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  1. Content type: Research

    Treatment with anti-tuberculosis drugs may cause patients to experience serious adverse effects. Genetic factors, such as polymorphisms of CYP genes, may increase the likelihood of a patient experiencing such adv...

    Authors: Marty Richardson, Jamie Kirkham, Kerry Dwan, Derek J. Sloan, Geraint Davies and Andrea L. Jorgensen

    Citation: Systematic Reviews 2018 7:204

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  2. Content type: Protocol

    In low- and middle-income countries (LMICs), the burden of non-communicable diseases (NCDs) is growing against an existing burden of other diseases such as HIV/AIDS. Integrated models of care can help address ...

    Authors: Jeannine Uwimana Nicol, Anke Rohwer, Taryn Young, Charlotte M Bavuma and Joerg J Meerpohl

    Citation: Systematic Reviews 2018 7:203

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    The Correction to this article has been published in Systematic Reviews 2019 8:36

  3. Content type: Protocol

    Musculoskeletal injuries (strains/sprains, contusions, dislocations, and fractures) are the most common injury sustained in a road traffic crash. They can have a long-term impact upon the ability to engage in ...

    Authors: Elise M. Gane, Charlotte L. Brakenridge, Esther J. Smits and Venerina Johnston

    Citation: Systematic Reviews 2018 7:202

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  4. Content type: Protocol

    Malaria control and prevention efforts continue to rely heavily on the use of medicines especially artemisinin agents. However, currently, the emergence of artemisinin resistance threatens this effort globally...

    Authors: Moses Ocan, Dickens Akena, Sam Nsobya, Moses R. Kamya, Richard Senono, Alison Annet Kinengyere and Ekwaro Obuku

    Citation: Systematic Reviews 2018 7:199

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  5. Content type: Systematic review update

    There is scanty or inconclusive evidence on which cervical cancer screening tool is effective and suitable for human immunodeficiency virus (HIV)-seropositive women. The aim of this review was to assess, synth...

    Authors: Witness Mapanga, Brendan Girdler-Brown, Shingairai A. Feresu, Tsungai Chipato and Elvira Singh

    Citation: Systematic Reviews 2018 7:198

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  6. Content type: Protocol

    Stroke rehabilitation aims to optimise function and reduce complications post-stroke. Rehabilitation to optimise physical function post-stroke has beneficial effects for survivors of mild to moderate stroke. H...

    Authors: Mark P. McGlinchey, Jimmy James, Christopher McKevitt, Abdel Douiri, Sarah McLachlan and Catherine M. Sackley

    Citation: Systematic Reviews 2018 7:197

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  7. Content type: Research

    Universal health coverage (UHC) is a key area in post-2015 global agenda which has been incorporated as target for achieving health-related Sustainable Development Goals (SDGs). A global framework has been dev...

    Authors: K. M. Saif-Ur-Rahman, Iqbal Anwar, Md. Hasan, Shahed Hossain, Sohana Shafique, Fariha Haseen, Md. Khalequzzaman, Aminur Rahman and Shariful Islam

    Citation: Systematic Reviews 2018 7:196

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  8. Content type: Research

    This review assesses the utility of applying an automated content analysis method to the field of mental health policy development. We considered the possibility of using the Wordscores algorithm to assess res...

    Authors: Kristel Alla, Florin Oprescu, Wayne D. Hall, Harvey A. Whiteford, Brian W. Head and Carla S. Meurk

    Citation: Systematic Reviews 2018 7:194

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  9. Content type: Research

    Pediatric type 2 diabetes mellitus (T2DM) is a relatively new disease with increasing incidence corresponding to the obesity epidemic among youth. It is important for clinicians to have access to high-quality ...

    Authors: Meha Bhatt, Ahmed Nahari, Pei-Wen Wang, Emily Kearsley, Nicole Falzone, Sondra Chen, Erin Fu, Yaanu Jeyakumar, Justyna Zukowski, Laura Banfield, Lehana Thabane and M. Constantine Samaan

    Citation: Systematic Reviews 2018 7:193

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  10. Content type: Protocol

    Momordica charantia Linnaeus (Cucurbitaceae) has been used traditionally as a nutritious food and as a herbal medicine for type 2 diabetes mellitus. However, human studies that investigated its glycemic control h...

    Authors: Emanuel L. Peter, Serawit Deyno, Andrew Mtewa, Félicien Mushagalusa Kasali, Prakash B. Nagendrappa, Duncan Sesaazi, Casim Umba Tolo and Patrick Engeu Ogwang

    Citation: Systematic Reviews 2018 7:192

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  11. Content type: Research

    Originator trastuzumab (Herceptin®; H) is an antibody-targeted therapy to treat patients with human epidermal growth factor receptor 2-positive (HER2+) early breast cancer (EBC). We investigated the overall su...

