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  1. Population mail-out bowel screening programs are a convenient, cost-effective and sensitive method of detecting colorectal cancer (CRC). Despite the increased survival rates associated with early detection of ...

    Authors: Belinda C. Goodwin, Michael J. Ireland, Sonja March, Larry Myers, Fiona Crawford-Williams, Suzanne K. Chambers, Joanne F. Aitken and Jeff Dunn

    Citation: Systematic Reviews 2019 8:257

    Content type: Research

    Published on:

  2. Patient-based assessment of health services is becoming popular in measuring the standard of care. Both quantitative and qualitative methods are available. Patient satisfaction surveys are commonly used to rec...

    Authors: Maureen O. Akunne, Mathew J. Okonta, Chinwe V. Ukwe, Thomas L. Heise and Obinna I. Ekwunife

    Citation: Systematic Reviews 2019 8:256

    Content type: Protocol

    Published on:

  3. Epilepsy is one of the most common and serious brain conditions, characterised by recurrent unprovoked seizures. It affects about 1% of the population worldwide. Despite a range of antiepileptic drugs being av...

    Authors: Naomi Dvir, Muhammad S. Javaid, Nigel C. Jones, Kim L. Powell, Patrick Kwan, Terence J. O’Brien and Ana Antonic-Baker

    Citation: Systematic Reviews 2019 8:255

    Content type: Protocol

    Published on:

  4. Direct supplementation or food fortification with iron are two public health initiatives intended to reduce the prevalence of iron deficiency (ID) and iron deficiency anaemia (IDA) in 4–24-month-old infants. I...

    Authors: Dominic J. Hare, Sabine Braat, Bárbara R. Cardoso, Christopher Morgan, Ewa A. Szymlek-Gay and Beverley-Ann Biggs

    Citation: Systematic Reviews 2019 8:253

    Content type: Protocol

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  5. There is an increasing recognition that health intervention research requires methods and approaches that can engage with the complexity of systems, interventions, and the relations between systems and interve...

    Authors: Benjamin Hanckel, Mark Petticrew, James Thomas and Judith Green

    Citation: Systematic Reviews 2019 8:252

    Content type: Protocol

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  6. Heart failure is a highly prevalent disease with a global prevalence of 37 million, and the prevalence is increasing. Patients with heart failure are at an increased risk of death and morbidity. Traditionally,...

    Authors: Emil Eik Nielsen, Joshua Feinberg, Ilan Raymond, Michael Hecht Olsen, Frank Victor Steensgaard-Hansen and Janus Christian Jakobsen

    Citation: Systematic Reviews 2019 8:251

    Content type: Protocol

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  7. Chronic musculoskeletal pain affects the quality of life of older adults by interfering in their ability to perform activities of daily living. Aerobic exercise programs have been used in the treatment of vari...

    Authors: Naiane Teixeira Bastos de Oliveira, Irlei dos Santos, Gisela Cristiane Miyamoto and Cristina Maria Nunes Cabral

    Citation: Systematic Reviews 2019 8:250

    Content type: Protocol

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  8. Venous thromboembolism (VTE) is a common postoperative complication associated with significant morbidity and mortality. The use of prophylactic heparin postoperatively reduces this risk, and the use of extend...

    Authors: Bridget Heijkoop, Natalie Parker, George Kiroff and Daniel Spernat

    Citation: Systematic Reviews 2019 8:249

    Content type: Protocol

    Published on:

  9. Interpersonal psychotherapy (IPT) is an intervention that has established efficacy in the prevention and treatment of depressive disorders. Previous systematic reviews have not evaluated the effectiveness of I...

    Authors: Katherine S. Bright, Elyse M. Charrois, Muhammad Kashif Mughal, Abdul Wajid, Deborah McNeil, Scott Stuart, K. Alix Hayden and Dawn Kingston

    Citation: Systematic Reviews 2019 8:248

    Content type: Protocol

    Published on:

  10. Musculoskeletal injuries are the most common non-fatal injury from road traffic crashes. Even when the injuries are mild, they can cause pain which can affect return to work rates and work ability post-crash. ...

