Skip to main content

Quality of conduct and reporting in rapid reviews: an exploration of compliance with PRISMA and AMSTAR guidelines



Rapid reviews are an accelerated evidence synthesis approach intended to meet the timely needs of decision-makers in healthcare settings. Quality of conduct and reporting has been described in the rapid review literature; however, no formal assessment has been carried out using available instruments. The objective of this study was to explore compliance with conduct and reporting guidelines in rapid reviews published or posted online during 2013 and 2014.


We performed a comprehensive literature search for rapid reviews using multiple bibliographic databases (e.g. PubMed, MEDLINE, EMBASE, the Cochrane Library) through December 31, 2014. Grey literature was searched thoroughly, and health technology assessment agencies were surveyed to identify additional rapid review products. Candidate reviews were assessed for inclusion using pre-specified eligibility criteria. Detailed data was collected from the included reviews on study and reporting characteristics and variables significant to rapid reviews (e.g. nomenclature, definition). We evaluated the quality of conduct and reporting of included rapid reviews using the A Measurement Tool to Assess Systematic Reviews (AMSTAR) and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklists. Compliance with each checklist item was examined, and the sum of adequately reported items was used to describe overall compliance. Rapid reviews were stratified to explore differences in compliance related to publication status. The association between compliance and time to completion or length of publication was explored through univariate regression.


Sixty-six rapid reviews were included. There were heterogeneous nomenclature, research questions and approaches to rapid reviews. Compliance with AMSTAR and PRISMA checklists was poor. Published rapid reviews were compliant with individual PRISMA items more often than unpublished reviews, but no difference was seen in AMSTAR item compliance overall. There was evidence of an association between length of publication and time to completion and the number of adequately reported PRISMA or AMSTAR items.


Transparency and inadequate reporting are significant limitations of rapid reviews. Scientific editors, authors and producing agencies should ensure that the reporting of conduct and findings is accurate and complete. Further research may be warranted to explore reporting and conduct guidelines specific to rapid reviews and how these guidelines may be applied across the spectrum of rapid review approaches.

Peer Review reports


Healthcare decision-makers at all levels are under constant pressure to make timely evidence-informed policy or practice decisions. Although highly valued, the time needed to complete a full systematic review of the literature often exceeds the time that end-users have to evaluate evidence or incorporate it into their processes. Rapid reviews are an accelerated evidence synthesis approach specifically intended to meet the needs of knowledge users in healthcare settings [1, 2]. Ideally, to minimize potential sources of bias, a rapid review should follow frameworks for systematic review conduct, such as those published by the Cochrane Collaboration, as closely as time will allow. However, in order to pragmatically achieve timely delivery of evidence, certain concessions are often made in these processes. Attempts have been made to describe and assess rapid reviews through selection and careful appraisal of exemplar samples [1, 36]. The characteristics of rapid reviews, and the limitations of these products, have been described in previous work [1, 6, 7]. Heterogeneity of rapid review approaches and poor reporting of methods or processes have been consistently observed, making evaluation of these evidence products difficult [6]. This, in turn, makes it difficult for decision-makers to quantify any bias that may have been introduced or to judge how much value to place on the evidence contained in a rapid review.

Rapid reviews are created by a variety of producers worldwide, including individuals, independent research groups, and organizations and agencies, which offer rapid evidence services to their stakeholders. Many rapid review products are not published, and the majority are not indexed in health-related bibliographic databases (e.g. MEDLINE, CINAHL) [7]. The diverse nomenclature used to describe these approaches also makes it difficult to identify rapid reviews using traditional search methods. This is complicated further by the lack of an accepted or validated definition for rapid reviews, which results in the term ‘rapid review’ having different meanings to the assortment of stakeholders who produce or use them [2, 8].

There are currently no guidelines or accepted rules for the reporting or conduct of rapid reviews. The Preferred Reporting Items of Systematic Reviews and Meta-Analyses (PRISMA) statement and the A Measurement Tool to Assess Systematic Reviews (AMSTAR) checklist are reliable and practical instruments designed to help end-users discriminate between systematic reviews with a focus on quality of reporting and conduct [9, 10]. Both have become widely accepted by publishing agencies and evidence producers since 2011. Given the aim of rapid reviews to optimize to the extent possible a systematic process while synthesizing evidence and balancing the timely requirements of healthcare decision-making, it is feasible that these tools could also be applied to rapid reviews. No studies to date have applied validated reporting or conduct instruments such as PRISMA or AMSTAR to rapid reviews with the goal of assessing the quality of conduct and reporting, although previous work has suggested this task may be helpful to improve reporting transparency [4].

Given the above, and the importance of rapid reviews to decision-makers, this study was carried out to explore the general study characteristics of these research products. We also aimed to evaluate the quality of both process and reporting in both journal-published and unpublished (grey literature) rapid evidence synthesis products through measurement of compliance with the PRISMA and AMSTAR checklists. The secondary aims were to explore whether the time to completion or the length of the report influenced instrument compliance.


The strategy for locating rapid reviews and assessing the quality of their conduct and reporting involved three fundamental steps. First, a protocol was developed in August 2011 in consultation with methodological experts in knowledge synthesis, health technology assessment (HTA), and evidence-based decision-making. Second, a broad and comprehensive literature search was carried out to identify published and unpublished samples of rapid reviews produced internationally since 2005. Third, an in-depth examination of the characteristics of the included rapid reviews was conducted. We examined the quality of reporting and process for both published and unpublished rapid reviews using validated tools (AMSTAR and PRISMA) and compared the results to identify areas for improvement. In addition, we explored a variety of common themes identified in previously published work in the area of accelerated evidence synthesis.

Information sources

Comprehensive literature searches were conducted with the assistance of an experienced medical information specialist knowledgeable in evidence synthesis and rapid reviews. Search strategies were peer-reviewed [11] and used both controlled vocabulary (e.g. National Library of Medicine’s MeSH terms) and keywords. Between October 25 and 31, 2011 we searched PubMed, MEDLINE (Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily and Ovid MEDLINE(R) 1948 to Present;), EMBASE (Ovid, 1980 to 2011 Week 42), the Cochrane library, York Centre for Reviews and Dissemination (CRD) Database of Abstracts of Reviews of Effects (DARE), NHS Economic Evaluation Database (EED) and HTA, Web of Science, National Library of Medicine Gateway, and CINAHL (EBSCOHost). Search updates were carried out monthly until December 31, 2014 (see Additional file 1).

A thorough grey literature search was conducted using CADTH’s Grey matters: A search tool for evidence-based medicine ( to identify rapid reviews not formally published in peer-reviewed journals and rapid reviews produced by organizations and agencies whose products are not indexed in the bibliographic databases searched. The grey literature search was augmented by a general Internet search (Google/Google Scholar) to identify web-based reports. The searches were supplemented by reviewing the bibliographies of key papers and conference proceedings, citation mapping and hand searching of HTA agencies known to deliver rapid review services. The searches were large in scope and intentionally unrestricted in order to capture the wide variety of published and unpublished products falling under the global term of ‘rapid review’.

Scan of HTA agency rapid reviews

In order to more comprehensively identify rapid review producers, we supplemented the formal literature search with an email scan of International Network of Agencies for Health Technology Assessment (INAHTA) agencies circulated in November 2011. Each organization was asked:

  1. 1.

    Does your agency currently undertake rapid review?

  2. 2.

    What timeframes do you offer for your rapid review products?

  3. (a)

    If NO, does your agency have plans to produce rapid reviews in the future?

  4. (b)

    If YES, what type of rapid review products does your agency produce?

  5. 3.

    Are your rapid reviews publicly available on your website? If so, can you please forward the URL/address?

Screening and selection

Broad eligibility criteria were piloted on a sample of 100 database records following the literature search. These criteria were revised to improve specificity and then applied to each title and abstract identified by one reviewer (LAT) in a standardized manner. A second review author (SK) screened a random sample (10 %) of excluded records. Any uncertainties were resolved by discussion and consensus with a third review author (TC or DM). Any candidate rapid review passing the initial selection criteria with a definite or unclear status, along with all potential samples identified in the grey literature search, was obtained in full-text format. One reviewer (SK) applied the eligibility criteria and made a final decision for inclusion.

Eligibility criteria

Due to the diversity of methodologies, production timelines and nomenclature used in the previous rapid review research [13], we followed inclusive selection criteria to identify candidate studies (Fig. 1).

