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  1. Content type: Protocol

    There has been little focus in the literature on how to build genetic testing and counseling services in low- and middle-income countries in a responsible, ethical, and culturally appropriate manner. It is unc...

    Authors: Adrina Zhong, Benedict Darren and Helen Dimaras

    Citation: Systematic Reviews 2017 6:140

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  2. Content type: Protocol

    Pain reduction can be achieved by lowering proinflammatory cytokine levels in the blood. Transcutaneous electrical nerve stimulation (TENS) is a non-invasive physiotherapeutic resource for pain management, but...

    Authors: Tábata Cristina do Carmo Almeida, Francisco Winter dos Santos Figueiredo, Valter Cordeiro Barbosa Filho, Luiz Carlos de Abreu, Fernando Luiz Affonso Fonseca and Fernando Adami

    Citation: Systematic Reviews 2017 6:139

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  3. Content type: Research

    Tobacco smoking is a leading cause of disease and premature mortality among Aboriginal and Torres Strait Islander (Indigenous) Australians. While the daily smoking prevalence among Indigenous Australians has d...

    Authors: Catherine Chamberlain, Susan Perlen, Sue Brennan, Lucie Rychetnik, David Thomas, Raglan Maddox, Noore Alam, Emily Banks, Andrew Wilson and Sandra Eades

    Citation: Systematic Reviews 2017 6:135

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  4. Content type: Protocol

    The prevalence of menopause in women with or at risk of chronic kidney disease is increasing globally. Although international guidelines on menopause recommend the use of postmenopausal hormone therapy with or...

    Authors: Sandra M. Dumanski, Sharanya Ramesh, Matthew T. James, Amy Metcalfe, Kara Nerenberg, Ellen W. Seely, Helen Lee Robertson and Sofia B. Ahmed

    Citation: Systematic Reviews 2017 6:134

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  5. Content type: Protocol

    N-of-1 trials are multiple cross-over trials done in individual participants, generating individual treatment effect information. While reporting guidelines for the CONSORT Extension for N-of-1 trials (CENT) a...

    Authors: Antony J. Porcino, Salima Punja, An-Wen Chan, Richard Kravitz, Aaron Orkin, Philippe Ravaud, Christopher H. Schmid and Sunita Vohra

    Citation: Systematic Reviews 2017 6:132

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  6. Content type: Protocol

    Predicting outcomes in those with chronic kidney disease or following transplantation is challenging, and current models lack detailed patient-level information. Frailty and poor functional status are risk fac...

    Authors: Kendra E. Brett, Alexandria Bennett, Lindsay J. Ritchie and Greg A. Knoll

    Citation: Systematic Reviews 2017 6:133

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  7. Content type: Protocol

    Frailty is a common syndrome affecting 5–17% of community-dwelling older adults. Various interventions are used to prevent or treat frailty. Given the diversity of singular and multi-faceted frailty interventi...

    Authors: Ahmed M. Negm, Courtney C. Kennedy, Lehana Thabane, Areti-Angeliki Veroniki, Jonathan D. Adachi, Julie Richardson, Ian D. Cameron, Aidan Giangregorio and Alexandra Papaioannou

    Citation: Systematic Reviews 2017 6:130

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  8. Content type: Protocol

    Body size, nutrition and socioeconomic position (SEP) in early life have been associated with a range of later life health outcomes. Epigenetic regulation is one mechanism through which these early life factor...

    Authors: Jane Maddock, Wahyu Wulaningsih and Rebecca Hardy

    Citation: Systematic Reviews 2017 6:129

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  9. Content type: Research

    Despite the growing interest in assessing the quality of care for depression, there is little evidence to support measurement of the quality of primary care for depression. This study identified evidence-based...

    Authors: Yelena Petrosyan, Yeva Sahakyan, Jan M. Barnsley, Kerry Kuluski, Barbara Liu and Walter P. Wodchis

    Citation: Systematic Reviews 2017 6:126

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  10. Content type: Protocol

    Medication-related adverse events have been estimated to be responsible for 5700 deaths and cost the UK £750 million annually. This burden falls disproportionately on older people. Outcomes from interventions ...

    Authors: Ian Maidment, Andrew Booth, Judy Mullan, Jane McKeown, Sylvia Bailey and Geoffrey Wong

    Citation: Systematic Reviews 2017 6:125

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  11. Content type: Protocol

    This is a protocol for a systematic review of the impact of health coaching on changing the health behaviour of offenders. Prisoners are more likely to suffer from health-related issues when compared to the ge...

