economy, social functioning, and stigma can hamper improve...

    Authors: Farid Carranza Navarro, Neri Alejandro Álvarez Villalobos, Andrea Muriel Contreras Muñoz, Andrea Fernanda Guerrero Medrano, Natalia Sofía Tamayo Rodríguez and Erasmo Saucedo Uribe

    Citation: Systematic Reviews 2021 10:65

    Content type: Protocol

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  8. Cystic fibrosis (CF) is a genetically inherited, life-limiting condition, affecting ~90,000 people globally. Physical activity (PA) and exercise form an integral component of CF management, and have been highl...

    Authors: Owen W. Tomlinson, Sarah Denford, Alan R. Barker, Jane E. Schneiderman, Emma S. Campisi, Helen Douglas, Sarah Rand, Melitta A. McNarry, Kelly A. Mackintosh and Craig A. Williams

    Citation: Systematic Reviews 2021 10:64

    Content type: Protocol

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  9. Antidepressant medicines are used to manage symptoms of low back pain. The efficacy, acceptability, and safety of antidepressant medicines for low back pain (LBP) are not clear. We aimed to evaluate the effica...

    Authors: Michael C. Ferraro, Matthew K. Bagg, Michael A. Wewege, Aidan G. Cashin, Hayley B. Leake, Rodrigo R. N. Rizzo, Matthew D. Jones, Sylvia M. Gustin, Richard Day, Colleen K. Loo and James H. McAuley

    Citation: Systematic Reviews 2021 10:62

    Content type: Research

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  10. Health practitioners and researchers must be able to measure and assess maternal care quality in facilities to monitor, intervene, and reduce global maternal mortality rates. On the global scale, there is a ge...

    Authors: Kyrah K. Brown, Godfred O. Boateng, Peace Ossom-Williamson and Laura Haygood

    Citation: Systematic Reviews 2021 10:61

    Content type: Protocol

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  11. Childhood hypertension is a growing public health problem. Simultaneously, hypovitaminosis D is widespread in this population and could be associated with hypertension. This study systematically reviewed the l...

    Authors: Myriam Abboud, Fatme Al Anouti, Dimitrios Papandreou, Rana Rizk, Nadine Mahboub and Suzan Haidar

    Citation: Systematic Reviews 2021 10:60

    Content type: Systematic review update

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  12. Globally, very preterm birth is a health concern leading to various developmental difficulties such as poor motor and/or cognitive function. For infants born very preterm, family-centered care (FCC) might prom...

    Authors: Manasa Kolibylu Raghupathy, Bhamini Krishna Rao, Shubha R. Nayak, Alicia J. Spittle and Shradha S. Parsekar

    Citation: Systematic Reviews 2021 10:59

    Content type: Protocol

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  13. The relationship between cancer with overweight and obesity has been extensively reported. However, the association between urinary cancers with these risk factors remains unclear, with existing reports showin...

    Authors: Jiyuan Shi, Liang Zhao, Ya Gao, Mingming Niu, Meili Yan, Yamin Chen, Ziwei Song, Xueni Ma, Peng Wang and Jinhui Tian

    Citation: Systematic Reviews 2021 10:58

    Content type: Research

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  14. Obstructed labor accounted for 22% of obstetrical complications and 9% of all maternal deaths in low- and middle-income countries. Even though there are separate studies regarding obstructed labor and its comp...

    Authors: Yordanos Gizachew Yeshitila, Melaku Desta and Abraham Kebede

    Citation: Systematic Reviews 2021 10:57

    Content type: Protocol

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  15. High tibial osteotomy (HTO) has been used for over 60 years in clinical practice and mainly comprises two major techniques: closed wedge high tibial osteotomy (CWHTO) and open wedge high tibial osteotomy (OWHT...

