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  1. Acute hypoxemic respiratory failure is one of the leading causes of intensive care unit admission and is associated with high mortality. Noninvasive oxygenation strategies such as high-flow nasal cannula, stan...

    Authors: Bruno L. Ferreyro, Federico Angriman, Laveena Munshi, Lorenzo Del Sorbo, Niall D. Ferguson, Bram Rochwerg, Michelle J. Ryu, Refik Saskin, Hannah Wunsch, Bruno R. da Costa and Damon C. Scales

    Citation: Systematic Reviews 2020 9:95

    Content type: Protocol

    Published on:

  2. Recognising the influence of context and the context-sensitive nature of quality improvement (QI) interventions is crucial to implementing effective improvements and successfully replicating them in new settin...

    Authors: Emma Coles, Julie Anderson, Margaret Maxwell, Fiona M. Harris, Nicola M. Gray, Gill Milner and Stephen MacGillivray

    Citation: Systematic Reviews 2020 9:94

    Content type: Research

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  3. Sub-Saharan Africa carries the greatest burden of HIV-infection with increasing drug resistance burden, which requires improved patient management and monitoring. Current WHO recommendations suggest transition...

    Authors: Ezechiel Ngoufack Jagni Semengue, Maria Mercedes Santoro, Valantine Ngum Ndze, Beatrice Dambaya, Desiré Takou, Georges Teto, Alex Durand Nka, Lavinia Fabeni, Alison Wiyeh, Francesca Ceccherini-Silberstein, Vittorio Colizzi, Carlo-Federico Perno and Joseph Fokam

    Citation: Systematic Reviews 2020 9:93

    Content type: Protocol

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  4. Epilepsy affects nearly 50 million people worldwide. Self-management is critical for individuals with epilepsy in order to maintain optimal physical, cognitive, and emotional health. Implementing and adopting ...

    Authors: Allison A. Lewinski, Abigail Shapiro, Jennifer M. Gierisch, Karen M. Goldstein, Dan V. Blalock, Matthew W. Luedke, Adelaide M. Gordon, Hayden B. Bosworth, Connor Drake, Jeffrey D. Lewis, Saurabh R. Sinha, Aatif M. Husain, Tung T. Tran, Megan G. Van Noord and John W. Williams Jr

    Citation: Systematic Reviews 2020 9:92

    Content type: Research

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  5. The importance of teaching the skills and practice of evidence-based medicine (EBM) for medical professionals has steadily grown in recent years. Alongside this growth is a need to evaluate the effectiveness o...

    Authors: Bharathy Kumaravel, Jasmine Heath Hearn, Leila Jahangiri, Rachel Pollard, Claire J. Stocker and David Nunan

    Citation: Systematic Reviews 2020 9:91

    Content type: Research

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  6. Globally, miniscule improvements have been implemented regarding equality, inclusion, access, and protection of people with diverse gender identities whilst accessing health care facilities of which transgende...

    Authors: Delarise M. Mulqueeny, Senzelokuhle M. Nkabini and Tivani P. Mashamba-Thompson

    Citation: Systematic Reviews 2020 9:90

    Content type: Protocol

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  7. The necessity of antibiotic prophylaxis for postoperative urinary tract infections (UTIs) after transurethral resection of bladder tumours is controversial. This potentially leads to the overuse of antibiotic ...

    Authors: Kathrin Bausch, Soheila Aghlmandi, Sarah Ursula Sutter, Linda Maria Stamm, Hannah Ewald, Christian Appenzeller-Herzog, Jan Adam Roth, Andreas F. Widmer and Hans-Helge Seifert

    Citation: Systematic Reviews 2020 9:89

    Content type: Protocol

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  8. People living with HIV (PLHIV) are at a high risk of developing HPV-related cancers. HPV-related malignancies occur frequently and/or are high among PLHIV, with cervical cancer as a designated AIDS-defining co...