    Authors: Charlotte L. Brakenridge, Elise M. Gane, Esther J. Smits, Nicole E. Andrews and Venerina Johnston

    Citation: Systematic Reviews 2019 8:247

    Content type: Protocol

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  11. Despite increasing survival, cardiovascular disease remains the primary cause of death worldwide with an estimated 7.4 million annual deaths. The main symptom of ischaemic heart disease is chest pain (angina p...

    Authors: Ulver Spangsberg Lorenzen, Katrine Bredahl Buggeskov, Emil Eik Nielsen, Naqash Javaid Sethi, Christian Lildal Carranza, Christian Gluud and Janus Christian Jakobsen

    Citation: Systematic Reviews 2019 8:246

    Content type: Protocol

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  12. The optimal duration of anticoagulation after a first unprovoked venous thromboembolism (VTE) remains controversial. Deciding to stop or continue anticoagulant therapy indefinitely after completing 3 to 6 mont...

    Authors: Faizan Khan, Miriam Kimpton, Tobias Tritschler, Grégoire Le Gal, Brian Hutton, Dean A. Fergusson and Marc A. Rodger

    Citation: Systematic Reviews 2019 8:245

    Content type: Protocol

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  13. Alcohol use disorders (AUDs) in people living with HIV/AIDS (PLWH) are a significant impediment to achieving virological control. HIV non-suppression in PLWH with AUDs is mainly attributable to sub-optimal ant...

    Authors: Munyaradzi Madhombiro, Alfred Musekiwa, James January, Alfred Chingono, Melanie Abas and Soraya Seedat

    Citation: Systematic Reviews 2019 8:244

    Content type: Systematic review update

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  14. The large and increasing number of new studies published each year is making literature identification in systematic reviews ever more time-consuming and costly. Technological assistance has been suggested as ...

    Authors: Christopher R. Norman, Mariska M. G. Leeflang, Raphaël Porcher and Aurélie Névéol

    Citation: Systematic Reviews 2019 8:243

    Content type: Methodology

    Published on:

  15. New onset atrial fibrillation is the most commonly encountered arrhythmia in critically unwell patients with a reported incidence of 4% to 29%. The occurrence of new onset atrial fibrillation may precipitate a...

    Authors: Brian W. Johnston, Ruaraidh Hill, Rui Duarte, Chung Shen Chean, Danny F. McAuley, Bronagh Blackwood, Nathan Pace and Ingeborg D. Welters

    Citation: Systematic Reviews 2019 8:242

    Content type: Protocol

    Published on:

  16. Information on subgroup assessments in systematic reviews (SR) of atrial fibrillation (AF) is limited. This review aims to describe subgroup analyses in AF SRs to inform the design of SRs and randomized trials...

    Authors: Miney Paquette, Ahlam Mohammed Alotaibi, Robby Nieuwlaat, Nancy Santesso and Lawrence Mbuagbaw

    Citation: Systematic Reviews 2019 8:241

    Content type: Research

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  17. Food control is defined as a mandatory regulatory activity of enforcement aimed at ensuring that all foods during production, handling, storage, processing, and distribution are safe, wholesome, and fit for hu...

    Authors: Sizwe Makhunga, Tivani Mashamba-Thompson, Mbuzeleni Hlongwa and Khumbulani Hlongwana

    Citation: Systematic Reviews 2019 8:240

    Content type: Systematic review update

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  18. Cardiotoxicity is a known complication and one of the most adverse effects from the use of conventional treatments such as anthracyclines and trastuzumab in breast cancer (BC) care. This phenomenon has been as...

    Authors: Pedro Antunes, Dulce Esteves, Célia Nunes, Anabela Amarelo, José Fonseca-Moutinho, Vera Afreixo, Henrique Costa, Alberto Alves and Ana Joaquim

    Citation: Systematic Reviews 2019 8:239

    Content type: Protocol

    Published on:

  19. Actinic keratoses (AK) are common precancerous lesions of the skin due to cumulative sun exposure. A variety of interventions are available for the treatment; however, the majority of randomised controlled tri...

