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  1. Content type: Protocol

    There exist many evidence-based interventions available to manage procedural pain in children and neonates, yet they are severely underutilized. Parents play an important role in the management of their child’...

    Authors: Allison Gates, Kassi Shave, Robin Featherstone, Kelli Buckreus, Samina Ali, Shannon Scott and Lisa Hartling

    Citation: Systematic Reviews 2017 6:109

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  2. Content type: Protocol

    The use of fat grafting as a reconstructive surgical option is becoming much more common. Adipose-derived stem cells found in fat grafts are believed to facilitate wound healing via differentiation into fibrob...

    Authors: Oliver J. Smith, Muholan Kanapathy, Ankur Khajuria, Max Prokopenko, Nadine Hachach-Haram, Haroon Mann and Ash Mosahebi

    Citation: Systematic Reviews 2017 6:111

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  3. Content type: Research

    It is not known, whether outcome reporting in trials of total joint arthroplasty in the recent years is adequate or not. Our objective was to assess whether outcomes reported in total joint replacement (TJR) t...

    Authors: Peter D. H. Wall, Bethan L. Richards, Andrew Sprowson, Rachelle Buchbinder and Jasvinder A. Singh

    Citation: Systematic Reviews 2017 6:106

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  4. Content type: Protocol

    Achilles tendinopathy is one of the most common overuse injuries in recreational and competitive runners, yet the clinical significance and frequency of abnormal sonographic characteristics in runners remains ...

    Authors: Prue Molyneux, Matthew Carroll, Sarah Stewart, Angela Brenton-Rule and Keith Rome

    Citation: Systematic Reviews 2017 6:108

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  5. Content type: Research

    Debates about the benefits and harms of mammography continue despite the accumulation of evidence. We sought to quantify the disagreement across systematic reviews of mammography and determine whether author o...

    Authors: Smriti Raichand, Adam G. Dunn, Mei-Sing Ong, Florence T. Bourgeois, Enrico Coiera and Kenneth D. Mandl

    Citation: Systematic Reviews 2017 6:105

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  6. Content type: Protocol

    Ventilator-associated pneumonia (VAP) is defined as the occurrence of pneumonia in patients receiving mechanical ventilation for more than 48 h after endotracheal intubation. The implementation of effective or...

    Authors: Zhigang Zhang, Yuying Hou, Jun Zhang, Bo Wang, Juxia Zhang, Ailing Yang, Ge Li and Jinhui Tian

    Citation: Systematic Reviews 2017 6:103

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  7. Content type: Protocol

    Polypharmacy, the concurrent use of multiple medications, consistently evokes a negative connotation, notably because it is associated with a plethora of adverse events. Nonetheless, the number of individuals ...

    Authors: Caroline Sirois, Marie-Laure Laroche, Line Guénette, Edeltraut Kröger, Dan Cooper and Valérie Émond

    Citation: Systematic Reviews 2017 6:104

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  8. Content type: Protocol

    Diabetic foot disease is associated with major morbidity, mortality, costs, and reduction of a person’s quality of life. Investigating the epidemiology of diabetic foot disease is the backbone of diabetic foot...

    Authors: Jaap J. van Netten, Mendel Baba and Peter A. Lazzarini

    Citation: Systematic Reviews 2017 6:101

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  9. Content type: Protocol

    Cardiorespiratory fitness (CRF) is a physical condition that is now well established as a predictor of numerous adverse health outcomes, independent of physical activity levels. In order to be able to improve ...

    Authors: Nita Perumal, Gert B.M. Mensink, Thomas Keil and Jonas David Finger

    Citation: Systematic Reviews 2017 6:102

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  10. Content type: Protocol

    With an ageing population and increasing numbers of people with life-limiting illness, there is a growing demand for palliative day services. There is a need to measure and demonstrate the quality of these ser...

    Authors: Seán R. O’Connor, Martin Dempster and Noleen K. McCorry

    Citation: Systematic Reviews 2017 6:100

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  11. Content type: Research

    Fibromyalgia (FM) is a chronic, debilitating pain disorder. Dissatisfaction with conventional medicine can lead people with FM to turn to complementary and alternative medicine (CAM). Two previous overviews of...

    Authors: Rachel Perry, Verity Leach, Philippa Davies, Chris Penfold, Andy Ness and Rachel Churchill

    Citation: Systematic Reviews 2017 6:97

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  12. Content type: Protocol

    Parkinson’s disease (PD) is a progressive neurodegenerative condition that has genetic susceptibility, aging, and exposure to certain chemicals as risk factors. In recent decades, epidemiological and experimen...

    Authors: Carolina Vaccari, Regina El Dib and João Lauro V. de Camargo

    Citation: Systematic Reviews 2017 6:98

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  13. Content type: Protocol

    Hyperglycaemia-induced oxidative damage is a well-established factor implicated in the development of diabetic cardiomyopathy (DCM) in diabetic individuals. Some of the well-known characteristics of DCM includ...