    Authors: Nadja Almondes, Denise Downie, Ayse B. Cinar, Derek Richards and Ruth Freeman

    Citation: Systematic Reviews 2017 6:127

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  12. Content type: Research

    The use of information technology, including internet- and telephone-based resources, is becoming an alternative and supporting method of providing many forms of services in a healthcare and health management ...

    Authors: Martin J Downes, Merehau C Mervin, Joshua M Byrnes and Paul A Scuffham

    Citation: Systematic Reviews 2017 6:128

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  13. Content type: Research

    Understanding how physical activity (PA) influences cognitive function in populations with cognitive impairments, such as dementia, is an increasingly studied topic yielding numerous published systematic revie...

    Authors: Azeem Rathore and Barbara Lom

    Citation: Systematic Reviews 2017 6:124

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  14. Content type: Protocol

    Multiple reviews demonstrated high variability in effectiveness and cost-effectiveness outcomes among studies on breast cancer screening (BCS) programmes. No study to our knowledge has summarized the current e...

    Authors: O. Mandrik, O. I. Ekwunife, N. Zielonke, F. Meheus, J. L. Severens, S. K. Lhachimi and R. Murillo

    Citation: Systematic Reviews 2017 6:122

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  15. Content type: Protocol

    Anxiety and depression are common in young people and are associated with a range of adverse outcomes. Research has suggested a relationship between emotional disorder and poor school attendance, and thus poor...

    Authors: Katie Finning, Darren Moore, Obioha C. Ukoumunne, Emilia Danielsson-Waters and Tamsin Ford

    Citation: Systematic Reviews 2017 6:121

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  16. Content type: Protocol

    Cellular-based therapies represent a platform technology within the rapidly expanding field of regenerative medicine and are distinct from conventional therapeutics—offering a unique approach to managing what ...

    Authors: David Pettitt, Zeeshaan Arshad, Benjamin Davies, James Smith, Anna French, Doug Cole, Kim Bure, Sue Dopson, David DiGiusto, Jeff Karp, Brock Reeve, Richard Barker, Georg Holländer and David Brindley

    Citation: Systematic Reviews 2017 6:120

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  17. Content type: Protocol

    Stress ulcer prophylaxis is considered standard of care in many critically ill patients in the intensive care unit (ICU). However, the quality of evidence supporting this has recently been questioned, and clin...

    Authors: Søren Marker, Anders Perner, Jørn Wetterslev, Marija Barbateskovic, Janus Christian Jakobsen, Mette Krag, Anders Granholm, Carl Thomas Anthon and Morten Hylander Møller

    Citation: Systematic Reviews 2017 6:118

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  18. Content type: Protocol

    Network meta-analysis, a method to synthesise evidence from multiple treatments, has increased in popularity in the past decade. Two broad approaches are available to synthesise data across networks, namely, a...

    Authors: Amalia (Emily) Karahalios, Georgia Salanti, Simon L. Turner, G. Peter Herbison, Ian R. White, Areti Angeliki Veroniki, Adriani Nikolakopoulou and Joanne E. Mckenzie

    Citation: Systematic Reviews 2017 6:119

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  19. Content type: Research

    The methodological quality and completeness of reporting of the systematic reviews (SRs) is fundamental to optimal implementation of evidence-based health care and the reduction of research waste. Methods exis...

    Authors: Kusala Pussegoda, Lucy Turner, Chantelle Garritty, Alain Mayhew, Becky Skidmore, Adrienne Stevens, Isabelle Boutron, Rafael Sarkis-Onofre, Lise M. Bjerre, Asbjørn Hróbjartsson, Douglas G. Altman and David Moher

    Citation: Systematic Reviews 2017 6:117

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  20. Content type: Protocol

    Preliminary evidence suggests statins may reduce major perioperative vascular events. However, evidence is limited to observational studies, underpowered trials, and non-comprehensive systematic reviews. This ...

    Authors: Erica Aranha Suzumura, Rodrigo Antonini Ribeiro, Leticia Kawano-Dourado, Pedro Gabriel de Barros e Silva, Claudia Oliveira, Mabel Fernandes Figueiró, Alexandre Biasi Cavalcanti, Renato D. Lopes and Otavio Berwanger

    Citation: Systematic Reviews 2017 6:116

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  21. Content type: Protocol

    The practicality of applying evidence to healthcare systems with the aim of implementing change is an ongoing challenge for practitioners, policy makers, and academics. Shared decision- making (SDM), a method ...

    Authors: Gary Groot, Tamara Waldron, Tracey Carr, Linda McMullen, Lori-Ann Bandura, Shelley-May Neufeld and Vicky Duncan

    Citation: Systematic Reviews 2017 6:114

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  22. Content type: Protocol

    Evidence highlights a high prevalence of common mental health disorders in armed forces veterans and their families, with depression, anxiety, alcohol misuse and anger being more common than PTSD. This paper p...