    Authors: Kabelo Matjie Bridget Lekoane, Desmond Kuupiel, Tivani P. Mashamba-Thompson and Themba G. Ginindza

    Citation: Systematic Reviews 2020 9:88

    Content type: Research

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  9. Food and nutrition literacy is a newly emerged concept to connect food-related knowledge and skills to healthy diets. Its promotion is important to protect children as they eat too many low-nutrient, high-ener...

    Authors: Azam Doustmohammadian, Nasrin Omidvar and Elham Shakibazadeh

    Citation: Systematic Reviews 2020 9:87

    Content type: Protocol

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  10. Tobacco consumption is the leading cause of preventable death globally. The global mortality burden of tobacco use lies predominantly in low- to middle-income countries (LMICs). There is much evidence on the e...

    Authors: Navin Kumar, Jessica Ainooson, Ameera Billings, Grace Chen, Lauren Cueto, Kamila Janmohamed, Jeannette Jiang, Raymond Niaura and Amy Zhang

    Citation: Systematic Reviews 2020 9:86

    Content type: Protocol

    Published on:

  11. Surgical interventions for the treatment of stress urinary incontinence (SUI) in women are commonly employed following the failure of minimally invasive therapies. Due to the limited information available on t...

    Authors: Mehdi Javanbakht, Eoin Moloney, Miriam Brazzelli, Sheila Wallace, Muhammad Imran Omar, Ash Monga, Lucky Saraswat, Phil Mackie, Mari Imamura, Jemma Hudson, Michal Shimonovich, Graeme MacLennan, Luke Vale and Dawn Craig

    Citation: Systematic Reviews 2020 9:85

    Content type: Research

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  12. Most of the major cities in the developed western countries are characterized by an increasing multiculturalism brought by the immigrant population. The immigrant communities face challenges in the new environ...

    Authors: Tanvir C. Turin, Nashit Chowdhury, Mahzabin Ferdous, Marcus Vaska, Nahid Rumana, Rudra Dahal, Nafiza Rahman and Mohammad Z. I. Chowdhury

    Citation: Systematic Reviews 2020 9:84

    Content type: Protocol

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  13. Non-melanoma skin cancer, which includes basal cell carcinoma and cutaneous squamous cell carcinoma, is the commonest malignancy worldwide. The mainstay of treatment is surgical excision. Despite this being an...

    Authors: Grant S. Nolan, Justin C. R. Wormald, Ailbhe L. Kiely, Joshua P. Totty and Abhilash Jain

    Citation: Systematic Reviews 2020 9:83

    Content type: Protocol

    Published on:

  14. Emergency telehealth has been used to improve accessibility of rural and remote patients to specialist care. Evidence to date has demonstrated effectiveness and cost-effectiveness of telehealth in rural and re...

    Authors: Christina Tsou, Suzanne Robinson, James Boyd, Andrew Jamieson, Robert Blakeman, Kylie Bosich, Justin Yeung, Stephanie Waters and Delia Hendrie

    Citation: Systematic Reviews 2020 9:82

    Content type: Protocol

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  15. So far, only one meta-analysis has estimated the prevalence of rheumatoid arthritis (RA) in Africa. Out of 10 studies included in that meta-analysis, nine came from sub-Saharan African countries and had been p...

    Authors: Mickael Essouma, Jan René Nkeck, Francky Teddy Endomba, Jean Joel Bigna and Stéphane Ralandison

    Citation: Systematic Reviews 2020 9:81

    Content type: Protocol

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  16. Cancer predominates in adults over age 65. Cancer treatments are known to create physical and psychosocial challenges, which may be amplified for older adults with cancer.

    Authors: Kristen R. Haase, Martine Puts, Schroder Sattar, Mikaela Gray, Cindy Kenis, Valentina Donison, Steven Hall, Bianca McLean, Aria Wills and Doris Howell

    Citation: Systematic Reviews 2020 9:80

    Content type: Protocol

    Published on:

  17. Cervical cancer has become a major public health challenge in developing countries with a reported age-standardised incidence rate of about 17.9/100,000/year and lifetime risks approaching 1 in 20 in some sett...