    Authors: Phiwayinkosi V. Dludla, Bongani B. Nkambule, Stephanie C. Dias and Rabia Johnson

    Citation: Systematic Reviews 2017 6:96

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  14. Content type: Protocol

    Short and poor sleep have been associated with adverse health outcomes in adults, such as overweight/obesity and type 2 diabetes, especially among women. Women therefore represent an important target for inter...

    Authors: Lydi-Anne Vézina-Im, Jennette Palcic Moreno, Theresa A. Nicklas and Tom Baranowski

    Citation: Systematic Reviews 2017 6:95

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  15. Content type: Protocol

    Clinical supervision by a senior therapist is a very common practice in psychotherapist training and psychiatric care settings. Though clinical supervision is advocated by most educational and governing instit...

    Authors: Sven Alfonsson, Åsa Spännargård, Thomas Parling, Gerhard Andersson and Tobias Lundgren

    Citation: Systematic Reviews 2017 6:94

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  16. Content type: Protocol

    Knowledge translation (KT) activities can reduce the gap between “what is known” and “what is done”. Several factors hinder or facilitate KT activities including individual characteristics and organizational a...

    Authors: Anastasia A. Mallidou, Pat Atherton, Liza Chan, Noreen Frisch, Stephanie Glegg and Gayle Scarrow

    Citation: Systematic Reviews 2017 6:93

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  17. Content type: Protocol

    Elective knee surgery is performed to reduce chronic pain and improve function in degenerate knees. Treatment of acute post-operative pain is suboptimal in 75% of patients despite multimodal analgesic approach...

    Authors: Hasan Raza Mohammad, Marialena Trivella, Thomas W. Hamilton, Louise Strickland, David Murray and Hemant Pandit

    Citation: Systematic Reviews 2017 6:92

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  18. Content type: Protocol

    Endovascular interventional radiology (EIR) is an increasingly popular, mini invasive treatment option for patient with symptomatic vascular disease. The EIR practiced by qualified hands is an effective, well-...

    Authors: Kaoutar Mellouk Aid, Hervé Tchala Vignon Zomahoun, Abdelmajid Soulaymani, Karin Lebascle, Stephane Silvera, Pascal Astagneau and Benoit Misset

    Citation: Systematic Reviews 2017 6:89

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  19. Content type: Protocol

    Over 85% of cervical cancer cases and deaths occur in developing countries. HIV-seropositive women are more likely to develop precancerous lesions that lead to cervical cancer than HIV-negative women. However,...

    Authors: Witness Mapanga, Ahmed Elhakeem, Shingairai A. Feresu, Fresier Maseko and Tsungai Chipato

    Citation: Systematic Reviews 2017 6:91

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  20. Content type: Protocol

    Guidelines and evidence-based drug treatment recommendations are usually based on the results of clinical trials, which have limited generalisability in routine clinical settings due to their restrictive eligi...

    Authors: Weyinmi A. Demeyin, Julia Frost, Obioha C. Ukoumunne, Simon Briscoe and Nicky Britten

    Citation: Systematic Reviews 2017 6:90

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  21. Content type: Protocol

    Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by deficiency in acid beta-glucosidase. GD exhibits a wide clinical spectrum of disease severity with an unpredictable natural c...

    Authors: Tatiana Raskovalova, Patrick B. Deegan, Ruby Yang, Elena Pavlova, Jérome Stirnemann, José Labarère, Ari Zimran, Pramod K. Mistry and Marc Berger

    Citation: Systematic Reviews 2017 6:87

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  22. Content type: Protocol

    Prognosis research is on the rise, its importance recognised because chronic health conditions and diseases are increasingly common and costly. Prognosis systematic reviews are needed to collate and synthesise...

    Authors: Nadia Corp, Joanne L. Jordan, Jill A. Hayden, Emma Irvin, Robin Parker, Andrea Smith and Danielle A. van der Windt

    Citation: Systematic Reviews 2017 6:88

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  23. Content type: Systematic review update

    The objective of this review was to update a systematic review of associations between living near an animal feeding operation (AFO) and human health.

    Authors: Annette M. O’Connor, Brent W. Auvermann, Rungano S. Dzikamunhenga, Julie M. Glanville, Julian P. T. Higgins, Shelley P. Kirychuk, Jan M. Sargeant, Sarah C. Totton, Hannah Wood and Susanna G. Von Essen

    Citation: Systematic Reviews 2017 6:86

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  24. Content type: Protocol

    Learning activities are fundamental for the development of expertise in physiotherapy practice. Continuing professional development (CPD) encompasses formal and informal learning activities undertaken by physi...

