Table 2 Meta-analysis based on several subgroups showing the effect of NSAID administration on bone volume and density measurements (μ CT assessment) of healing bones after fracture
μ CT assessment (bone) NSAID vs control | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Subgroup | N | SZ NSAID | SZ C. | SMD | 95% CI | P effect | Q statistic | P withinheterog. | I2% | P betweenheterog. |
Overall | 5 | 48 | 39 | − 1.63 | [− 2.87,− 0.39] | 0.01 | 23.98 | < 0.001 | 83.32 | – |
Species | ||||||||||
Rats | 2 | 7 | 3 | NA | NA | NA | NA | NA | NA | 0.193 |
Mice | 3 | 31 | 31 | − 1.03 | [− 2.55, 0.48] | 0.18 | 9.95 | 0.007 | 0 | |
Sex | ||||||||||
Female | 1 | 5 | 5 | NA | NA | NA | NA | NA | NA | 0.851 |
Male | 4 | 43 | 43 | − 1.73 | [− 3.06, − 0.27] | 0.029 | 23.755 | < 0.001 | 87.37 | |
Age/weeks | ||||||||||
< 8 | 0 | NA | NA | NA | NA | NA | NA | NA | NA | 0.007 |
8–16 | 4 | 38 | 34 | − 1.04 | [− 1.98, − 0.10] | 0.03 | 10.157 | 0.017 | 70.46 | |
> 16 | 0 | NA | NA | NA | NA | NA | NA | NA | NA | |
Not mentioned | 1 | 10 | 5 | NA | NA | NA | NA | NA | NA | |
Type of NSAID | ||||||||||
NS-COX | 5 | 48 | 39 | − 1.63 | [− 2.87, − 0.39] | 0.01 | 23.985 | < 0.001 | 83.32 | 1 |
S-COX2 | 0 | NA | NA | NA | NA | NA | NA | NA | NA | |
Time point | ||||||||||
< 21 days | 4 | 38 | 34 | − 1.04 | [− 1.98, − 0.10] | 0.03 | 10.157 | 0.017 | 70.46 | NA |
21–48 days | 1 | NA | NA | NA | NA | NA | NA | NA | NA | |
> 48 days | 0 | NA | NA | NA | NA | NA | NA | NA | NA | |
Type of fractured bone | ||||||||||
Femur | 4 | 38 | 34 | − 1.04 | [− 1.98, − 0.10] | 0.03 | 10.157 | 0.017 | 70.46 | 0.007 |
Tibia | 1 | NA | NA | NA | NA | NA | NA | NA | NA | |