    Authors: Witness Mapanga, Elvira Singh, Shingairai A. Feresu and Brendan Girdler-Brown

    Citation: Systematic Reviews 2020 9:79

    Content type: Systematic review update

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  18. Pre-eclampsia and being born small for gestational age are associated with significant maternal and neonatal morbidity and mortality. Placental dysfunction is a key pathological process underpinning these cond...

    Authors: Melanie Griffin, Alexander E. P. Heazell, Lucy C. Chappell, Jian Zhao and Deborah A. Lawlor

    Citation: Systematic Reviews 2020 9:78

    Content type: Protocol

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  19. A previous study found that 2 of 29 (6.9%) meta-analyses published in high-impact journals in 2009 reported included drug trials’ funding sources, and none reported trial authors’ financial conflicts of intere...

    Authors: Carla Benea, Kimberly A. Turner, Michelle Roseman, Lisa A. Bero, Joel Lexchin, Erick H. Turner and Brett D. Thombs

    Citation: Systematic Reviews 2020 9:77

    Content type: Research

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  20. A new type of coronavirus, novel coronavirus (COVID-19), is causing an increasing number of cases of pneumonia and was declared a Public Health Emergency of International Concern by the World Health Organizati...

    Authors: Yuxi Li, Xiaobo Liu, Liuxue Guo, Juan Li, Dongling Zhong, Yonggang Zhang, Mike Clarke and Rongjiang Jin

    Citation: Systematic Reviews 2020 9:75

    Content type: Protocol

    Published on:

  21. Autogenic training is a relaxation technique that uses systematic exercises to induce a general disconnection of the organism. It is used in conjunction with conventional medical care as part of disease manage...

    Authors: Maria Pilar Ramirez-Garcia, Jérôme Leclerc-Loiselle, Christine Genest, Renaud Lussier and Golsa Dehghan

    Citation: Systematic Reviews 2020 9:74

    Content type: Protocol

    Published on:

  22. Improving the speed of systematic review (SR) development is key to supporting evidence-based medicine. Machine learning tools which semi-automate citation screening might improve efficiency. Few studies have ...

    Authors: Amy Y. Tsou, Jonathan R. Treadwell, Eileen Erinoff and Karen Schoelles

    Citation: Systematic Reviews 2020 9:73

    Content type: Research

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  23. Dedicated air ambulance services provide a vital link for critically ill and injured patients to higher levels of care. The recent developments of pre-hospital and retrieval medicine create an opportunity for ...

    Authors: Kristin H. Edwards, Gerard FitzGerald, Richard C. Franklin and Mark Terrell Edwards

    Citation: Systematic Reviews 2020 9:72

    Content type: Protocol

    Published on:

  24. Alzheimer’s disease (AD) is a neurodegenerative disorder commonly associated with deficits of cognition and changes in behavior. Mild cognitive impairment (MCI) is the prodromal stage of AD that is defined by ...

    Authors: Maryam Ahmadzadeh, Gregory J. Christie, Theodore D. Cosco and Sylvain Moreno

    Citation: Systematic Reviews 2020 9:71

    Content type: Protocol

    Published on:

  25. Occlusive atherosclerotic disease of the anterior cerebral circulation is one of the most common causes of anterior circulation ischemia and stroke. Treatment options include medical therapies (including antip...

    Authors: Xuesong Bai, Yao Feng, Kun Yang, Tao Wang, Jichang Luo, Xue Wang, Feng Ling, Yan Ma and Liqun Jiao

    Citation: Systematic Reviews 2020 9:70

    Content type: Protocol

    Published on:

  26. The early recognition of invasive bacterial infections (IBI) in children can be difficult. Clinically it is often challenging to differentiate between the early stages of an IBI and a benign self-limiting vira...

    Authors: Michael Corr, Thomas Waterfield, Derek Fairley, James McKenna and Michael D. Shields

    Citation: Systematic Reviews 2020 9:69

    Content type: Protocol

    Published on:

  27. Internet gaming disorder (IGD) was included in the DSM-5 in 2013 as a condition requiring further research, and gaming disorder (GD) was included in the ICD-11 in 2018. Given the importance of including these ...

