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  1. A growing body of research highlights the pervasive harms of adverse childhood experiences (ACEs) on health throughout the life-course. However, findings from prior reviews and recent longitudinal studies inve...

    Authors: André Bussières, Jan Hartvigsen, Manuela L. Ferreira, Paulo H. Ferreira, Mark J. Hancock, Laura S. Stone, Timothy H. Wideman, Jill Boruff and Ask Elklit

    Citation: Systematic Reviews 2020 9:215

    Content type: Protocol

    Published on:

  2. The experience of loneliness during pregnancy and in new parenthood has not been targeted and developed as a program of research, despite evidence indicating that the incidence of loneliness is highest in thos...

    Authors: Jacqueline Kent-Marvick, Sara Simonsen, Ryoko Pentecost and Mary M. McFarland

    Citation: Systematic Reviews 2020 9:213

    Content type: Protocol

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  3. The relationship between motor performance and back pain in children and adolescents remains unclear. This article describes the protocol for a systematic review to summarize the knowledge about the associatio...

    Authors: Matias Noll, Niels Wedderkopp, Carolina Rodrigues Mendonça and Per Kjaer

    Citation: Systematic Reviews 2020 9:212

    Content type: Protocol

    Published on:

  4. Homelessness is a global issue and HIV, hepatitis C and tuberculosis are known to be prevalent in this group. Homeless populations face significant barriers to care. We aim to summarise evidence of treatment i...

    Authors: Luke Johnson, Dan Lewer, Robert W. Aldridge, Andrew C. Hayward and Alistair Story

    Citation: Systematic Reviews 2020 9:211

    Content type: Protocol

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  5. Weight loss maintenance is a challenge for people with type 2 diabetes mellitus (T2DM), which attenuates the long-term benefits of weight loss for diabetes management. Medication, specific dietary requirements...

    Authors: Sarah Sauchelli, Julia Bradley, Jennifer Cox, Clare England and Rachel Perry

    Citation: Systematic Reviews 2020 9:210

    Content type: Protocol

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  6. A significant cause of morbidity and mortality during pregnancy is maternal anaemia. The causes of anaemia and the sequelae are varied, and the prevention and management are public health challenges, especiall...

    Authors: Vinogrin Dorsamy, Chauntelle Bagwandeen and Jagadesa Moodley

    Citation: Systematic Reviews 2020 9:209

    Content type: Protocol

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  7. Clinical aggression episodes, that is aggression and externalising behaviours that create risk, in acute care hospitals are increasing. Acute care staff are often not confident or trained in the management of ...

    Authors: Marijke Mitchell, Charmaine Bernie, Fiona Newall and Katrina Williams

    Citation: Systematic Reviews 2020 9:208

    Content type: Protocol

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  8. Internet- and mobile-based interventions (IMI) are an effective and scalable low-threshold solution to reach people who are undersupplied by current healthcare. Adapting interventions to the cultural and ethni...

    Authors: Kerstin Spanhel, Sumeyye Balci, Harald Baumeister, Juergen Bengel and Lasse B. Sander

    Citation: Systematic Reviews 2020 9:207

    Content type: Protocol

    Published on:

  9. This systematic review aimed to investigate whether the administration of hypnotic medicines, z-drugs, melatonin or benzodiazepines, reduced pain intensity postoperatively.

    Authors: Edel T. O’Hagan, Markus Hübscher, Christopher B. Miller, Christopher J. Gordon, Sylvia Gustin, Nancy Briggs and James H. McAuley

    Citation: Systematic Reviews 2020 9:206

    Content type: Research

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  10. Integrated community case management (iCCM) is a community-based child health strategy designed to reduce deaths due to pneumonia, malaria, and diarrhea in low-income countries. Due to the integrated nature of...

    Authors: Aliya Karim, Daniel Cobos Muñoz, Daniel Mäusezahl and Don de Savigny

    Citation: Systematic Reviews 2020 9:205

    Content type: Protocol

    Published on:

  11. Maternal behaviours in pregnancy associated with adverse pregnancy, birth and health outcomes include tobacco smoking, poor nutrition, alcohol consumption and low physical activity, collectively referred to as...