Fig. 1

Eligibility criteria for rapid review selection

Rapid reviews were included regardless of publication status. The protocol was revised prior to data extraction to limit the eligibility of rapid reviews to those produced between January 1, 2013 and December 31, 2014. This revision was necessary in order to obtain a manageable sample of rapid reviews and to ensure that the samples collected reflected current practice given the continuous evolution of rapid review approaches between 2005 and 2014. We included all journal-published rapid reviews meeting the eligibility criteria in the specified timeframe and an equivalent number of agency-produced samples located in the grey literature. Hereafter, journal-published rapid reviews are referred to as ‘published’ while those located in the grey literature are referred to as ‘unpublished’ rapid reviews. Where organizations produced multiple rapid reviews in a single year, a random selection of two samples from all available 2013 or 2014 rapid reviews was made for inclusion. No more than two samples from a single organization were included.

Data abstraction

A single reviewer (SK) abstracted data into a Microsoft Excel 2007 spreadsheet standardized for the project. Five samples were used to pilot the form, and revisions were made before global extraction. Data was collected from included rapid reviews for study characteristics (e.g. primary author or agency, country, date posted or published, date submitted/accepted (if applicable), number of authors, eligibility and selection criteria, type of research questions, purpose, type of decision under consideration, number of outcomes, funding, use of supplemental appendices), methodological processes (approach, use of protocol/protocol elements reported, number of reviewers screening/extracting/performing assessment of research quality, search date, number of bibliographic databases searched, date/language or geographical filters applied to search or screening, additional search methods employed (e.g. grey literature, hand searching, trial registries, citation mapping) instruments used for quality assessment, use of Grading of Recommendations Assessment, Development and Evaluation (GRADE), types of study included, use of internal or external peer-review), author-reported limitations or disclaimers, rapid review definitions and nomenclature, length of report (in pages) and time frames for completion where reported. We also assessed if findings were framed in context with any reported decision-making need.

In the case where unpublished rapid review methods were not reported or a source document was referenced, agency and organization websites were checked for additional clarification of process. Details on methods or approach were extracted from additional source documents if described in such a way that no variation in process was expected and the process for all rapid review products was standardized and clear. Data were not used if the associated documentation stated that that the method was used ‘sometimes’ or that methods were report-specific.

Data synthesis and quality appraisal

Data were extracted for published and unpublished rapid reviews separately and then aggregated into a single table for evaluation. Variables were synthesized narratively and summarized using descriptive statistics (frequencies, proportions and percentages) and category groupings (e.g. number of authors, length in pages).

Two dimensions of rapid review reporting and methodological conduct were explored. First, we applied the A Measurement Tool to Assess Systematic Reviews (AMSTAR) checklist, an 11-item measurement tool validated to critically appraise the methodological quality of systematic reviews using currently understood knowledge on bias potentially introduced through conduct in evidence synthesis. We used the AMSTAR checklist to evaluate each included review to examine the overall, and by-item, quality of conduct. Response options for each domain were ‘yes’, ‘no’, ‘can’t answer’ and ‘not applicable’, and domains that were partially answered were recorded by noting which item was answered adequately. We counted each sufficiently reported domain (answer = ‘yes’) and summed responses based on a maximum possible count of 11.

Next, we evaluated the reporting quality of the rapid review samples using the PRISMA statement. The PRISMA statement is a 27-item (and 4-item flow diagram) measure of overall reporting strength for evidence syntheses reporting randomized controlled trials (RCTs). We chose this instrument as it is widely accepted as a scientific standard for reporting of secondary studies of RCTs that can also be applied to other types of research, including healthcare interventions. Response options for each item were ‘yes’, ‘no’ and ‘not applicable’, and we recorded items that were partially answered (e.g. for item 5, if the use of a protocol was mentioned but no registration number was provided). Each included study was evaluated individually, and we counted each sufficiently reported item (answer = ‘yes’) and summed responses based on a maximum possible count of 27.

Overall compliance with PRISMA and AMSTAR were calculated as an overall sum of adequately met items for each rapid review, a mean or median numbers of items reported adequately across all included rapid reviews (overall and by domain), and then stratified by publication status for exploratory analysis.

We explored the potential confounding effect of journal word limits (represented by length in pages) and the impact of time to completion on the number of PRISMA or AMSTAR items adequately reported or met. We carried out univariate regression in Microsoft Office Excel 2007 using the ‘Real Statistics’ data add-in ( Extracted data on the length of the publication (in pages, excluding references and appendices) and reported times to completion for all included studies were used. Rapid reviews were stratified by publication status for additional analyses and documented the proportion of adequately reported PRISMA and AMSTAR checklist items.


Selection of rapid review samples

Fourteen HTA agencies responded to the INAHTA scan, and their external web sites were searched for relevant rapid review products following the search for published and unpublished reports. The literature search yielded 5478 titles and abstracts after deduplication across databases. In total, 1008 articles were potentially relevant and their full-text was reviewed. Few rapid review samples in the published literature were located prior to 2011; however, samples of unpublished rapid reviews were plentiful. Following full-text review, 66 rapid reviews produced between 2013 and 2014 fulfilled our eligibility criteria and were included [1277]. Thirty-three were journal-published [1244] and 33 were unpublished [4577] rapid reviews. See Additional file 2 for a full list of included and excluded studies. Figure 2 shows a flow diagram of studies included using guidance from the PRISMA statement [78]. Four hundred unpublished rapid reviews met all other eligibility criteria but were not selected with the majority produced by a small number of agencies who author a high volume of rapid reviews per year e.g. (CADTH). The thirty-three published rapid reviews included were reported in 43 published articles together with companion studies [7986] for one included rapid review that was published in a journal as a series of 10 articles [19]. We considered these publications a single rapid review as they reported results by intervention from a single literature search. Thirty-one unpublished rapid reviews were located on the websites of their producing agency or organization. Two unpublished rapid reviews [72, 76] were located through contact with primary authors following expert input.

Fig. 2

PRISMA flow diagram

Characteristics of rapid reviews

Table 1 summarizes characteristics of the included rapid reviews. Detailed characteristics could not be reported and explored fully in this study and are reported elsewhere.Footnote 1 Sixty-six rapid reviews were included. Thirty-three were published in 25 unique journals, and the remaining 33 were produced by 31 unique evidence producers, including HTA agencies, academic research groups or international, national or local agencies. The number of rapid reviews published in peer-reviewed journals significantly increased between 2013 and 2014. All published rapid reviews and a majority (88 %) of the included unpublished samples self-identified as a rapid review somewhere in the title, abstract or body of the report. Unpublished studies that did not self-identify as a rapid review were categorized or labelled as a rapid review by their associated agency or organization website through a product description or additional source documentation. The most common countries of production were Canada, USA, the UK and Australia. The number of authors varied greatly amongst the included rapid reviews. Single authorship (a single named individual or attribution to the producing agency only with no individual listing of authors) was found only in the unpublished rapid review samples.

Table 1 Characteristics of the included rapid reviews (n = 66)

Nomenclature used to describe the accelerated or timely evidence synthesis process varied greatly amongst the included studies. The terms ‘rapid review’ (36 %), ‘rapid systematic review’ (15 %) or ‘rapid evidence assessment’ (15 %) were most common. Over 60 % of the research questions were aimed at the clinical efficacy or effectiveness of an intervention. Health economics, cost questions and those related to healthcare systems or service delivery were also frequent. Few samples addressed questions related to diagnostic or screening tests. A large proportion (88 %) of the included studies narratively summarized results.

Twelve [17, 18, 26, 29, 3234, 50, 64, 74, 76] studies considered meta-analysis, but data was insufficient for pooling which necessitated a narrative summary of results. Four [17, 26, 64, 74] rapid reviews conducted meta-analysis, and a single review conducted an indirect treatment comparison [76]. None of the included studies reported mentioned PRISMA or AMSTAR guidelines in their report, although one study did report using PRISMA-P guidelines for their protocol [76]. Included rapid reviews had a mean length in pages of 18.7 (standard deviation (SD) = 21.7) without considering references and appendices. Twelve percent (n = 3) of the journals publishing the included rapid reviews required PRISMA in their instructions to authors. We were unable to ascertain if any of the agencies or groups producing unpublished rapid reviews endorsed PRISMA or AMSTAR use.

Length of time taken to complete a rapid review

Although 98 % of our included samples used language describing rapid, accelerated or timely conduct and reporting of an evidence synthesis, very few reported how long it took to carry out the review. Three of the published rapid reviews [12, 29, 33] reported time to completion of 6 weeks (n = 2) or 8 weeks (n = 1). Eight of the unpublished rapid reviews reported actual time to completion [47, 48, 5860, 66, 70, 77] of between 3 and 18 weeks (mean 9.9, SD 4.8).

In published samples that did not report time to completion, we estimated duration in weeks through the use of the date of the literature search and calculated the number of days before the review was submitted to a journal. In 21 samples that reported both a date for the literature search and for journal submission, the mean time to completion was 36.3 weeks (SD 25.8).

