Bergese S, Castellon-Larios K. The effectiveness of a single dose of oral ibuprofen plus caffeine in acute postoperative pain in adults. Evid-Based Med. 2016;21(1):24. https://doi.org/10.1136/ebmed-2015-110278.
Article
PubMed
Google Scholar
Bhattacharyya T, Levin R, Vrahas MS, Solomon DH. Nonsteroidal antiinflammatory drugs and nonunion of humeral shaft fractures. Arthritis Rheum. 2005;53(3):364–7. https://doi.org/10.1002/art.21170.
Article
CAS
PubMed
Google Scholar
Moore RA, Derry S, McQuay HJ, Wiffen PJ. Single dose oral analgesics for acute postoperative pain in adults. Cochrane Database Syst Rev. 2011;(9):Cd008659.
Pozzi A, Gallelli L. Pain management for dentists: the role of ibuprofen. Annali di stomatologia. 2011;2(3-4 Suppl):3–24.
PubMed
Google Scholar
Vuolteenaho K, Moilanen T, Moilanen E. Non-steroidal anti-inflammatory drugs, cyclooxygenase-2 and the bone healing process. Basic Clin Pharmacol Toxicol. 2008;102(1):10–4. https://doi.org/10.1111/j.1742-7843.2007.00149.x.
Article
CAS
PubMed
Google Scholar
Altman RD, Latta LL, Keer R, Renfree K, Hornicek FJ, Banovac K. Effect of nonsteroidal antiinflammatory drugs on fracture healing: a laboratory study in rats. Journal of Orthopaedic Trauma. 1995;9(5):392–400. https://doi.org/10.1097/00005131-199505000-00006.
Article
CAS
PubMed
Google Scholar
Beck A, Krischak G, Sorg T, Augat P, Farker K, Merkel U, et al. Influence of diclofenac (group of nonsteroidal anti-inflammatory drugs) on fracture healing. Arch Orthop Trauma Surg. 2003;123(7):327–32. https://doi.org/10.1007/s00402-003-0537-5.
Article
CAS
PubMed
Google Scholar
Bo J, Sudmann E, Marton PF. Effect of indomethacin on fracture healing in rats. Acta Orthop Scand. 1976;47(6):588–99. https://doi.org/10.3109/17453677608988744.
Article
CAS
PubMed
Google Scholar
Cappello T, Nuelle JAV, Katsantonis N, Nauer RK, Lauing KL, Jagodzinski JE, et al. Ketorolac administration does not delay early fracture healing in a juvenile rat model: a pilot study. J Pediatric Orthop. 2013;33(4):415–21. https://doi.org/10.1097/BPO.0b013e318288b46f.
Article
Google Scholar
Gerstenfeld LC, Al-Ghawas M, Alkhiary YM, Cullinane DM, Krall EA, Fitch JL, et al. Selective and nonselective cyclooxygenase-2 inhibitors and experimental fracture-healing. Reversibility of effects after short-term treatment. J Bone Joint Surg Am Vol. 2007;89(1):114–25. https://doi.org/10.2106/00004623-200701000-00016.
Article
CAS
Google Scholar
Sandberg O, Aspenberg P. Different effects of indomethacin on healing of shaft and metaphyseal fractures. Acta Orthopaedica. 2015;86(2):243–7. https://doi.org/10.3109/17453674.2014.973328.
Article
PubMed
PubMed Central
Google Scholar
Simon AM, O'Connor JP, Simon AM, O'Connor JP. Dose and time-dependent effects of cyclooxygenase-2 inhibition on fracture-healing. J Bone Joint Surg Am Vol. 2007;89(3):500–11. https://doi.org/10.2106/JBJS.F.00127.
Article
Google Scholar
Zura R, Xiong Z, Einhorn T, Watson JT, Ostrum RF, Prayson MJ, et al. Epidemiology of fracture nonunion in 18 human bones. JAMA Surgery. 2016;151(11):e162775. https://doi.org/10.1001/jamasurg.2016.2775.
Article
PubMed
Google Scholar
Davis TR, Ackroyd CE. Non-steroidal anti-inflammatory agents in the management of Colles' fractures. Brit J Clin Pract. 1988;42(5):184–9.