    Authors: Luke O’Shea, Ed Watkins and Paul Farrand

    Citation: Systematic Reviews 2017 6:112

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  23. Content type: Protocol

    Hemodynamic instability during renal replacement therapy (HIRRT) in the form of intradialytic hypotension (IDH) is a frequent complication of hemodialysis in end-stage kidney disease (ESKD), and most studies h...

    Authors: Adrianna Douvris, Swapnil Hiremath, Lauralyn McIntyre, Lindsey Sikora, Catherine Weber and Edward G. Clark

    Citation: Systematic Reviews 2017 6:113

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  24. Content type: Protocol

    There exist many evidence-based interventions available to manage procedural pain in children and neonates, yet they are severely underutilized. Parents play an important role in the management of their child’...

    Authors: Allison Gates, Kassi Shave, Robin Featherstone, Kelli Buckreus, Samina Ali, Shannon Scott and Lisa Hartling

    Citation: Systematic Reviews 2017 6:109

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  25. Content type: Protocol

    The use of fat grafting as a reconstructive surgical option is becoming much more common. Adipose-derived stem cells found in fat grafts are believed to facilitate wound healing via differentiation into fibrob...

    Authors: Oliver J. Smith, Muholan Kanapathy, Ankur Khajuria, Max Prokopenko, Nadine Hachach-Haram, Haroon Mann and Ash Mosahebi

    Citation: Systematic Reviews 2017 6:111

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  26. Content type: Research

    It is not known, whether outcome reporting in trials of total joint arthroplasty in the recent years is adequate or not. Our objective was to assess whether outcomes reported in total joint replacement (TJR) t...

    Authors: Peter D. H. Wall, Bethan L. Richards, Andrew Sprowson, Rachelle Buchbinder and Jasvinder A. Singh

    Citation: Systematic Reviews 2017 6:106

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  27. Content type: Protocol

    Achilles tendinopathy is one of the most common overuse injuries in recreational and competitive runners, yet the clinical significance and frequency of abnormal sonographic characteristics in runners remains ...

    Authors: Prue Molyneux, Matthew Carroll, Sarah Stewart, Angela Brenton-Rule and Keith Rome

    Citation: Systematic Reviews 2017 6:108

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  28. Content type: Research

    Debates about the benefits and harms of mammography continue despite the accumulation of evidence. We sought to quantify the disagreement across systematic reviews of mammography and determine whether author o...

    Authors: Smriti Raichand, Adam G. Dunn, Mei-Sing Ong, Florence T. Bourgeois, Enrico Coiera and Kenneth D. Mandl

    Citation: Systematic Reviews 2017 6:105

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  29. Content type: Protocol

    Ventilator-associated pneumonia (VAP) is defined as the occurrence of pneumonia in patients receiving mechanical ventilation for more than 48 h after endotracheal intubation. The implementation of effective or...

    Authors: Zhigang Zhang, Yuying Hou, Jun Zhang, Bo Wang, Juxia Zhang, Ailing Yang, Ge Li and Jinhui Tian

    Citation: Systematic Reviews 2017 6:103

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  30. Content type: Protocol

    Polypharmacy, the concurrent use of multiple medications, consistently evokes a negative connotation, notably because it is associated with a plethora of adverse events. Nonetheless, the number of individuals ...

    Authors: Caroline Sirois, Marie-Laure Laroche, Line Guénette, Edeltraut Kröger, Dan Cooper and Valérie Émond

    Citation: Systematic Reviews 2017 6:104

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  31. Content type: Protocol

    Diabetic foot disease is associated with major morbidity, mortality, costs, and reduction of a person’s quality of life. Investigating the epidemiology of diabetic foot disease is the backbone of diabetic foot...

    Authors: Jaap J. van Netten, Mendel Baba and Peter A. Lazzarini

    Citation: Systematic Reviews 2017 6:101

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  32. Content type: Protocol

    Cardiorespiratory fitness (CRF) is a physical condition that is now well established as a predictor of numerous adverse health outcomes, independent of physical activity levels. In order to be able to improve ...

    Authors: Nita Perumal, Gert B.M. Mensink, Thomas Keil and Jonas David Finger

    Citation: Systematic Reviews 2017 6:102

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  33. Content type: Protocol

    With an ageing population and increasing numbers of people with life-limiting illness, there is a growing demand for palliative day services. There is a need to measure and demonstrate the quality of these ser...