    Authors: Theresa Steeb, Markus V. Heppt, Lars Becker, Christoph Kohl, Lars E. French and Carola Berking

    Citation: Systematic Reviews 2019 8:237

    Content type: Protocol

    Published on:

  20. Over the past decades, survival rates of children born with congenital heart disease (CHD) have increased dramatically. Progress in prenatal diagnosis, less-invasive catheter techniques and perioperative inten...

    Authors: Maria Feldmann, Cinzia Ullrich, Célina Bataillard, Walter Knirsch, Martina A. Gosteli-Peter, Beatrice Latal and Ulrike Held

    Citation: Systematic Reviews 2019 8:236

    Content type: Protocol

    Published on:

  21. Acute kidney injury (AKI) causes significant morbidity and mortality in humans, and there are currently no effective treatments to enhance renal recovery. MicroRNAs (miRNAs) are short chain nucleotides that re...

    Authors: Sarah Zankar, Rosendo A. Rodriguez, Jose Luis Vinas and Kevin D. Burns

    Citation: Systematic Reviews 2019 8:235

    Content type: Protocol

    Published on:

  22. Diabetes mellitus (DM) is burgeoning as a global chronic health condition. Some studies suggest that tuberculosis (TB) can even cause diabetes in those not previously known to be diabetic, which as a corollary...

    Authors: Sonia Menon, Joel Francis, Natasha Zdraveska, Alfred Dusabimana and Samit Bhattacharyya

    Citation: Systematic Reviews 2019 8:234

    Content type: Protocol

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  23. Following publication of the original article [1], the authors opted to correct the following reference on page 3:

    Authors: Yannish Naik, Peter Baker, Ian Walker, Taavi Tillmann, Kristin Bash, Darryl Quantz, Frances Hillier-Brown and Clare Bambra

    Citation: Systematic Reviews 2019 8:233

    Content type: Correction

    Published on:

    The original article was published in Systematic Reviews 2017 6:222

  24. Falling is the most common accident of daily living and the second most prevalent cause of accidental death in the world. The complex nature of risk factors associated with falling makes those at risk amongst ...

    Authors: Flavien Quijoux, Aliénor Vienne-Jumeau, François Bertin-Hugault, Marie Lefèvre, Philippe Zawieja, Pierre-Paul Vidal and Damien Ricard

    Citation: Systematic Reviews 2019 8:232

    Content type: Protocol

    Published on:

  25. A growing number of older adults experience mild cognitive impairment (MCI) and dementia. Recent technological advances allow for traditional cognitive interventions to be administered via computers and other ...

    Authors: Abdullah Al Mahmud, Reneta Slikboer, Jennifer Stargatt and Sunil Bhar

    Citation: Systematic Reviews 2019 8:231

    Content type: Protocol

    Published on:

  26. Heavy episodic drinking (HED) refers to alcohol consumption that exceeds the recommended threshold for a given episode and increases risk for diverse negative alcohol-related consequences. A pattern of weekly ...

    Authors: Tashia D. Petker, Jillian Halladay, Lana Vedelago, Mark A. Ferro, Jalie Tucker, Mark S. Goldman, James G. Murphy and James MacKillop

    Citation: Systematic Reviews 2019 8:230

    Content type: Protocol

    Published on:

  27. Persistent levels of low-grade inflammation and T lymphocyte activation are associated with insulin resistance and type 2 diabetes that eventually lead to the development of cardiovascular diseases. Interestin...

    Authors: Vuyolwethu Mxinwa, Tawanda M. Nyambuya, Phiwayinkosi V. Dludla and Bongani B. Nkambule

    Citation: Systematic Reviews 2019 8:229

    Content type: Protocol

    Published on:

  28. Diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS) are life-threatening complications of diabetes mellitus which require prompt treatment with large volume crystalloid fluid administration....

    Authors: Benjamin Gershkovich, Shane W. English, Mary-Anne Doyle, Kusum Menon and Lauralyn McIntyre

    Citation: Systematic Reviews 2019 8:228

    Content type: Protocol

    Published on:

  29. Type 2 diabetes mellitus (T2DM) is a major public health problem worldwide. It is characterized by the increased concentration of glucose in the blood and leads to damage of the body system, especially blood v...

