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  1. The North American opioid crisis is driven by opioid-related mortality and morbidity, including opioid use-associated infections (OUAIs), resulting in a substantial burden for society. Users of legal and illeg...

    Authors: Irina Kudrina, Svetlana Puzhko, Kristian B. Filion, Genevieve Gore, Elena Paraskevopoulos, Sarah Windle, Marc O. Martel and Mark J. Eisenberg
    Citation: Systematic Reviews 2021 10:298
    Content type: Protocol Published on:

  2. Peer-support programs are a useful social support strategy for populations trying to quit smoking who are willing to maintain smoking abstinence. This study is a protocol for a systematic review and meta-analy...

    Authors: Hyun-Ju Seo, Soo Young Kim, Dongah Park, Seung-Soo Sheen, Miyoung Choi, Bo-Hyoung Jang, Su Jung Lee and Youngju Cha
    Citation: Systematic Reviews 2021 10:296
    Content type: Protocol Published on:

  3. In many countries, children who are diagnosed with autism during the first 5 years of life are offered a range of early intervention options. These options vary considerably in the theoretical approaches and t...

    Authors: Katherine Pye, Hannah Jackson, Teresa Iacono and Alan Shiell
    Citation: Systematic Reviews 2021 10:295
    Content type: Protocol Published on:

  4. Despite the expectations regarding the effectiveness of chloroquine (CQ) and hydroxychloroquine (HCQ) for coronavirus disease (COVID-19) management, concerns about their adverse events have remained.

    Authors: Mayra Souza Botelho, Fernanda Bolfi, Renata Giacomini Occhiuto Ferreira Leite, Mauro Salles Ferreira Leite, Luisa Rocco Banzato, Luiza Teixeira Soares, Thaina Oliveira Felicio Olivatti, Amanda Sampaio Mangolim, Flávia Ramos Kazan Oliveira, Luciana Patrícia Fernandes Abbade, Joelcio Francisco Abbade, Ricardo Augusto Monteiro de Barros Almeida, Julia Simões Corrêa Galendi, Lehana Thabane and Vania dos Santos Nunes-Nogueira
    Citation: Systematic Reviews 2021 10:294
    Content type: Research Published on:

  5. Low levels of physical activity are common during the hospital stay and have been associated with negative health outcomes. Understanding barriers and enablers to physical activity during a hospital stay can i...

    Authors: Sven Jacobus Gertruda Geelen, Hanneke Corine van Dijk - Huisman, Robert Adriaan de Bie, Cindy Veenhof, Raoul Engelbert, Marike van der Schaaf and Antoine François Lenssen
    Citation: Systematic Reviews 2021 10:293
    Content type: Research Published on:

  8. Subclinical hypothyroidism is a thyroid disorder diagnosed from the laboratory blood test results of otherwise asymptomatic patients. It has been associated with poor cardiovascular outcomes, mortality and pro...

    Authors: Brenda S. Bauer, Amaya Azcoaga-Lorenzo, Utkarsh Agrawal and Colin McCowan
    Citation: Systematic Reviews 2021 10:290
    Content type: Protocol Published on:

  9. The coronavirus disease 19 (covid-19) pandemic has underscored the need to expedite clinical research, which may lead investigators to shift away from measuring patient-important outcomes (PIO), limiting resea...

    Authors: Mario A. Jimenez-Mora, Andrea Ramírez Varela, Jose F. Meneses-Echavez, Julia Bidonde, Adriana Angarita-Fonseca, Reed A. C. Siemieniuk, Dena Zeraatkar, Jessica J. Bartoszko, Romina Brignardello-Petersen, Kimia Honarmand, Bram Rochwerg, Gordon Guyatt and Juan José Yepes-Nuñez
    Citation: Systematic Reviews 2021 10:289
    Content type: Protocol Published on:

  10. Many prognostic models of diabetic microvascular complications have been developed, but their performances still varies. Therefore, we conducted a systematic review and meta-analysis to summarise the performan...

    Authors: Sigit Ari Saputro, Oraluck Pattanaprateep, Anuchate Pattanateepapon, Swekshya Karmacharya and Ammarin Thakkinstian
    Citation: Systematic Reviews 2021 10:288
    Content type: Research Published on:

  11. Though cervical cancer is largely preventable, it is still the second most common female cancer globally and the leading cause of cancer deaths among females in African. Though many efforts have been done to s...