    Authors: Jenna L. Hollis, Emma Doherty, Julia Dray, Danika Tremain, Mandy Hunter, Karen Takats, Christopher M. Williams, Henry Murray, Craig E. Pennell, Belinda Tully, John Wiggers, Justine B. Daly and Melanie Kingsland

    Citation: Systematic Reviews 2020 9:204

    Content type: Protocol

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  12. Gastroschisis is a congenital anomaly that needs surgical management for repositioning intestines into the abdominal cavity and for abdominal closure. Higher hospital or surgeon volume has previously been foun...

    Authors: Johannes Morche, Tim Mathes, Anja Jacobs, Lucas Wessel, Edmund A. M. Neugebauer and Dawid Pieper

    Citation: Systematic Reviews 2020 9:203

    Content type: Protocol

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  13. Maternal prenatal health has been shown to be an important influence on children’s developmental outcomes, which has led to an increased emphasis on providing more information to support clinical decisions in ...

    Authors: Janell Kwok, Hildigunnur Anna Hall, Aja Louise Murray and Bonnie Auyeung

    Citation: Systematic Reviews 2020 9:202

    Content type: Protocol

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  14. Thyroid eye disease is an autoimmune disorder of the orbital retrobulbar tissue commonly associated with dysthyroid status. The most frequent condition is hyperthyroidism, although it is also present in hypoth...

    Authors: Juliana Muñoz-Ortiz, Maria Camila Sierra-Cote, Estefanía Zapata-Bravo, Laura Valenzuela-Vallejo, Maria Alejandra Marin-Noriega, Pilar Uribe-Reina, Juan Pablo Terreros-Dorado, Marcela Gómez-Suarez, Karla Arteaga-Rivera and Alejandra de-la-Torre

    Citation: Systematic Reviews 2020 9:201

    Content type: Research

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  15. The burden of opioid use disorder (OUD) has been increasing in North America. Administration of medication-assisted treatments (MATs) for OUD on an individual-dose basis has been shown to affect patient respon...

    Authors: Caroul Chawar, Alannah Hillmer, Stephanie Sanger, Alessia D’Elia, Balpreet Panesar, Lucy Guan, Dave Xiaofei Xie, Nandini Bansal, Aamna Abdullah, Flavio Kapczinski, Guillaume Pare, Lehana Thabane and Zainab Samaan

    Citation: Systematic Reviews 2020 9:200

    Content type: Protocol

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  16. Philanthropists, charity leaders and policy-makers have increasingly recognised that the process of giving resources needs to be grounded in evidence—sometimes referred to as ‘evidence-based’ or ‘data-driven’ ...

    Authors: Caroline Greenhalgh and Paul Montgomery

    Citation: Systematic Reviews 2020 9:199

    Content type: Systematic review update

    Published on:

  17. Gambling and problem gambling are increasingly being viewed as a public health issue. European surveys have reported a high prevalence of gambling, and according to the Gambling Commission, in 2018, almost hal...

    Authors: Caryl Beynon, Nicola Pearce-Smith and Rachel Clark

    Citation: Systematic Reviews 2020 9:198

    Content type: Protocol

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  18. The inclusion of authors from diverse backgrounds and with different lived experiences is critical to ensuring the questions addressed in systematic reviews (SRs), as well as the subsequent conclusions and rec...

    Authors: Riaz Qureshi, Genie Han, Kolade Fapohunda, Samuel Abariga, Renee Wilson and Tianjing Li

    Citation: Systematic Reviews 2020 9:192

    Content type: Research

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  19. Data from studies with undergraduate and postgraduate taught students suggest that they are at an increased risk of having mental health problems, compared to the general population. By contrast, the literatur...

    Authors: Cassie M. Hazell, Laura Chapman, Sophie F. Valeix, Paul Roberts, Jeremy E. Niven and Clio Berry

    Citation: Systematic Reviews 2020 9:197

    Content type: Research

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  20. Mobility, one of the basic daily activities, helps in carrying out routine work, which contributes to people’s well-being. A lack of friendly and accessible infrastructure may act as a barrier, which limits ol...