    Authors: Mingliang He, Xihong Zhong, Zhong Li, Kun Shen and Wen Zeng

    Citation: Systematic Reviews 2021 10:56

    Content type: Systematic review update

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  16. The scale-up of evidence-based innovations is required to reduce waste and inequities in health and social services (HSS). However, it often tends to be a top-down process initiated by policy makers, and the v...

    Authors: Ali Ben Charif, Karine V. Plourde, Sabrina Guay-Bélanger, Hervé Tchala Vignon Zomahoun, Amédé Gogovor, Sharon Straus, Ron Beleno, Kathy Kastner, Robert K. D. McLean, Andrew J. Milat, Luke Wolfenden, Jean-Sébastien Paquette, Friedemann Geiger and France Légaré

    Citation: Systematic Reviews 2021 10:55

    Content type: Protocol

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  17. People living with human immunodeficiency virus (PLHIV) struggle with the challenges of living with a chronic disease and integrating antiretroviral treatment (ART) and care into their daily lives. The aims of...

    Authors: Lynn Hendricks, Ingrid Eshun-Wilson and Anke Rohwer

    Citation: Systematic Reviews 2021 10:54

    Content type: Methodology

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  18. Chronic pain is a common public health problem with negative consequences for individuals and societies. Fortunately, interdisciplinary chronic pain management has been shown to be effective for improving pati...

    Authors: Hervé Tchala Vignon Zomahoun, Regina Visca, Nicole George and Sara Ahmed

    Citation: Systematic Reviews 2021 10:53

    Content type: Protocol

    Published on:

  19. Physical inactivity is one of the major risk factors for non-communicable diseases. This systematic review and meta-analysis aimed to assess the effects of educational interventions on promoting regular physic...

    Authors: Babak Moeini, Forouzan Rezapur-Shahkolai, Saeed Bashirian, Amin Doosti-Irani, Maryam Afshari and Azam Geravandi

    Citation: Systematic Reviews 2021 10:52

    Content type: Systematic review update

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  20. Coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 strain, was first identified in late 2019 in China. The outcomes of patients affected by the virus can worsen, deve...

    Authors: Marcela Larissa Costa, Carlos Adriano Santos Souza, Ana Caroline Cardoso Silva, Dayane Franciely Conceição Santos, Edilene Fernandes Nonato, Francismayne Batista Santana, Giselle dos Santos Dias, Jessyca Teles Barreto, Laís Santos Costa, Maria Carolina Barros Costa, Tamila das Neves Ferreira, Jeniffer Santos Santana, Raquel Simões Mendes-Netto, Tereza Virgínia Silva Bezerra do Nascimento, Marco Antônio Prado Nunes and Márcia Ferreira Cândido de Souza

    Citation: Systematic Reviews 2021 10:51

    Content type: Protocol

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  21. Depression is one of the most prevalent mental disorders among an estimated 25.6 million people living with HIV (PLHIV) in sub-Saharan Africa (SSA). The depression rate is higher in HIV-seropositive men who ha...

    Authors: Delarise M. Mulqueeny, Senzelokuhle M. Nkabini and Manduleli H. Pokiya

    Citation: Systematic Reviews 2021 10:50

    Content type: Protocol

    Published on:

  22. Psychosocial health issues such as depression and social isolation are an important cause of morbidity and premature mortality for older adults and people with dementia. Social robots are promising technologic...

    Authors: Wei Qi Koh, Simone Anna Felding, Elaine Toomey and Dympna Casey

    Citation: Systematic Reviews 2021 10:49

    Content type: Protocol

    Published on:

  23. The COVID-19 pandemic is creating severe issues for healthcare and broad social structures, exposing societal vulnerabilities. Among the populations affected by COVID-19 are people engaged in substance use, su...

    Authors: Navin Kumar, Kamila Janmohamed, Kate Nyhan, Silvia S. Martins, Magdalena Cerda, Deborah Hasin, Jenny Scott, Richard Pates, Lilian Ghandour, Mayyada Wazaify and Kaveh Khoshnood

    Citation: Systematic Reviews 2021 10:48

    Content type: Protocol

    Published on:

  24. More than 75% of patients presenting to the Emergency Department are suffering symptoms of pain. Despite this, 67% will not receive any analgesia. Methoxyflurane is a fluorinated hydrocarbon gas which has anal...