    Authors: Edmund Leahy, Lucy Chipchase and Felicity Blackstock

    Citation: Systematic Reviews 2017 6:83

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  25. Content type: Protocol

    Approximately 5 to 10% of critically ill patients transition from acute critical illness to a state of persistent and in some cases chronic critical illness. These patients have unique and complex needs that r...

    Authors: Louise Rose, Laura Istanboulian, Laura Allum, Lisa Burry, Craig Dale, Nicholas Hart, Claire Kydonaki, Pam Ramsay, Natalie Pattison and Bronwen Connolly

    Citation: Systematic Reviews 2017 6:84

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  26. Content type: Protocol

    Experiencing mental ill health adds a layer of complexity for individuals in touch with the justice system and for those responsible for working in the justice service with these individuals, such as frontline...

    Authors: Eddie Kane, Emily Evans and Farhad Shokraneh

    Citation: Systematic Reviews 2017 6:85

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  27. Content type: Protocol

    Spitz nevi are uncommon melanocytic neoplasms found in children. Historically, the diagnosis and management of these tumors has lacked consensus among oncologists, pathologists, plastic surgeons, and dermatolo...

    Authors: Jean Abboud, Michael Stein, Michele Ramien and Claudia Malic

    Citation: Systematic Reviews 2017 6:81

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  28. Content type: Protocol

    Hemorrhage is a major cause of early mortality following a traumatic injury. The progression and consequences of significant blood loss occur quickly as death from hemorrhagic shock or exsanguination often occ...

    Authors: Alexandre Tran, Maher Matar, Ewout W. Steyerberg, Jacinthe Lampron, Monica Taljaard and Christian Vaillancourt

    Citation: Systematic Reviews 2017 6:80

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  29. Content type: Research

    Cochrane primarily aims to systematically review trials of effectiveness that are important to inform clinical decisions. Editorial groups support authors to achieve high-quality reviews and prioritise review ...

    Authors: Jasmin Alloo, Sanya Vallath, Chris Del Mar, Matt Carter, Sarah Thorning and Justin Clark

    Citation: Systematic Reviews 2017 6:82

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  30. Content type: Commentary

    When randomized trials have addressed multiple interventions for the same health problem, network meta-analyses (NMAs) permit researchers to statistically pool data from individual studies including evidence f...

    Authors: L. Mbuagbaw, B. Rochwerg, R. Jaeschke, D. Heels-Andsell, W. Alhazzani, L. Thabane and Gordon H. Guyatt

    Citation: Systematic Reviews 2017 6:79

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  31. Content type: Research

    Previous studies investigating the mental health of migrants have shown mixed results. The increased availability of register data has led to a growing number of register-based studies in this research area. T...

    Authors: Kishan Patel, Anne Kouvonen, Ciara Close, Ari Väänänen, Dermot O’Reilly and Michael Donnelly

    Citation: Systematic Reviews 2017 6:78

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  32. Content type: Protocol

    Alcohol dependence is common and serious cause of social and physical harm. However, the optimal management of those with moderate and severe alcohol dependence in primary and community care after detoxificati...

    Authors: Hung-Yuan Cheng, Roy G. Elbers, Julian P. T. Higgins, Abigail Taylor, Georgina J. MacArthur, Luke McGuinness, Sarah Dawson, José A. López-López, Sean Cowlishaw, Matthew Hickman and David Kessler

    Citation: Systematic Reviews 2017 6:77

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  33. Content type: Protocol

    Alcohol use is the behaviour that has the most significant impact on the mortality and morbidity of young people, and binge drinking is becoming the norm among this population. The burden of disease of binge d...

    Authors: Jennifer Hasselgård-Rowe, Barbara Broers and Dagmar M. Haller

    Citation: Systematic Reviews 2017 6:76

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  34. Content type: Protocol

    Women in high resource nations are increasingly delaying childbearing until their thirties. Delayed childbearing poses challenges for the spacing of a woman’s pregnancies. Inter-pregnancy intervals <12 months ...

    Authors: Mani Asgharpour, Sofia Villarreal, Laura Schummers, Jennifer Hutcheon, Dorothy Shaw and Wendy V. Norman

    Citation: Systematic Reviews 2017 6:75

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  35. Content type: Protocol

    Overviews of systematic reviews (overviews) attempt to systematically retrieve and summarize the results of multiple systematic reviews (SRs) for a given condition or public health problem. Two prior descripti...

    Authors: Dawid Pieper, Michelle Pollock, Ricardo M. Fernandes, Roland Brian Büchter and Lisa Hartling

    Citation: Systematic Reviews 2017 6:73

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  36. Content type: Protocol

    Atrial fibrillation is the most common arrhythmia of the heart with a prevalence of approximately 2% in the western world. Atrial flutter, another arrhythmia, occurs less often with an incidence of approximate...

