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  1. Vestibular compensation is a homeostatic process that occurs in the central nervous system in response to peripheral vestibular dysfunction. Experimental studies in rodent models have suggested that unilateral...

    Authors: Rajiv Wijesinghe and Aaron Camp

    Citation: Systematic Reviews 2020 9:145

    Content type: Research

    Published on:

  2. Vitamin D (vitD) deficiency is a global childhood health problem. Food fortification is a promising strategy to curb vitD deficiency. We aimed to assess the effectiveness of utilizing vitD fortification in sta...

    Authors: Reem Al Khalifah, Rawan Alsheikh, Yossef Alnasser, Rana Alsheikh, Nora Alhelali, Ammar Naji and Nouf Al Backer

    Citation: Systematic Reviews 2020 9:144

    Content type: Research

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  3. Acute liver failure is a rare syndrome with significant morbidity and mortality, particularly in absence of transplantation as a rescue therapy. An important mechanism contributing to mortality is hyperammonem...

    Authors: Andrea M. Robinson, C. J. Karvellas, Joanna C. Dionne, Robin Featherstone, Meghan Sebastianski, Ben Vandermeer and Oleksa G. Rewa

    Citation: Systematic Reviews 2020 9:143

    Content type: Protocol

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  4. Health practitioners from different professions, and with differing competencies, need to collaborate to provide quality care. Competencies in interprofessional working need developing in undergraduate educati...

    Authors: Renée Allvin, Carl Thompson and Samuel Edelbring

    Citation: Systematic Reviews 2020 9:142

    Content type: Protocol

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  5. There is no consensus on the role of inflammatory markers in identifying chorioamnionitis in preterm prelabour rupture of membranes (PPROM). We set out to evaluate the accuracy of maternal blood C-reactive pro...

    Authors: Angela Koech Etyang, Geoffrey Omuse, Abraham Mwaniki Mukaindo and Marleen Temmerman

    Citation: Systematic Reviews 2020 9:141

    Content type: Research

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  6. A model that can predict treatment response for a patient with specific baseline characteristics would help decision-making in personalized medicine. The aim of the study is to develop such a model in the trea...

    Authors: Yan Luo, Konstantina Chalkou, Ryo Yamada, Satoshi Funada, Georgia Salanti and Toshi A. Furukawa

    Citation: Systematic Reviews 2020 9:140

    Content type: Protocol

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  7. US opioid prescribing and use escalated over the last two decades, with parallel increases in opioid misuse, opioid-related deaths, and concerns about diversion. Postoperatively prescribed opioids contribute t...

    Authors: Lori Schirle, Amanda L. Stone, Matthew C. Morris, Sarah S. Osmundson, Philip D. Walker, Mary S. Dietrich and Stephen Bruehl

    Citation: Systematic Reviews 2020 9:139

    Content type: Research

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  8. Alcohol use is a challenging problem which attributes to more than 5% of the overall global burden of disease. It is more common among persons with HIV infection than the general population. Although there are...

    Authors: Birhanie Mekuriaw, Zelalem Belayneh, Alemayehu Molla and Tsegaye Mehare

    Citation: Systematic Reviews 2020 9:138

    Content type: Protocol

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  9. Diabetes is a highly prevalent chronic disease that places a large burden on individuals and health care systems. Models predicting the risk (also called predictive models) of other conditions often compare pe...

    Authors: Ruth Ndjaboue, Imen Farhat, Carol-Ann Ferlatte, Gérard Ngueta, Daniel Guay, Sasha Delorme, Noah Ivers, Baiju R. Shah, Sharon Straus, Catherine Yu and Holly O. Witteman

    Citation: Systematic Reviews 2020 9:137

    Content type: Protocol

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  10. Work-related musculoskeletal disorders impose a significant and most often underappreciated burden to the individual, nation, healthcare system, and society as a whole. To the best of our knowledge, there is a...

    Authors: Tsiwaye Gebreyesus, Kalkidan Nigussie, Moges Gashaw and Balamurugan Janakiraman

    Citation: Systematic Reviews 2020 9:136

    Content type: Protocol

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  11. Metabolic syndrome is a constellation of various cardiovascular and type 2 diabetes risk factors, such as abdominal obesity, atherogenic dyslipidemia, high blood pressure, and high blood glucose, but its preva...