    Authors: Nazia Darvesh, Amruta Radhakrishnan, Chantelle C. Lachance, Vera Nincic, Jane P. Sharpe, Marco Ghassemi, Sharon E. Straus and Andrea C. Tricco

    Citation: Systematic Reviews 2020 9:68

    Content type: Research

    Published on:

  28. Hypoxemia is a severe condition associated with high rates of mortality, particularly in low- and middle-income countries (LMICs) with poor access to oxygen therapy. Despite its clinical significance, there ha...

    Authors: Felix Lam, Rami Subhi, Jason Houdek, Kate Schroder, Audrey Battu and Hamish Graham

    Citation: Systematic Reviews 2020 9:67

    Content type: Protocol

    Published on:

  29. Breast cancer is one of the most common malignancies in women worldwide, and one of the leading causes of cancer-related death. Programmed cell death 1 (PD-1) and its ligand (PD-L1) are key physiologic suppres...

    Authors: Isnard Elman Litvin, Machline Paim Paganella, Eliana Marcia Wendland and Adriana Vial Roehe

    Citation: Systematic Reviews 2020 9:66

    Content type: Protocol

    Published on:

  30. This protocol outlines a systematic review methodology, aiming to assess the recent evidence-base for the impact of testing strategies and approaches on access to testing, testing coverage, and linkage to care...

    Authors: Suzanna C. Francis, Arun Parajuli, Otilia Mardh, Jane Falconer, Aura Andreasen and Emma Harding-Esch

    Citation: Systematic Reviews 2020 9:64

    Content type: Protocol

    Published on:

  31. Traumatic cervicogenic dizziness is dizziness that is temporally associated with neck pain and injury after other causes of dizziness have been excluded. It can lead to activity limitations and participation r...

    Authors: Carrie W. Hoppes, Anthony J. Romanello, Kathryn E. Gaudette, William K. Herron, Anne E. McCarthy, Catherine J. McHale, Joan Bares, Rose Turner and Susan L. Whitney

    Citation: Systematic Reviews 2020 9:62

    Content type: Protocol

    Published on:

  32. Attachment in the parent-infant dyads is fundamental for growth and development of children born prematurely. However, the natural process of attachment is interrupted just after preterm birth, and emotional a...

    Authors: Ah. Rim Kim, Soo-yeon Kim and Ji Eun Yun

    Citation: Systematic Reviews 2020 9:61

    Content type: Protocol

    Published on:

  33. Unwanted anticholinergic effects are both underestimated and frequently overlooked. Failure to identify adverse drug reactions (ADRs) can lead to prescribing cascades and the unnecessary use of over-the-counte...

    Authors: Maria-Sophie Brueckle, Elizabeth T. Thomas, Svenja E. Seide, Maximilian Pilz, Ana Isabel Gonzalez-Gonzalez, Truc Sophia Nguyen, Sebastian Harder, Paul P. Glasziou, Ferdinand M. Gerlach and Christiane Muth

    Citation: Systematic Reviews 2020 9:59

    Content type: Protocol

    Published on:

  34. Cognitive impairment is a common and frequently under-recognized complication of chronic kidney disease (CKD). Although there is extensive literature on cognitive interventions that can ameliorate cognitive im...

    Authors: Janine F. Farragher, Katherine E. Stewart, Tyrone G. Harrison, Lisa Engel, Samantha E. Seaton and Brenda R. Hemmelgarn

    Citation: Systematic Reviews 2020 9:58

    Content type: Protocol

    Published on:

  35. Globally, low back pain (LBP) is a major public health problem affecting mainly adults of the working class and is the leading cause of disability. The estimated lifetime prevalence of LBP is 50 to 80%. From 1...

    Authors: Morris Kahere and Themba Ginindza

    Citation: Systematic Reviews 2020 9:57

    Content type: Protocol

    Published on:

  36. Both high-intensity interval training and moderate-intensity continuous training demonstrate beneficial physiological outcomes for active and insufficiently active populations. However, it remains unclear whet...