CAS
PubMed
Google Scholar
Adolphson P, Abbaszadegan H, Jonsson U, Dalen N, Sjoberg HE, Kalen S. No effects of piroxicam on osteopenia and recovery after Colles' fracture. A randomized, double-blind, placebo-controlled, prospective trial. Arch Orthop Trauma Surg. 1993;112(3):127–30. https://doi.org/10.1007/BF00449987.
Article
CAS
PubMed
Google Scholar
Sagi HC, Jordan CJ, Barei DP, Serrano-Riera R, Steverson B. Indomethacin prophylaxis for heterotopic ossification after acetabular fracture surgery increases the risk for nonunion of the posterior wall. J Orthop Trauma. 2014;28(7):377–83. https://doi.org/10.1097/BOT.0000000000000049.
Article
PubMed
Google Scholar
Marquez-Lara A, Hutchinson ID, Nunez F, Jr., Smith TL, Miller AN. Nonsteroidal anti-inflammatory drugs and bone-healing: a systematic review of research quality. JBJS Rev. 2016;4(3):1–14.
Dimmen S, Nordsletten L, Madsen JE. Parecoxib and indomethacin delay early fracture healing: a study in rats. Clin Orthop. 2009;467(8):1992–9. https://doi.org/10.1007/s11999-009-0783-0.
Article
PubMed
PubMed Central
Google Scholar
Endo K, Sairyo K, Komatsubara S, Sasa T, Egawa H, Ogawa T, et al. Cyclooxygenase-2 inhibitor delays fracture healing in rats. Acta Orthopaedica. 2005;76(4):470–4. https://doi.org/10.1080/17453670510041439.
Article
PubMed
Google Scholar
Inal S, Kabay S, Cayci MK, Kuru HI, Altikat S, Akkas G, et al. Comparison of the effects of dexketoprofen trometamol, meloxicam and diclofenac sodium on fibular fracture healing, kidney and liver: an experimental rat model. Injury. 2014;45(3):494–500. https://doi.org/10.1016/j.injury.2013.10.002.
Article
PubMed
Google Scholar
Chappard D, Basle MF, Aguado E, Goyenvalle E, Nyangoga H. A non-steroidal anti-inflammatory drug (ketoprofen) does not delay beta-TCP bone graft healing. Acta Biomaterialia. 2010;6(8):3310–7.
Article
Google Scholar
Donovan M, George M, Petersen E, Fredericks D, Femino JE, Lack WD, et al. Effect of aspirin on bone healing in a rabbit ulnar osteotomy model. J Bone Joint Surg – Am Vol. 2013;95(6):488–96.
Article
Google Scholar
Goodman SB, Ma T, Miyanishi K, Smith RL, Oh K, Wadsworth S, et al. Effects of a p38 MAP kinase inhibitor on bone ingrowth and tissue differentiation in rabbit chambers. J Biomed Materials Res Part A. 2007;81(2):310–6.
Article
CAS
Google Scholar
Singh A, Shekhar S, Saraf SK, Garbyal RS. Effect of etoricoxib on fracture healing - an experimental study. Biomed Res. 2011;22(1):52–6.
CAS
Google Scholar
Morgan EF, De Giacomo A, Gerstenfeld LC. Overview of skeletal repair (fracture healing and its assessment). Methods Mol Biol. 2014;1130:13–31. https://doi.org/10.1007/978-1-62703-989-5_2.
Article
CAS
PubMed
PubMed Central
Google Scholar
Histing T, Garcia P, Holstein JH, Klein M, Matthys R, Nuetzi R, et al. Small animal bone healing models: standards, tips, and pitfalls results of a consensus meeting. Bone. 2011;49(4):591–9. https://doi.org/10.1016/j.bone.2011.07.007.
Article
CAS
PubMed
Google Scholar
Bissinger O, Kreutzer K, Gotz C, Hapfelmeier A, Pautke C, Vogt S, et al. A biomechanical, micro-computertomographic and histological analysis of the influence of diclofenac and prednisolone on fracture healing in vivo. BMC Musculoskelet Disord. 2016;17(1):383. https://doi.org/10.1186/s12891-016-1241-2.
Article
CAS
PubMed
PubMed Central
Google Scholar
Foux A, Black RC, Uhthoff HK. Quantitative measures for fracture healing: an in-vitro biomechanical study. J Biomech Eng. 1990;112(4):401–6. https://doi.org/10.1115/1.2891203.
