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  1. Content type: Protocol

    Childhood obesity has become a global epidemic irrespective of the socioeconomic status of a country or nation. Obesity increases the risk of various diseases in children, for example asthma, sleep apnea, bone...

    Authors: Abdul Wajid, Muhammad Kashif Mughal, Deborah McNeil, Helen Lee Robertson and Dawn Kingston

    Citation: Systematic Reviews 2018 7:133

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  2. Content type: Protocol

    Breast cancer and its treatment can have many physical and psychological effects on affected women. Women’s personal goals may provide insight into their priorities and motivations in the context of breast can...

    Authors: Andrea Chow, Justin Presseau, Iris Perelman, Lindsey Sikora and Dean Fergusson

    Citation: Systematic Reviews 2018 7:132

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  3. Content type: Protocol

    Angiotensin-converting enzyme inhibitors (ACEis) and angiotensin II receptor blockers (ARBs) efficaciously reduce systolic blood pressure (BP), a well-established risk factor for myocardial infarction (MI). Bo...

    Authors: Jonathan A. Batty, Mengyao Tang, Marlous Hall, Roberto Ferrari, Martin H. Strauss and Alistair S. Hall

    Citation: Systematic Reviews 2018 7:131

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  4. Content type: Protocol

    Unsafe abortion is a neglected public health problem contributing for 13% of maternal death worldwide. In Africa, 99% of abortions are unsafe resulting in one maternal death per 150 cases. The prevalence of un...

    Authors: Merhawi Gebremedhin, Agumasie Semahegn, Tofik Usmael and Gezahegn Tesfaye

    Citation: Systematic Reviews 2018 7:130

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  5. Content type: Methodology

    Studies published in languages other than English are often neglected when research teams conduct systematic reviews. Literature on how to deal with non-English studies when conducting reviews have focused on ...

    Authors: Lauge Neimann Rasmussen and Paul Montgomery

    Citation: Systematic Reviews 2018 7:129

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  6. Content type: Protocol

    Interprofessional collaboration (IPC) is a core demand of policymakers, funding parties, and health care professionals in practice. Although the causal mechanism from increased IPC to improved patient outcomes...

    Authors: Laura Kaiser, Sina Bartz, Edmund A. M. Neugebauer, Barbara Pietsch and Dawid Pieper

    Citation: Systematic Reviews 2018 7:126

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  7. Content type: Protocol

    The prevalence of hypertension is a major public health challenge. Despite it being highly preventable, hypertension is responsible for a significant proportion of global morbidity and mortality. Common method...

    Authors: C. Noone, C. P. Dwyer, J. Murphy, J. Newell and G. J. Molloy

    Citation: Systematic Reviews 2018 7:128

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  8. Content type: Protocol

    Southern Africa has long been vulnerable to climate-induced disasters, especially droughts and floods. The severity and frequency of disasters increased in the early 1980s, continuously eroding livelihoods, wh...

    Authors: Joseph K. Kamara, Nidhi Wali, Kingsley Agho and Andre M. N. Renzaho

    Citation: Systematic Reviews 2018 7:127

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  9. Content type: Research

    Gastrointestinal (GI) conditions are highly prevalent, and their standard diagnostic tests are costly and carry risks. There is a need for new, cost-effective, non-invasive tests. Our main objective was to ass...

    Authors: Andrisha-Jade Inderjeeth, K. Mary Webberley, Josephine Muir and Barry J. Marshall

    Citation: Systematic Reviews 2018 7:124

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  10. Content type: Protocol

    Current guidelines identify the choice of fluid resuscitation as important in minimizing the incidence of secondary brain injury from cerebral edema. It is widely accepted that isotonic crystalloid resuscitati...

    Authors: Mary Thompson, Lauralyn McIntyre, Brian Hutton, Alexandre Tran, Dianna Wolfe, Jamie Hutchison, Dean Fergusson, Alexis F. Turgeon and Shane W. English

    Citation: Systematic Reviews 2018 7:125

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  11. Content type: Protocol

    Patients with multiple myeloma (MM) are often treated with chemotherapy, radiation, and, if indicated, autologous stem cell transplant. In addition to side effects of the treatment, patients with MM often have...