    Authors: Ayele Semachew Kasa, Tadesse Dagget, Yeshiwork Beyene, Getnet Dessie, Aklilu Endalamaw, Yinager Workineh, Emiru Ayalew, Balew Zeleke, Sitotaw Kerie, Getasew Mulat and Worku Animaw
    Citation: Systematic Reviews 2021 10:287
    Content type: Research Published on:

  12. Approaches for rapid reviews that focus on streamlining systematic review methods are not always suitable for exploring complex policy questions, as developing and testing theories to explain these complexitie...

    Authors: Michael G. Wilson, Sandy Oliver, G. J. Melendez-Torres, John N. Lavis, Kerry Waddell and Kelly Dickson
    Citation: Systematic Reviews 2021 10:286
    Content type: Research Published on:

  14. Hemodynamic assessment in patients with pulmonary arterial hypertension (PAH) is essential for risk stratification and pharmacological management. However, the prognostic value of the hemodynamic changes after...

    Authors: Shih-Hsien Sung, Wan-Yu Yeh, Chern-En Chiang, Chi-Jung Huang, Wei-Ming Huang, Chen-Huan Chen and Hao-Min Cheng
    Citation: Systematic Reviews 2021 10:284
    Content type: Research Published on:

  15. Burnout is a syndrome caused by chronic stress in the workplace that has not been successfully managed. Although prevalence of burnout is well documented in different fields, little is known about this syndrom...

    Authors: Sharareh Azedi Tehrani, Abbasali Keshtkar, Akilesh Ramasamy and Majid Fadaei
    Citation: Systematic Reviews 2021 10:283
    Content type: Protocol Published on:

  16. Non-traumatic coma is a common acute childhood presentation to healthcare facilities in Africa and is associated with high morbidity and mortality. Historically, the majority of cases were attributed to cerebr...

    Authors: Stephen T. J. Ray, Charlotte Fuller, Alexandra Boubour, Laura J. Bonnett, David G. Lalloo, Karl B. Seydel and Michael J. Griffiths
    Citation: Systematic Reviews 2021 10:282
    Content type: Protocol Published on:

  17. The primary objective of this study is twofold: (1) to examine the effect of COVID-19 safety measures, enacted to prevent transmission of SARS-nCOV-2, on total physical activity in the adult general population...

    Authors: Fabian Schwendinger, Denis Infanger, Elena Pocecco, Joséphine Gander, Timo Hinrichs and Arno Schmidt-Trucksäss
    Citation: Systematic Reviews 2021 10:281
    Content type: Protocol Published on:

  18. The aim of this study was to review the scientific evidence and describe the ocular treatment-emergent adverse events (TEAEs) related to pharmacological treatment in patients with multiple sclerosis.

    Authors: Juliana Muñoz-Ortiz, Juliana Reyes-Guanes, Estefanía Zapata-Bravo, Laura Mora-Muñoz, Juan Antonio Reyes-Hurtado, Luis Octavio Tierradentro-García, William Rojas-Carabali, Marcela Gómez-Suarez and Alejandra de-la-Torre
    Citation: Systematic Reviews 2021 10:280
    Content type: Systematic review update Published on:

  19. People with disabilities (PWDs) remain among the poorest and least empowered population. They experience limited access to basic services, especially in low- and middle-income countries (LMIC). The infringemen...

    Authors: Sithembiso Blose, Saul Cobbing and Verusia Chetty
    Citation: Systematic Reviews 2021 10:279
    Content type: Protocol Published on:

  20. Rapid and accurate diagnosis of paediatric tuberculosis (TB) is key to manage the disease and to control and prevent its transmission. Collection of quality sputum samples without invasion methods from paediat...

    Authors: Emmanuel Oladipo Babafemi, Benny P. Cherian, Beatrice Ouma and Gilbert Mangua Mogoko
    Citation: Systematic Reviews 2021 10:278
    Content type: Research Published on:

  21. Men who have sex with men (MSM) are disproportionately affected by HIV in China. Globally, younger MSM are at higher risk for incident HIV infections, but there has been substantial variation in the estimates ...

