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  1. Arts-based activities are being increasingly suggested as a valuable activity for people living with dementia in terms of countering the negative aspects of their condition. The potential for such programmes t...

    Authors: Gill Windle, Samantha Gregory, Andrew Newman, Anna Goulding, Dave O'Brien and Clive Parkinson

    Citation: Systematic Reviews 2014 3:91

    Content type: Protocol

    Published on:

  3. Recurrent miscarriage is generally defined as three or more miscarriages before gestational week 20. Recurrent miscarriage affects 1% of all women and the condition can only be explained by parental chromosome...

    Authors: Pia Egerup, Jane Lindschou, Christian Gluud and Ole Bjarne Christiansen

    Citation: Systematic Reviews 2014 3:89

    Content type: Protocol

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  4. To improve quality of care and patient outcomes, health system decision-makers need to identify and implement effective interventions. An increasing number of systematic reviews document the effects of quality...

    Authors: Noah Ivers, Andrea C Tricco, Thomas A Trikalinos, Issa J Dahabreh, Kristin J Danko, David Moher, Sharon E Straus, John N Lavis, Catherine H Yu, Kaveh Shojania, Braden Manns, Marcello Tonelli, Timothy Ramsay, Alun Edwards, Peter Sargious, Alison Paprica…

    Citation: Systematic Reviews 2014 3:88

    Content type: Protocol

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  5. Abacavir is one of the recommended nucleoside reverse transcriptase inhibitors (NRTIs) for the treatment of HIV infections among children and adolescents. However, there are concerns that the antiviral efficac...

    Authors: Olatunji O Adetokunboh, Anel Schoonees and Charles S Wiysonge

    Citation: Systematic Reviews 2014 3:87

    Content type: Protocol

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  6. The cluster randomized crossover (CRXO) design is gaining popularity in trial settings where individual randomization or parallel group cluster randomization is not feasible or practical. In a CRXO trial, not ...

    Authors: Sarah J Arnup, Andrew B Forbes, Brennan C Kahan, Katy E Morgan, Steve McDonald and Joanne E McKenzie

    Citation: Systematic Reviews 2014 3:86

    Content type: Protocol

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  7. Tobacco use is the single most preventable cause of death in the world. Evidence indicates that behaviours such as tobacco use can influence social networks, and that social network structures can influence be...

    Authors: Raglan Maddox, Rachel Davey, Ray Lovett, Anke van der Sterren, Joan Corbett and Tom Cochrane

    Citation: Systematic Reviews 2014 3:85

    Content type: Protocol

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  8. Current early childhood systems of care are not geared to respond to the complex needs of preschoolers at risk for mental health problems in a timely, coordinated, multidisciplinary, and comprehensive fashion....

    Authors: Normand J Carrey, Janet A Curran, Robin Greene, Alicia Nolan and Alan McLuckie

    Citation: Systematic Reviews 2014 3:84

    Content type: Protocol

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  9. Asthma is a frequent chronic inflammatory disease of the airways, and the assessment of health-related quality of life (HrQoL) is important in both research and routine care. Various asthma-specific measures o...

    Authors: Christian Apfelbacher, Priya Paudyal, Alpaslan Bülbül and Helen Smith

    Citation: Systematic Reviews 2014 3:83

    Content type: Protocol

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  10. The grading of recommendation, assessment, development and evaluation (GRADE) approach is widely implemented in health technology assessment and guideline development organisations throughout the world. GRADE ...

    Authors: Nick Meader, Kristel King, Alexis Llewellyn, Gill Norman, Jennifer Brown, Mark Rodgers, Thirimon Moe-Byrne, Julian PT Higgins, Amanda Sowden and Gavin Stewart

    Citation: Systematic Reviews 2014 3:82

    Content type: Methodology

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  11. The concept of early health technology assessment, discussed well over a decade, has now been collaboratively implemented by industry, government, and academia to select and expedite the development of emergin...

    Authors: Ba’ Pham, Hong Anh Thi Tu, Dolly Han, Petros Pechlivanoglou, Fiona Miller, Valeria Rac, Warren Chin, Andrea C Tricco, Mike Paulden, Joanna Bielecki and Murray Krahn

    Citation: Systematic Reviews 2014 3:81

    Content type: Protocol

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  12. Assessment of design heterogeneity conducted prior to meta-analysis is infrequently reported; it is often presented post hoc to explain statistical heterogeneity. However, design heterogeneity determines the m...