    Authors: Deepa Jeevanantham, Venkadesan Rajendran, Line Tremblay, Céline Larivière and Andrew Knight

    Citation: Systematic Reviews 2018 7:118

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  12. Content type: Protocol

    Breast milk composition has been reported to vary significantly between individual women and between different populations. However, the composition is also known to vary within the same woman between differen...

    Authors: Gabriela E. Leghi, Philippa F. Middleton and Beverly S. Muhlhausler

    Citation: Systematic Reviews 2018 7:122

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  13. Content type: Protocol

    Lynch syndrome is the most common inherited cancer syndrome, which predisposes individuals to a number of different cancers, principally colorectal and endometrial cancer. The early diagnosis of Lynch syndrome...

    Authors: Neil A. J. Ryan, Dominic Blake, Marcus Cabrera-Dandy, Mark A. Glaire, D. Gareth Evans and Emma J. Crosbie

    Citation: Systematic Reviews 2018 7:121

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  14. Content type: Protocol

    The first signs of serious mental illnesses (SMIs) including schizophrenia, bipolar disorder and major depression are likely to occur before the age of 25. The combination of high prevalence of severe mental h...

    Authors: Lindsay H. Dewa, Elizabeth Cecil, Lynne Eastwood, Ara Darzi and Paul Aylin

    Citation: Systematic Reviews 2018 7:123

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  15. Content type: Protocol

    The rate of caesarean sections increased in the last decades to about 30% of births in western populations. Many caesarean sections are electively planned without an urgent medical reason for mother or child. ...

    Authors: Barbara Prediger, Stephanie Polus, Tim Mathes, Stefanie Bühn, Frank Louwen, Edmund A. M. Neugebauer and Dawid Pieper

    Citation: Systematic Reviews 2018 7:119

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  16. Content type: Protocol

    Heterozygous familial hypercholesterolaemia (FH) is a genetic disorder characterised by elevated levels of low density lipoprotein (LDL) cholesterol from birth, estimated to affect 1 in 250 of the UK populatio...

    Authors: Fiona J. Kinnear, Rachel Perry, Aidan Searle, Julian P. Hamilton-Shield and Fiona E. Lithander

    Citation: Systematic Reviews 2018 7:120

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  17. Content type: Research

    Clinical study reports (CSRs) are produced for marketing authorisation applications. They often contain considerably more information about, and data from, clinical trials than corresponding journal publicatio...

    Authors: Alex Hodkinson, Kristina Charlotte Dietz, Carol Lefebvre, Su Golder, Mark Jones, Peter Doshi, Carl Heneghan, Tom Jefferson, Isabelle Boutron and Lesley Stewart

    Citation: Systematic Reviews 2018 7:117

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  18. Content type: Protocol

    The prevalence of axial spondyloarthritis (axSpA) is estimated between 0.15 and 1.2%, with many of those patients experiencing severe fatigue. Current axSpA assessment guidance recommends use of a single-item ...

    Authors: Nathan A. Pearson, Jonathan C. Packham, Helen Parsons and Kirstie L. Haywood

    Citation: Systematic Reviews 2018 7:116

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  19. Content type: Protocol

    With age, the acuity of the five senses (i.e., hearing, sight, taste, smell, touch) is reduced. These types of sensory changes can affect day-to-day activities, making it more difficult for individuals to comm...

    Authors: Chantal Backman, Michelle Crick, Danielle Cho-Young, Megan Scharf and Beverley Shea

    Citation: Systematic Reviews 2018 7:115

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  20. Content type: Research

    The importance of sex and gender considerations in research is being increasingly recognized. Evidence indicates that sex and gender can influence intervention effectiveness. We assessed the extent to which se...

    Authors: Jennifer Petkovic, Jessica Trawin, Omar Dewidar, Manosila Yoganathan, Peter Tugwell and Vivian Welch

    Citation: Systematic Reviews 2018 7:113

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  21. Content type: Systematic review update

    Approximately 14% of Africans infected with HIV are over the age of 50, yet few intervention studies focus on improving access to care, retention in care, and adherence to antiretroviral therapy (ART) in this ...

