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Systematic Reviews


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  1. Content type: Protocol

    Pre-exposure prophylaxis (PrEP) with antiretrovirals is an efficacious and effective intervention to decrease the risk of HIV (human immunodeficiency virus) acquisition. Yet drug and delivery costs prohibit ac...

    Authors: Kednapa Thavorn, Howsikan Kugathasan, Darrell H. S. Tan, Nasheed Moqueet, Stefan D. Baral, Becky Skidmore, Derek MacFadden, Anna Simkin and Sharmistha Mishra

    Citation: Systematic Reviews 2018 7:47

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  2. Content type: Protocol

    DNA methylation (global and gene-specific) has been reported as an epigenetic mechanism that could be involved in the pathogenesis of type 2 diabetes mellitus (T2DM). Furthermore, epigenetic therapy has been s...

    Authors: Tinashe Mutize, Zibusiso Mkandla and Bongani B. Nkambule

    Citation: Systematic Reviews 2018 7:46

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  3. Content type: Research

    Machine learning tools can expedite systematic review (SR) processes by semi-automating citation screening. Abstrackr semi-automates citation screening by predicting relevant records. We evaluated its performa...

    Authors: Allison Gates, Cydney Johnson and Lisa Hartling

    Citation: Systematic Reviews 2018 7:45

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  4. Content type: Protocol

    Technology has been implemented since the 1970s with the hope of improving glycaemic control and reducing the burden of complications for those living with type 1 diabetes. A clinical and cost-effectiveness co...

    Authors: Anthony Pease, Clement Lo, Arul Earnest, Danny Liew and Sophia Zoungas

    Citation: Systematic Reviews 2018 7:44

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  5. Content type: Protocol

    Epidemiology and the reporting characteristics of systematic reviews (SRs) and meta-analyses (MAs) are well known. However, no study has analyzed the influence of protocol features on the probability that a st...

    Authors: Juan Ruano, Francisco Gómez-García, Jesús Gay-Mimbrera, Macarena Aguilar-Luque, José Luis Fernández-Rueda, Jesús Fernández-Chaichio, Patricia Alcalde-Mellado, Pedro J. Carmona-Fernandez, Juan Luis Sanz-Cabanillas, Isabel Viguera-Guerra, Francisco Franco-García, Manuel Cárdenas-Aranzana, José Luis Hernández Romero, Marcelino Gonzalez-Padilla, Beatriz Isla-Tejera and Antonio Velez Garcia-Nieto

    Citation: Systematic Reviews 2018 7:43

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  6. Content type: Protocol

    Rapid response teams have been widely adopted across the world. Although evidence for their efficacy is not clear, they remain a popular means to detect and react to patient deterioration. This may in part be ...

    Authors: Michael K. Xu, Kathleen G. Dobson, Lehana Thabane and Alison E. Fox-Robichaud

    Citation: Systematic Reviews 2018 7:42

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  7. Content type: Protocol

    Digital storytelling is an arts-based research method with potential to elucidate complex narratives in a compelling manner, increase participant engagement, and enhance the meaning of research findings. This ...

    Authors: Kendra L. Rieger, Christina H. West, Amanda Kenny, Rishma Chooniedass, Lisa Demczuk, Kim M. Mitchell, Joanne Chateau and Shannon D. Scott

    Citation: Systematic Reviews 2018 7:41

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  8. Content type: Protocol

    Despite the existence of human papilloma virus (HPV) vaccines with demonstrated safety and effectiveness and funded HPV vaccination programs, coverage rates are persistently lower and cervical cancer burden hi...

    Authors: Kelly J. Mrklas, Shannon MacDonald, Melissa A. Shea-Budgell, Nancy Bedingfield, Heather Ganshorn, Sarah Glaze, Lea Bill, Bonnie Healy, Chyloe Healy, Juliet Guichon, Amy Colquhoun, Christopher Bell, Ruth Richardson, Rita Henderson, James Kellner, Cheryl Barnabe…

    Citation: Systematic Reviews 2018 7:40

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  9. Content type: Methodology

    Overviews of systematic reviews are a relatively new approach to synthesising evidence, and research methods and associated guidance are developing. Within this paper we aim to help readers understand key issu...

    Authors: Harriet Hunt, Alex Pollock, Pauline Campbell, Lise Estcourt and Ginny Brunton

    Citation: Systematic Reviews 2018 7:39

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  10. Content type: Protocol

    Health behaviors directly impact the health of individuals, and populations. Since individuals tend to engage in multiple unhealthy behaviors such as smoking, excessive alcohol use, physical inactivity, and ea...

    Authors: Nadia Minian, Wayne K. deRuiter, Mathangee Lingam, Tricia Corrin, Rosa Dragonetti, Heather Manson, Valerie H. Taylor, Laurie Zawertailo, Arezoo Ebnahmady, Osnat C. Melamed, Terri Rodak, Margaret Hahn and Peter Selby

    Citation: Systematic Reviews 2018 7:38

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  11. Content type: Protocol

    Physical activity has been cited as a potential symptomatic treatment option for people living with dementia. At present, much of the research concerning physical activity and dementia considers older adults, ...