    Authors: Michelle D Althuis, Douglas L Weed and Cara L Frankenfeld

    Citation: Systematic Reviews 2014 3:80

    Content type: Methodology

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  13. Pelvic inflammatory disease (PID) is the result of infection ascending through the endocervix to the uterus and fallopian tubes. Inflammation driven by infected host cells appears to be central to the developm...

    Authors: Divya Dhasmana, Emma Hathorn, Racheal McGrath, Anjum Tariq and Jonathan DC Ross

    Citation: Systematic Reviews 2014 3:79

    Content type: Research

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  15. Authors: Pablo Alonso-Coello, Alonso Carrasco-Labra, Romina Brignardello-Petersen, Ignacio Neumann, Elie A Akl, Xin Sun, Bradley C Johnston, Matthias Briel, Jason W Busse, Demián Glujovsky, Carlos E Granados, Alfonso Iorio, Affan Irfan, Laura Martínez García, Reem A Mustafa, Anggie Ramirez-Morera…

    Citation: Systematic Reviews 2014 3:76

    Content type: Erratum

    Published on:

    The original article was published in Systematic Reviews 2013 2:113

  17. Systematic reviews, a cornerstone of evidence-based medicine, are not produced quickly enough to support clinical practice. The cost of production, availability of the requisite expertise and timeliness are of...

    Authors: Guy Tsafnat, Paul Glasziou, Miew Keen Choong, Adam Dunn, Filippo Galgani and Enrico Coiera

    Citation: Systematic Reviews 2014 3:74

    Content type: Commentary

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  18. Whilst the majority of young people succeed in education and make a positive transition to the world of work and adult life, recent statistics identify that youth comprise 40% of the world's unemployed, equati...

    Authors: Emily J Oliver, Lauren Mawn, Helen J Stain, Clare L Bambra, Carole Torgerson, Anita Oliver and Chris Bridle

    Citation: Systematic Reviews 2014 3:73

    Content type: Protocol

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  19. There is no consensus in the literature regarding the effectiveness of lifestyle modification interventions, including recommendations about specific diet or exercise program for patients with breast cancer. D...

    Authors: Maicon Falavigna, Karine Margarites Lima, Juliana Giacomazzi, Diego d’Avila Paskulin, Luciano Serpa Hammes, Rodrigo Antonini Ribeiro and Daniela Dornelles Rosa

    Citation: Systematic Reviews 2014 3:72

    Content type: Protocol

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  20. Digestive disorders pose significant burdens to millions of people worldwide in terms of morbidity, mortality and healthcare costs. Turmeric has been traditionally used for conditions associated with the diges...

    Authors: Kednapa Thavorn, Muhammad M Mamdani and Sharon E Straus

    Citation: Systematic Reviews 2014 3:71

    Content type: Protocol

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  22. Placenta-mediated pregnancy complications include pre-eclampsia, late pregnancy loss, placental abruption, and the small-for-gestational age newborn. They are leading causes of maternal, fetal, and neonatal mo...

    Authors: Marc A Rodger, Nicole J Langlois, Johanna IP de Vries, Évelyne Rey, Jean-Christophe Gris, Ida Martinelli, Ekkehard Schleussner, Timothy Ramsay, Ranjeeta Mallick, Becky Skidmore, Saskia Middeldorp, Shannon Bates, David Petroff, Dick Bezemer, Marion E van Hoorn, Carolien NH Abheiden…

    Citation: Systematic Reviews 2014 3:69

    Content type: Protocol

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  23. Epilepsy affects about 1% of the general population. Anti-epileptic drugs (AEDs) prevent or terminate seizures in individuals with epilepsy. Pregnant women with epilepsy may continue taking AEDs. Many of these...

    Authors: Andrea C Tricco, Elise Cogo, Veroniki A Angeliki, Charlene Soobiah, Brian Hutton, Brenda R Hemmelgarn, David Moher, Yaron Finkelstein and Sharon E Straus

    Citation: Systematic Reviews 2014 3:68

    Content type: Protocol

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  24. An exponential increase in the number of systematic reviews published, and constrained resources for new reviews, means that there is an urgent need for guidance on explicitly and transparently integrating exi...

    Authors: Karen A Robinson, Evelyn P Whitlock, Maya E Oneil, Johanna K Anderson, Lisa Hartling, Donna M Dryden, Mary Butler, Sydne J Newberry, Melissa McPheeters, Nancy D Berkman, Jennifer S Lin and Stephanie Chang

    Citation: Systematic Reviews 2014 3:60

    Content type: Research

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  25. Systematic reviews that address policy and practice questions in relation to complex interventions frequently need not only to assess the efficacy of a given intervention but to identify which intervention - a...