    Authors: Nicholas Kofi Adjei, Florence Samkange-Zeeb, Mihiretu Kebede, Maham Saleem, Thomas L. Heise and Hajo Zeeb

    Citation: Systematic Reviews 2020 9:134

    Content type: Protocol

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  12. Community-based peer and community health worker-led diabetes self-management programs (COMP-DSMP) can benefit diabetes care, but the supporting evidence has been inadequately assessed. This systematic review ...

    Authors: Mahmoud Werfalli, Peter J. Raubenheimer, Mark Engel, Alfred Musekiwa, Kirsten Bobrow, Nasheeta Peer, Cecilia Hoegfeldt, Sebastiana Kalula, Andre Pascal Kengne and Naomi S. Levitt

    Citation: Systematic Reviews 2020 9:133

    Content type: Research

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  13. Network meta-analyses (NMAs) of psoriasis treatments, undertaken as part of the NICE Single Technology Appraisal (STA) process, have included heterogeneous studies. When there is inconsistency or heterogeneity...

    Authors: Ros Wade, Sahar Sharif-Hurst and Sofia Dias

    Citation: Systematic Reviews 2020 9:132

    Content type: Research

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  14. Delirium is an acute confusional state, common in critical illness and associated with cognitive decline. There is no effective pharmacotherapy to prevent or treat delirium, although it is scientifically plaus...

    Authors: Cathrine A. McKenzie, Valerie J. Page, W. David Strain, Bronagh Blackwood, Marlies Ostermann, David Taylor, Peter E. Spronk and Daniel F. McAuley

    Citation: Systematic Reviews 2020 9:131

    Content type: Protocol

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  15. Despite the enormous financial and humanistic burden of chronic low back pain (CLBP), there is little consensus on what constitutes the best treatment options from a multitude of competing interventions. The o...

    Authors: Trevor Thompson, Sofia Dias, Damian Poulter, Sharon Weldon, Lucy Marsh, Claire Rossato, Jae Il Shin, Joseph Firth, Nicola Veronese, Elena Dragioti, Brendon Stubbs, Marco Solmi, Christopher G. Maher, Andrea Cipriani and John P. A. Ioannidis

    Citation: Systematic Reviews 2020 9:130

    Content type: Protocol

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  16. According to the UK’s Office for National Statistics, England and Wales reported a 2.9% increase in sexual aggression cases (3.4 million females and 631,000 males) between 2009 and 2019. In Scotland, sexual ag...

    Authors: Delarise Maud Mulqueeny, Jennifer Roberts and Senzelokuhle Mpumelelo Nkabini

    Citation: Systematic Reviews 2020 9:129

    Content type: Protocol

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  17. Healthy aging (HA) is a contemporary challenge for population health worldwide. Electronic health (e-Health) interventions have the potential to support empowerment and education of adults aged 50 and over.

    Authors: Ronald Buyl, Idrissa Beogo, Maaike Fobelets, Carole Deletroz, Philip Van Landuyt, Samantha Dequanter, Ellen Gorus, Anne Bourbonnais, Anik Giguère, Kathleen Lechasseur and Marie-Pierre Gagnon

    Citation: Systematic Reviews 2020 9:128

    Content type: Research

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  18. Six core behavioural risk factors (poor diet, physical activity, sedentary behaviour, alcohol misuse, smoking and unhealthy sleep patterns) have been identified as strong determinants of chronic disease, such ...

    Authors: Louise Thornton, Bridie Osman, Annie B. Wescott, Matthew Sunderland, Katrina Champion, Olivia Green, Frances Kay-Lambkin, Tim Slade, Nickie Newton, Cath Chapman, Maree Teesson, Katherine Mills, Louise Birrell, David Lubans, Pepijn Van de Ven, John Torous…

    Citation: Systematic Reviews 2020 9:127

    Content type: Protocol

    Published on:

  19. Perinatal loss is a traumatic and complex experience that contributes to negative maternal psychological states and adverse outcomes impacting fetal development, maternal-fetal/infant bonding, marital/partner ...