Methodological quality of rapid reviews: compliance with the AMSTAR checklist

Figure 3 shows the proportion of rapid reviews (n = 66) that adequately met the individual AMSTAR checklist domains. Overall, compliance with the 11 items was poor. The median number of AMSTAR domains fulfilled was 4 (interquartile range (IQR) = 2.5 to 6.0) out of the maximum possible 11 items. Domains were adequately met 39 % of the time, on average, in the 66 included rapid review samples.

Fig. 3

Star chart depicting proportions of rapid reviews adequately reporting AMSTAR items (n = 66). COI conflict of interest

Items that were better reported than others were the appropriateness of the methods used to combine the findings of studies (item 9, 91 %), the aggregated study characteristics (item 6, 61 %), assessment and documentation of study quality (item 7, 52 %), appropriately forming conclusions based on the quality of the included studies (item 8, 48 %) and listing study sources of funding (item 11, 52 %). Compliance was extremely poor for the inclusion of a priori design of the research question(s) and inclusion criteria (item 1, 24 %), duplicate study selection and extraction (item 2, 15 %), use of the publication status as an inclusion criterion (item 4, 36 %) and providing a list of included and excluded studies (item 5, 9 %). Further exploration of item 2 (duplicate study selection and extraction) showed that 23 % of rapid reviews limited either study selection or data extraction to a single reviewer (with or without checking by a second reviewer) and only partially met this domain. Seventy-four percent of rapid reviews partially met item 5 by providing references for included studies but not excluded studies. Only two rapid reviews [58, 59] reported any formal assessment of publication bias, and none presented any graphical aids (e.g. funnel plot) to support their evaluation.

Variables associated with AMSTAR reporting

Exploratory univariate regression for AMSTAR could not be carried out for any variable as the data for the 66 included rapid review samples did not satisfy the normality assumption according to a Shapiro-Wilk test. Square root and logarithmic data transformations were attempted but did not normalize the distribution.

The smaller set of 11 rapid reviews reporting time to completion was normally distributed according to a Shapiro-Wilk test. Results of the exploratory regression on this variable showed that longer time to completion was significantly associated with an increase in the number of AMSTAR domains met (regression coefficient 1.7, 95 % confidence interval (CI) 0.2 to 3.2).

Reporting of rapid reviews stratified by publication status: compliance with the AMSTAR checklist

The mean number of AMSTAR domains adequately met for published rapid reviews was 4.2 (SD 2.2) out of the maximum possible of 11 and 4.3 when unpublished (SD 2.5). Table 2 reports the proportion of published and unpublished rapid reviews meeting individual AMSTAR domain specifications (answer = ‘yes’). A higher proportion of unpublished rapid reviews provided an a priori design (item 1) and searched for reports regardless of their publication type (grey literature, item 4) when compared to published reviews, although none of the 66 included rapid reviews reported this more than one third of the time. Higher proportions of published rapid reviews met the AMSTAR requirements for appropriately combining the findings of studies (item 9) and for declaring sources of support through conflict of interest statements (item 11). Poor reporting of excluded studies led to extremely low number of ‘yes’ responses for item 5 in all rapid reviews, and similar proportions of rapid reviews met AMSTAR domain requirements for the reporting of literature searches (Fig. 4). Many rapid reviews received ‘partial’ responses for this domain as two or more databases were searched in a large proportion of rapid reviews; however, they did not employ supplementary strategies, or methods were so restricted (e.g. searched only 2 years of literature) that the strategy could not be considered comprehensive to fulfil this domain requirement in the studies evaluated.

Table 2 Comparison of compliance to conduct standards outlined by AMSTAR
Fig. 4

Star chart depicting proportions of rapid reviews adequately reporting AMSTAR checklist items, by publication status (n = 66: n = 33 published, n = 33 unpublished). COI conflict of interest

Variables associated with AMSTAR reporting, stratified by publication status

Results from a univariate regression on the length of publication (in pages) showed no association with number of overall AMSTAR items fulfilled when published rapid reviews were analysed. Data for the unpublished rapid review samples were normalized using a square root transformation prior to analysis. Regression coefficients showed a significant association (regression coefficient 6.2 (95 % CI 2.99 to 9.43)) between the length of report and the total number of AMSTAR items met. The sample size of rapid reviews reporting time to completion (n = 11) was insufficient for regression analyses.

Reporting of rapid reviews: compliance with the PRISMA statement

The mean number of adequately reported PRISMA items was 13.2 (SD 6.0) out of the maximum possible 27. Items were adequately reported 49 % of the time on average in the 66 included rapid review samples. Figure 5 shows the proportion of rapid reviews that adequately reported the individual PRISMA checklist items. Individual items that were reported well in a large proportion of rapid reviews were the following: describing all information sources in the search (item 7, 81 %), presenting the main results of the review in a synthesis of results (item 21, 88 %), summarizing the main findings with relevance to key groups (item 24, 74 %) and providing general interpretation and context for the results of the review in the conclusions (item 26, 89 %). Other items were very poorly reported, such as indicating if a protocol exists or is registered (item 5, 6 %), describing the process of data collection (item 10, 30 %) and discussing the study limitations at the study/outcome and review level (item 25, 40 %). Less than 50 % of rapid reviews described the methods used for assessing risk of bias in individual studies (item 12, 44 %) or presented data on the risk of bias in each study (item 19, 48 %).

Fig. 5

Star chart depicting proportions of rapid reviews meeting PRISMA reporting guidelines by item (n = 66)

Due to the narrative description of results in most of the included rapid review samples, items 16 (additional analyses—methods, 6 %) and 23 (additional analyses—results, 8 %) were often given responses of ‘not applicable’ in the rapid review samples. Summary measures (item 13) were also poorly reported in a large proportion of included studies. Of the 14 rapid reviews who stated their intention to carry out meta-analyses in their methods, only 4 (29 %) reported the effect measure that would be considered in their analyses. Three included unpublished rapid reviews were ‘empty’, meaning that no candidate studies met the eligibility requirements.

A total number of PRISMA items reported by rapid review were used in a subsequent exploratory regression as the data were normally distributed according to a Shapiro-Wilk test (with some negative skewness and kurtosis).

Variables associated with PRISMA reporting

Exploratory regression analyses were carried out for the total number of PRISMA items adequately reported using report length and time to completion as variables. The length of the primary publication in pages (without appendices or references) was associated with an increase of 1.45 PRISMA items adequately reported (95 % CI 0.6 to 2.3). A smaller set of rapid reviews (n = 11) reporting time to completion did not find a significant correlation between the number of weeks required to complete a rapid review and the number of PRISMA checklist items adequately reported (regression coefficient 0.23 (95 % CI −0.27 to 0.72)).

Reporting of rapid reviews stratified by publication status: compliance with the PRISMA statement

The mean number of adequately reported PRISMA items for published rapid reviews was 14.5 (SD 4.7) out of the maximum possible 27 and 11.7 when unpublished (SD 6.8). Items were adequately reported 53 % of the time, on average, in the 33 included published rapid review samples and 44 % of the time in unpublished samples. Table 3 shows the results of a comparison of total number rapid reviews adequately reporting PRISMA items, stratified by publication status. PRISMA items are better reported in published rapid reviews for the five categories: identifying the report as a rapid or accelerated evidence synthesis (a slight modification to the item for the purposes of this review) in the title (item 1), using a structured abstract (without protocol registration number considered) (item 2), stating the selection process for inclusion of studies (item 9), providing a general interpretation of results in the form of conclusions (item 26) and declaring sources of funding for the rapid review (item 27). Published rapid reviews more often described information sources, syntheses of results, results of the study selection process and synthesis of results (Fig. 6). Unpublished rapid reviews were more likely to clearly state eligibility criteria (item 6) for article selection and present a full electronic search strategy (item 8) and study characteristics (item 18). Rapid reviews reported study rationale, risk of bias methods and results, synthesis of results and summaries of evidence equally, regardless of publication status.

Table 3 Comparison of compliance to PRISMA reporting guidelines
Fig. 6

Star chart depicting proportions of rapid reviews adequately reporting PRISMA items, by publication status (n = 66: n = 33 published, n = 33 unpublished)

Variables associated with PRISMA reporting, stratified by publication status

A number of PRISMA items adequately reported were analysed in a subsequent exploratory regression stratified by publication status as the data were normally distributed according to a Shapiro-Wilk test. Separate univariate regression analyses were carried out for the PRISMA item compliance using the length of report and time to completion as variables, stratified by publication status. Results for the published rapid review samples showed that the length of the primary publication was associated with a significant increase in PRISMA items adequately reported (regression coefficient 0.4, 95 % CI 0.1–0.6). The length of publication in the unpublished samples was associated with a larger increase in adequately reported PRISMA items (regression coefficient 2.5, 95 % CI 1.3–3.6).