    Authors: Florence R. Wilson, Megan E. Coombes, Christine Brezden-Masley, Mariya Yurchenko, Quinlan Wylie, Reuben Douma, Abhishek Varu, Brian Hutton, Becky Skidmore and Chris Cameron

    Citation: Systematic Reviews 2018 7:191

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  12. Content type: Research

    Schools can play an important role in promoting health. However, many education policies and institutions are increasingly emphasising academic attainment targets, which appear to be diminishing the time avail...

    Authors: Tara Tancred, Sara Paparini, G. J. Melendez-Torres, James Thomas, Adam Fletcher, Rona Campbell and Chris Bonell

    Citation: Systematic Reviews 2018 7:190

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  13. Content type: Protocol

    Evidence from diverse areas of medicine (e.g., cardiovascular disease, diabetes) indicates that healthcare providers (HCPs) often do not adhere to clinical practice guidelines (CPGs) despite a clear indication...

    Authors: Joshua A. Rash, Norman Buckley, Jason W. Busse, Tavis S. Campbell, Kim Corace, Lynn Cooper, David Flusk, Alfonso Iorio, Kim L. Lavoie, Patricia A. Poulin and B. Skidmore

    Citation: Systematic Reviews 2018 7:189

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  14. Content type: Protocol

    Shoulder pain is a common problem in the general population and is responsible for prolonged periods of disability, loss of productivity, absence from work and inability to carry out household activities. Rota...

    Authors: Gemma Greenall, Andrew Carr, David Beard, Jonathan Rees, Amar Rangan, Naomi Merritt, Melina Dritsaki, Navraj S. Nagra, Mathew Baldwin, Sally Hopewell and Jonathan A. Cook

    Citation: Systematic Reviews 2018 7:187

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  15. Content type: Protocol

    A patent microvascular anastomosis is of paramount importance in free tissue transfer. Anastomotic coupler devices provide an alternative to technically demanding hand-sewn venous anastomosis. Various advantag...

    Authors: Timo Rodi, Alexander Geierlehner, Afshin Mosahebi, Grigorios Tanos and Justin Conrad Rosen Wormald

    Citation: Systematic Reviews 2018 7:186

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  16. Content type: Protocol

    Congenital diaphragmatic hernia is a rare and life-threatening anomaly that occurs during fetal development and results in an incomplete or incorrect formation of the diaphragm. Surgical therapy of the diaphra...

    Authors: Johannes Morche, Tim Mathes, Anja Jacobs, Barbara Pietsch, Lucas Wessel, Sabine Gruber, Edmund A. M. Neugebauer and Dawid Pieper

    Citation: Systematic Reviews 2018 7:185

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  17. Content type: Protocol

    Inflammatory bowel disease (IBD) is a debilitating chronic disease characterised by inflammation and ulceration of the gastrointestinal tract. It is associated with a range of debilitating symptoms and reduced...

    Authors: Sophie Elizabeth Beese, Isobel Marion Harris, David Moore and Janine Dretzke

    Citation: Systematic Reviews 2018 7:184

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  18. Content type: Systematic review update

    Nearly 15% of pregnancies end in fatal perinatal obstetric complications including bleeding, infections, hypertension, obstructed labour and complications of abortion. Globally, an estimated 10.7 million women...

    Authors: Ayele Geleto, Catherine Chojenta, Abdulbasit Musa and Deborah Loxton

    Citation: Systematic Reviews 2018 7:183

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  19. Content type: Research

    Visual impairment from diabetic retinopathy (DR) is an increasing global public health concern, which is preventable with screening and early treatment. Digital retinal imaging has become a preferred choice as...

    Authors: Mapa Mudiyanselage Prabhath Nishantha Piyasena, Gudlavalleti Venkata S. Murthy, Jennifer L. Y. Yip, Clare Gilbert, Tunde Peto, Iris Gordon, Suwin Hewage and Sureshkumar Kamalakannan

    Citation: Systematic Reviews 2018 7:182

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  20. Content type: Protocol

    There are growing professional expectations for nurses to engage in and develop competence in evidence-informed decision-making (EIDM) due to opportunities for improved client and community outcomes and provis...

    Authors: Emily Belita, Jennifer Yost, Janet E. Squires, Rebecca Ganann, Trish Burnett and Maureen Dobbins

    Citation: Systematic Reviews 2018 7:181

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  21. Content type: Protocol

    Liver transplant recipients suffer many complications, but few intraoperative interventions supported by high-quality evidence have been found effective to reduce their incidence or severity. Fluid balance has...

    Authors: François Martin Carrier, Michaël Chassé, Han Ting Wang, Pierre Aslanian, Marc Bilodeau and Alexis F. Turgeon

    Citation: Systematic Reviews 2018 7:180

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  22. Content type: Protocol

    Parents of babies admitted to neonatal units experience an arduous emotional journey. Feelings of helplessness, fear, sadness, guilt, grief and anger are common. These feelings can lead to anxiety, depression ...