    Authors: James Thomas, Alison O’Mara-Eves and Ginny Brunton

    Citation: Systematic Reviews 2014 3:67

    Content type: Methodology

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  26. Anemia is a prevalent condition in critically ill patients and red blood cell transfusions are frequent. Although transfusions at low hemoglobin levels have been shown to be associated with equivalent or bette...

    Authors: Amélie Boutin, Michaël Chassé, Michèle Shemilt, François Lauzier, Lynne Moore, Ryan Zarychanski, Jacques Lacroix, Dean A Fergusson, Philippe Desjardins and Alexis F Turgeon

    Citation: Systematic Reviews 2014 3:66

    Content type: Protocol

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  27. Key performance indicators (KPIs) are used to identify where organisational performance is meeting desired standards and where performance requires improvement. Valid and reliable KPIs depend on the availabili...

    Authors: Brenda Gannon, Cheryl Jones, Abel Wakai and Ronan O’Sullivan

    Citation: Systematic Reviews 2014 3:65

    Content type: Protocol

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  28. Patients with end-stage renal disease who receive kidney transplants have improved survival and quality of life compared to patients on dialysis. Unfortunately, transplant patients often have a low vitamin D c...

    Authors: Caitlin C Hesketh, Greg A Knoll, Amber O Molnar, Anne Tsampalieros and Deborah L Zimmerman

    Citation: Systematic Reviews 2014 3:64

    Content type: Protocol

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  29. Power and precision are greater in meta-analyses than individual study analyses. However, dichotomisation of continuous outcomes in certain studies poses a problem as estimates from primary studies can only be...

    Authors: Mercy Ofuya, Odile Sauzet and Janet L Peacock

    Citation: Systematic Reviews 2014 3:63

    Content type: Methodology

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  30. Social anxiety is among the most prevalent and debilitating affective disturbances manifest in people with psychosis. It is usually accompanied by high levels of depression and leads to significant social disa...

    Authors: Maria Michail, Max Birchwood and Lynda Tait

    Citation: Systematic Reviews 2014 3:62

    Content type: Protocol

    Published on:

  31. Health behaviours are important determinants of health and adoption of unhealthy behaviour is considered as one of the mechanisms through which immigrants’ health changes over time in the host country. The cha...

    Authors: Suresh Joshi, Santosh Jatrana, Yin Paradies and Naomi Priest

    Citation: Systematic Reviews 2014 3:61

    Content type: Protocol

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  33. The number of systematic reviews (SRs)/meta-analyses (MAs) has increased dramatically in China over the past decades. However, evaluation of quality of reporting of systematic reviews published has not been un...

    Authors: Jin-long Li, Long Ge, Ji-chun Ma, Qiao-ling Zeng, Lu Yao, Ni An, Jie-xian Ding, Yu-hong Gan and Jin-hui Tian

    Citation: Systematic Reviews 2014 3:58

    Content type: Methodology

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  34. Nurses and allied health care professionals (physiotherapists, occupational therapists, speech and language pathologists, dietitians) form more than half of the clinical health care workforce and play a centra...

    Authors: Wendy A Gifford, Paul Holyoke, Janet E Squires, Douglas Angus, Lucie Brosseau, Mary Egan, Ian D Graham, Carol Miller and Lars Wallin

    Citation: Systematic Reviews 2014 3:57

    Content type: Protocol

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  35. The Health Information Technology for Economic and Clinical Health (HITECH) Act subsidizes implementation by hospitals of electronic health records with computerized provider order entry (CPOE), which may redu...

    Authors: Teryl K Nuckols, Crystal Smith-Spangler, Sally C Morton, Steven M Asch, Vaspaan M Patel, Laura J Anderson, Emily L Deichsel and Paul G Shekelle

    Citation: Systematic Reviews 2014 3:56

    Content type: Research

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  36. There has been a renewed interest in the place of birth, including intended home birth, for low risk women. In the absence of adequately-sized randomised controlled trials, a recent Cochrane review recommended...

    Authors: Eileen K Hutton, Angela Reitsma, Julia Thorpe, Ginny Brunton and Karyn Kaufman

    Citation: Systematic Reviews 2014 3:55

    Content type: Protocol

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  38. Cardiac magnetic resonance (CMR) myocardial perfusion imaging has been suggested as a non-invasive alternative to pressure wire guided fractional flow reserve (FFR) in detecting haemodynamically significant ob...