Our study provides a comprehensive assessment of the design and reporting characteristics of a large, recent cohort of rapid reviews. A detailed examination of baseline characteristics showed a heterogeneous mix of nomenclature, research questions and approaches to rapid reviews from a relatively small number of countries. The rapid review samples showed poor compliance with both the PRISMA and AMSTAR checklists. Only selected items in both instruments were adequately addressed by any rapid review. Stratification by publication status revealed that a higher proportion of published rapid reviews adequately complied with PRISMA guidelines compared to the unpublished samples. There was no difference in the number of AMSTAR domains met when publication status was considered. There was evidence of an association between the length of publication (PRISMA) and time to completion (AMSTAR) on the total number of items reported or met in this cohort of rapid reviews. This relationship with the length of report was reciprocated when the rapid reviews were stratified by publication status. To our knowledge, this is the first study to explore the compliance of rapid reviews with the PRISMA and AMSTAR instruments or any other standardized tool that captures adequacy of reporting and conduct. No other publications have aimed to study published rapid reviews or make comparisons taking publication status into consideration.

This research follows previous studies examining the transparency of process and quality of reporting in rapid reviews without the use of standardized tools or instruments. In line with the results of previous work, many of the identified studies did not report methods in sufficient detail [1, 3, 5], a problem not unique to rapid reviews [87]. Although there were differences in the number of PRISMA and AMSTAR items met when published and unpublished reviews were considered separately, the limited details reported in the rapid reviews prevented a comprehensive evaluation in some domains, notably literature search, quality assessment, screening, selection and extraction, all of which are important contributors to the reproducibility and evaluation of a review. Any or all of these components may be tailored or even omitted as part of the streamlining processes designed to expedite systematic review completion times [3] so were unable to ascertain whether the reporting omissions were attributable to the rapid review approach or simply poor reporting [88]. Evaluations of reporting characteristics in systematic reviews and meta-analyses have noted similar shortcomings as were found in this study, especially in non-Cochrane reviews [8890].

Research protocols are a key feature of systematic reviews, and their absence leaves rapid reviews open to selective reporting of results or conclusions and facilitates post hoc modifications of approach [91]. Our findings show that few rapid review authors are reporting the use of protocols in their publications and even fewer are registering or publishing them. This is reflected in the poor compliance with related items in both the PRISMA and AMSTAR checklists. Our results conflict with a recent report by Polisena et al. who reported a cross-sectional review of processes and methods based on a survey of 29 international rapid review programmes [4]. Their results showed that 96.6 % (n = 28) of the agencies queried incorporated protocol development into their rapid review process. Many of the rapid reviews included in this study were produced by the agencies and organizations in the Polisena survey. There are a number of reasons that authors or organizations may choose not register their rapid review protocols, including the belief that systems like PROSPERO are for systematic reviews only, which emphasizes the viewpoint that a rapid review is not a systematic review [7]. Authors of rapid reviews may use a more condensed version of a protocol to ensure a timely start to the review process, but we were unable to assess this in our samples. Rapid reviews also show variety in the types of study questions they answer, including public health, health services and system questions. Applicability of PROSPERO or Preferred Reporting Items for Systematic Review and Meta-Analysis for protocols (PRISMA-P) guidance outside of the realm of therapeutic efficacy may be questioned [92], although they may still provide useful guidance to authors of rapid reviews [93].

It is concerning that the reporting of limitations specific to the conduct of the rapid review was consistently poor given the inherent methodological tailoring which motivates the approach; however, this finding is consistent with previous work. Ganann et al. also found that very few rapid reviews discussed potential limitations or any potential bias that may have been introduced due to methodological concessions [1]. Some rapid reviews in this study reported limitations, but a large proportion highlighted issues related to the quality of the included studies rather than weaknesses in approach or conduct. Disclaimers were used, most often in unpublished reports, to highlight caveats to end-users; however, most focused on the currency of the review or vaguely referenced that the review could not be considered comprehensive. It is particularly important for rapid reviews to have a comprehensive limitation section to enable the end-user to judge the validity of the methods employed, the studies included and ultimately how applicable the findings of the review may be for their own purposes.

Less than half of rapid reviews reported a structured summary or abstract. When the rapid review samples were stratified by their publication status, results changed significantly. We found that almost all journal-published samples reported structured abstracts, as is usually required by the journal, while few unpublished samples did. Many of the unpublished rapid reviews did use executive summaries to highlight key findings; however, most were either too lengthy to provide the reader with the intended brief overview of the report and did not summarize methods in any capacity. This may be attributable to the different aim of unpublished rapid reviews, which may be presented to end-users alongside additional support documentation (e.g. research summary document). It is probable that these rapid reviews are not aimed at being a stand-alone product like a journal article [94]. Still, the Organization for Economic Co-operation and Development (OECD) and others still highlight the need for key messages over and beyond the executive summary as they often cannot read detailed the findings from HTA products and must have critical messages communicated for better knowledge translation and uptake [94, 95].

Although closely related, it is important to keep the concepts of reporting and conduct separate when considering these findings. The low number of items completely met, and large proportion of domains of partially met for AMSTAR may be attributable to more stringent or rigid assessment requirements (when compared to items in PRISMA). For example, the use of single reviewers to screen literature or extract data resulted in low number of AMSTAR items adequately meeting related domains. It is possible that a more granular AMSTAR assessment criterion would capture the methodological tailoring intrinsic to rapid reviews in a way that is more descriptive to the end-user. Further detail on the individual methods tailored in a rapid review, if captured by AMSTAR, would allow for more careful consideration of what is acceptable or not and where bias, if any, was likely to be introduced. It may be useful to have subdomains for item 1 where the use of a protocol would be kept separate from the description of eligibility criteria or the PICO, item 2 (duplicate study selection and data extraction) or item 5 (list of included and excluded studies). While not aimed at rapid reviews, a modification to the AMSTAR checklist in the form of R (revised)-AMSTAR has been proposed and validated [96] but was not developed or endorsed by the AMSTAR research group. R-AMSTAR considers three to four more detailed criteria per original AMSTAR item, which in principle may be more applicable to assessment of rapid reviews. This tool was later assessed to have poor measurement properties compared to the original instrument in a sample of systematic reviews, so further research or revision may be required before investigation of its use can be considered [96, 97].

Regression models were used to explore the influence of article length and completion time on the number of PRISMA and AMSTAR items adequately reported or met. Longer manuscript length was associated with higher compliance with PRISMA guidelines while AMSTAR compliance increased with time to completion. No previous studies have assessed rapid reviews using these methods, so there is little evidence to aid with interpretation of the significance of this result. Findings suggest reporting quality is compromised when not enough space is provided for a fulsome description. Results from a study on the reporting of meta-analyses of surgical interventions had similar findings [89] and demonstrate that this is not a problem specific to rapid reviews alone.

The term ‘rapid review’ implies that time is a significant factor in the conduct and reporting of this evidence synthesis approach. The influence of time was significant in our regression, and rapid reviews with longer time to completion (in weeks) showed a higher proportion of PRISMA and AMSTAR items adequately reported or met. Harker and Kleijnen examined a sample of rapid reviews and estimated time taken to complete based on the last search date and date published [3]. Their results showed a significant association between the length of time taken and the number of rapid review methodologies that reported clearly and closely adhered to recommended systematic review guidelines from Cochrane or the York Centre for Reviews and Dissemination (CRD). This empirical evidence may actually conflict with the stance of researchers and knowledge users on this topic. In a recent study on research producer and healthcare decision-maker opinions and attitudes towards rapid reviews, Kelly et al. (2015, under review) noted there is a salient viewpoint amongst this mixed group of evidence producers and knowledge users that reduced review time is not necessarily associated with a lower quality of review and they asserted that quality can be maintained even when rigour is reduced. Our analyses did not take into account the differences in rapid review approach. It may be more sensible to consider reporting and conduct of rapid reviews while also examining the variation in review approach (from an evidence brief or map to a fully comprehensive report that resembles a systematic review in almost all facets) which may also influence time to completion. Data were insufficient to explore these factors through multiple regression, but this may be a valuable research objective going forward.

Strengths and limitations

The strengths of this research include a protocol-driven design (available on request through the corresponding author), a complete and far ranging search and a detailed exploration into the reporting and conduct of rapid reviews.