    Authors: Alexandre Santos, Chris Lonsdale, David Lubans, Diego Vasconcellos, Nathanial Kapsal, Mathew Vis-Dunbar and Mary E. Jung

    Citation: Systematic Reviews 2020 9:56

    Content type: Protocol

    Published on:

  37. School feeding programs are beneficial for the physical, mental, and psychosocial development of school-age children and adolescents, particularly those in low- and middle-income countries (LMICs). While schoo...

    Authors: Dongqing Wang and Wafaie W. Fawzi

    Citation: Systematic Reviews 2020 9:55

    Content type: Protocol

    Published on:

  38. Non-infectious scleritis is a potentially sight-threatening condition in which the sclera, the white outer layer of the eye, becomes inflamed. Whilst scleritis can be infective, the majority of cases are due t...

    Authors: Sathana Ingaralingam, Saaeha Rauz, Philip I. Murray and Robert J. Barry

    Citation: Systematic Reviews 2020 9:54

    Content type: Protocol

    Published on:

  39. As systematic reviews’ limited coverage of the medical literature necessitates decision-making based on unsystematic review, we investigated a possible advantage of systematic review (aside from dataset size a...

    Authors: Michael Saginur, Dean Fergusson, Tinghua Zhang, Karen Yeates, Tim Ramsay, George Wells and David Moher

    Citation: Systematic Reviews 2020 9:53

    Content type: Research

    Published on:

  40. In sub-Saharan Africa (SSA), malnutrition remains a major public health challenge, particularly among children under 5 years of age. Despite nutritional screening tools being developed and available to detect ...

    Authors: Tlharihani Phisac Maphosa, Delarise Maud Mulqueeny, Ernest Osei, Desmond Kuupiel and Tivani P. Mashamba-Thompson

    Citation: Systematic Reviews 2020 9:52

    Content type: Protocol

    Published on:

  41. Precarious employment has become an urgent public health issue at a global scale with potential consequences for quality of life and health of employees, especially in vulnerable groups such as migrants. The p...

    Authors: Ozlem Koseoglu Ornek, Tobias Weinmann, Julia Waibel and Katja Radon

    Citation: Systematic Reviews 2020 9:50

    Content type: Protocol

    Published on:

  42. Colorectal cancer, a prevalent malignancy worldwide, is associated with numerous modifiable and non-modifiable risk factors that play a role in the early detection and successful treatment of cancer. Despite i...

    Authors: Undine Antonia Stark, Thomas Frese, Susanne Unverzagt and Alexander Bauer

    Citation: Systematic Reviews 2020 9:49

    Content type: Protocol

    Published on:

  43. Equine-assisted treatments of the motor system appear to have an effect on the neuromuscular system and aim to improve the pathological condition of children with cerebral palsy. Hippotherapy is a distinct for...

    Authors: Martin Häusler and Nicole Heussen

    Citation: Systematic Reviews 2020 9:48

    Content type: Protocol

    Published on:

  44. Central nervous system tumors remain the leading cause of cancer-related mortality amongst children with solid tumors, with medulloblastoma (MB) representing the most common pediatric brain malignancy. Despite...

    Authors: Ashley A. Adile, Michelle M. Kameda-Smith, David Bakhshinyan, Laura Banfield, Sabra K. Salim, Forough Farrokhyar and Adam J. Fleming

    Citation: Systematic Reviews 2020 9:47

    Content type: Protocol

    Published on:

  45. Behavior change is not simple, and the introduction of guidelines or protocols does not mean that they will be followed. As such, implementation strategies are vital for the uptake and sustainability of change...

    Authors: Alex Aregbesola, Ahmed M. Abou-Setta, Maya M. Jeyaraman, George Okoli, Otto Lam, Kathryn M. Sibley and Terry P. Klassen

    Citation: Systematic Reviews 2020 9:46

    Content type: Protocol

    Published on:

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