    Authors: Divya Sussana Patil, Uday Narayan Yadav, Sobin George, Marco Helbich, Dick Ettema and Ajay Bailey

    Citation: Systematic Reviews 2020 9:196

    Content type: Protocol

    Published on:

  21. Hypertension is a disease with significant clinical and socio-economic consequences. The reduction in cardiovascular mortality and morbidity in patients treated for hypertension is directly related to the magn...

    Authors: Elena Filipova, Stela Dineva, Katya Uzunova, Velichka Pavlova, Krassimir Kalinov and Toni Vekov

    Citation: Systematic Reviews 2020 9:195

    Content type: Systematic review update

    Published on:

  22. Several cardiovascular pathologies cause heart failure. Heart failure with reduced ejection fraction (HFrEF) is deteriorated by neurohormonal activation, so neurohormonal antagonists are recommended in HFrEF p...

    Authors: Rama Krishna Guggilla, Pawel Mateusz Sowa, Jacek Jamiolkowski, Siamala Sinnadurai, Adnan Amin and Karol Adam Kaminski

    Citation: Systematic Reviews 2020 9:194

    Content type: Protocol

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  23. Arteriovenous (AV) hemodialysis access creation is recommended by international guidelines as the preferred method of hemodialysis access. However, most AV access sites will require revision to maintain patenc...

    Authors: Mark Rockley, Sudhir Nagpal, Ashish Gupta and Derek J. Roberts

    Citation: Systematic Reviews 2020 9:193

    Content type: Protocol

    Published on:

  24. Antenatal care is one of the continua of reproductive health care, and inadequate antenatal care utilization results in an adverse feto-maternal outcome. Pregnancy intention is an essential factor that plays a...

    Authors: Tadesse Tolossa, Ebisa Turi, Getahun Fetensa, Ginenus Fekadu and Fassikaw Kebede

    Citation: Systematic Reviews 2020 9:191

    Content type: Research

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  25. With the legalization of cannabis in Canada, there is an increase trend in use. Cannabis has been known to have several health implications, one of which is the development of cannabis use disorder (CUD). CUD ...

    Authors: Alannah Hillmer, Caroul Chawar, Stephanie Sanger, Alessia D’Elia, Mehreen Butt, Raveena Kapoor, Flavio Kapczinski, Guillaume Pare, Lehana Thabane and Zainab Samaan

    Citation: Systematic Reviews 2020 9:190

    Content type: Protocol

    Published on:

  26. Metastasectomy is performed on a select cohort of patients with advanced and/or recurrent bone and soft tissue sarcomas because of the potential for long term relapse free and overall survival associated with ...

    Authors: Ying Wang, Megan Delisle, Denise Smith and Amirrtha Srikanthan

    Citation: Systematic Reviews 2020 9:189

    Content type: Protocol

    Published on:

  27. Hospitalized newborn infants may require analgesia and sedation either for the management of procedural pain, during or after surgery, and other painful conditions. The benefits and harms of opioids administer...

    Authors: Mari Kinoshita, Katarzyna Stempel, Israel Junior Borges do Nascimento, Dhashini Naidu Vejayaram, Elisabeth Norman and Matteo Bruschettini

    Citation: Systematic Reviews 2020 9:183

    Content type: Protocol

    Published on:

  28. Mesenchymal stem cells (MSCs) are multipotent cells that demonstrate therapeutic potential for the treatment of acute and chronic inflammatory-mediated conditions. Especially for acute conditions, it is critic...

    Authors: Chintan Dave, Andrea McRae, Emily Doxtator, Shirley H. J. Mei, Katrina Sullivan, Dianna Wolfe, Josee Champagne and Lauralyn McIntyre

    Citation: Systematic Reviews 2020 9:188

    Content type: Protocol

    Published on:

  29. Recent surveys of Canadian cannabis users reflect increasing consumption rates, some of whom may have diabetes. However, healthcare providers have limited information resources on the effects of recreational c...

    Authors: Caroline J. Porr, Patricia Rios, Harpreet S. Bajaj, Aoife M. Egan, Celine Huot, Ryan Batten, Lisa Bishop, Devonne Ryan, Erin Davis, Nazia Darvesh, Arifur Rahman, Shabnam Asghari, Lily Acheampong and Andrea C. Tricco

    Citation: Systematic Reviews 2020 9:187

    Content type: Research

    Published on:

  30. According to the United Nation High Commissioner for Refugee Global Trends report in 2019, on average, there are 2.7 refugees per 1000 national population in high-income countries, where girls and women attrib...