    Authors: Michael M. Eager, Grant S. Nolan, Kathryn Tonks, Anoopama Ramjeeawon and Natalie Taylor

    Citation: Systematic Reviews 2021 10:47

    Content type: Protocol

    Published on:

  25. Of the 15–20% of youth in North America affected by a chronic health condition (e.g., type 1 diabetes, cystic fibrosis) and/or mental health or neurodevelopmental disorder (e.g., depression, eating disorder, A...

    Authors: Kyleigh Schraeder, Brooke Allemang, Cathie Scott, Kerry McBrien, Gina Dimitropoulos, Ashley Felske and Susan Samuel

    Citation: Systematic Reviews 2021 10:46

    Content type: Protocol

    Published on:

  26. Dental and oral health workers have direct contact with respiratory aerosols of patients during procedures. This study aimed to determine the main concerns of dental and oral health workers globally during COV...

    Authors: Peivand Bastani, Mohammadtaghi Mohammadpour, Arash Ghanbarzadegan, Kostas Kapellas and Loc Giang Do

    Citation: Systematic Reviews 2021 10:45

    Content type: Research

    Published on:

  27. In recent years, we have seen the incorporation of magnetic resonance imaging (MRI) simulators into radiotherapy centres and the emergence of the new technology of MR linacs. However, the significant health ca...

    Authors: Sarah Elliott, Alexandra Berlangieri, Jason Wasiak, Michael Chao and Farshad Foroudi

    Citation: Systematic Reviews 2021 10:44

    Content type: Protocol

    Published on:

  28. Cancer patients are particularly vulnerable to COVID-19, partially owing to their compromised immune systems and curbed or cut cancer healthcare services caused by the pandemic. As a result, cancer caregivers ...

    Authors: Zhaohui Su, Dean McDonnell, Bin Liang, Jennifer Kue, Xiaoshan Li, Sabina Šegalo, Shailesh Advani, Bertha E. Flores and Jing Wang

    Citation: Systematic Reviews 2021 10:43

    Content type: Protocol

    Published on:

  29. Healthcare settings are complex, and the decision-making process is usually complicated, too. Precise use of best evidence from different sources for increasing the desired outcomes is the result of EBM. There...

    Authors: Tahereh Shafaghat, Mohammad Hasan Imani Nasab, Mohammad Amin Bahrami, Zahra Kavosi, Mahsa Roozrokh Arshadi Montazer, Mohammad Kazem Rahimi Zarchi and Peivand Bastani

    Citation: Systematic Reviews 2021 10:42

    Content type: Research

    Published on:

  30. Mental health problems are common in the working population and represent a growing concern internationally, with potential impacts on workers, organisations, workplace health and compensation authorities, lab...

    Authors: Charlotte Paterson, Caleb Leduc, Margaret Maxwell, Birgit Aust, Benedikt L. Amann, Arlinda Cerga-Pashoja, Evelien Coppens, Chrisje Couwenbergh, Cliodhna O’Connor, Ella Arensman and Birgit A. Greiner

    Citation: Systematic Reviews 2021 10:41

    Content type: Protocol

    Published on:

  31. Inflammation scores based on general inflammation markers as leucocyte count or C-reactive protein have been evaluated as prognostic markers of inferior survival in several cancers. In small cell lung cancer (...

    Authors: Anne Winther-Larsen, Ninna Aggerholm-Pedersen and Birgitte Sandfeld-Paulsen

    Citation: Systematic Reviews 2021 10:40

    Content type: Research

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  32. Literature searches underlie the foundations of systematic reviews and related review types. Yet, the literature searching component of systematic reviews and related review types is often poorly reported. Gui...