Limitations of this study may influence the interpretation and applicability of our findings. Due to the diversity of approaches, timelines and nomenclature employed by rapid review producers, it was difficult to apply a standardized selection criteria and some subjectivity by the reviewers may have influenced inclusion of candidate rapid reviews. Specifically, the eligibility criterion of 9 months for the time to completion of rapid reviews was difficult to apply; therefore, most reviews met the inclusion criteria by self-identifying as an accelerated, rapid or timely review of evidence in the title, abstract or full-text. As we were unable to corroborate time to completion in most articles, we cannot exclude that some producers may have undertaken comprehensive systematic reviews (with little tailoring of methods) in an accelerated fashion using additional resources. Although Moher et al. acknowledge that this approach may still be a type of rapid review, the inclusion of these comprehensive but timely reports may skew the study of the tailored methods [93].

Similarly, the noted heterogeneity of terminology may have led to some rapid reviews being missed. Although we limited the rapid reviews we retrieved to a cross section of samples from 2013 and 2014, we believe we captured a comprehensive representation of reviews in both the published and grey literature. The addition of the INAHTA scan also supplemented our search and identified smaller organizations producing rapid reviews that helped add to our unpublished samples. Additionally, when the protocol was amended to restrict the date of publication for the included rapid reviews to 2013 and 2014, some rapid review producers were omitted from the sample, having not published rapid reviews within our eligibility timeline. This necessitated the inclusion of two rapid review samples each from two HTA producers (CADTH, Health Quality Ontario).

In this study, we explored two influential variables and their association with the PRISMA and AMSTAR checklists through univariate regression. Further exploration of other influential variables is warranted including the inclusion of primary or secondary studies (or both), type of research questions, purpose or type of rapid review approach or journal factors such as PRISMA endorsement or impact factor. In addition, looking at the total aggregate number of items adequately reported or met for both instruments as absolute measures of compliance is a weakness. These summary totals have limited utility to end-users, as there is currently no accepted cut-off denoting low, moderate or high quality of conduct or reporting based on these totals. We have described individual domain compliance in an effort to make results more practical and to facilitate interpretation in the context of rapid reviews. These instruments were designed for use with systematic reviews and meta-analyses of therapeutic interventions, and it could be argued that measuring our sample rapid reviews involving a variety of research question types on the same scale is unfair. However, there are limited studies comparing the methods of rapid reviews to those of more fulsome systematic reviews [5, 98100]. Instruments like PRISMA or AMSTAR enable comparisons of rapid reviews in a standardized manner to each other. This could be extended to allow for comparisons against other evidence synthesis products. These tools provide evidence producers with a concise, consistent way to ensure that reviews are transparently and adequately reported to end-users, which enables decision-makers to assess findings they receive with confidence, especially when they must do so urgently when decisions cannot wait.

We included three ‘empty’ rapid reviews, where no studies of interest were eligible for inclusion. There is no clear-cut way to assess these reviews, and although some have suggested these studies should be excluded, we elected to include them [101]. Although AMSTAR and PRISMA compliance was low in these samples, these empty reviews are valuable to end-users as they highlight knowledge gaps, communicate topics to reduce duplication and indicate that state of evidence at a certain point of time, which is often the primary objective of a rapid review [102]. Care should be taken to prevent publication bias [103]. The authors of the empty rapid review samples in this study still provided conclusions based on a broader review of relevant literature but often failed to highlight these shortcomings to the end-user. In many of the other included rapid reviews, eligibility criteria were expanded to consider more evidence when no studies of a certain type were located, an iterative process that is common in both systematic and rapid reviews [2, 9]. Without a protocol that is posted or registered, it is difficult to assess whether these modifications were appropriate, even when the processes are well-described. Additionally, a series of 10 rapid reviews on chronic pain that used a single search were included as a single rapid review with accompanying companion articles. Although it would not have changed the results of this study, it is worth mentioning that employing a single search for multiple evidence reviews may be an approach used to expedite the process, and it may have been more appropriate to consider these reviews individually.


Rapid review products vary greatly, and it is complicated and onerous to compare and contrast the numerous approaches used. Standardized reporting and conduct checklists such as AMSTAR and PRISMA provide a useful way to compare and contrast rapid reviews across a number of key domains. This assessment of 66 rapid reviews shows that conduct and reporting are often inadequate and unclear. This is a significant limitation attributable to rapid reviews, although this problem is not unique to this approach. Poor descriptions of research activities result in research that is not replicable and end-users are unable to sufficiently assess potential for bias in the reports. Arguably, clear and complete descriptions of conduct and transparent reporting of research activities are more important in rapid reviews as they inherently tailor gold standard review methodology. Editorial insistence may help to encourage compliance in published reports; however, scientific editors, authors and producing agencies all have a responsibility to ensure that the reporting of conduct and findings in the research products they produce or publish is appropriate and complete. Our results show that future research may be warranted to define reporting or conduct guidelines specific to rapid reviews. This is not to imply that existing guidelines are inadequate, but further work to evaluate their adequacy for assessing rapid reviews may be required. It is unclear whether guidelines specific to rapid reviews are necessary or desired by the evidence producers and users and whether these types of products would be applicable across the spectrum of rapid review approaches.


  1. 1.

    Note: The rapid review characteristics presented in this study are free from selective reporting. The surplus of study and methodological characteristics could not be adequately addressed in a single manuscript and will be explored in a future manuscript.



A Measurement Tool to Assess Systematic Reviews


confidence interval


York Centre for Reviews and Dissemination


Grading of Recommendations Assessment, Development and Evaluation


health technology assessment


International Network of Agencies for Health Technology Assessment


interquartile range


Organization for Economic Co-operation and Development


Preferred Reporting Items of Systematic Reviews and Meta-Analyses


randomized controlled trial


standard deviation


  1. 1.

    Ganann R, Ciliska D, Thomas H. Expediting systematic reviews: methods and implications of rapid reviews. Implement Sci. 2010;5:56.

    Article  PubMed  PubMed Central  Google Scholar 

  2. 2.

    Khangura S, Konnyu K, Cushman R, Grimshaw J, Moher D. Evidence summaries: the evolution of a rapid review approach. Syst Rev. 2012;1:10.

    Article  PubMed  PubMed Central  Google Scholar 

  3. 3.

    Harker J, Kleijnen J. What is a rapid review? A methodological exploration of rapid reviews in health technology assessments. Int J Evid Based Healthc. 2012;10(4):397–410.

    Article  PubMed  Google Scholar 

  4. 4.

    Polisena J, Garritty C, Kamel C, Stevens A, Abou-Setta AM. Rapid review programs to support health care and policy decision making: a descriptive analysis of processes and methods. Syst Rev. 2015;4:26. doi:10.1186/s13643-015-0022-6.

    Article  PubMed  PubMed Central  Google Scholar 

  5. 5.

    Watt A, Cameron A, Sturm L, Lathlean T, Babidge W, Blamey S, Facey K, Hailey D, Norderhaug I, Maddern G. Rapid reviews versus full systematic reviews: an inventory of current methods and practice in health technology assessment. Int J Technol Assess Health Care. 2008;24(2):133–9.

    PubMed  Google Scholar 

  6. 6.

    Hartling L, Guise JM, Kato E, Anderson J, Aronson N, Belinson S, Berliner E, Dryden D, Featherstone R, Foisy M, Mitchell M, Motu’apuaka M, Noorani H, Paynter R, Robinson KA, Schoelles K, Umscheid CA, Whitlock E. AHRQ comparative effectiveness reviews. EPC methods: an exploration of methods and context for the production of rapid reviews. Rockville (MD): Agency for Healthcare Research and Quality (US); 2015.

    Google Scholar 

  7. 7.

    Tricco AC, Antony J, Straus SE. Systematic reviews vs. rapid reviews: what’s the difference? Vancouver, BC: CADTH Rapid Reviews Summit; 2015. Available at:

    Google Scholar 

  8. 8.

    Schunemann HJ, Moja L. Reviews: rapid! rapid! rapid! …and systematic. Syst Rev. 2015;4:4.

    Article  PubMed  PubMed Central  Google Scholar 

  9. 9.

    Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6, e1000097.

    Article  PubMed  PubMed Central  Google Scholar 

  10. 10.

    Shea BJ, Hamel C, Wells GA, Bouter LM, Kristjansson E, Grimshaw J, Henry DA, Boers M. AMSTAR is a reliable and valid measurement tool to assess the methodological quality of systematic reviews. J Clin Epidemiol. 2009;62(10):1013–20.

    Article  PubMed  Google Scholar 

  11. 11.

    Sampson M, McGowan J, Lefebvre C, Moher D, Grimshaw J. PRESS: Peer Review of Electronic Search Strategies. Ottawa: Canadian Agency for Drugs and Technologies in Health; 2008.

    Google Scholar 

  12. 12.

    Banbury A, Roots A, Nancarrow S. Rapid review of applications of e-health and remote monitoring for rural residents. Aust J Rural Health. 2014;22(5):211–22.

    Article  PubMed  Google Scholar 

  13. 13.

