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  1. Improving the speed of systematic review (SR) development is key to supporting evidence-based medicine. Machine learning tools which semi-automate citation screening might improve efficiency. Few studies have ...

    Authors: Amy Y. Tsou, Jonathan R. Treadwell, Eileen Erinoff and Karen Schoelles

    Citation: Systematic Reviews 2020 9:73

    Content type: Research

    Published on:

  2. Dedicated air ambulance services provide a vital link for critically ill and injured patients to higher levels of care. The recent developments of pre-hospital and retrieval medicine create an opportunity for ...

    Authors: Kristin H. Edwards, Gerard FitzGerald, Richard C. Franklin and Mark Terrell Edwards

    Citation: Systematic Reviews 2020 9:72

    Content type: Protocol

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  3. The early recognition of invasive bacterial infections (IBI) in children can be difficult. Clinically it is often challenging to differentiate between the early stages of an IBI and a benign self-limiting vira...

    Authors: Michael Corr, Thomas Waterfield, Derek Fairley, James McKenna and Michael D. Shields

    Citation: Systematic Reviews 2020 9:69

    Content type: Protocol

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  4. Internet gaming disorder (IGD) was included in the DSM-5 in 2013 as a condition requiring further research, and gaming disorder (GD) was included in the ICD-11 in 2018. Given the importance of including these ...

    Authors: Nazia Darvesh, Amruta Radhakrishnan, Chantelle C. Lachance, Vera Nincic, Jane P. Sharpe, Marco Ghassemi, Sharon E. Straus and Andrea C. Tricco

    Citation: Systematic Reviews 2020 9:68

    Content type: Research

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  5. Hypoxemia is a severe condition associated with high rates of mortality, particularly in low- and middle-income countries (LMICs) with poor access to oxygen therapy. Despite its clinical significance, there ha...

    Authors: Felix Lam, Rami Subhi, Jason Houdek, Kate Schroder, Audrey Battu and Hamish Graham

    Citation: Systematic Reviews 2020 9:67

    Content type: Protocol

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  6. Breast cancer is one of the most common malignancies in women worldwide, and one of the leading causes of cancer-related death. Programmed cell death 1 (PD-1) and its ligand (PD-L1) are key physiologic suppres...

    Authors: Isnard Elman Litvin, Machline Paim Paganella, Eliana Marcia Wendland and Adriana Vial Roehe

    Citation: Systematic Reviews 2020 9:66

    Content type: Protocol

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  7. This protocol outlines a systematic review methodology, aiming to assess the recent evidence-base for the impact of testing strategies and approaches on access to testing, testing coverage, and linkage to care...

    Authors: Suzanna C. Francis, Arun Parajuli, Otilia Mardh, Jane Falconer, Aura Andreasen and Emma Harding-Esch

    Citation: Systematic Reviews 2020 9:64

    Content type: Protocol

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  8. Traumatic cervicogenic dizziness is dizziness that is temporally associated with neck pain and injury after other causes of dizziness have been excluded. It can lead to activity limitations and participation r...

    Authors: Carrie W. Hoppes, Anthony J. Romanello, Kathryn E. Gaudette, William K. Herron, Anne E. McCarthy, Catherine J. McHale, Joan Bares, Rose Turner and Susan L. Whitney

    Citation: Systematic Reviews 2020 9:62

    Content type: Protocol

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  9. Attachment in the parent-infant dyads is fundamental for growth and development of children born prematurely. However, the natural process of attachment is interrupted just after preterm birth, and emotional a...

    Authors: Ah. Rim Kim, Soo-yeon Kim and Ji Eun Yun

    Citation: Systematic Reviews 2020 9:61

    Content type: Protocol

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  10. Unwanted anticholinergic effects are both underestimated and frequently overlooked. Failure to identify adverse drug reactions (ADRs) can lead to prescribing cascades and the unnecessary use of over-the-counte...

    Authors: Maria-Sophie Brueckle, Elizabeth T. Thomas, Svenja E. Seide, Maximilian Pilz, Ana Isabel Gonzalez-Gonzalez, Truc Sophia Nguyen, Sebastian Harder, Paul P. Glasziou, Ferdinand M. Gerlach and Christiane Muth

    Citation: Systematic Reviews 2020 9:59

    Content type: Protocol

    Published on:

  11. Cognitive impairment is a common and frequently under-recognized complication of chronic kidney disease (CKD). Although there is extensive literature on cognitive interventions that can ameliorate cognitive im...