    Authors: Harriet Hunt, Rebecca Whear, Kate Boddy, Leanna Wakely, Alison Bethel, Christopher Morris, Rebecca Abbott, Susan Prosser, Andrew Collinson, Jennifer Kurinczuk and Jo Thompson-Coon

    Citation: Systematic Reviews 2018 7:179

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  23. Content type: Protocol

    Data on the effects of motivational interviewing (MI) on modifying unhealthy lifestyles and promoting weight status during childhood is controversial. Adolescents are more prone to assume higher personal respo...

    Authors: Parisa Amiri, Elham Kazemian, Mohammad Masih Mansouri-Tehrani, Ahmad Khalili and Atieh Amouzegar

    Citation: Systematic Reviews 2018 7:178

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  24. Content type: Protocol

    Chronic diseases contribute to about half of the adult disease burden in the South Asian region. Meanwhile, physical activity levels are declining despite the global evidence of its role in the prevention of c...

    Authors: Susan Paudel, Alice J. Owen, Ebenezer Owusu-Addo and Ben J. Smith

    Citation: Systematic Reviews 2018 7:177

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  25. Content type: Research

    Outcome after nerve repair of the hand needs standardized psychometrically robust measures. We aimed to systematically review the psychometric properties of available functional, motor, and sensory assessment ...

    Authors: Marisa de Cássia Registro Fonseca, Valéria Meireles Carril Elui, Emily Lalone, Natália Claro da Silva, Rafael Inácio Barbosa, Alexandre Márcio Marcolino, Flávia Pessoni Faleiros Macedo Ricci and Joy C. MacDermid

    Citation: Systematic Reviews 2018 7:175

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  26. Content type: Protocol

    People with mobility impairments may have difficulties in everyday life motor activities, and assessing these difficulties is crucial to plan rehabilitation interventions and evaluate their effectiveness. Wear...

    Authors: Fabian Marcel Rast and Rob Labruyère

    Citation: Systematic Reviews 2018 7:174

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  27. Content type: Protocol

    Acute kidney injury (AKI) refers to a broad spectrum of kidney damage and is attributed a high morbidity and mortality rate at all degrees of severity. Obesity increases the risk for developing AKI. However, s...

    Authors: Maria P Barrett, David Moore, Fang Gao Smith and Indranil Dasgupta

    Citation: Systematic Reviews 2018 7:173

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  28. Content type: Research

    Systematic reviews (SRs) depend on comprehensive searches for evidence to provide balanced, accurate results. Requesting published and unpublished studies from pharmaceutical manufacturers has been proposed as...

    Authors: Marian S. McDonagh, Sujata Thakurta and Kim Peterson

    Citation: Systematic Reviews 2018 7:172

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  29. Content type: Protocol

    Respiratory failure requiring mechanical ventilation is a common manifestation of end-organ damage among patients with sepsis and has a high morbidity and mortality rate, as well as substantial associated trea...

    Authors: Thomas P. Clyde, Michael Coletta, Christopher Jones, Hope Kilgannon, Brian M. Fuller, Stephen Trzeciak and Brian W. Roberts

    Citation: Systematic Reviews 2018 7:171

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  30. Content type: Research

    Postpartum hemorrhage (PPH) and the amount of blood loss are directly related to management of the third stage of labor. No previous report has compared the effects of carbetocin to those of misoprostol. The a...

    Authors: Mohamed A. Abd El Aziz, Ahmed Iraqi, Parvin Abedi and Shayesteh Jahanfar

    Citation: Systematic Reviews 2018 7:170

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  31. Content type: Protocol

    Acute critical bleeding is one of the most feared complications during treatment with oral anticoagulating agents. As more patients undergo treatment with anticoagulating agents, critically bleeding episodes i...

    Authors: Christian Ovesen, Jan Purrucker, Christian Gluud, Janus Christian Jakobsen, Hanne Christensen and Thorsten Steiner

    Citation: Systematic Reviews 2018 7:169

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  32. Content type: Research

    Conducting systematic reviews is time-consuming but crucial to construct evidence-based patient decision aids, clinical practice guidelines and decision analyses. New methods might enable developers to produce...

    Authors: Øystein Eiring, Kjetil Gundro Brurberg, Kari Nytrøen and Magne Nylenna

    Citation: Systematic Reviews 2018 7:168

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  33. Content type: Protocol

    The burden of non-communicable diseases such as type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVDs) has drastically increased in developing countries over the years. Although recent evidence poi...

    Authors: Tawanda M. Nyambuya, Phiwayinkosi V. Dludla and Bongani B. Nkambule

    Citation: Systematic Reviews 2018 7:167

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  34. Content type: Protocol

    Systematic information retrieval generally requires a two-step selection process for studies, which is conducted by two persons independently of one another (double-screening approach). To increase efficiency,...