    Beall RF, Baskerville N, Golfam M, Saeed S, Little J. Modes of delivery in preventive intervention studies: a rapid review. Eur J Clin Invest. 2014;44(7):688–96.

    Article  PubMed  Google Scholar 

  14. 14.

    Brunton G, Paraskeva N, Caird J, Bird KS, Kavanagh J, Kwan I, Stansfield C, Rumsey N, Thomas J. Psychosocial predictors, assessment, and outcomes of cosmetic procedures: a systematic rapid evidence assessment. Aesthetic Plast Surg. 2014;38(5):1030–40.

    Article  PubMed  Google Scholar 

  15. 15.

    Bungay H, Vella-Burrows T. The effects of participating in creative activities on the health and well-being of children and young people: a rapid review of the literature. Perspect Public Health. 2013;133(1):44–52.

    Article  PubMed  Google Scholar 

  16. 16.

    Chaiyachati KH, Ogbuoji O, Price M, Suthar AB, Negussie EK, Barnighausen T. Interventions to improve adherence to antiretroviral therapy: a rapid systematic review. Aids. 2014;28 Suppl 2:S187–204.

    Article  PubMed  Google Scholar 

  17. 17.

    Cooper CL, Hind D, Duncan R, Walters S, Lartey A, Lee E, Bradburn M. A rapid review indicated higher recruitment rates in treatment trials than in prevention trials. J Clin Epidemiol. 2015;68(3):347–54.

    Article  PubMed  Google Scholar 

  18. 18.

    Costello RB, Lentino CV, Boyd CC, O’Connell ML, Crawford CC, Sprengel ML, Deuster PA. The effectiveness of melatonin for promoting healthy sleep: a rapid evidence assessment of the literature. Nutr J. 2014;13:106.

    Article  PubMed  PubMed Central  Google Scholar 

  19. 19.

    Delgado R, York A, Lee C, Crawford C, Buckenmaier III C, Schoomaker E, Crawford P. Assessing the quality, efficacy, and effectiveness of the current evidence base of active self-care complementary and integrative medicine therapies for the management of chronic pain: a rapid evidence assessment of the literature. Pain Med. 2014;15(1):S9–S20.

    Article  PubMed  Google Scholar 

  20. 20.

    Dennis SM, Harris M, Lloyd J, Powell Davies G, Faruqi N, Zwar N. Do people with existing chronic conditions benefit from telephone coaching? A rapid review. Aust Health Rev. 2013;37(3):381–8.

    PubMed  Google Scholar 

  21. 21.

    Dorresteijn PM, Ipenburg NA, Murphy KJ, Smit M, Van Vulpen JK, Wegner I, Stegeman I, Grolman W. Rapid systematic review of normal audiometry results as a predictor for benign paroxysmal positional vertigo. Otolaryngol Head Neck Surg. 2014;150(6):919–24.

    Article  PubMed  Google Scholar 

  22. 22.

    Garrett B, Taverner T, Masinde W, Gromala D, Shaw C, Negraeff M. A rapid evidence assessment of immersive virtual reality as an adjunct therapy in acute pain management in clinical practice. Clin J Pain. 2014;30(12):1089–98.

    Article  PubMed  Google Scholar 

  23. 23.

    Hithersay R, Strydom A, Moulster G, Buszewicz M. Carer-led health interventions to monitor, promote and improve the health of adults with intellectual disabilities in the community: a systematic review. Res Dev Disabil. 2014;35(4):887–907.

    Article  PubMed  Google Scholar 

  24. 24.

    Jarrett N, Scott I, Addington-Hall J, Amir Z, Brearley S, Hodges L, Richardson A, Sharpe M, Stamataki Z, Stark D, Siller C, Ziegler L, Foster C. Informing future research priorities into the psychological and social problems faced by cancer survivors: a rapid review and synthesis of the literature. Eur J Oncol Nurs. 2013;17(5):510–20.

    CAS  Article  PubMed  Google Scholar 

  25. 25.

    Khorsan R, Crawford C, Ives JA, Walter AR, Jonas WB. The effect of omega-3 fatty acids on biomarkers of inflammation: a rapid evidence assessment of the literature. Mil Med. 2014;179(11 Suppl):2–60.

    Article  PubMed  Google Scholar 

  26. 26.

    Kim DG, Choi YY, An JY, Kwon IG, Cho I, Kim YM, Bae JM, Song MG, Noh SH. Comparing the short-term outcomes of totally intracorporeal gastroduodenostomy with extracorporeal gastroduodenostomy after laparoscopic distal gastrectomy for gastric cancer: a single surgeon’s experience and a rapid systematic review with meta-analysis. Surg Endosc. 2013;27(9):3153–61.

    Article  PubMed  Google Scholar 

  27. 27.

    Lal S, Adair CE. E-mental health: a rapid review of the literature. Psychiatr Serv. 2014;65(1):24–32.

    Article  PubMed  Google Scholar 

  28. 28.

    Loveday HP, Wilson JA, Kerr K, Pitchers R, Walker JT, Browne J. Association between healthcare water systems and Pseudomonas aeruginosa infections: a rapid systematic review. J Hosp Infect. 2014;86(1):7–15.

    CAS  Article  PubMed  Google Scholar 

  29. 29.

    Luckett T, Phillips J, Agar M, Virdun C, Green A, Davidson PM. Elements of effective palliative care models: a rapid review. BMC Health Serv Res. 2014;14:136.

    Article  PubMed  PubMed Central  Google Scholar 

  30. 30.

    McLean SL, Blenkinsopp A, Bennett MI. Using haloperidol as an antiemetic in palliative care: informing practice through evidence from cancer treatment and postoperative contexts. J Pain Palliat Care Pharmacother. 2013;27(2):132–5.

    Article  PubMed  Google Scholar 

  31. 31.

    Menear M, Briand C. Implementing a continuum of evidence-based psychosocial interventions for people with severe mental illness: part 1-review of major initiatives and implementation strategies. Can J Psychiatry. 2014;59(4):178–86.

    PubMed  PubMed Central  Google Scholar 

  32. 32.

    Moe-Byrne T, Chambers D, Harden M, McDaid C. Behaviour change interventions to promote prescribing of generic drugs: a rapid evidence synthesis and systematic review. BMJ Open. 2014;4(5), e004623.

    Article  PubMed  PubMed Central  Google Scholar 

  33. 33.

    Ndumbe-Eyoh S, Moffatt H. Intersectoral action for health equity: a rapid systematic review. BMC Public Health. 2013;13:1056.

    Article  PubMed  PubMed Central  Google Scholar 

  34. 34.

    Paton F, Chambers D, Wilson P, Eastwood A, Craig D, Fox D, Jayne D, McGinnes E. Effectiveness and implementation of enhanced recovery after surgery programmes: a rapid evidence synthesis. BMJ Open. 2014;4(7), e005015.

    Article  PubMed  PubMed Central  Google Scholar 

  35. 35.

    Reinink H, Wegner I, Stegeman I, Grolman W. Rapid systematic review of repeated application of the epley maneuver for treating posterior BPPV. Otolaryngol Head Neck Surg. 2014;151(3):399–406.

    Article  PubMed  Google Scholar 

  36. 36.

    Saeed S, Golfam M, Beall RF, Ashbury FD, Palmer LJ, Little J. Effectiveness of individual-focused interventions to prevent chronic disease. Eur J Clin Invest. 2014;44(9):883–91.

    Article  PubMed  Google Scholar 

  37. 37.

    Treanor CJ, Donnelly M. The late effects of cancer and cancer treatment: a rapid review. J Community Support Oncol. 2014;12(4):137–48.

    CAS  PubMed  Google Scholar 

  38. 38.

    Trivedy CR, Cooke MW. Unscheduled return visits (URV) in adults to the emergency department (ED): a rapid evidence assessment policy review. Emerg Med J. 2013;28.

  39. 39.

    van der Scheer-Horst ES, Van Benthem PP, Bruintjes TD, Van Leeuwen RB, van der Zaag-Loonen HJ. The efficacy of vestibular rehabilitation in patients with benign paroxysmal positional vertigo: a rapid review. Otolaryngol Head Neck Surg. 2014;151(5):740–5.

    Article  PubMed  Google Scholar 

  40. 40.

    van der Veen EL, Van Hulst RA, De Ru JA. Hyperbaric oxygen therapy in acute acoustic trauma: a rapid systematic review. Otolaryngol Head Neck Surg. 2014;151(1):42–5.

    Article  PubMed  Google Scholar 

  41. 41.

    Van Duijn JG, Isfordink LM, Nij Bijvank JA, Stapper CW, Van Vuren AJ, Wegner I, Kortekaas MF, Grolman W. Rapid systematic review of the epley maneuver for treating posterior canal benign paroxysmal positional vertigo. Otolaryngol Head Neck Surg. 2014;150(6):925–32.