    Authors: Rebabonye B Pharithi, Martinus Meela, Thomas Kropmans, Frank Ward, Michael Conway and Michael Newell

    Citation: Systematic Reviews 2014 3:53

    Content type: Protocol

    Published on:

  39. Obesity is a significant public health issue and is socially patterned, with greater prevalence of obesity observed in the most socioeconomically disadvantaged groups. Recent evidence suggests that the prevale...

    Authors: Alexandra Chung, Kathryn Backholer, Evelyn Wong, Claire Palermo, Catherine Keating and Anna Peeters

    Citation: Systematic Reviews 2014 3:52

    Content type: Protocol

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  40. Antiretroviral therapy reduces mother-to-child transmission of human immunodeficiency virus (HIV) during pregnancy, delivery, and breastfeeding. However, these agents have been associated with preterm birth, a...

    Authors: Andrea C Tricco, Jesmin Antony, Veroniki A Angeliki, Huda Ashoor, Brian Hutton, Brenda R Hemmelgarn, David Moher, Yaron Finkelstein, Kevin Gough and Sharon E Straus

    Citation: Systematic Reviews 2014 3:51

    Content type: Protocol

    Published on:

  41. The purpose of this systematic review is to assess the effectiveness of brief interventions (BIs) as part of the Screening, Brief Intervention, and Referral to Treatment (SBIRT) model for reducing the nonmedic...

    Authors: Matthew M Young, Adrienne Stevens, James Galipeau, Tyler Pirie, Chantelle Garritty, Kavita Singh, Fatemeh Yazdi, Mohammed Golfam, Misty Pratt, Lucy Turner, Amy Porath-Waller, Cheryl Arratoon, Nancy Haley, Karen Leslie, Rhoda Reardon, Beth Sproule…

    Citation: Systematic Reviews 2014 3:50

    Content type: Research

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  42. Care homes in the UK rely on general practice for access to specialist medical and nursing care as well as referral to therapists and secondary care. Service delivery to care homes is highly variable in both q...

    Authors: Claire Goodman, Adam L Gordon, Finbarr Martin, Sue L Davies, Steve Iliffe, Clive Bowman, Justine Schneider, Julienne Meyer, Christina Victor, Heather Gage, John RF Gladman and Tom Dening

    Citation: Systematic Reviews 2014 3:49

    Content type: Protocol

    Published on:

  43. Acute respiratory distress syndrome (ARDS) in humans is caused by an unchecked proinflammatory response that results in diffuse and severe lung injury, and it is associated with a mortality rate of 35 to 45%. ...

    Authors: Manoj M Lalu, David Moher, John Marshall, Dean Fergusson, Shirley HJ Mei, Malcolm Macleod, Gilly Griffin, Alexis F Turgeon, Michael Rudnicki, Jason Fishman, Marc T Avey, Becky Skidmore, Jeremy M Grimshaw, Duncan J Stewart, Kavita Singh and Lauralyn McIntyre

    Citation: Systematic Reviews 2014 3:48

    Content type: Protocol

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  45. Categorizing an inherently continuous predictor in prognostic analyses raises several critical methodological issues: dependence of the statistical significance on the number and position of the chosen cut-poi...

    Authors: Benjamin Kasenda, Willi Sauerbrei, Patrick Royston and Matthias Briel

    Citation: Systematic Reviews 2014 3:46

    Content type: Protocol

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  46. Use of methadone for the treatment of opioid addiction is an effective harm-reduction approach, although variability in treatment outcomes among individuals has been reported. Men and women with opioid addicti...

    Authors: Monica Bawor, Brittany B Dennis, Rebecca Anglin, Meir Steiner, Lehana Thabane and Zainab Samaan

    Citation: Systematic Reviews 2014 3:45

    Content type: Protocol

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  50. Several aggregate data meta-analyses suggest that treatment guided by the serum concentration of natriuretic peptides (B-type natriuretic peptide (BNP) or its derivative N-terminal pro-B-type natriuretic pepti...

    Authors: Maria Pufulete, Julian PT Higgins, Chris A Rogers, Lucy Dreyer, William Hollingworth, Mark Dayer, Angus Nightingale, Theresa McDonagh and Barnaby C Reeves

    Citation: Systematic Reviews 2014 3:41

    Content type: Protocol

    Published on:

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ISSN: 2046-4053