    Authors: Elyse M. Charrois, Katherine S. Bright, Abdul Wajid, Muhammad Kashif Mughal, K. Alix Hayden and Dawn Kingston

    Citation: Systematic Reviews 2020 9:125

    Content type: Protocol

    Published on:

  20. Current understandings of the etiology of traumatic brain injury (TBI) and the trajectory of care significantly lack consideration for the inclusion of Black populations. The global prevalence of TBI is increa...

    Authors: Samira Omar, LLana James, Angela Colantonio and Stephanie A. Nixon

    Citation: Systematic Reviews 2020 9:124

    Content type: Protocol

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  21. Barriers to receiving optimal healthcare exist for Indigenous populations globally for a range of reasons. To overcome such barriers and enable greater access to basic and specialist care, developments in info...

    Authors: Rachel Reilly, Jacqueline Stephens, Jasmine Micklem, Catalin Tufanaru, Stephen Harfield, Ike Fisher, Odette Pearson and James Ward

    Citation: Systematic Reviews 2020 9:123

    Content type: Research

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  22. Chronic musculoskeletal pain represents an enormous burden in society. Best-practice care for chronic musculoskeletal pain suggests adoption of self-management strategies. Telehealth interventions (e.g., video...

    Authors: Lívia G. Fernandes, Hemakumar Devan, Steven J. Kamper, Christopher M. Williams and Bruno T. Saragiotto

    Citation: Systematic Reviews 2020 9:122

    Content type: Protocol

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  23. First responders are a high-risk population for occupational stress injuries as they often encounter prolonged stress within their line of work. The aim of this rapid overview of reviews is to summarize existi...

    Authors: Jesmin Antony, Raman Brar, Paul A. Khan, Marco Ghassemi, Vera Nincic, Jane P. Sharpe, Sharon E. Straus and Andrea C. Tricco

    Citation: Systematic Reviews 2020 9:121

    Content type: Research

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  24. Continuous glucose monitorings (CGMs) have been used to manage diabetes with reasonable glucose control amongst patients with type 2 diabetes (T2D) in recent decades. CGMs measure interstitial fluid glucose le...

    Authors: Mingyue Zheng, Yunting Luo, Wei Lin, Adeel Khoja, Qian He, Shenqiao Yang, Xuan Zhao and Peng Hu

    Citation: Systematic Reviews 2020 9:120

    Content type: Protocol

    Published on:

  25. With an increase in wildfire activity across the globe and growing numbers of personnel involved each year, it is necessary to explore the health impacts of occupational exposure to wildfires and the practices...

    Authors: Erica Koopmans, Trina Fyfe, Mike Eadie and Chelsea A. Pelletier

    Citation: Systematic Reviews 2020 9:119

    Content type: Protocol

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  26. Peripheral nerves are constant targets of traumatic injury which may result in neurotmesis and which invariably requires surgical treatment. In view of this, tissue engineering studies developed biomaterials w...

    Authors: Ana Camila Nobre de Lacerda Brito, Sara Emanuely Veríssimo Santos, Wilayane Alves Martins, Paulo César da Silva Queiroz, Wenddy Wyllie Damascena Sougey, Paula Ketilly Nascimento Alves, Kalline Lourenço Ribeiro, Maria Danielly Lima de Oliveira and Sílvia Regina Arruda de Moraes

    Citation: Systematic Reviews 2020 9:118

    Content type: Protocol

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  27. Meta-analysts rely on the availability of data from previously conducted studies. That is, they rely on primary study authors to register their outcome data, either in a study’s text or on publicly available w...

    Authors: Joshua R. Polanin, Dorothy L. Espelage, Jennifer K. Grotpeter, Alberto Valido, Katherine M. Ingram, Cagil Torgal, America El Sheikh and Luz E. Robinson

    Citation: Systematic Reviews 2020 9:116

    Content type: Methodology

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  28. This work aimed to identify studies of interventions seeking to address mental health inequalities, studies assessing the economic impact of such interventions and factors which act as barriers and those that ...

