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  1. The prevalence of type 2 diabetes mellitus (T2DM) is growing in China. Depression is a significant complication of T2DM, leading to poor management of T2DM. Thus, early detection and treatment of depression in...

    Authors: Xiaobo Liu, Chao Dong, Hong Jiang, Dongling Zhong, Yuxi Li, Huiling Zhang, Jun Zhang, Jin Fan, Juan Li, Li Guan and Rongjiang Jin

    Citation: Systematic Reviews 2021 10:302

    Content type: Protocol

    Published on:

  2. The global prevalence of diabetes is nearly 9%, with an upward trend in type 2 diabetes mellitus (T2DM) and gestational diabetes (GDM). Although evidence shows that vulnerable groups are affected disproportion...

    Authors: Jessica Breuing, Christine Joisten, Annika Lena Neuhaus, Simone Heß, Lena Kusche, Fabiola Haas, Mark Spiller and Dawid Pieper

    Citation: Systematic Reviews 2021 10:301

    Content type: Research

    Published on:

  3. To the best of our knowledge, a scoping review of the published literature investigating the determinants of adult stroke survivors’ reintegration to normal living has not been conducted. This scoping review a...

    Authors: Michael Opeoluwa Ogunlana, Pragashnie Govender, Olufemi Oyeleye Oyewole and Ifeoma Blessing Nwosu

    Citation: Systematic Reviews 2021 10:300

    Content type: Protocol

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  4. The COVID-19 pandemic has devastated the global community with nearly 4.9 million deaths as of October 2021. While organ transplant (OT) recipients (OTr) may be at increased risk for severe COVID-19 due to the...

    Authors: Alexis H. Lerner, Elizabeth J. Klein, Anna Hardesty, Orestis A. Panagiotou, Chelsea Misquith and Dimitrios Farmakiotis

    Citation: Systematic Reviews 2021 10:299

    Content type: Protocol

    Published on:

  5. The North American opioid crisis is driven by opioid-related mortality and morbidity, including opioid use-associated infections (OUAIs), resulting in a substantial burden for society. Users of legal and illeg...

    Authors: Irina Kudrina, Svetlana Puzhko, Kristian B. Filion, Genevieve Gore, Elena Paraskevopoulos, Sarah Windle, Marc O. Martel and Mark J. Eisenberg

    Citation: Systematic Reviews 2021 10:298

    Content type: Protocol

    Published on:

  6. Idiopathic pulmonary fibrosis (IPF) is one of the common types of interstitial lung disease having high prevalence and mortality worldwide. As a result of patient-centred hindering factors of adherence to cent...

    Authors: Revati Amin, K. Vaishali, G. Arun Maiya, Aswini Kumar Mohapatra, Uday Narayan Yadav and Shradha S. Parsekar

    Citation: Systematic Reviews 2021 10:297

    Content type: Protocol

    Published on:

  7. Peer-support programs are a useful social support strategy for populations trying to quit smoking who are willing to maintain smoking abstinence. This study is a protocol for a systematic review and meta-analy...

    Authors: Hyun-Ju Seo, Soo Young Kim, Dongah Park, Seung-Soo Sheen, Miyoung Choi, Bo-Hyoung Jang, Su Jung Lee and Youngju Cha

    Citation: Systematic Reviews 2021 10:296

    Content type: Protocol

    Published on:

  8. In many countries, children who are diagnosed with autism during the first 5 years of life are offered a range of early intervention options. These options vary considerably in the theoretical approaches and t...

    Authors: Katherine Pye, Hannah Jackson, Teresa Iacono and Alan Shiell

    Citation: Systematic Reviews 2021 10:295

    Content type: Protocol

    Published on:

  9. Despite the expectations regarding the effectiveness of chloroquine (CQ) and hydroxychloroquine (HCQ) for coronavirus disease (COVID-19) management, concerns about their adverse events have remained.

    Authors: Mayra Souza Botelho, Fernanda Bolfi, Renata Giacomini Occhiuto Ferreira Leite, Mauro Salles Ferreira Leite, Luisa Rocco Banzato, Luiza Teixeira Soares, Thaina Oliveira Felicio Olivatti, Amanda Sampaio Mangolim, Flávia Ramos Kazan Oliveira, Luciana Patrícia Fernandes Abbade, Joelcio Francisco Abbade, Ricardo Augusto Monteiro de Barros Almeida, Julia Simões Corrêa Galendi, Lehana Thabane and Vania dos Santos Nunes-Nogueira

    Citation: Systematic Reviews 2021 10:294

    Content type: Research

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  10. Low levels of physical activity are common during the hospital stay and have been associated with negative health outcomes. Understanding barriers and enablers to physical activity during a hospital stay can i...