    Article  PubMed  Google Scholar 

  42. 42.

    Wegner I, Niesten ME, Van Werkhoven CH, Grolman W. Rapid systematic review of the epley maneuver versus vestibular rehabilitation for benign paroxysmal positional vertigo. Otolaryngol Head Neck Surg. 2014;151(2):201–7.

    Article  PubMed  Google Scholar 

  43. 43.

    Wolfenden L, Carruthers J, Wyse R, Yoong S. Translation of tobacco control programs in schools: findings from a rapid review of systematic reviews of implementation and dissemination interventions. Health Promot J Austr. 2014;25(2):136–8.

    CAS  Article  PubMed  Google Scholar 

  44. 44.

    Zeno SA, Purvis D, Crawford C, Lee C, Lisman P, Deuster PA. Warm-ups for military fitness testing: rapid evidence assessment of the literature. Med Sci Sports Exerc. 2013;45(7):1369–76.

    Article  PubMed  Google Scholar 

  45. 45.

    Self-care support for people with COPD. [Internet] UK. York University, Centre for Reviews and Dissemination/National Institute for Health Research 2014. Available from:

  46. 46.

    Lead Exposures Among Recreational Shooters. [Internet] Ontario, Canada. Public Health Ontario2014. Available from:

  47. 47.

    Australian Safety and Efficacy Register of New Interventional Procedures – Surgical (ASERNIP-S). Online programs for weight loss. Brisbane. ASERNIP-S. 2013. Available from:

  48. 48.

    Canadian Centre on Substance Abuse. Universal, Family-based Substance Abuse Prevention for Youth. [Internet]. CCSA. 2014. Available from:

  49. 49.

    World Health Organization. Personal protective equipment in the context of filovirus disease outbreak response. [Internet]. World Health Organization (WHO). 2014. Available from:

  50. 50.

    Baidoobonso S. Effect of supportive interventions on informal caregivers of people at the end of life: a rapid review. Health Quality Ontario. 2014. Available from:

  51. 51.

    Burrowes N. Body image—a rapid evidence assessment of the literature. London, England: United Kingdom Government Equalities Office and the Department for Culture, Media & Sport; 2013. Available from:

    Google Scholar 

  52. 52.

    CADTH. Sofosbuvir for the treatment of patients with genotype 4 hepatitis C: a review of the clinical efficacy, cost-effectiveness, and guidelines. [Internet]. CADTH. 2014. Available from: h

  53. 53.

    Department of Veterans Affairs, Evidence-based Synthesis Program (ESP). Evidence map of yoga for high-impact conditions affecting veterans. [Internet] Washington, USA: Department of Veterans Affairs, Veterans Health Administration, Quality Enhancement Research Initiative, Health Services Research and Development Service; 2014; Available from:

  54. 54.

    D’Eath, M, Barry, MM, Sixsmith, J. A rapid evidence review of health advocacy for communicable diseases. [Internet] Ireland. Health Promotion Research Centre, University of Ireland Galway; 2014. Available from:

  55. 55.

    Scottish Health Technologies Group. Transcathetyer aortic valve implantation (TAVI) for severe symptomatic aortic stenosis in adults who are not eligible for surgery. [Internet] Scotland. Scottish Health Technologies Group; 2014. Available from:

  56. 56.

    Gurgacz, SL, Lambert, R, Vogan, A, R, Cooter, K, Mutimer, G, Maddern. ASERNIP-S report no. 81 - Breast prosthesis implantation for reconstructive and cosmetic surgery: a rapid review. Adelaide, South Australia. Australian Safety and Efficacy Register of New Interventional Procedures-Surgical (ASERNIP-S); 2013. Available from:

  57. 57.

    Hirji, MM, Wilson, MG, Yacoub, K, Bhuiya, A. Identifying suicide prevention interventions. [Internet]. McMaster Health Forum, McMaster University, Canada; 2014. Available from:

  58. 58.

    Hiscock, H, Perera, P, McLean, K, Roberts, G. Variation in paediatric clinical practice: an evidence check review brokered by the Sax Institute ( for NSW Kids and Families. November 2014. Available from:

  59. 59.

    ECRI Institute. Automated technologies for patient room disinfection and decontamination of biosafety level 4 infectious agents, including Ebola virus. [Internet]. ECRI Institute. 2014. Available from:

  60. 60.

    Institute of Health Economics. Total prosthetic replacement of the temporomandibular joint: a rapid evidence assessment and economic analysis. Edmonton, Alberta. Institute of Health Economics; 2013. Available from:

  61. 61.

    Lapczak, N, Hertz, S. Review of evidence on effective postpartum smoking relapse prevention interventions. [Internet]. Region of Peel, Canada. 2014. Available from:

  62. 62.

    Leof, A, Gerrity, M, Thielke, A, King, V. Sofosbuvir for the treatment of hepatitis C and evaluation of the 2014 American Association for the Study of Liver Diseases treatment guidelines. [Internet] USA. Oregon Health and Safety University - Centre for Evidence-based Policy; 2014. Available from:

  63. 63.

    Masso, M, Thompson, C. Rapid review of the nurse practitioner literature. [Internet] New South Wales. Government of New South Wales, Australia. 2014. Available from:

  64. 64.

    Miani, C, Ball, S, Pitchforth, E, Exley, J, King, S, Roland, M, Fuld, J, Nolte, E. Organisational interventions to reduce length of stay in hospital: a rapid evidence assessment. [Internet]. RAND Corporation for the National Institute for Health Research; 2014. Available from:

  65. 65.

    NA, Lannin, J, Morarty, K, Laver. Segmented rehabilitation: a rapid review. Melbourne, Australia. Departments of Occupational Therapy, La Trobe University and Alfred Health for The Institute for Safety, Compensation and Recovery Research (ISCRR); 2013 Contract No.: ISCRR Research Report # 022.029-R1C. Available from:

  66. 66.

    Navarro, P, Bornstein, S, O’Loughlin, J. Strategies for health promotion: healthy dietary habits. [Internet] Canada. Newfoundland & Labrador Centre for Applied Health Research (NLCAHR), Contextualized Health Research Synthesis Program (CHRSP); 2014. Available from:

  67. 67.

    68. Ontario HIV Treatment Network. What is the effectiveness of supervised injections? [Internet]. Ontario HIV Treatment Network. 2014. Available from:

  68. 68.

    Health Quality Ontario. Vitamin B12 and cognitive function: an evidence-based analysis [Internet]. 2013. Available from:

  69. 69.

    Parry, R, Seymour, J, Whittaker, B, Bird, I, Cox, C. Rapid evidence review: pathways focused on the dying phase in end of life care and their key components. United Kingdom. British Department of Health, Sue Ryder Care Centre for the Study of Supportive Palliative and End of Life Care UoN; 2013. Available from:

  70. 70.

    Stansfield C, Rumse N, Thomas J. Psychosocial predictors, assessment and outcomes of cosmetic interventions: a systematic rapid evidence review. London: EPPI-Centre, Social Science Research Unit, Institute of Education, University of London; 2013. Available from:

    Google Scholar 

  71. 71.

    Syful Azlie Md Fuzi. Ecological disinfectant (product name redacted for agency posting). Putrajaya, Malaysia. Health Technology Assessment Section (MaHTAS), Medical Development Division, Ministry of Health Malaysia. 2013. Available from:

  72. 72.

    The Knowledge Synthesis (KS) Group, KS Canada, Ottawa Methods Centre, Ottawa Hospital Research Institute. Do outcomes vary among different curricula or models of delivery for pre-licensure nursing education? A rapid review. Ottawa. 2013.

    Google Scholar 

  73. 73.

    The Knowledge Synthesis Group and Cochrane Collaborators. Ottawa Methods Centre, Ottawa Hospital Research Institute. Effects of performing complex pediatric intracavitary (IC) surgical procedures in specialized versus non-specialized centers in high risk children: Cochrane response rapid review. The Cochrane Collaboration: Ottawa, Ontario, Canada; 2013.

    Google Scholar 

  74. 74.

    Turner, J, Preston, L, Booth, A, O’Keeffe, C, Campbell, F, Jesurasa, A, Cooper, K, Goyder, E. What evidence is there for a relationship between organizational features and patient outcomes in congenital heart disease services? A rapid review. [Internet]. School for Health and Related Research (ScHARR), University of Sheffield. 2014. Available from:

  75. 75.

    Ubido, J, Scott-Samuel, A. An evaluation of the cost effectiveness of monitored dosage systems (MDS) as an aid to maintaining independence in taking medication. Liverpool Public Health Observatory; 2014. Available from:,monitored,dosage,system_,final.pdf.

