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Table 2 Meta-analysis based on several subgroups showing the effect of NSAID administration on bone volume and density measurements (μ CT assessment) of healing bones after fracture

From: Non-steroidal anti-inflammatory drugs and bone healing in animal models—a systematic review and meta-analysis

μ CT assessment (bone)
NSAID vs control
Subgroup N SZ
NSAID
SZ
C.
SMD 95% CI P effect Q statistic P withinheterog. I2% P betweenheterog.
Overall 5 48 39 − 1.63 [− 2.87,− 0.39] 0.01 23.98 < 0.001 83.32
Species
Rats 2 7 3 NA NA NA NA NA NA 0.193
Mice 3 31 31 − 1.03 [− 2.55, 0.48] 0.18 9.95 0.007 0  
Sex
Female 1 5 5 NA NA NA NA NA NA 0.851
Male 4 43 43 − 1.73 [− 3.06, − 0.27] 0.029 23.755 < 0.001 87.37  
Age/weeks
< 8 0 NA NA NA NA NA NA NA NA 0.007
8–16 4 38 34 − 1.04 [− 1.98, − 0.10] 0.03 10.157 0.017 70.46  
> 16 0 NA NA NA NA NA NA NA NA  
Not mentioned 1 10 5 NA NA NA NA NA NA  
Type of NSAID
NS-COX 5 48 39 − 1.63 [− 2.87, − 0.39] 0.01 23.985 < 0.001 83.32 1
S-COX2 0 NA NA NA NA NA NA NA NA  
Time point
< 21 days 4 38 34 − 1.04 [− 1.98, − 0.10] 0.03 10.157 0.017 70.46 NA
21–48 days 1 NA NA NA NA NA NA NA NA  
> 48 days 0 NA NA NA NA NA NA NA NA  
Type of fractured bone
Femur 4 38 34 − 1.04 [− 1.98, − 0.10] 0.03 10.157 0.017 70.46 0.007
Tibia 1 NA NA NA NA NA NA NA NA  
  1. N number of comparisons in analysis, SZ NSAID number of animals in non-steroidal anti-inflammatory drug (NSAID) group, SZ C. number of animals in control group, SMD standardized means of differences (Hedges’ g), CI confidence interval, NS-COX non-selective cyclooxygenase inhibitor, S-COX2 selective cyclooxygenase 2 inhibitor, NA not analyzed because of insufficient data