    Authors: Wenting Huang, Liming Wang, Mi Guodong, Ryan J. Zahn, Jennifer Taussig, Shenita R. Peterson, Stefan Baral, Renee H. Moore, Xiaojie Huang, Jianhua Hou, Patrick S. Sullivan and Aaron J. Siegler
    Citation: Systematic Reviews 2021 10:277
    Content type: Protocol Published on:

  22. Evidence suggests that there are substantial inconsistencies in the practice of anesthesia. There has not yet been a comprehensive summary of the anesthesia literature that can guide future knowledge translati...

    Authors: Sylvain Boet, Joseph K. Burns, Olivia Cheng-Boivin, Hira Khan, Kendra Derry, Deric Diep, Abdul Hadi Djokhdem, Sung Wook Um, Johnny W. Huang, Danica Paré, Mimi Deng, Liza Begunova, Linda Yi Ning Fei, Maryam Bezzahou, Pium Sonali Andrahennadi, Elysia Grose…
    Citation: Systematic Reviews 2021 10:276
    Content type: Research Published on:

    The Correction to this article has been published in Systematic Reviews 2022 11:24

  23. Historically, eating disorders were not identified in older populations and it is only in more recent times that there is greater recognition of the existence of eating disorders among the elderly. This is des...

    Authors: Megha Mulchandani, Namrata Shetty, Agatha Conrad, Petra Muir and Beth Mah
    Citation: Systematic Reviews 2021 10:275
    Content type: Systematic review update Published on:

  24. Early pregnancy loss (unintended pregnancy loss before 20 completed weeks of gestation) is a common adverse pregnancy outcome, with previous evidence reporting incidence ranging from 10 to 30% of detected preg...

    Authors: L. Schummers, N. Oveisi, M. S. Ohtsuka, J. A. Hutcheon, K. A. Ahrens, J. Liauw and W. V. Norman
    Citation: Systematic Reviews 2021 10:274
    Content type: Protocol Published on:

  26. Multimorbidity, defined as the co-existence of two or more chronic conditions, presents significant challenges to patients, healthcare providers and health systems. Despite this, there is ongoing uncertainty a...

    Authors: Susan M. Smith, Emma Wallace, Barbara Clyne, Fiona Boland and Martin Fortin
    Citation: Systematic Reviews 2021 10:271
    Content type: Research Published on:

  27. Numerous studies report changes in neuromuscular control in people with low back pain (LBP). However, the relationship between pain and altered neuromuscular control is challenging to unravel given the heterog...

    Authors: Valter Devecchi, Deborah Falla, Hélio V. Cabral and Alessio Gallina
    Citation: Systematic Reviews 2021 10:270
    Content type: Protocol Published on:

  28. Intrapartum mistreatment of women is an ubiquitous public health and human rights challenge. The issue reportedly has severe maternal and neonatal outcomes including mortality, and generally leads to a decreas...

    Authors: Helen H. Habib, Jefferson Mwaisaka, Kwasi Torpey, Ernest Tei Maya and Augustine Ankomah
    Citation: Systematic Reviews 2021 10:269
    Content type: Protocol Published on:

  29. Complex interventions in health care are characterized by multiple interacting components as well as by numerous nonlinear interactions with the social systems within which they are being implemented. The proc...

    Authors: Tina Quasdorf, Lauren Clack, Franziska Laporte Uribe, Daniela Holle, Martin Berwig, Daniel Purwins, Marie-Therese Schultes and Martina Roes
    Citation: Systematic Reviews 2021 10:268
    Content type: Protocol Published on:

  31. Cardiopulmonary arrest (CPA) is an urgency, which is associated with high mortality. This systematic review evaluated the relationship between baseline cortisol level and the outcome of resuscitated CPA patients.

    Authors: Adeleh Sahebnasagh, Paria Soltani Nejad, Amin Salehi-Abargouei, Mohammad Hossein Dehghani and Fatemeh Saghafi
    Citation: Systematic Reviews 2021 10:266
    Content type: Research Published on:

  32. Cardiac surgery with cardiopulmonary bypass (CPB) is associated with a systemic inflammatory syndrome that adversely impacts cardiopulmonary function and can contribute to prolonged postoperative recovery. Int...

    Authors: Joel Bierer, David Horne, Roger Stanzel, Mark Henderson, Leah Boulos and Jill Hayden
    Citation: Systematic Reviews 2021 10:265
    Content type: Protocol Published on:

  33. Venous thromboembolism (VTE) and bleeding are serious and potentially fatal complications of surgical procedures. Pharmacological thromboprophylaxis decreases the risk of VTE but increases the risk of major po...