    Authors: Sarah DeSa, Akalewold T. Gebremeskel and Sanni Yaya

    Citation: Systematic Reviews 2020 9:186

    Content type: Protocol

    Published on:

  32. Systematic reviews of medical devices are particularly challenging as the quality of evidence tends to be more limited than evidence on pharmaceutical products. This article describes the methods used to ident...

    Authors: Ros Wade, Sahar Sharif-Hurst, Melissa Harden, Matthew Walton, Lindsay Claxton, Robert Hodgson and Alison Eastwood

    Citation: Systematic Reviews 2020 9:184

    Content type: Research

    Published on:

  33. Acute low back pain is associated with pain and disability, but symptoms are often self-healing. The effectiveness of exercise therapy for acute low back pain remains uncertain with conflicting evidence from s...

    Authors: Marc Karlsson, Anna Bergenheim, Maria E. H. Larsson, Lena Nordeman, Maurits van Tulder and Susanne Bernhardsson

    Citation: Systematic Reviews 2020 9:182

    Content type: Research

    Published on:

  34. Diet during infancy and early childhood can have implications on child growth, health, and developmental trajectories. Yet, poor dietary habits are common in young children, who often consume diets that are no...

    Authors: Jacklyn Jackson, Luke Wolfenden, Alice Grady, Melanie Lum, Alecia Leonard, Sam McCrabb, Alix Hall, Nicole Pearson, Courtney Barnes and Sze Lin Yoong

    Citation: Systematic Reviews 2020 9:181

    Content type: Protocol

    Published on:

  35. Signals of adverse drug reactions (ADRs) form the basis of some regulatory risk-minimization actions in pharmacovigilance. Reviews of limited scope have highlighted that such signals are mostly supported by re...

    Authors: Daniele Sartori, Jeffrey K. Aronson and Igho J. Onakpoya

    Citation: Systematic Reviews 2020 9:180

    Content type: Protocol

    Published on:

  36. A comprehensive overview of treatments of common fractures is missing, although it would be important for shared decision-making in clinical practice. The aim was to determine benefits and harms of surgical co...

    Authors: Søren T. Skou, Carsten B. Juhl, Kristoffer B. Hare, L. Stefan Lohmander and Ewa M. Roos

    Citation: Systematic Reviews 2020 9:179

    Content type: Research

    Published on:

  38. Indigenous communities are often portrayed from a deficit-based lens; however, Indigenous communities have self-determined perspectives of health and well-being that are strength based. The objective of this s...

    Authors: K. Thiessen, M. Haworth-Brockman, R. Stout, P. Moffitt, J. Gelowitz, J. Schneider and L. Demczuk

    Citation: Systematic Reviews 2020 9:177

    Content type: Protocol

    Published on:

  39. Vitamin D deficiency can play a role in extraskeletal functions that are involved with a set of risk factors associated with metabolic syndrome (MetS). The purpose of this review is to investigate the impact o...

    Authors: Séphora Louyse Silva Aquino, Aline Tuane Oliveira Cunha, Josivan Gomes Lima, Karine Cavalcanti Maurício Sena-Evangelista, Antonio Gouveia Oliveira, Ricardo Ney Cobucci and Lucia Fatima Campos Pedrosa

    Citation: Systematic Reviews 2020 9:176

    Content type: Protocol

    Published on:

  40. Use of electroencephalography (EEG) is currently recommended by the American Clinical Neurophysiology Society for a wide range of indications, including diagnosis of nonconvulsive status epilepticus and evalua...

    Authors: Shaurya Taran, Wael Ahmed, Esther Bui, Lara Prisco, Cecil D. Hahn and Victoria A. McCredie

    Citation: Systematic Reviews 2020 9:175

    Content type: Protocol

    Published on:

  41. Malaria is one of the major contributing risk factors for poor development of children living in low- and middle-income countries (LMICs). However, little is known about the specific domains of cognition and b...