    Authors: Siw Waffenschmidt, Elke Hausner, Wiebke Sieben, Thomas Jaschinski, Marco Knelangen and Inga Overesch

    Citation: Systematic Reviews 2018 7:166

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  35. Content type: Protocol

    Dyslipidemia is a major risk factor in triggering cardiovascular events, which can lead to the death of millions of people around the world. Thus, several pharmacological and non-pharmacological therapeutic st...

    Authors: Patricia M. Fortes, Solomar M. Marques, Karolline A. Viana, Luciane R. Costa, Alessandra V. Naghettini and Paulo Sucasas Costa

    Citation: Systematic Reviews 2018 7:165

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  36. Content type: Protocol

    Ethnic minorities in multi-ethnic societies like the UK and USA have poorer outcomes for some cancer types when compared with the majority. The causes of ethnic inequalities in cancer outcomes are complex and ...

    Authors: Bogdan Chiva Giurca, William Hamilton and Tanimola Martins

    Citation: Systematic Reviews 2018 7:164

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  37. Content type: Protocol

    Osteoarthritis is a degenerative joint disease that is highly prevalent worldwide. Knee osteoarthritis is the most common form of osteoarthritis and is a major cause of pain and disability. However, there rema...

    Authors: En Lin Goh, Winston Choong Ngan Lou, Swathikan Chidambaram and Shaocheng Ma

    Citation: Systematic Reviews 2018 7:162

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  38. Content type: Research

    Diabetes mellitus (DM) poses a significant risk for the development of active tuberculosis (TB) and complicates its treatment. However, there is inconclusive evidence on whether the TB-DM co-morbidity is assoc...

    Authors: Balewgizie Sileshi Tegegne, Melkamu Merid Mengesha, Andreas A. Teferra, Mamaru Ayenew Awoke and Tesfa Dejenie Habtewold

    Citation: Systematic Reviews 2018 7:161

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  39. Content type: Research

    Attentional bias modification (ABM) interventions have been developed to address addiction by reducing attentional bias for substance-related cues. This study provides a systematic review of the effectiveness ...

    Authors: Janika Heitmann, Elise C. Bennik, Madelon E. van Hemel-Ruiter and Peter J. de Jong

    Citation: Systematic Reviews 2018 7:160

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  40. Content type: Methodology

    Overviews of systematic reviews (SRs) attempt to systematically retrieve and summarise the results of multiple systematic reviews. This is the second of two papers from a study aiming to develop a comprehensiv...

    Authors: Carole Lunny, Sue E. Brennan, Steve McDonald and Joanne E. McKenzie

    Citation: Systematic Reviews 2018 7:159

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  41. Content type: Protocol

    Magnetic resonance spectroscopy (MRS) is a non-invasive analytical technique that investigates the presence and concentrations of brain metabolites. In the context of major depressive disorder (MDD), MRS has r...

    Authors: Thomas Drago, Patrick W O’Regan, Ivan Welaratne, Shane Rooney, Aoife O’Callaghan, Marissa Malkit, Elena Roman, Kirk J Levins, Lauren Alexander, Denis Barry, Erik O’Hanlon, Veronica O’Keane and Darren William Roddy

    Citation: Systematic Reviews 2018 7:158

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  42. Content type: Protocol

    According to the United Nations Trends in Contraceptive Use 2015 report, at least one in ten married or in-union women in most regions of the world has an unmet need for family planning. Family Planning 2020 r...

    Authors: Shimona Prosad, Tivani P Mashamba-Thompson and Elizabeth Ojewole

    Citation: Systematic Reviews 2018 7:157

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  43. Content type: Research

    Postpartum haemorrhage is a direct cause of maternal death worldwide and usually occurs during the third stage of labour. Most women receive some type of prophylactic management, which may include pharmacologi...

    Authors: Yuko Masuzawa, Yaeko Kataoka, Kana Fujii and Satomi Inoue

    Citation: Systematic Reviews 2018 7:156

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  44. Content type: Protocol

    By 2035, older adults will outnumber children for the first time in the United States (US). In light of its aging population, the US has supported services focused on enabling older adults to continue living i...

    Authors: Amy Rosenwohl-Mack, Karen Schumacher, Min-Lin Fang and Yoshimi Fukuoka

    Citation: Systematic Reviews 2018 7:155

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  45. Content type: Protocol

    Surgical site infection describes an infectious complication of surgical wounds. This single complication is thought to occur in close to 20% of surgical cases. This complication has been described in all kind...

    Authors: Dawid Pieper, Tanja Rombey, Johannes Doerner, Julian-Dario Rembe, Hubert Zirngibl, Konstantinos Zarras and Peter C. Ambe

    Citation: Systematic Reviews 2018 7:152

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