    Authors: Laura-Louise Arundell, Helen Greenwood, Helen Baldwin, Eleanor Kotas, Shubulade Smith, Kasia Trojanowska and Chris Cooper

    Citation: Systematic Reviews 2020 9:115

    Content type: Research

    Published on:

  29. Neurotrauma is an important global health problem. The largest cause of neurotrauma worldwide is road traffic collisions (RTCs), particularly in low- and middle-income countries (LMICs). Neurotrauma and RTCs a...

    Authors: Santhani M Selveindran, Tamara Tango, Muhammad Mukhtar Khan, Daniel Martin Simadibrata, Peter J. A. Hutchinson, Carol Brayne, Christine Hill, Franco Servadei, Angelos G. Kolias, Andres M. Rubiano, Alexis J. Joannides and Hamisi K. Shabani

    Citation: Systematic Reviews 2020 9:114

    Content type: Research

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  30. Water, sanitation, and hygiene interventions often fail to show long-term impact on diarrhoeal and/or intestinal parasite risk in many low- and middle-income countries. Less attention has been paid to wider co...

    Authors: Benn Sartorius, Hugo Legge and Rachel Pullan

    Citation: Systematic Reviews 2020 9:113

    Content type: Protocol

    Published on:

  31. The literature on the implementation of knowledge products is extensive. However, this literature is still difficult to interpret for policymakers and other stakeholders when faced with choosing implementation...

    Authors: Hervé Tchala Vignon Zomahoun, José Massougbodji, André Bussières, Aliki Thomas, Dahlia Kairy, Claude Bernard Uwizeye, Nathalie Rheault, Ali Ben Charif, Ella Diendéré, Léa Langlois, Sébastien Tchoubi, Serigne Abib Gaye and France Légaré

    Citation: Systematic Reviews 2020 9:112

    Content type: Protocol

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  32. To date multimorbidity has not received much attention in health policies, even though multiple chronic diseases put high demands on the health care system in industrial nations. Enormous costs of care and a p...

    Authors: Simone Schweda and Inga Krauss

    Citation: Systematic Reviews 2020 9:110

    Content type: Protocol

    Published on:

  33. Environmental factors such as pollution, pesticide exposure and socio-demographic location have been implicated as a pressure capable of altering genetic make-up. Altered genetic sequence of genes encoding enz...

    Authors: Nkosinathi Banhela, Pragalathan Naidoo and Saloshni Naidoo

    Citation: Systematic Reviews 2020 9:109

    Content type: Research

    Published on:

  34. COVID-19 is a rapidly spreading virus infection that has quickly caused extensive burden to individual, families, countries, and the globe. No intervention has yet been proven effective for the treatment of CO...

    Authors: Sophie Juul, Niklas Nielsen, Peter Bentzer, Areti Angeliki Veroniki, Lehana Thabane, Adam Linder, Sarah Klingenberg, Christian Gluud and Janus Christian Jakobsen

    Citation: Systematic Reviews 2020 9:108

    Content type: Protocol

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  35. Endovascular therapy is a fundamental treatment for peripheral arterial disease. However, the success rate of endovascular therapy remains poor, as a third of patients with critical limb ischemia ultimately re...

    Authors: Mark Rockley, Prasad Jetty and George Wells

    Citation: Systematic Reviews 2020 9:107

    Content type: Protocol

    Published on:

  36. Antibiotics are prescribed frequently for upper respiratory tract infections (URTIs) even though most URTIs do not require antibiotics. This over-prescription contributes to antibiotic resistance which is a ma...

    Authors: Sameh Mortazhejri, Patrick Jiho Hong, Ashley M. Yu, Brian Younho Hong, Dawn Stacey, R. Sacha Bhatia and Jeremy M. Grimshaw

    Citation: Systematic Reviews 2020 9:106

    Content type: Research

    Published on:

  37. Despite recent improvements in the burden of cardiovascular disease (CVD) in the UK, deaths from CVD are relatively high compared with other high-income countries. An estimated 7 million people in the UK are l...