    Authors: Melissa L. Rethlefsen, Shona Kirtley, Siw Waffenschmidt, Ana Patricia Ayala, David Moher, Matthew J. Page and Jonathan B. Koffel

    Citation: Systematic Reviews 2021 10:39

    Content type: Research

    Published on:

  33. Systematic reviews involve searching multiple bibliographic databases to identify eligible studies. As this type of evidence synthesis is increasingly pursued, the use of various electronic platforms can help ...

    Authors: Sandra McKeown and Zuhaib M. Mir

    Citation: Systematic Reviews 2021 10:38

    Content type: Methodology

    Published on:

  34. Global responses to the COVID-19 pandemic have exposed and exacerbated existing socioeconomic and health inequities that disproportionately affect the sexual health and well-being of many populations, includin...

    Authors: Navin Kumar, Kamila Janmohamed, Kate Nyhan, Laura Forastiere, Wei-Hong Zhang, Anna Kågesten, Maximiliane Uhlich, Sarah M. Van de Velde, Joel M. Francis, Jennifer T. Erausquin, Elin C. Larsson, Denton Callander, John Scott, Victor Minichiello and Joseph D. Tucker

    Citation: Systematic Reviews 2021 10:37

    Content type: Protocol

    Published on:

  35. Preoperative anemia is a common comorbidity that often necessitates allogeneic blood transfusion (ABT). As there is a risk associated with blood transfusions, preoperative intravenous iron (IV) has been propos...

    Authors: Abdelsalam M. Elhenawy, Steven R. Meyer, Sean M. Bagshaw, Roderick G. MacArthur and Linda J. Carroll

    Citation: Systematic Reviews 2021 10:36

    Content type: Research

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  36. Chimeric antigen receptor (CAR) T cell therapy has had great success in treating patients with relapsed or refractory B cell malignancies, with CD19-targeting therapies now approved in many countries. However,...

    Authors: Komal Adeel, Nathan J. Fergusson, Risa Shorr, Harold Atkins and Kevin A. Hay

    Citation: Systematic Reviews 2021 10:35

    Content type: Protocol

    Published on:

  37. All individuals should have the right to engage meaningfully in occupations that meet their aspirations and life goals as well as promote their health and well-being. For individuals with disability, meaningfu...

    Authors: Jacqueline Nhu Quynh Pho, Aidan Christopher Tan, Katrina Chaudhary, Sonia Hines, Caroline Ellison, Vivian Isaac and David Lim

    Citation: Systematic Reviews 2021 10:34

    Content type: Protocol

    Published on:

  38. A variety of public health interventions have been undertaken in low- and middle-income countries (LMICs) to prevent morbidity and mortality associated with household air pollution (HAP) due to cooking, heatin...

    Authors: Katherine E. Woolley, Emma Dickinson-Craig, Suzanne E. Bartington, Tosin Oludotun, Bruce Kirenga, Shelton T. Mariga, Telesphore Kabera, April Coombe, Francis D. Pope, Ajit Singh, William R. Avis, Rosie Day, David Warburton, Semira Manaseki-Holland, David J. Moore and G. Neil Thomas

    Citation: Systematic Reviews 2021 10:33

    Content type: Protocol

    Published on:

  39. Progressive language difficulties arise in many neurodegenerative conditions, causing significant impact upon patients and families. This occurs most obviously in primary progressive aphasia (PPA) but can also...

    Authors: Sharon A. Savage, Aida Suárez-González, Alice Cassani, Ragaviveka Gopalan and Joshua Stott

    Citation: Systematic Reviews 2021 10:32

    Content type: Protocol

    Published on:

  40. Malaria is the most common vector-borne disease transmitted to humans by Anopheles mosquitoes. Endectocides and especially ivermectin will be available as a vector control tool soon. The current review could be v...