  76. 76.

    Ontario Drug Policy Research Network (ODPRN). Rapid review unit. Comparative safety and effectiveness of inhaled long-acting agents (corticosteroids, beta agonists) for chronic obstructive pulmonary disease (COPD): a rapid review and network meta-analysis. Toronto: ODPRN, St. Michaels Hospital; 2014.

    Google Scholar 

  77. 77.

    Public Health Wales. Primary care in Wales: rapid review of models and policy. [Internet] Wales. Public Health Wales; 2014. Available from:

  78. 78.

    Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med. 2009;6, e1000100.

    Article  PubMed  PubMed Central  Google Scholar 

  79. 79.

    Crawford C, Lee C, Bingham J, for the Active Self-Care Therapies for Pain Working Group. Sensory art therapies for the self-management of chronic pain symptoms. Pain Med. 2014;15:S66–75.

    Article  PubMed  Google Scholar 

  80. 80.

    Crawford C, Lee C, Buckenmaier C, Schoomaker E, Petri R, Jonas W, for the Active Self-Care Therapies for Pain Working Group. The current state of the science for active self-care complementary and integrative medicine therapies in the management of chronic pain symptoms: lessons learned, directions for the future. Pain Med. 2014;15:S104–13.

    Article  PubMed  Google Scholar 

  81. 81.

    Crawford C, Lee C, Freilich D, for the Active Self-Care Therapies for Pain Working Group. Effectiveness of active self-care complementary and integrative medicine therapies: options for the management of chronic pain symptoms. Pain Med. 2014;15:S86–95.

    Article  PubMed  Google Scholar 

  82. 82.

    Crawford C, Lee C, May T, for the Active Self-Care Therapies for Pain Working Group. Physically oriented therapies for the self-management of chronic pain symptoms. Pain Med. 2014;15:S54–65.

    Article  PubMed  Google Scholar 

  83. 83.

    Lee C, Crawford C, Hickey A, for the Active Self-Care Therapies for Pain Working Group. Mind–body therapies for the self-management of chronic pain symptoms. Pain Med. 2014;15:S21–39.

    Article  PubMed  Google Scholar 

  84. 84.

    Lee C, Crawford C, Schoomaker E, for the Active Self-Care Therapies for Pain Working Group. Movement therapies for the self-management of chronic pain symptoms. Pain Med. 2014;15:S40–53.

    Article  PubMed  Google Scholar 

  85. 85.

    Lee C, Crawford C, Swann S, for the Active Self-Care Therapies for Pain Working Group. Multimodal, integrative therapies for the self-management of chronic pain symptoms. Pain Med. 2014;15:S76–85.

    Article  PubMed  Google Scholar 

  86. 86.

    Lee C, Crawford C, Teo L, Spevak C, for the Active Self-Care Therapies for Pain Working Group. An analysis of the various chronic pain conditions captured in a systematic review of active self-care complementary and integrative medicine therapies for the management of chronic pain symptoms. Pain Med. 2014;15:S96–S103.

    Article  PubMed  Google Scholar 

  87. 87.

    Glasziou P, Altman DG, Bossuyt P, Boutron I, Clarke M, Julious S,Michie S, Moher D, Wager E. Reducing waste from incomplete or unusable reports of biomedical research. Lancet. 2014;383(9913):267–76.

    Article  PubMed  Google Scholar 

  88. 88.

    Windsor B, Popovich I, Jordan V, Showell M, Shea B, Farquhar C. Methodological quality of systematic reviews in subfertility: a comparison of Cochrane and non-Cochrane systematic reviews in assisted reproductive technologies. Hum Reprod. 2012;27(12):3460–6.

    CAS  Article  PubMed  Google Scholar 

  89. 89.

    Adie S, Ma D, Harris IA, Naylor JM, Craig JC. Quality of conduct and reporting of meta-analyses of surgical interventions. Ann Surg. 2015;261(4):685–94.

    Article  PubMed  Google Scholar 

  90. 90.

    Papageorgiou SN, Papadopoulos MA, Athanasiou AE. Reporting characteristics of meta-analyses in orthodontics: methodological assessment and statistical recommendations. Eur J Orthod. 2014;36(1):74–85.

    Article  PubMed  Google Scholar 

  91. 91.

    92. Cochrane Handbook for Systematic Reviews of Interventions, Version 5.1.0 [updated March 2011]: The Cochrane Collaboration; 2011. Available from

  92. 92.

    Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA, Group, Prisma- P. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ. 2015;349:g7647.

    Article  PubMed  Google Scholar 

  93. 93.

    Moher, D. Do we need a rapid review reporting guideline? Is PRISMA-P helpful when generating a RR protocol? Available at: CADTH Rapid Reviews Summit, Vancouver, BC. [Internet], February 2015.

  94. 94.

    Organization for Economic Co-operation and Development. The OECD health project—health technology and decision making. Available at:

  95. 95.

    Martens PJ, Roos NP. When health services researchers and policy makers interact: tales from the tectonic plates. Healthcare Policy. 2005;1(1):72–84.

    PubMed  PubMed Central  Google Scholar 

  96. 96.

    Kung J, Chiappelli F, Cajulis OO, Avezova R, Kossan G, Chew L, Maida CA. From systematic reviews to clinical recommendations for evidence-based health care: validation of revised assessment of multiple systematic reviews (R-AMSTAR) for grading of clinical relevance. Open Dent J. 2010;4:84–91.

    PubMed  PubMed Central  Google Scholar 

  97. 97.

    Pieper D, Buechter RB, Li L, Prediger B, Eikermann M. Systematic review found AMSTAR, but not R(evised)-AMSTAR, to have good measurement properties. J Clin Epidemiol. 2015;68(5):574–83.

    Article  PubMed  Google Scholar 

  98. 98.

    Maddern G. Rapid reviews or full health technology assessments—what are the needs in decision making? Health Technol Asses Int Meeting 2008 Montreal Canada. 2008.

    Google Scholar 

  99. 99.

    Van de Velde S, De Buck E, Dieltjens T, Aertgeerts B. Medicinal use of potato-derived products: conclusions of a rapid versus full systematic review. Phytother Res. 2011;25(5):787–8.

    Article  PubMed  Google Scholar 

  100. 100.

    Watt A, Cameron A, Sturm L, Lathlean T, Babidge W, Blamey S, Facey K, Hailey D, Norderhaug I, Maddern G. Rapid versus full systematic reviews: validity in clinical practice? ANZ J Surg. 2008;78(11):1037–40.

    Article  PubMed  Google Scholar 

  101. 101.

    Whitlock EP, Lin JS, Chou R, Shekelle P, Robinson KA. Using existing systematic reviews in complex systematic reviews. Ann Intern Med. 2008;148(10):776–82.

    Article  PubMed  Google Scholar 

  102. 102.

    Lang A, Edwards N, Fleiszer A. Empty systematic reviews: hidden perils and lessons learned. J Clin Epidemiol. 2007;60(6):595–7.

    Article  PubMed  Google Scholar 

  103. 103.

    Tricco AC, Moher D, Chen MH, Daniel R. Factors predicting completion and time to publication of Cochrane reviews. Open Medicine. 2009;3(4):e210–4.

    PubMed  PubMed Central  Google Scholar 

Download references


The authors would like to acknowledge Leigh-Ann Topfer (LAT) for her assistance with the literature search and updates and for helping with the initial screening of the rapid review samples. We would also like to thank the Canadian Agency for Drugs and Technologies in Health for their support on this work and all INAHTA survey respondents for taking the time to respond. This research received no funding from any agency in the public, commercial or not-for-profit sectors.

Author information



Corresponding author

Correspondence to Shannon E Kelly.

Additional information

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

SK, DM and TC concieved and designed the study. SK carried out the acquisition of the data. SK, TC and DM contributed to the analysis and interpretation of the data. SK participated in the drafting of the manuscript. SK, TC and DM contributed to the critical revision of the study. All authors read and approved the final manuscript.

Additional files

Additional file 1:

Search Strategy. Search Strategy and MeSH/keywords used for searching. (DOCX 32 kb)

Additional file 2:

Included and Excluded Study Lists. Details the sample of rapid reviews included in this manuscript and reports excluded studies. (DOCX 27 kb)

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Kelly, S.E., Moher, D. & Clifford, T.J. Quality of conduct and reporting in rapid reviews: an exploration of compliance with PRISMA and AMSTAR guidelines. Syst Rev 5, 79 (2016).

Download citation


  • Rapid review
  • Decision-making
  • Methodology
  • Conduct
  • Quality
  • Evidence synthesis
  • Accelerated methods
  • Reporting
  • Research transparency
  • Time factors