    Authors: Janine F. Farragher, Katherine E. Stewart, Tyrone G. Harrison, Lisa Engel, Samantha E. Seaton and Brenda R. Hemmelgarn

    Citation: Systematic Reviews 2020 9:58

    Content type: Protocol

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  12. Globally, low back pain (LBP) is a major public health problem affecting mainly adults of the working class and is the leading cause of disability. The estimated lifetime prevalence of LBP is 50 to 80%. From 1...

    Authors: Morris Kahere and Themba Ginindza

    Citation: Systematic Reviews 2020 9:57

    Content type: Protocol

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  13. Both high-intensity interval training and moderate-intensity continuous training demonstrate beneficial physiological outcomes for active and insufficiently active populations. However, it remains unclear whet...

    Authors: Alexandre Santos, Chris Lonsdale, David Lubans, Diego Vasconcellos, Nathanial Kapsal, Mathew Vis-Dunbar and Mary E. Jung

    Citation: Systematic Reviews 2020 9:56

    Content type: Protocol

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  14. School feeding programs are beneficial for the physical, mental, and psychosocial development of school-age children and adolescents, particularly those in low- and middle-income countries (LMICs). While schoo...

    Authors: Dongqing Wang and Wafaie W. Fawzi

    Citation: Systematic Reviews 2020 9:55

    Content type: Protocol

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  15. Non-infectious scleritis is a potentially sight-threatening condition in which the sclera, the white outer layer of the eye, becomes inflamed. Whilst scleritis can be infective, the majority of cases are due t...

    Authors: Sathana Ingaralingam, Saaeha Rauz, Philip I. Murray and Robert J. Barry

    Citation: Systematic Reviews 2020 9:54

    Content type: Protocol

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  16. As systematic reviews’ limited coverage of the medical literature necessitates decision-making based on unsystematic review, we investigated a possible advantage of systematic review (aside from dataset size a...

    Authors: Michael Saginur, Dean Fergusson, Tinghua Zhang, Karen Yeates, Tim Ramsay, George Wells and David Moher

    Citation: Systematic Reviews 2020 9:53

    Content type: Research

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  17. In sub-Saharan Africa (SSA), malnutrition remains a major public health challenge, particularly among children under 5 years of age. Despite nutritional screening tools being developed and available to detect ...

    Authors: Tlharihani Phisac Maphosa, Delarise Maud Mulqueeny, Ernest Osei, Desmond Kuupiel and Tivani P. Mashamba-Thompson

    Citation: Systematic Reviews 2020 9:52

    Content type: Protocol

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  18. Precarious employment has become an urgent public health issue at a global scale with potential consequences for quality of life and health of employees, especially in vulnerable groups such as migrants. The p...

    Authors: Ozlem Koseoglu Ornek, Tobias Weinmann, Julia Waibel and Katja Radon

    Citation: Systematic Reviews 2020 9:50

    Content type: Protocol

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  19. Colorectal cancer, a prevalent malignancy worldwide, is associated with numerous modifiable and non-modifiable risk factors that play a role in the early detection and successful treatment of cancer. Despite i...

    Authors: Undine Antonia Stark, Thomas Frese, Susanne Unverzagt and Alexander Bauer

    Citation: Systematic Reviews 2020 9:49

    Content type: Protocol

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  20. Equine-assisted treatments of the motor system appear to have an effect on the neuromuscular system and aim to improve the pathological condition of children with cerebral palsy. Hippotherapy is a distinct for...

    Authors: Martin Häusler and Nicole Heussen

    Citation: Systematic Reviews 2020 9:48

    Content type: Protocol

    Published on:

  21. Central nervous system tumors remain the leading cause of cancer-related mortality amongst children with solid tumors, with medulloblastoma (MB) representing the most common pediatric brain malignancy. Despite...

    Authors: Ashley A. Adile, Michelle M. Kameda-Smith, David Bakhshinyan, Laura Banfield, Sabra K. Salim, Forough Farrokhyar and Adam J. Fleming

    Citation: Systematic Reviews 2020 9:47

    Content type: Protocol

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  22. Behavior change is not simple, and the introduction of guidelines or protocols does not mean that they will be followed. As such, implementation strategies are vital for the uptake and sustainability of change...