Article
CAS
PubMed
Google Scholar
O'Connor AM, Sargeant JM. Critical appraisal of studies using laboratory animal models. ILAR J. 2014;55(3):405–17. https://doi.org/10.1093/ilar/ilu038.
Article
CAS
PubMed
Google Scholar
Gerstenfeld LC, Wronski TJ, Hollinger JO, Einhorn TA. Application of histomorphometric methods to the study of bone repair. J Bone Mineral Res. 2005;20(10):1715–22. https://doi.org/10.1359/JBMR.050702.
Article
Google Scholar
Hacker SA, Healey RM, Yoshioka M, Coutts RD. A methodology for the quantitative assessment of articular cartilage histomorphometry. Osteoarthritis Cartilage. 1997;5(5):343–55. https://doi.org/10.1016/S1063-4584(97)80038-6.
Article
CAS
PubMed
Google Scholar
Al-Waeli H, Ana Paula Reboucas MM, Mansour A, Tamimi F, Nicolau B. Non steroidal anti inflammatory drugs and bone healing in animal models systematic review and meta analysis; 2017.
Google Scholar
de Vries RBM, Hooijmans CR, Langendam MW, van Luijk J, Leenaars M, Ritskes-Hoitinga M, et al. A protocol format for the preparation, registration and publication of systematic reviews of animal intervention studies. Evid-Based Preclinical Med. 2015;2(1):1–9.
Article
Google Scholar
Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan-a web and mobile app for systematic reviews. Systematic reviews. 2016;5(1):210. https://doi.org/10.1186/s13643-016-0384-4.
Article
PubMed
PubMed Central
Google Scholar
Hooijmans CR, Rovers MM, de Vries RB, Leenaars M, Ritskes-Hoitinga M, Langendam MW. SYRCLE's risk of bias tool for animal studies. BMC Med Res Methodol. 2014;14(1):43. https://doi.org/10.1186/1471-2288-14-43.
Article
PubMed
PubMed Central
Google Scholar
Kilkenny C, Parsons N, Kadyszewski E, Festing MF, Cuthill IC, Fry D, et al. Survey of the quality of experimental design, statistical analysis and reporting of research using animals. PLoS One. 2009;4(11):e7824. https://doi.org/10.1371/journal.pone.0007824.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chalmers I, Hedges LV, Cooper H. A brief history of research synthesis. Eval Health Prof. 2002;25(1):12–37. https://doi.org/10.1177/0163278702025001003.
Article
PubMed
Google Scholar
Vesterinen HM, Sena ES, Egan KJ, Hirst TC, Churolov L, Currie GL, et al. Meta-analysis of data from animal studies: a practical guide. J Neurosci Methods. 2014;221:92–102. https://doi.org/10.1016/j.jneumeth.2013.09.010.
Article
CAS
PubMed
Google Scholar
Hedges LV, Olkin I. Statistical methods for meta-analysis. Academic Press; 2014.
Hooijmans CR, IntHout J, Ritskes-Hoitinga M, Rovers MM. Meta-analyses of animal studies: an introduction of a valuable instrument to further improve healthcare. ILAR J. 2014;55(3):418–26. https://doi.org/10.1093/ilar/ilu042.
Article
CAS
PubMed
PubMed Central
Google Scholar
Petitti DB. Approaches to heterogeneity in meta-analysis. Stat Med. 2001;20(23):3625–33. https://doi.org/10.1002/sim.1091.
Article
CAS
PubMed
Google Scholar
Pierce CA. Software Review: Borenstein, M., Hedges, L. V., Higgins, J. P. T., & Rothstein, H. R. (2006). Comprehensive meta-analysis (Version 2.2.027) [Computer software]. Englewood, NJ: Biostat. Organ Res Methods. 2008;11(1):188–91. https://doi.org/10.1177/1094428106296641.
Article
Google Scholar
Akman Ş, Gögüs A, Sener N, Bilgiç B, Aksoy B, Seckin F. Effect of diclofenac sodium on union of tibial fractures in rats. Adv Therapy. 2002;19(3):119–25. https://doi.org/10.1007/BF02850267.
Article
CAS
Google Scholar
Allen HL, Wase A, Bear WT. Indomethacin and aspirin: effect of nonsteroidal anti-inflammatory agents on the rate of fracture repair in the rat. Acta Orthop Scand. 1980;51(4):595–600. https://doi.org/10.3109/17453678008990848.