    Authors: Sven Jacobus Gertruda Geelen, Hanneke Corine van Dijk - Huisman, Robert Adriaan de Bie, Cindy Veenhof, Raoul Engelbert, Marike van der Schaaf and Antoine François Lenssen

    Citation: Systematic Reviews 2021 10:293

    Content type: Research

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  11. Subclinical hypothyroidism is a thyroid disorder diagnosed from the laboratory blood test results of otherwise asymptomatic patients. It has been associated with poor cardiovascular outcomes, mortality and pro...

    Authors: Brenda S. Bauer, Amaya Azcoaga-Lorenzo, Utkarsh Agrawal and Colin McCowan

    Citation: Systematic Reviews 2021 10:290

    Content type: Protocol

    Published on:

  12. The coronavirus disease 19 (covid-19) pandemic has underscored the need to expedite clinical research, which may lead investigators to shift away from measuring patient-important outcomes (PIO), limiting resea...

    Authors: Mario A. Jimenez-Mora, Andrea Ramírez Varela, Jose F. Meneses-Echavez, Julia Bidonde, Adriana Angarita-Fonseca, Reed A. C. Siemieniuk, Dena Zeraatkar, Jessica J. Bartoszko, Romina Brignardello-Petersen, Kimia Honarmand, Bram Rochwerg, Gordon Guyatt and Juan José Yepes-Nuñez

    Citation: Systematic Reviews 2021 10:289

    Content type: Protocol

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  13. Many prognostic models of diabetic microvascular complications have been developed, but their performances still varies. Therefore, we conducted a systematic review and meta-analysis to summarise the performan...

    Authors: Sigit Ari Saputro, Oraluck Pattanaprateep, Anuchate Pattanateepapon, Swekshya Karmacharya and Ammarin Thakkinstian

    Citation: Systematic Reviews 2021 10:288

    Content type: Research

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  14. Though cervical cancer is largely preventable, it is still the second most common female cancer globally and the leading cause of cancer deaths among females in African. Though many efforts have been done to s...

    Authors: Ayele Semachew Kasa, Tadesse Dagget, Yeshiwork Beyene, Getnet Dessie, Aklilu Endalamaw, Yinager Workineh, Emiru Ayalew, Balew Zeleke, Sitotaw Kerie, Getasew Mulat and Worku Animaw

    Citation: Systematic Reviews 2021 10:287

    Content type: Research

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  15. Approaches for rapid reviews that focus on streamlining systematic review methods are not always suitable for exploring complex policy questions, as developing and testing theories to explain these complexitie...

    Authors: Michael G. Wilson, Sandy Oliver, G. J. Melendez-Torres, John N. Lavis, Kerry Waddell and Kelly Dickson

    Citation: Systematic Reviews 2021 10:286

    Content type: Research

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  16. Hemodynamic assessment in patients with pulmonary arterial hypertension (PAH) is essential for risk stratification and pharmacological management. However, the prognostic value of the hemodynamic changes after...

    Authors: Shih-Hsien Sung, Wan-Yu Yeh, Chern-En Chiang, Chi-Jung Huang, Wei-Ming Huang, Chen-Huan Chen and Hao-Min Cheng

    Citation: Systematic Reviews 2021 10:284

    Content type: Research

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  17. Burnout is a syndrome caused by chronic stress in the workplace that has not been successfully managed. Although prevalence of burnout is well documented in different fields, little is known about this syndrom...

    Authors: Sharareh Azedi Tehrani, Abbasali Keshtkar, Akilesh Ramasamy and Majid Fadaei

    Citation: Systematic Reviews 2021 10:283

    Content type: Protocol

    Published on:

  18. Non-traumatic coma is a common acute childhood presentation to healthcare facilities in Africa and is associated with high morbidity and mortality. Historically, the majority of cases were attributed to cerebr...