    Authors: Thanitsara Rittiphairoj, Krit Pongpirul, Noel T. Mueller and Tianjing Li

    Citation: Systematic Reviews 2019 8:227

    Content type: Protocol

    Published on:

  30. Results of medical tests are the main source to inform clinical decision making. The main information to assess the usefulness of medical tests for correct discrimination of patients are accuracy measures. For...

    Authors: Tim Mathes and Dawid Pieper

    Citation: Systematic Reviews 2019 8:226

    Content type: Methodology

    Published on:

  31. Tuberculosis (TB) diagnosis in children is a major challenge with up to 94% of children with TB treated empirically in TB high-burden countries. Paediatric tuberculosis (PTB) remains a major cause of morbidity...

    Authors: Emmanuel O. Babafemi, Benny P. Cherian, Betty Ouma and Gilbert Mogoko

    Citation: Systematic Reviews 2019 8:225

    Content type: Protocol

    Published on:

  32. Impacts of early childhood development (ECD) interventions (such as fostering attachment and responsiveness through communication, play and stimulation) are well known. Globally, there is increasing recognitio...

    Authors: Karen M. Edmond, Natalie A. Strobel, Claire Adams and Dan McAullay

    Citation: Systematic Reviews 2019 8:224

    Content type: Protocol

    Published on:

  33. Traffic-related air pollution (TRAP) is one of the major sources of exposure in urban areas and has been associated with a wide range of adverse human health effects. Much of the Canadian population is regular...

    Authors: Carlyn J. Matz, Marika Egyed, Robyn Hocking, Shayesta Seenundun, Nick Charman and Nigel Edmonds

    Citation: Systematic Reviews 2019 8:223

    Content type: Protocol

    Published on:

  34. Cognitive changes associated with mild cognitive impairment or mild dementia can lead to difficulties in completing instrumental activities of daily living. The ability to live independently at home and in the...

    Authors: Nikki Tulliani, Michelle Bissett, Rosalind Bye, Katrina Chaudhary, Paul Fahey and Karen P. Y. Liu

    Citation: Systematic Reviews 2019 8:222

    Content type: Protocol

    Published on:

  35. Atrial fibrillation (AF) is the arrhythmia most commonly diagnosed in clinical practice. It is associated with significant morbidity and mortality. Prevalence of AF and complications of AF, estimated by hospit...

    Authors: Janine Dretzke, Naomi Chuchu, Winnie Chua, Larissa Fabritz, Susan Bayliss, Dipak Kotecha, Jonathan J. Deeks, Paulus Kirchhof and Yemisi Takwoingi

    Citation: Systematic Reviews 2019 8:221

    Content type: Protocol

    Published on:

  36. Musculoskeletal disorders (MSDs) are the leading cause of work disability and sickness absence worldwide. The prevalence of MSDs increases with age, consequently challenging sustainable employability among the...

    Authors: Karina Glies Vincents Seeberg, Lars Louis Andersen, Elizabeth Bengtsen and Emil Sundstrup

    Citation: Systematic Reviews 2019 8:219

    Content type: Protocol

    Published on:

  37. Hyperglycemia in pregnancy (HIP) has been recently differentiated between diabetes in pregnancy (DIP) and gestational diabetes mellitus (GDM). The proposed protocol is relevant, and clinical concern is due to ...

    Authors: Bianca Fioravanti Nicolosi, Debora F. Leite, Jussara Mayrink, Renato T. Souza, José Guilherme Cecatti and Iracema de Mattos Paranhos Calderon

    Citation: Systematic Reviews 2019 8:218

    Content type: Protocol

    Published on:

  38. Lung cancer is the most commonly diagnosed cancer with 11.6% of the total cases attributable to lung cancer. It is currently the leading cause of death among cancer-related deaths worldwide. This is a major pu...

    Authors: Siyabonga B. Dlamini, Benn Sartorius and Themba Ginindza

    Citation: Systematic Reviews 2019 8:217

    Content type: Protocol

    Published on:

  39. To inform recommendations by the Canadian Task Force on Preventive Health Care by systematically reviewing direct evidence on the effectiveness and acceptability of screening adults 40 years and older in prima...