Article
CAS
PubMed
Google Scholar
Bergenstock M, Min W, Simon AM, Sabatino C, O'Connor JP. A comparison between the effects of acetaminophen and celecoxib on bone fracture healing rats. J Orthop Trauma. 2005;19(10):717–23. https://doi.org/10.1097/01.bot.0000184144.98071.5d.
Article
PubMed
Google Scholar
Brown KM, Saunders MM, Kirsch T, Donahue HJ, Reid JS. Effect of COX-2-specific inhibition on fracture-healing in the rat femur. J Bone Joint Surg - Am Vol. 2004;86(1):116–23. https://doi.org/10.2106/00004623-200401000-00017.
Article
Google Scholar
Giordano V, Giordano M, Knackfuss IG, Apfel MIR, Gomes RDC. Effect of tenoxicam on fracture healing in rat tibiae. Injury. 2003;34(2):85–94. https://doi.org/10.1016/S0020-1383(02)00199-7.
Article
PubMed
Google Scholar
Krischak GD, Augat P, Blakytny R, Claes L, Kinzl L, Beck A. The non-steroidal anti-inflammatory drug diclofenac reduces appearance of osteoblasts in bone defect healing in rats. Arch Orthop Trauma Surg. 2007;127(6):453–8. https://doi.org/10.1007/s00402-007-0288-9.
Article
CAS
PubMed
Google Scholar
Li K-H, Cheng L, Zhu Y, Deng G-B, Long H-T. Effects of a selective cyclooxygenase-2 inhibitor (celecoxib) on fracture healing in rats. Indian J Orthop. 2013;47(4):395–401. https://doi.org/10.4103/0019-5413.114930.
Article
PubMed
PubMed Central
Google Scholar
Sudmann E, Bang G. Indomethacin-induced inhibition of haversian remodelling in rabbits. Acta Orthop Scand. 1979;50(6 Pt 1):621–7. https://doi.org/10.3109/17453677908991283.
Article
CAS
PubMed
Google Scholar
Utvag SE, Fuskevag OM, Shegarfi H, Reikeras O. Short-term treatment with COX-2 inhibitors does not impair fracture healing. J Invest Surg. 2010;23(5):257–61. https://doi.org/10.3109/08941939.2010.481009.
Article
PubMed
Google Scholar
Tiseo BC, Namur GN, De Paula EJL, Mattar R Jr, De Oliveira CRGCM. Experimental study of the action of COX-2 selective nonsteroidal anti-inflammatory drugs and traditional anti-inflammatory drugs in bone regeneration. Clinics. 2006;61(3):223–30. https://doi.org/10.1590/S1807-59322006000300007.
Article
PubMed
Google Scholar
Simon AM, Manigrasso MB, O'Connor JP. Cyclo-oxygenase 2 function is essential for bone fracture healing. J Bone Mineral Res. 2002;17(6):963–76. https://doi.org/10.1359/jbmr.2002.17.6.963.
Article
CAS
Google Scholar
Sassioto MC, Inouye CM, Aydos RD, Figueiredo AS. Bone repair in rats treated with sodic diclofenac and calcitonin. Acta Cirurgica Brasileira. 2006;21(suppl 4):40–4. https://doi.org/10.1590/S0102-86502006001000010.
Article
PubMed
Google Scholar
Reikeraas O, Engebretsen L. Effects of ketoralac tromethamine and indomethacin on primary and secondary bone healing. An experimental study in rats. Arch Orthop Trauma Surg. 1998;118(1):50–2. https://doi.org/10.1007/s004020050310.
Article
CAS
PubMed
Google Scholar
Mullis BH, Copland ST, Weinhold PS, Miclau T, Lester GE, Bos GD. Effect of COX-2 inhibitors and non-steroidal anti-inflammatory drugs on a mouse fracture model. Injury. 2006;37(9):827–37. https://doi.org/10.1016/j.injury.2005.12.018.
Article
PubMed
Google Scholar
Matsumoto MA, De Oliveira A, Ribeiro Junior PD, Nary Filho H, Ribeiro DA. Short-term administration of non-selective and selective COX-2 NSAIDs do not interfere with bone repair in rats. J Mol Histol. 2008;39(4):381–7. https://doi.org/10.1007/s10735-008-9176-z.