    Authors: Stephen T. J. Ray, Charlotte Fuller, Alexandra Boubour, Laura J. Bonnett, David G. Lalloo, Karl B. Seydel and Michael J. Griffiths

    Citation: Systematic Reviews 2021 10:282

    Content type: Protocol

    Published on:

  19. The primary objective of this study is twofold: (1) to examine the effect of COVID-19 safety measures, enacted to prevent transmission of SARS-nCOV-2, on total physical activity in the adult general population...

    Authors: Fabian Schwendinger, Denis Infanger, Elena Pocecco, Joséphine Gander, Timo Hinrichs and Arno Schmidt-Trucksäss

    Citation: Systematic Reviews 2021 10:281

    Content type: Protocol

    Published on:

  20. The aim of this study was to review the scientific evidence and describe the ocular treatment-emergent adverse events (TEAEs) related to pharmacological treatment in patients with multiple sclerosis.

    Authors: Juliana Muñoz-Ortiz, Juliana Reyes-Guanes, Estefanía Zapata-Bravo, Laura Mora-Muñoz, Juan Antonio Reyes-Hurtado, Luis Octavio Tierradentro-García, William Rojas-Carabali, Marcela Gómez-Suarez and Alejandra de-la-Torre

    Citation: Systematic Reviews 2021 10:280

    Content type: Systematic review update

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  21. People with disabilities (PWDs) remain among the poorest and least empowered population. They experience limited access to basic services, especially in low- and middle-income countries (LMIC). The infringemen...

    Authors: Sithembiso Blose, Saul Cobbing and Verusia Chetty

    Citation: Systematic Reviews 2021 10:279

    Content type: Protocol

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  22. Rapid and accurate diagnosis of paediatric tuberculosis (TB) is key to manage the disease and to control and prevent its transmission. Collection of quality sputum samples without invasion methods from paediat...

    Authors: Emmanuel Oladipo Babafemi, Benny P. Cherian, Beatrice Ouma and Gilbert Mangua Mogoko

    Citation: Systematic Reviews 2021 10:278

    Content type: Research

    Published on:

  23. Men who have sex with men (MSM) are disproportionately affected by HIV in China. Globally, younger MSM are at higher risk for incident HIV infections, but there has been substantial variation in the estimates ...

    Authors: Wenting Huang, Liming Wang, Mi Guodong, Ryan J. Zahn, Jennifer Taussig, Shenita R. Peterson, Stefan Baral, Renee H. Moore, Xiaojie Huang, Jianhua Hou, Patrick S. Sullivan and Aaron J. Siegler

    Citation: Systematic Reviews 2021 10:277

    Content type: Protocol

    Published on:

  24. Evidence suggests that there are substantial inconsistencies in the practice of anesthesia. There has not yet been a comprehensive summary of the anesthesia literature that can guide future knowledge translati...

    Authors: Sylvain Boet, Joseph K. Burns, Olivia Cheng-Boivin, Hira Khan, Kendra Derry, Deric Diep, Abdul Hadi Djokhdem, Sung Wook Um, Johnny W. Huang, Danica Paré, Mimi Deng, Liza Begunova, Linda Yi Ning Fei, Maryam Bezzahou, Pium Sonali Andrahennadi, Elysia Grose…

    Citation: Systematic Reviews 2021 10:276

    Content type: Research

    Published on:

  25. Historically, eating disorders were not identified in older populations and it is only in more recent times that there is greater recognition of the existence of eating disorders among the elderly. This is des...

    Authors: Megha Mulchandani, Namrata Shetty, Agatha Conrad, Petra Muir and Beth Mah

    Citation: Systematic Reviews 2021 10:275

    Content type: Systematic review update

    Published on:

  26. Early pregnancy loss (unintended pregnancy loss before 20 completed weeks of gestation) is a common adverse pregnancy outcome, with previous evidence reporting incidence ranging from 10 to 30% of detected preg...