    Authors: Fereshteh Ghahvechi Khaligh, Abbas Jafari, Elena Silivanova, Mikhail Levchenko, Bahlol Rahimi and Saber Gholizadeh

    Citation: Systematic Reviews 2021 10:30

    Content type: Systematic review update

    Published on:

  41. Despite the extensive research that has been conducted to date, practice often differs from established guidelines and will vary between individuals and organisations. It has been noted that the global uptake ...

    Authors: Sarah Hassan, Vincent Chan, Julie Stevens and Ieva Stupans

    Citation: Systematic Reviews 2021 10:29

    Content type: Research

    Published on:

  42. Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. To decrease the high case fatality rates and morbidity for sepsis and septic shock, there is a need to increa...

    Authors: Ivana Pepic, Robert Feldt, Lars Ljungström, Richard Torkar, Daniel Dalevi, Hanna Maurin Söderholm, Lars-Magnus Andersson, Marina Axelson-Fisk, Katarina Bohm, Bengt Arne Sjöqvist and Stefan Candefjord

    Citation: Systematic Reviews 2021 10:28

    Content type: Protocol

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  43. Vision loss due to diabetic retinopathy can largely be prevented or delayed through treatment. Patients with vision-threatening diabetic retinopathy are typically offered laser or intravitreal injections which...

    Authors: Covadonga Bascaran, Nyawira Mwangi, Fabrizio D’Esposito, Charles Cleland, Iris Gordon, Juan Alberto Lopez Ulloa, Ranad Maswadi, Shaffi Mdala, Jacqueline Ramke, Jennifer R. Evans and Matthew Burton

    Citation: Systematic Reviews 2021 10:27

    Content type: Protocol

    Published on:

  44. Phantom limb pain (PLP) is a prevalent problem for children after amputation because of the chemotherapy treatment. Gabapentin is a potential option to manage PLP after amputation in pediatric oncology. Howeve...

    Authors: Shuang Jiang, Meng-meng Zhou, Rong Xia, Jing-hui Bai and Li-hui Yan

    Citation: Systematic Reviews 2021 10:26

    Content type: Protocol

    Published on:

  45. Telephone-based digital triage is widely used by services that provide urgent care. This involves a call handler or clinician using a digital triage tool to generate algorithm-based care advice, based on a pat...

    Authors: Vanashree Sexton, Jeremy Dale and Helen Atherton

    Citation: Systematic Reviews 2021 10:25

    Content type: Protocol

    Published on:

  46. Major depressive disorder is common, debilitating, and affects feelings, thoughts, mood, and behaviors. Childhood and adolescence are critical periods for the development of depression and adolescence is marke...

    Authors: Andrew Beck, John C. LeBlanc, Kate Morissette, Candyce Hamel, Becky Skidmore, Heather Colquhoun, Eddy Lang, Ainsley Moore, John J. Riva, Brett D. Thombs, Scott Patten, Heather Bragg, Ian Colman, Gary S. Goldfield, Stuart Gordon Nicholls, Kathleen Pajer…

    Citation: Systematic Reviews 2021 10:24

    Content type: Protocol

    Published on:

  47. Structural stigma in health systems experienced by consumers diagnosed with Borderline Personality Disorder (BPD) is a widespread phenomenon that causes major health inequities and harm for this population. St...

    Authors: Pauline Klein, Alicia Kate Fairweather, Sharon Lawn, Helen Margaret Stallman and Paul Cammell

    Citation: Systematic Reviews 2021 10:23

    Content type: Protocol

    Published on:

  48. Chronic obstructive pulmonary disease (COPD) is increasingly contributing to the disease burden in South Asia. This review will summarize the prevalence and risk factors of COPD in South Asia and the intervent...

    Authors: Rafiqul Islam, Md. Tarek Hossain, Nantu Chakma, Afroza Khanom, Tapas Mazumder and Md. Tauhidul Islam

    Citation: Systematic Reviews 2021 10:20

    Content type: Protocol

    Published on:

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