    Authors: Lauri I. Lavikainen, Gordon H. Guyatt, Yung Lee, Rachel J. Couban, Anna L. Luomaranta, Ville J. Sallinen, Ilkka E. J. Kalliala, Paul J. Karanicolas, Rufus Cartwright, Riikka L. Aaltonen, Kaisa Ahopelto, Karoliina M. Aro, Ines Beilmann-Lehtonen, Marco H. Blanker, Jovita L. Cárdenas, Samantha Craigie…
    Citation: Systematic Reviews 2021 10:264
    Content type: Protocol Published on:

  34. Scoping reviews are an increasingly common approach to evidence synthesis with a growing suite of methodological guidance and resources to assist review authors with their planning, conduct and reporting. The ...

    Authors: Micah D. J. Peters, Casey Marnie, Heather Colquhoun, Chantelle M. Garritty, Susanne Hempel, Tanya Horsley, Etienne V. Langlois, Erin Lillie, Kelly K. O’Brien, Ӧzge Tunçalp, Michael G. Wilson, Wasifa Zarin and Andrea C. Tricco
    Citation: Systematic Reviews 2021 10:263
    Content type: Commentary Published on:

  35. To analyze the effectiveness and quality of stroke clinical practice guidelines (CPGs) published in recent years in order to guide future guideline developers to develop better guidelines.

    Authors: Shuya Lu, Xufei Luo, Xiaojia Ni, Haoxuan Li, Miaomiao Meng, Yefeng Cai, Yunlan Liu, Mengjuan Ren, Yanrui Sun and Yaolong Chen
    Citation: Systematic Reviews 2021 10:262
    Content type: Research Published on:

  36. There is a growing interest in scaling effective health innovations to promote equitable access to high-quality health services worldwide. However, multiple challenges persist in scaling innovations. In this s...

    Authors: France Légaré, Karine V. Plourde, Ali Ben Charif, Amédé Gogovor, Francesca Katherine Brundisini, Robert K. D. McLean, Andrew Milat, Nathalie Rheault, Luke Wolfenden and Hervé Tchala Vignon Zomahoun
    Citation: Systematic Reviews 2021 10:261
    Content type: Protocol Published on:

  37. Citizen engagement in research is an emerging practice that involves members of the general public in research processes such as priority setting, planning, decision-making, research conduct, implementation, e...

    Authors: Anmol Shahid, Brianna K. Rosgen, Karla D. Krewulak, Diane L. Lorenzetti, Nadine Foster, Bonnie G. Sept, Jeanna Parsons Leigh, Henry T. Stelfox and Kirsten M. Fiest
    Citation: Systematic Reviews 2021 10:260
    Content type: Protocol Published on:

  38. Adult scoliosis represents a distinct subgroup of scoliosis patients for whom the diagnosis can have a large impact on their health-related quality of life (HR-QOL). Therefore, HR-QOL patient-reported outcome ...

    Authors: James E. Archer, Charles Baird, Adrian Gardner, Alison B. Rushton and Nicola R. Heneghan
    Citation: Systematic Reviews 2021 10:259
    Content type: Protocol Published on:

  39. Public safety occupations are well-recognized to be dangerous and stressful. Despite recent attention on post-traumatic stress injuries among public safety personnel, there has been considerably less attention...

    Authors: Janette Leroux, Rachel Richmond, Sara Fitzpatrick, Hannah Kirkland, Deborah Norris, Alyson Mahar, Joy MacDermid, Rachel Dekel and Heidi Cramm
    Citation: Systematic Reviews 2021 10:258
    Content type: Protocol Published on:

  40. The stressful nature of medical training and other work-related factors put postgraduate medical trainees at high risk of burnout and poor psychological wellbeing. This has negative implications for patient ca...

    Authors: Belinda Balhatchet, Heike Schütze, Nicole Williams and Bruce Ashford
    Citation: Systematic Reviews 2021 10:257
    Content type: Protocol Published on:

  41. Cardiovascular diseases (CVDs) are health problems that demonstrate high death and prevalence rates, and exhibit large health inequalities across different socio-economic status. Although interest in community...