    Authors: L. Schummers, N. Oveisi, M. S. Ohtsuka, J. A. Hutcheon, K. A. Ahrens, J. Liauw and W. V. Norman

    Citation: Systematic Reviews 2021 10:274

    Content type: Protocol

    Published on:

  27. Authors: Sylvain Boet, Cole Etherington, David Nicola, Andrew Beck, Susan Bragg, Ian D. Carrigan, Sarah Larrigan, Cassandra T. Mendonca, Isaac Miao, Tatyana Postonogova, Benjamin Walker, José De Wit, Karim Mohamed, Nadia Balaa, Manoj Mathew Lalu, Daniel I. McIsaac…

    Citation: Systematic Reviews 2021 10:272

    Content type: Correction

    Published on:

    The original article was published in Systematic Reviews 2018 7:218

  28. Multimorbidity, defined as the co-existence of two or more chronic conditions, presents significant challenges to patients, healthcare providers and health systems. Despite this, there is ongoing uncertainty a...

    Authors: Susan M. Smith, Emma Wallace, Barbara Clyne, Fiona Boland and Martin Fortin

    Citation: Systematic Reviews 2021 10:271

    Content type: Research

    Published on:

  29. Numerous studies report changes in neuromuscular control in people with low back pain (LBP). However, the relationship between pain and altered neuromuscular control is challenging to unravel given the heterog...

    Authors: Valter Devecchi, Deborah Falla, Hélio V. Cabral and Alessio Gallina

    Citation: Systematic Reviews 2021 10:270

    Content type: Protocol

    Published on:

  30. Intrapartum mistreatment of women is an ubiquitous public health and human rights challenge. The issue reportedly has severe maternal and neonatal outcomes including mortality, and generally leads to a decreas...

    Authors: Helen H. Habib, Jefferson Mwaisaka, Kwasi Torpey, Ernest Tei Maya and Augustine Ankomah

    Citation: Systematic Reviews 2021 10:269

    Content type: Protocol

    Published on:

  31. Complex interventions in health care are characterized by multiple interacting components as well as by numerous nonlinear interactions with the social systems within which they are being implemented. The proc...

    Authors: Tina Quasdorf, Lauren Clack, Franziska Laporte Uribe, Daniela Holle, Martin Berwig, Daniel Purwins, Marie-Therese Schultes and Martina Roes

    Citation: Systematic Reviews 2021 10:268

    Content type: Protocol

    Published on:

  32. Cardiopulmonary arrest (CPA) is an urgency, which is associated with high mortality. This systematic review evaluated the relationship between baseline cortisol level and the outcome of resuscitated CPA patients.

    Authors: Adeleh Sahebnasagh, Paria Soltani Nejad, Amin Salehi-Abargouei, Mohammad Hossein Dehghani and Fatemeh Saghafi

    Citation: Systematic Reviews 2021 10:266

    Content type: Research

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  33. Cardiac surgery with cardiopulmonary bypass (CPB) is associated with a systemic inflammatory syndrome that adversely impacts cardiopulmonary function and can contribute to prolonged postoperative recovery. Int...

    Authors: Joel Bierer, David Horne, Roger Stanzel, Mark Henderson, Leah Boulos and Jill Hayden

    Citation: Systematic Reviews 2021 10:265

    Content type: Protocol

    Published on:

  34. Venous thromboembolism (VTE) and bleeding are serious and potentially fatal complications of surgical procedures. Pharmacological thromboprophylaxis decreases the risk of VTE but increases the risk of major po...

    Authors: Lauri I. Lavikainen, Gordon H. Guyatt, Yung Lee, Rachel J. Couban, Anna L. Luomaranta, Ville J. Sallinen, Ilkka E. J. Kalliala, Paul J. Karanicolas, Rufus Cartwright, Riikka L. Aaltonen, Kaisa Ahopelto, Karoliina M. Aro, Ines Beilmann-Lehtonen, Marco H. Blanker, Jovita L. Cárdenas, Samantha Craigie…

    Citation: Systematic Reviews 2021 10:264

    Content type: Protocol

    Published on:

  35. Scoping reviews are an increasingly common approach to evidence synthesis with a growing suite of methodological guidance and resources to assist review authors with their planning, conduct and reporting. The ...

    Authors: Micah D. J. Peters, Casey Marnie, Heather Colquhoun, Chantelle M. Garritty, Susanne Hempel, Tanya Horsley, Etienne V. Langlois, Erin Lillie, Kelly K. O’Brien, Ӧzge Tunçalp, Michael G. Wilson, Wasifa Zarin and Andrea C. Tricco

    Citation: Systematic Reviews 2021 10:263

    Content type: Commentary

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  36. To analyze the effectiveness and quality of stroke clinical practice guidelines (CPGs) published in recent years in order to guide future guideline developers to develop better guidelines.