    Authors: Naqash J. Sethi, Sanam Safi, Joshua Feinberg, Emil E. Nielsen, Christian Gluud and Janus C. Jakobsen

    Citation: Systematic Reviews 2017 6:71

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  37. Content type: Protocol

    HIV self-testing (HIVST) is becoming popular with policy makers and commissioners globally, with a key aim of expanding access through reducing barriers to testing for individuals at risk of HIV infection. HIV...

    Authors: T. Charles Witzel, Peter Weatherburn, Fiona M. Burns, Cheryl C. Johnson, Carmen Figueroa and Alison J. Rodger

    Citation: Systematic Reviews 2017 6:72

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  38. Content type: Protocol

    The objective of this study will be to synthesize the epidemiological evidence and evaluate the validity of the associations between central nervous system disorders and the risk of developing or dying from ca...

    Authors: Ferrán Catalá-López, Brian Hutton, Jane A. Driver, Matthew J. Page, Manuel Ridao, José M. Valderas, Adolfo Alonso-Arroyo, Jaume Forés-Martos, Salvador Martínez, Ricard Gènova-Maleras, Diego Macías-Saint-Gerons, Benedicto Crespo-Facorro, Eduard Vieta, Alfonso Valencia and Rafael Tabarés-Seisdedos

    Citation: Systematic Reviews 2017 6:69

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  39. Content type: Protocol

    The majority of a child’s language development occurs in the first 5 years of life when brain development is most rapid. There are significant long-term benefits to supporting all children’s language and liter...

    Authors: Laureen J. McIntyre, Laurie-ann M. Hellsten, Julia Bidonde, Catherine Boden and Carolyn Doi

    Citation: Systematic Reviews 2017 6:70

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  40. Content type: Protocol

    Evidence suggests a relationship between human immunodeficiency virus (HIV) infection and chronic obstructive pulmonary disease (COPD). Although the high burden of COPD and the HIV disease is clearly demonstra...

    Authors: Jean Joel R. Bigna, Angeladine Malaha Kenne and Serra Lem Asangbeh

    Citation: Systematic Reviews 2017 6:68

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  41. Content type: Protocol

    Failure to promptly identify deterioration in hospitalised patients is associated with delayed admission to intensive care units (ICUs) and poor outcomes. Existing vital sign-based Early Warning Score (EWS) al...

    Authors: James Malycha, Tim Bonnici, Katarina Sebekova, Tatjana Petrinic, Duncan Young and Peter Watkinson

    Citation: Systematic Reviews 2017 6:67

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  42. Content type: Protocol

    Cancer survivors face a range of negative physical and psychological effects that can be mitigated by participating in physical activity. Despite this, most do not meet recommended levels. Health care provider...

    Authors: Jennifer Brunet, Amanda Wurz, Connor O’Rielly, Doris Howell, Mathieu Bélanger and Jonathan Sussman

    Citation: Systematic Reviews 2017 6:66

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  43. Content type: Research

    A rigorous systematic review and meta-analysis focused on randomised controlled trials (RCTs) of non-individualised homeopathic treatment has not previously been reported. We tested the null hypothesis that th...

    Authors: Robert T. Mathie, Nitish Ramparsad, Lynn A. Legg, Jürgen Clausen, Sian Moss, Jonathan R. T. Davidson, Claudia-Martina Messow and Alex McConnachie

    Citation: Systematic Reviews 2017 6:63

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  44. Content type: Protocol

    Comprehensive geriatric assessment (CGA) is an integrated model of care involving a geriatrician and an interdisciplinary team and can prioritize and manage complex health needs of older adults with multimorbi...

    Authors: Charlene Soobiah, Caitlin Daly, Erik Blondal, Joycelyne Ewusie, Joanne Ho, Meghan J. Elliott, Rossini Yue, Jayna Holroyd-Leduc, Barbara Liu, Sharon Marr, Jenny Basran, Andrea C. Tricco, Jemila Hamid and Sharon E. Straus

    Citation: Systematic Reviews 2017 6:65

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  45. Content type: Research

    Spinal manipulative therapy (SMT) is a widely used manual treatment, but many reviews exist with conflicting conclusions about the safety of SMT. We performed an overview of reviews to elucidate and quantify t...

    Authors: Sabrina Mai Nielsen, Simon Tarp, Robin Christensen, Henning Bliddal, Louise Klokker and Marius Henriksen

    Citation: Systematic Reviews 2017 6:64

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  46. Content type: Protocol

    Parental sensitivity is the interaction process by which parents (a) recognize cues from their infant, (b) interpret these cues adequately, (c) identify an appropriate response and (d) apply this response in a...

    Authors: Andréane Lavallée, Marilyn Aita, Anne Bourbonnais and Gwenaëlle De Clifford-Faugère

    Citation: Systematic Reviews 2017 6:62

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