    Authors: Seán R. O’Connor, Martin Dempster and Noleen K. McCorry

    Citation: Systematic Reviews 2017 6:100

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  34. Content type: Research

    Fibromyalgia (FM) is a chronic, debilitating pain disorder. Dissatisfaction with conventional medicine can lead people with FM to turn to complementary and alternative medicine (CAM). Two previous overviews of...

    Authors: Rachel Perry, Verity Leach, Philippa Davies, Chris Penfold, Andy Ness and Rachel Churchill

    Citation: Systematic Reviews 2017 6:97

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  35. Content type: Protocol

    Parkinson’s disease (PD) is a progressive neurodegenerative condition that has genetic susceptibility, aging, and exposure to certain chemicals as risk factors. In recent decades, epidemiological and experimen...

    Authors: Carolina Vaccari, Regina El Dib and João Lauro V. de Camargo

    Citation: Systematic Reviews 2017 6:98

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  36. Content type: Protocol

    Hyperglycaemia-induced oxidative damage is a well-established factor implicated in the development of diabetic cardiomyopathy (DCM) in diabetic individuals. Some of the well-known characteristics of DCM includ...

    Authors: Phiwayinkosi V. Dludla, Bongani B. Nkambule, Stephanie C. Dias and Rabia Johnson

    Citation: Systematic Reviews 2017 6:96

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  37. Content type: Protocol

    Short and poor sleep have been associated with adverse health outcomes in adults, such as overweight/obesity and type 2 diabetes, especially among women. Women therefore represent an important target for inter...

    Authors: Lydi-Anne Vézina-Im, Jennette Palcic Moreno, Theresa A. Nicklas and Tom Baranowski

    Citation: Systematic Reviews 2017 6:95

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  38. Content type: Protocol

    Clinical supervision by a senior therapist is a very common practice in psychotherapist training and psychiatric care settings. Though clinical supervision is advocated by most educational and governing instit...

    Authors: Sven Alfonsson, Åsa Spännargård, Thomas Parling, Gerhard Andersson and Tobias Lundgren

    Citation: Systematic Reviews 2017 6:94

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  39. Content type: Protocol

    Knowledge translation (KT) activities can reduce the gap between “what is known” and “what is done”. Several factors hinder or facilitate KT activities including individual characteristics and organizational a...

    Authors: Anastasia A. Mallidou, Pat Atherton, Liza Chan, Noreen Frisch, Stephanie Glegg and Gayle Scarrow

    Citation: Systematic Reviews 2017 6:93

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  40. Content type: Protocol

    Elective knee surgery is performed to reduce chronic pain and improve function in degenerate knees. Treatment of acute post-operative pain is suboptimal in 75% of patients despite multimodal analgesic approach...

    Authors: Hasan Raza Mohammad, Marialena Trivella, Thomas W. Hamilton, Louise Strickland, David Murray and Hemant Pandit

    Citation: Systematic Reviews 2017 6:92

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  41. Content type: Protocol

    Endovascular interventional radiology (EIR) is an increasingly popular, mini invasive treatment option for patient with symptomatic vascular disease. The EIR practiced by qualified hands is an effective, well-...

    Authors: Kaoutar Mellouk Aid, Hervé Tchala Vignon Zomahoun, Abdelmajid Soulaymani, Karin Lebascle, Stephane Silvera, Pascal Astagneau and Benoit Misset

    Citation: Systematic Reviews 2017 6:89

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  42. Content type: Protocol

    Over 85% of cervical cancer cases and deaths occur in developing countries. HIV-seropositive women are more likely to develop precancerous lesions that lead to cervical cancer than HIV-negative women. However,...

    Authors: Witness Mapanga, Ahmed Elhakeem, Shingairai A. Feresu, Fresier Maseko and Tsungai Chipato

    Citation: Systematic Reviews 2017 6:91

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  43. Content type: Protocol

    Guidelines and evidence-based drug treatment recommendations are usually based on the results of clinical trials, which have limited generalisability in routine clinical settings due to their restrictive eligi...

    Authors: Weyinmi A. Demeyin, Julia Frost, Obioha C. Ukoumunne, Simon Briscoe and Nicky Britten

    Citation: Systematic Reviews 2017 6:90

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  44. Content type: Protocol

    Prognosis research is on the rise, its importance recognised because chronic health conditions and diseases are increasingly common and costly. Prognosis systematic reviews are needed to collate and synthesise...

    Authors: Nadia Corp, Joanne L. Jordan, Jill A. Hayden, Emma Irvin, Robin Parker, Andrea Smith and Danielle A. van der Windt

    Citation: Systematic Reviews 2017 6:88

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