    Authors: Shuya Lu, Xufei Luo, Xiaojia Ni, Haoxuan Li, Miaomiao Meng, Yefeng Cai, Yunlan Liu, Mengjuan Ren, Yanrui Sun and Yaolong Chen

    Citation: Systematic Reviews 2021 10:262

    Content type: Research

    Published on:

  37. There is a growing interest in scaling effective health innovations to promote equitable access to high-quality health services worldwide. However, multiple challenges persist in scaling innovations. In this s...

    Authors: France Légaré, Karine V. Plourde, Ali Ben Charif, Amédé Gogovor, Francesca Katherine Brundisini, Robert K. D. McLean, Andrew Milat, Nathalie Rheault, Luke Wolfenden and Hervé Tchala Vignon Zomahoun

    Citation: Systematic Reviews 2021 10:261

    Content type: Protocol

    Published on:

  38. Citizen engagement in research is an emerging practice that involves members of the general public in research processes such as priority setting, planning, decision-making, research conduct, implementation, e...

    Authors: Anmol Shahid, Brianna K. Rosgen, Karla D. Krewulak, Diane L. Lorenzetti, Nadine Foster, Bonnie G. Sept, Jeanna Parsons Leigh, Henry T. Stelfox and Kirsten M. Fiest

    Citation: Systematic Reviews 2021 10:260

    Content type: Protocol

    Published on:

  39. Adult scoliosis represents a distinct subgroup of scoliosis patients for whom the diagnosis can have a large impact on their health-related quality of life (HR-QOL). Therefore, HR-QOL patient-reported outcome ...

    Authors: James E. Archer, Charles Baird, Adrian Gardner, Alison B. Rushton and Nicola R. Heneghan

    Citation: Systematic Reviews 2021 10:259

    Content type: Protocol

    Published on:

  40. Public safety occupations are well-recognized to be dangerous and stressful. Despite recent attention on post-traumatic stress injuries among public safety personnel, there has been considerably less attention...

    Authors: Janette Leroux, Rachel Richmond, Sara Fitzpatrick, Hannah Kirkland, Deborah Norris, Alyson Mahar, Joy MacDermid, Rachel Dekel and Heidi Cramm

    Citation: Systematic Reviews 2021 10:258

    Content type: Protocol

    Published on:

  41. The stressful nature of medical training and other work-related factors put postgraduate medical trainees at high risk of burnout and poor psychological wellbeing. This has negative implications for patient ca...

    Authors: Belinda Balhatchet, Heike Schütze, Nicole Williams and Bruce Ashford

    Citation: Systematic Reviews 2021 10:257

    Content type: Protocol

    Published on:

  42. Cardiovascular diseases (CVDs) are health problems that demonstrate high death and prevalence rates, and exhibit large health inequalities across different socio-economic status. Although interest in community...

    Authors: Juhyeon Yang, Eunsim Kim and Bohyun Park

    Citation: Systematic Reviews 2021 10:256

    Content type: Protocol

    Published on:

  43. Knowledge translation (KT) is an important means of improving the health service quality. Most research on the effectiveness of KT strategies has focused on individual strategies, i.e., those directly targetin...

    Authors: Karine Latulippe, Annie LeBlanc, Marie-Pierre Gagnon, Katia Boivin, Pascale Lavoie, Joëlle Dufour, Emmanuelle Paquette Raynard, Eve Richard and Marie-Ève Lamontagne

    Citation: Systematic Reviews 2021 10:255

    Content type: Protocol

    Published on:

  44. Mild traumatic brain injury (mTBI) is an increasing public health problem that can lead to persistent symptoms that have several functional consequences. Understanding the prognosis of a condition is an import...

    Authors: Julien Déry, Élaine De Guise, Ève-Line Bussières and Marie-Eve Lamontagne

    Citation: Systematic Reviews 2021 10:254

    Content type: Protocol

    Published on:

  45. The upper respiratory tract of children is colonized by various microbial species during the healthy state, whereas the lungs are believed to be sterile. In children with respiratory infections, micro-organism...

    Authors: Richa Rao, Jeanne M. Dsouza and Joseph L. Mathew

    Citation: Systematic Reviews 2021 10:253

    Content type: Protocol

    Published on:

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