    Authors: Alex Aregbesola, Ahmed M. Abou-Setta, Maya M. Jeyaraman, George Okoli, Otto Lam, Kathryn M. Sibley and Terry P. Klassen

    Citation: Systematic Reviews 2020 9:46

    Content type: Protocol

    Published on:

  23. Self-care behaviors in people living with type 2 diabetes are important to achieving optimal glycemic control. Major depression in type 2 diabetes is associated with decreased adherence to self-care behaviors....

    Authors: Monika Shrestha, Ashley Ng, Amal Al-Ghareeb, Fatimah Alenazi and Richard Gray

    Citation: Systematic Reviews 2020 9:45

    Content type: Research

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  24. No study has looked at differences of pooled estimates—such as meta-analyses—of corresponding study documents of the same intervention. In this study, we compared meta-analyses of human papillomavirus (HPV) va...

    Authors: Lars Jørgensen, Peter C. Gøtzsche and Tom Jefferson

    Citation: Systematic Reviews 2020 9:42

    Content type: Research

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    The Commentary to this article has been published in Systematic Reviews 2020 9:41

  25. Nurses make up the largest constituent of the health workforce. The success of health care interventions depends on nurses’ ability and willingness to provide quality health care services. A well-implemented p...

    Authors: Cynthia Zandile Madlabana, Tivani Phosa Mashamba-Thompson and Inge Petersen

    Citation: Systematic Reviews 2020 9:40

    Content type: Protocol

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  26. The best evidence-enhanced recovery care pathway is yet to be defined for patients undergoing spinal surgery. Minimally invasive surgery, multimodal analgesia, early mobilization, and early postoperative nutri...

    Authors: Ana Licina, Andrew Silvers, Harry Laughlin, Jeremy Russell and Crispin Wan

    Citation: Systematic Reviews 2020 9:39

    Content type: Protocol

    Published on:

  27. Knee osteoarthritis is a common, chronic condition and main contributor to global disability. Total knee arthroplasty (TKA) is the most successful treatment for end-stage knee osteoarthritis. It is assumed tha...

    Authors: Tanja Rombey, Käthe Goossen, Jessica Breuing, Tim Mathes, Simone Hess, Rene Burchard and Dawid Pieper

    Citation: Systematic Reviews 2020 9:38

    Content type: Protocol

    Published on:

  28. Surgical site infections (SSIs) are among the most common healthcare-associated infections. Under-nutrition is an important risk factor for SSIs and can lead to delayed wound healing and longer hospital stays....

    Authors: Nicholas Ralph, Lindsay Brown, Kristy L. McKillop, Jed Duff, Sonya Osborne, Victoria R. Terry, Karen-Leigh Edward, Rachel King and Edward Barui

    Citation: Systematic Reviews 2020 9:37

    Content type: Protocol

    Published on:

  29. Older adults spend up to 23 h daily sitting or lying while in hospital. Sedentary behaviour (SB) within a hospital setting is often associated with poor health outcomes including physical and cognitive decline...

    Authors: Unyime S. Jasper, Lalit Yadav, Agathe Daria Jadczak, Solomon Yu, Renuka Visvanathan and Joanne Dollard

    Citation: Systematic Reviews 2020 9:36

    Content type: Protocol

    Published on:

  30. Relapse prevention is an important objective in the management of serious mental illness (SMI). While community mental health nurses (CMHN) might be well-placed to support people with SMI in averting relapse, ...

    Authors: Matthew J. Leach, Martin Jones, Dan Bressington, Adrian Jones, Fiona Nolan, Kuda Muyambi, Marianne Gillam and Richard Gray

    Citation: Systematic Reviews 2020 9:35

    Content type: Research

    Published on:

  31. Around twenty million new cases and ten million of deaths were attributed to cancer in 2018. Physical exercise, as main component of prehabilitation programs, has been associated with clinical improvements in ...

    Authors: Jose F. Meneses-Echávez, Andrés F. Loaiza-Betancur, Víctor Díaz-López and Andrés M. Echavarría-Rodríguez

    Citation: Systematic Reviews 2020 9:34

    Content type: Protocol

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  32. Understanding the long-term health effects of low to moderate alcohol consumption is important for establishing thresholds for minimising the lifetime risk of harm. Recent research has elucidated the dose-resp...