    Authors: Olalekan A. Uthman, Lena Al-Khudairy, Chidozie U. Nduka, Rachel Court, Hema Mistry, G . J. Melendez-Torres, Sian Taylor-Phillips and Aileen Clarke

    Citation: Systematic Reviews 2020 9:105

    Content type: Protocol

    Published on:

  38. With technological advances, there has been increasing interest in developing contactless and/or non-invasive wearable technologies that continuously monitor vital signs in the clinical setting, and in particu...

    Authors: Peter Y. Chan, John McNeil, Tam Nguyen, Nicholas Ryan and Ingrid Hopper

    Citation: Systematic Reviews 2020 9:104

    Content type: Protocol

    Published on:

  39. Vascular endothelial growth factor (VEGF) is one of the angiogenesis regulators, which plays an important role in tumor angiogenesis and tumor progression. Current studies have found that VEGF plays an importa...

    Authors: Mingzhu Song, Huiping Wang and Qianling Ye

    Citation: Systematic Reviews 2020 9:103

    Content type: Systematic review update

    Published on:

  40. A growing number of studies suggest that social isolation and loneliness are associated with premature mortality and are more prevalent among people with mental illness than in the general population, outlinin...

    Authors: Adriano Winterton, Linn Rødevand, Lars T. Westlye, Nils Eiel Steen, Ole A. Andreassen and Daniel S. Quintana

    Citation: Systematic Reviews 2020 9:102

    Content type: Protocol

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  41. Many epidemiological studies have investigated the prevalence of type 2 diabetes in individuals with a psychiatric disorder. In an umbrella review, we aim to systematically summarize existing systematic review...

    Authors: N. Lindekilde, S. Scheuer, F. Rutters, J. E. Henriksen, K. H. Rubin, M. Lasgaard, G. S. Andersen and F. Pouwer

    Citation: Systematic Reviews 2020 9:101

    Content type: Protocol

    Published on:

  42. The fourth meeting of the International Collaboration for Automation of Systematic Reviews (ICASR) was held 5–6 November 2019 in The Hague, the Netherlands. ICASR is an interdisciplinary group whose goal is to...

    Authors: Annette M. O’Connor, Paul Glasziou, Michele Taylor, James Thomas, René Spijker and Mary S. Wolfe

    Citation: Systematic Reviews 2020 9:100

    Content type: Commentary

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  43. Cotton workers are exposed to various hazards in the textile industry that might result in different ailments including hypertension (HTN). However, few attempts have been made to systematically review the pre...

    Authors: Naureen Akber Ali and Anam Shahil Feroz

    Citation: Systematic Reviews 2020 9:99

    Content type: Protocol

    Published on:

  44. Gasless laparoscopy, developed in the early 1990s, was a means to minimize the clinical and financial challenges of pneumoperitoneum and general anaesthesia. It has been used in a variety of procedures such as...

    Authors: Haitham Shoman, Simone Sandler, Alexander Peters, Ameer Farooq, Magdalen Gruendl, Shauna Trinh, James Little, Alex Woods, William Bolton, Abubakar Abioye and David Ljungman

    Citation: Systematic Reviews 2020 9:98

    Content type: Protocol

    Published on:

  45. Network meta-analysis (NMA) has rapidly grown in use during the past decade for the comparison of healthcare interventions. While its general use in the comparison of conventional medicines has been studied pr...

    Authors: Misty Pratt, Susan Wieland, Nadera Ahmadzai, Claire Butler, Dianna Wolfe, Kusala Pussagoda, Becky Skidmore, Argie Veroniki, Patricia Rios, Andrea C. Tricco and Brian Hutton

    Citation: Systematic Reviews 2020 9:97

    Content type: Research

    Published on:

  46. In children and adolescents, anxiety disorders (ADs) are among the most prevalent mental disorders. While there is a solid empirical foundation to support CBT as an evidence-based treatment for childhood ADs, ...

    Authors: Kathrin Schopf, Cornelia Mohr, Michael W. Lippert, Katharina Sommer, Andrea Hans Meyer and Silvia Schneider

    Citation: Systematic Reviews 2020 9:96

    Content type: Protocol

    Published on:

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