    Authors: Juhyeon Yang, Eunsim Kim and Bohyun Park
    Citation: Systematic Reviews 2021 10:256
    Content type: Protocol Published on:

  42. Knowledge translation (KT) is an important means of improving the health service quality. Most research on the effectiveness of KT strategies has focused on individual strategies, i.e., those directly targetin...

    Authors: Karine Latulippe, Annie LeBlanc, Marie-Pierre Gagnon, Katia Boivin, Pascale Lavoie, Joëlle Dufour, Emmanuelle Paquette Raynard, Eve Richard and Marie-Ève Lamontagne
    Citation: Systematic Reviews 2021 10:255
    Content type: Protocol Published on:

  43. Mild traumatic brain injury (mTBI) is an increasing public health problem that can lead to persistent symptoms that have several functional consequences. Understanding the prognosis of a condition is an import...

    Authors: Julien Déry, Élaine De Guise, Ève-Line Bussières and Marie-Eve Lamontagne
    Citation: Systematic Reviews 2021 10:254
    Content type: Protocol Published on:

  44. The upper respiratory tract of children is colonized by various microbial species during the healthy state, whereas the lungs are believed to be sterile. In children with respiratory infections, micro-organism...

    Authors: Richa Rao, Jeanne M. Dsouza and Joseph L. Mathew
    Citation: Systematic Reviews 2021 10:253
    Content type: Protocol Published on:

  45. Dementia prevalence is increasing globally and yet evidence suggest that gaps exist in dementia-specific knowledge among health and social care practitioners. Technological modes of educational delivery may be...

    Authors: Kevin Muirhead, Leah Macaden, Keith Smyth, Colin Chandler, Charlotte Clarke, Rob Polson and Chris O’Malley
    Citation: Systematic Reviews 2021 10:252
    Content type: Research Published on:

  46. Adults with learning disabilities have an increased disposition to unhealthy lifestyle behaviours which often occur simultaneously. Existing studies focus on complex interventions targeting unhealthy diet, phy...

    Authors: Dikshyanta Rana, Sophie Westrop, Evi Germeni, Arlene McGarty, Louisa Ells, Phillippa Lally, Michael McEwan, Craig Melville, Leanne Harris and Olivia Wu
    Citation: Systematic Reviews 2021 10:251
    Content type: Protocol Published on:

  47. Serious mental illnesses (SMI) such as schizophrenia and bipolar disorder first develop between ages 14 and 25. Once diagnosed, young peoples’ health can deteriorate, and it is therefore vital to detect this e...

    Authors: Lindsay H. Dewa, Arturas Kalniunas, Stephen Orleans-Foli, Sofia Pappa and Paul Aylin
    Citation: Systematic Reviews 2021 10:250
    Content type: Research Published on:

  48. Mesenchymal stromal cells (MSCs) have significant immunomodulatory and tissue repair capabilities, mediated partly by conditioned media or through secreted extracellular vesicles (MSC-EVs). Infection with SARS...

    Authors: Aidan M. Kirkham, Madeline Monaghan, Adrian J. M. Bailey, Risa Shorr, Manoj M. Lalu, Dean A. Fergusson and David S. Allan
    Citation: Systematic Reviews 2021 10:249
    Content type: Protocol Published on:

  49. The number of individuals with a visual impairment in the UK was estimated a few years ago to be around 1.8 million. People can be visually impaired from birth, childhood, early adulthood or later in life. Tho...

    Authors: Sally J. Giles, Maria Panagioti, Lisa Riste, Sudeh Cheraghi-Sohi, Penny Lewis, Isabel Adeyemi, Karen Davies, Rebecca Morris, Denham Phipps, Christine Dickenson, Darren Ashcroft and Caroline Sanders
    Citation: Systematic Reviews 2021 10:248
    Content type: Protocol Published on:

  50. Anorexia nervosa (AN) is associated with structural brain abnormalities. Studies have reported less cerebral tissue and more cerebrospinal fluid (CSF) in individuals with AN relative to healthy controls, altho...

    Authors: Melissa J Dreier, Avery L. Van De Water, Danielle L. Kahn, Kendra R. Becker, Kamryn T. Eddy, Jennifer J. Thomas, Laura M. Holsen, Elizabeth A. Lawson, Madhusmita Misra, Amanda E. Lyall and Lauren Breithaupt
    Citation: Systematic Reviews 2021 10:247
    Content type: Protocol Published on:
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