Article
CAS
PubMed
Google Scholar
Gerstenfeld LC, Thiede M, Siebert K, Mielke C, Phippard D, Svagr B, et al. Differential inhibition of fracture healing by non-selective and cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs. J Orthop Res. 2003;21(4):670–5. https://doi.org/10.1016/S0736-0266(03)00003-2.
Article
CAS
PubMed
Google Scholar
Dimmen S, Nordsletten L, Engebretsen L, Steen H, Madsen JE. Negative effect of parecoxib on bone mineral during fracture healing in rats. Acta Orthop. 2008;79(3):438–44. https://doi.org/10.1080/17453670710015373.
Article
PubMed
Google Scholar
Lin HN, Cottrell J, O'Connor JP. Variation in lipid mediator and cytokine levels during mouse femur fracture healing. J Orthopaedic Res. 2016;34(11):1883–93. https://doi.org/10.1002/jor.23213.
Article
CAS
Google Scholar
O'Connor JP, Manigrasso MB, Kim BD, Subramanian S. Fracture healing and lipid mediators. BoneKEy Reports. 2014;3:517.
PubMed
PubMed Central
Google Scholar
Su B, O'Connor JP. NSAID therapy effects on healing of bone, tendon, and the enthesis. J Appl Physiol. 2013;115(6):892–9. https://doi.org/10.1152/japplphysiol.00053.2013.
Article
CAS
PubMed
PubMed Central
Google Scholar
O'Connor JP, Simon AM, Manigrasso MB. Cyclooxygenase-2 function is essential for bone fracture healing. Inflammopharmacol. 2003;11(4):541–3.
Google Scholar
Spiro AS, Beil FT, Baranowsky A, Barvencik F, Schilling AF, Nguyen K, et al. BMP-7-induced ectopic bone formation and fracture healing is impaired by systemic NSAID application in C57BL/6-mice. J Orthop Res. 2010;28(6):785–91. https://doi.org/10.1002/jor.21044.
Article
CAS
PubMed
Google Scholar
Sevimli R, Üzel M, Sayar H, Kalender AM, Dökmeci O. The effect of dexketoprofen trometamol on the healing of diaphysis fractures of rat tibia. Acta Orthopaedica et Traumatologica Turcica. 2013;47(6):423–9. https://doi.org/10.3944/AOTT.2013.3093.
Article
PubMed
Google Scholar
Dorey FJ, Kody MH, Kabo JM, More RC, Meals RA. The effects of two nonsteroidal antiinflammatory drugs on limb swelling, joint stiffness, and bone torsional strength following fracture in a rabbit model. Clin Orthop. 1989;0(247):306-312.
Huo MH, Troiano NW, Pelker RR, Gundberg CM, Friedlaender GE. The influence of ibuprofen on fracture repair: biomechanical, biochemical, histologic, and histomorphometric parameters in rats. J Orthop Res. 1991;9(3):383–90. https://doi.org/10.1002/jor.1100090310.
Article
CAS
PubMed
Google Scholar
Huss MK, Felt SA, Pacharinsak C. Influence of pain and analgesia on orthopedic and wound-healing models in rats and mice. Comp Med. 2019;69(6):535–45. https://doi.org/10.30802/AALAS-CM-19-000013.
Article
CAS
PubMed
PubMed Central
Google Scholar
Borgeat A, Ofner C, Saporito A, Farshad M, Aguirre J. The effect of nonsteroidal anti-inflammatory drugs on bone healing in humans: A qualitative, systematic review. J Clin Anesth. 2018;49:92–100. https://doi.org/10.1016/j.jclinane.2018.06.020.
Article
CAS
PubMed
Google Scholar
Haffner-Luntzer M, Kovtun A, Rapp AE, Ignatius A. Mouse Models in Bone Fracture Healing Research. Curr Mol Biol Reports. 2016;2(2):101–11. https://doi.org/10.1007/s40610-016-0037-3.
Article
Google Scholar
Peric M, Dumic-Cule I, Grcevic D, Matijasic M, Verbanac D, Paul R, et al. The rational use of animal models in the evaluation of novel bone regenerative therapies. Bone. 2015;70:73–86. https://doi.org/10.1016/j.bone.2014.07.010.
Article
CAS
PubMed
Google Scholar