    Authors: Michelle Gates, Jennifer Pillay, Guylène Thériault, Heather Limburg, Roland Grad, Scott Klarenbach, Christina Korownyk, Donna Reynolds, John J. Riva, Brett D. Thombs, Gregory A. Kline, William D. Leslie, Susan Courage, Ben Vandermeer, Robin Featherstone and Lisa Hartling

    Citation: Systematic Reviews 2019 8:216

    Content type: Protocol

    Published on:

  40. Osteoarthritis is a debilitating condition as well as a growing global health problem, and total knee arthroplasty is an effective treatment for advanced stages of disease. Unplanned 30-day hospital readmissio...

    Authors: Daniel Gould, Michelle Dowsey, Tim Spelman, Imkyeong Jo, Wassif Kabir, Jason Trieu and Peter Choong

    Citation: Systematic Reviews 2019 8:215

    Content type: Protocol

    Published on:

  41. Acute kidney injury requiring dialysis (AKI-D) during hospitalization is associated with both in-hospital and post-discharge mortality. Its incidence has risen over time in Canada and the USA. While the majori...

    Authors: Carol Wang, Swapnil Hiremath, Lindsey Sikora, Manish M. Sood, Jennifer Kong and Edward Clark

    Citation: Systematic Reviews 2019 8:214

    Content type: Protocol

    Published on:

  42. Historically, individual doctors were responsible for maintaining their own professional competence. More recently, changing patient expectations, debate about the appropriateness of professional self-regulati...

    Authors: Anél Wiese, Emer Galvin, Charlotte Merrett, Irina Korotchikova, Dubhfeasa Slattery, Lucia Prihodova, Hilary Hoey, Ann O’Shaughnessy, Jantze Cotter, Janet O’Farrell, Mary Horgan and Deirdre Bennett

    Citation: Systematic Reviews 2019 8:213

    Content type: Protocol

    Published on:

  43. Thrombotic microangiopathy is an uncommon complication of snake envenoming associated with a subset of snakebite cases presenting with venom-induced consumption coagulopathy. It presents with microangiopathic ...

    Authors: Tina Noutsos, Bart J. Currie and Geoffrey K. Isbister

    Citation: Systematic Reviews 2019 8:212

    Content type: Protocol

    Published on:

  44. A growing body of literature indicates that, worldwide, immigrants experience health deterioration after their arrival into their adopted country, and moreover, they have lower vitamin D compared to the native...

    Authors: Said Yousef, Jesse Elliott, Douglas Manuel, Ian Colman, Manny Papadimitropoulos, Alomgir Hossain, Nathalie Leclair and George A. Wells

    Citation: Systematic Reviews 2019 8:211

    Content type: Protocol

    Published on:

  45. Several individual epidemiological studies in Ethiopia suggest that syphilis is a public health problem. However, to the best of our knowledge, there is no synthesized and meta-analysis data on the epidemiolog...

    Authors: Kindie Mitiku Kebede, Dejene Derseh Abateneh, Alemayehu Sayih Belay and Gizachew Ayele Manaye

    Citation: Systematic Reviews 2019 8:210

    Content type: Protocol

    Published on:

  46. Insufficient iodine intake in pregnancy is associated with many adverse pregnancy outcomes. About 90% of African countries are at risk of iodine deficiency due to poor soils and dietary goitrogens. Pregnancy p...

    Authors: Charles Bitamazire Businge, Benjamin Longo-Mbenza and Andre Pascal Kengne

    Citation: Systematic Reviews 2019 8:209

    Content type: Protocol

    Published on:

  47. Neuropathic pain affects 7–10% of people, but responds poorly to pharmacotherapy, indicating a need for better treatments. Mechanistic research on neuropathic pain frequently uses human surrogate models of the...

    Authors: Victoria J. Madden, Gillian J. Bedwell, Prince C. Chikezie, Andrew S. C. Rice and Peter R. Kamerman

    Citation: Systematic Reviews 2019 8:208

    Content type: Protocol

    Published on:

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