    Authors: Andrew Sentoogo Ssemata, Jacquelline Ann Nakitende, Simon Kizito, Elizabeth C. Whipple, Paul Bangirana, Noeline Nakasujja, Chandy C. John and Megan S. McHenry

    Citation: Systematic Reviews 2020 9:174

    Content type: Protocol

    Published on:

  42. Healthcare workers (HCWs) are at particular risk during pandemics and epidemics of highly virulent diseases with significant morbidity and case fatality rate. These diseases include severe acute respiratory sy...

    Authors: Ana Licina, Andrew Silvers and Rhonda L. Stuart

    Citation: Systematic Reviews 2020 9:173

    Content type: Systematic review update

    Published on:

  43. Home-based hospitalization (HBH) offers an alternative delivery model to hospital care. There has been a remarkable increase in pilot initiatives and deployment of this model to optimize services offered to a ...

    Authors: Christiane Pereira Martins Casteli, Gisèle Irène Claudine Mbemba, Serge Dumont, Clémence Dallaire, Lucille Juneau, Elisabeth Martin, Marie-Claude Laferrière and Marie-Pierre Gagnon

    Citation: Systematic Reviews 2020 9:172

    Content type: Research

    Published on:

  44. With the rapid development of technologies for type 1 diabetes, economic evaluations are integral in guiding cost-effective clinical and policy decisions. We therefore aimed to review and synthesise the curren...

    Authors: Anthony Pease, Ella Zomer, Danny Liew, Clement Lo, Arul Earnest and Sophia Zoungas

    Citation: Systematic Reviews 2020 9:171

    Content type: Research

    Published on:

  45. The World Health Organization declared on March 11, 2020, that the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) has escalated from epidemic into pandemic. As the initial outbreak ...

    Authors: Yuxi Li, Juan Li, Dongling Zhong, Yue Zhang, Yonggang Zhang, Yan Guo, Mike Clarke and Rongjiang Jin

    Citation: Systematic Reviews 2020 9:170

    Content type: Protocol

    Published on:

  46. Psychological stress is a prevalent factor in inflammatory bowel disease (IBD) with detrimental effects on patients’ quality of life and possibly disease course. Although the aetiology of symptom exacerbation ...

    Authors: Mariyana Schoultz, Michelle Beattie, Trish Gorely and Janni Leung

    Citation: Systematic Reviews 2020 9:169

    Content type: Research

    Published on:

  47. Behavioural weight management programmes are effective in assisting people with overweight or obesity to lose excess body weight. Yet, many still struggle to attain their weight loss goals in such programmes. ...

    Authors: Meigan Thomson, Anne Martin, Jennifer Logue, Valerie Wells and Sharon A. Simpson

    Citation: Systematic Reviews 2020 9:168

    Content type: Protocol

    Published on:

  48. Medical cannabis (MC) is currently being used as an adjunct to opiates given its analgesic effects and potential to reduce opiate addiction. This review assessed if MC used in combination with opioids to treat...

    Authors: Babasola O. Okusanya, Ibitola O. Asaolu, John E. Ehiri, Linda Jepkoech Kimaru, Abidemi Okechukwu and Cecilia Rosales

    Citation: Systematic Reviews 2020 9:167

    Content type: Research

    Published on:

  49. Professional identity development is an area of contemporary interest within medical education. It can be defined as ‘the foundational process one experiences during the transformation from lay person to physi...

    Authors: Megan El Brown, Paul Whybrow, Gavin Kirwan and Gabrielle M. Finn

    Citation: Systematic Reviews 2020 9:166

    Content type: Protocol

    Published on:

  50. Caregivers of women with breast cancer in low-and-middle-income countries experience significant physical and economic burdens. The review aimed to map the evidence of studies that had reported on the experien...

    Authors: Grace Kusi, Adwoa Bemah Boamah Mensah, Kofi Boamah Mensah, Veronica Millicent Dzomeku, Felix Apiribu, Precious Adade Duodu, Bakinam Adamu, Pascal Agbadi and Kwadwo Osei Bonsu

    Citation: Systematic Reviews 2020 9:165

    Content type: Systematic review update

    Published on:

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