    Authors: Chloe Rodgers, David Rogerson, Judy Stevenson and Davina Porock

    Citation: Systematic Reviews 2018 7:36

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  12. Content type: Protocol

    In South Africa (home of the largest HIV epidemic globally), there are high levels of mobility. While studies produced in the recent past provide useful perspectives to the mobility-HIV risk linkage, systemati...

    Authors: Armstrong Dzomba, Kaymarlin Govender, Tivani P. Mashamba-Thompson and Frank Tanser

    Citation: Systematic Reviews 2018 7:37

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  13. Content type: Protocol

    While effective engagement of patients and families in treatment is increasingly viewed as a priority for many healthcare systems, much remains to be learned about the nature and outcomes of approaches that se...

    Authors: Donna Goodridge, Chrysanthus Henry, Erin Watson, Meghan McDonald, Lucia New, Elizabeth L. Harrison, Murray Scharf, Erika Penz, Steve Campbell and Thomas Rotter

    Citation: Systematic Reviews 2018 7:35

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  14. Content type: Protocol

    The benefits of trauma registries have been well described. The crucial data they provide may guide injury prevention strategies, inform resource allocation, and support advocacy and policy. This has been show...

    Authors: Tiffany Paradis, Etienne St-Louis, Tara Landry and Dan Poenaru

    Citation: Systematic Reviews 2018 7:33

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  15. Content type: Protocol

    Contrast-induced acute kidney injury (CI-AKI) is defined as worsening of renal function after the administration of iodinated contrast material. In patients with cardiovascular disease, kidney disease, and/or ...

    Authors: Swapnil Hiremath, Jeanne Françoise Kayibanda, Benjamin J. W. Chow, Dean Fergusson, Greg A. Knoll, Wael Shabana, Brianna Lahey, Olivia McBride, Alexandra Davis and Ayub Akbari

    Citation: Systematic Reviews 2018 7:34

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  16. Content type: Research

    The annual prevalence of falls in people with dementia ranges from 47 to 90%. Falls are a common reason for hospital admission in people with dementia, and there is limited research evidence regarding the care...

    Authors: Shannon Robalino, Sarange B. Nyakang’o, Fiona R. Beyer, Chris Fox and Louise M. Allan

    Citation: Systematic Reviews 2018 7:31

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  17. Content type: Protocol

    Randomised control trials are regarded as the gold standard for evaluating the effectiveness and efficacy of healthcare interventions with thousands of trials published every year. Despite significant investme...

    Authors: Adel El Feky, Katie Gillies, Heidi Gardner, Cynthia Fraser and Shaun Treweek

    Citation: Systematic Reviews 2018 7:30

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  18. Content type: Protocol

    Cholera is a highly infectious diarrheal disease spread via fecal contamination of water and food sources; it is endemic in parts of Africa and Asia and recent outbreaks have been reported in Haiti, the Zambia...

    Authors: Karin Diaconu, Jennifer Falconer, Fiona O’May, Miguel Jimenez, Joe Matragrano, Betty Njanpop-Lafourcade and Alastair Ager

    Citation: Systematic Reviews 2018 7:29

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  19. Content type: Research

    The purpose of this study was to identify and analyse currently available knowledge on information needs of people with diabetes mellitus, also considering possible differences between subgroups and associated...

    Authors: Lisa Biernatzki, Silke Kuske, Jutta Genz, Michaela Ritschel, Astrid Stephan, Christina Bächle, Sigrid Droste, Sandra Grobosch, Nicole Ernstmann, Nadja Chernyak and Andrea Icks

    Citation: Systematic Reviews 2018 7:27

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  20. Content type: Research

    While in its early years the HIV epidemic affected primarily the male and the young, nowadays, the population living with HIV/AIDS is approximately 24% women, and its age composition has shifted towards older ...

    Authors: Gaelen P. Adam, Mengyang Di, Susan Cu-Uvin, Christopher Halladay, Bryant T. Smith, Suchitra Iyer and Thomas A. Trikalinos

    Citation: Systematic Reviews 2018 7:25

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  21. Content type: Research

    Many interventions have been developed to promote respect and social inclusion among older people, but the evidence on their impacts on health has not been synthesised. This systematic review aims to appraise ...

    Authors: S. Ronzi, L. Orton, D. Pope, N. K. Valtorta and N. G. Bruce

    Citation: Systematic Reviews 2018 7:26

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  22. Content type: Protocol

    Cognitive impairment is characterized by problems in thinking, memory, language, and judgment that are greater than cognitive changes in normal aging. Considering the unprecedented growth of the older adult po...

    Authors: ASM Borhan, Patricia Hewston, Dafna Merom, Courtney Kennedy, George Ioannidis, Nancy Santesso, Pasqualina Santaguida, Lehana Thabane and Alexandra Papaioannou

    Citation: Systematic Reviews 2018 7:24

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  23. Content type: Protocol

    Insulin standard treatment of T1DM cannot cure the patients as different chronic complications occurred subsequently. Investigations on a curative treatment in T1DM propose cell replacement or maintenance inst...

    Authors: Sedigheh Madani, Bagher Larijani, Abbas Ali Keshtkar and Ali Tootee

    Citation: Systematic Reviews 2018 7:23

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