    Authors: Sue E. Brennan, Steve McDonald, Matthew J. Page, Jane Reid, Stephanie Ward, Andrew B. Forbes and Joanne E. McKenzie

    Citation: Systematic Reviews 2020 9:33

    Content type: Research

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  33. A new tool, “risk of bias (ROB) instrument for non-randomized studies of exposures (ROB-NRSE),” was recently developed. It is important to establish consistency in its application and interpretation across rev...

    Authors: Maya M. Jeyaraman, Nameer Al-Yousif, Reid C. Robson, Leslie Copstein, Chakrapani Balijepalli, Kimberly Hofer, Mir S. Fazeli, Mohammed T. Ansari, Andrea C. Tricco, Rasheda Rabbani and Ahmed M. Abou-Setta

    Citation: Systematic Reviews 2020 9:32

    Content type: Protocol

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  34. Anemia is the most common hematologic disorder of children in the globe. There are fragmented and inconclusive study findings on under-five anemia in Ethiopia. Understanding the distribution of anemia is an im...

    Authors: Amare Belachew and Tilahun Tewabe

    Citation: Systematic Reviews 2020 9:31

    Content type: Systematic review update

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  35. Several studies employing the effectiveness of solar disinfection water treatment method for reducing diarrhea have reported heterogeneous outcomes, necessitating a systematic review to provide an exhaustive s...

    Authors: Negasa Eshete Soboksa, Sirak Robele Gari, Abebe Beyene Hailu, Dereje Oljira Donacho and Bezatu Mengistie Alemu

    Citation: Systematic Reviews 2020 9:30

    Content type: Protocol

    Published on:

  36. Prescription drugs are controlled medicines due to their potential risks of being diverted, misused, and abused. Since the introduction of antiretroviral (ARVs) drugs, HIV is currently regarded as a chronic co...

    Authors: Buyisile Chibi, Neusa Fernanda Torres and Tivani P. Mashamba-Thompson

    Citation: Systematic Reviews 2020 9:29

    Content type: Protocol

    Published on:

  37. The prevalence of overweight is increasing worldwide in children. Multi-component interventions incorporating diet, physical activity, and behavioural change have been shown to reduce body mass index (BMI). Wh...

    Authors: Rajeeb Rashid, Paolo Perego, Laura Condon, Janus Christian Jakobsen, Jane Lindschou, Christian Gluud, Giuseppe Andreoni and Inge Lissau

    Citation: Systematic Reviews 2020 9:28

    Content type: Protocol

    Published on:

  38. Many control methods have been implemented to tackle onchocerciasis and great successes have been achieved, leading to a paradigm shift from control of morbidity to interruption of transmission and ultimately ...

    Authors: Hugues C. Nana-Djeunga, André Domche, Yannick Niamsi-Emalio, Henri C. Moungui, Martin Walker, Maria-Gloria Basáñez and Joseph Kamgno

    Citation: Systematic Reviews 2020 9:27

    Content type: Protocol

    Published on:

  39. Gender inequality within academic medicine and dentistry is a well-recognised issue, but one which is not completely understood in terms of its causes, or interventions to facilitate equality. This systematic ...

    Authors: Jennifer V. E. Brown, Paul E. S. Crampton, Gabrielle M. Finn and Jessica E. Morgan

    Citation: Systematic Reviews 2020 9:26

    Content type: Protocol

    Published on:

  40. Whilst effective treatments exist for substance use and alcohol use disorders, they are not commonly practised. Studies have shown that only a small percentage of services provide evidence-based treatments suc...

    Authors: Eva Louie, Emma L. Barrett, Andrew Baillie, Paul Haber and Kirsten C. Morley

    Citation: Systematic Reviews 2020 9:25

    Content type: Protocol

    Published on:

  41. Traumatic brain injury (TBI) is a leading cause of death and disability. Recently, a paradigm shift in our understanding of moderate-to-severe TBI has led to its reconceptualization as a progressive neurodegen...

    Authors: Bhanu Sharma, Alana Changoor, Leanne Monteiro, Brenda Colella and Robin Green

    Citation: Systematic Reviews 2020 9:23

    Content type: Protocol

    Published on:

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