    Authors: Lucia Knight, Ferdinand C. Mukumbang and Enid Schatz

    Citation: Systematic Reviews 2018 7:114

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  22. Content type: Research

    We estimated the effectiveness of serial B-type natriuretic peptide (BNP) blood testing to guide up-titration of medication compared with symptom-guided up-titration of medication in patients with heart failur...

    Authors: Maria Pufulete, Rachel Maishman, Lucy Dabner, Julian P. T. Higgins, Chris A. Rogers, Mark Dayer, John MacLeod, Sarah Purdy, William Hollingworth, Morten Schou, Manuel Anguita-Sanchez, Patric Karlström, Michael Kleiner Shochat, Theresa McDonagh, Angus K. Nightingale and Barnaby C. Reeves

    Citation: Systematic Reviews 2018 7:112

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  23. Content type: Methodology

    The evaluation of imprecision is a key dimension of the grading of the confidence in the estimate. Grading of Recommendations Assessment, Development and Evaluation (GRADE) gives recommendations on how to down...

    Authors: Greta Castellini, Matteo Bruschettini, Silvia Gianola, Christian Gluud and Lorenzo Moja

    Citation: Systematic Reviews 2018 7:110

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  24. Content type: Research

    Clinical research investigating effective intervention strategies for adolescents to improve health behaviors has shifted to the application of motivational interviewing (MI). Evidence indicates that MI is an ...

    Authors: Christina Mutschler, Erica Naccarato, Jen Rouse, Caitlin Davey and Kelly McShane

    Citation: Systematic Reviews 2018 7:109

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  25. Content type: Protocol

    Malaria remains one of the leading causes of morbidity and mortality in most low- and middle-income countries. Chloroquine is a previously cheap and effective antimalarial agent whose loss to resistance result...

    Authors: Moses Ocan, Dickens Akena, Sam Nsobya, Moses R. Kamya, Richard Senono, Alison Annet Kinengyere and Ekwaro A. Obuku

    Citation: Systematic Reviews 2018 7:108

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  26. Content type: Protocol

    Rates of cannabis use are highest during emerging adulthood (age 18–25), with the prevalence of near daily and daily increasing among this age group. Emerging adults are clinically challenging in terms of harm...

    Authors: Jillian Halladay, Tashia Petker, Allan Fein, Catharine Munn and James MacKillop

    Citation: Systematic Reviews 2018 7:106

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  27. Content type: Protocol

    Daily iron-folic acid supplementation reduces anemia and various adverse obstetric outcomes such as preterm delivery, low birthweight, hemorrhage, and perinatal and maternal morbidity and mortality. However, i...

    Authors: Mohammed Akibu, Tesfalidet Tekelab, Abdella Amano, Merga Besho, Stephanie Grutzmacher, Mesfin Tadese and Tesfa Dejenie Habtewold

    Citation: Systematic Reviews 2018 7:107

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  28. Content type: Protocol

    Metformin is one of the most commonly used drugs for type 2 diabetes mellitus (T2DM). Despite its efficacy and safety, metformin is frequently associated with highly variable glycemic responses, which is hypot...

    Authors: Edith Pascale Mofo Mato, Magellan Guewo-Fokeng, M. Faadiel Essop and Peter Mark Oroma Owira

    Citation: Systematic Reviews 2018 7:105

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  29. Content type: Protocol

    A recent paradigm shift within the intensive care discipline has led to implementation of protocols to drive early recovery from the intensive care unit (ICU). These protocols belong to a large knowledge, tran...

    Authors: David Wyler, Michael Esterlis, Brittany Burns Dennis, Andrew Ng and Abhijit Lele

    Citation: Systematic Reviews 2018 7:104

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  30. Content type: Research

    Gastrointestinal cancer patients are susceptible to significant postoperative morbidity. The aim of this systematic review was to examine the effects of preoperative exercise therapy (PET) on patients undergoi...

    Authors: Sarah A. Vermillion, Alston James, Robert D. Dorrell, Peter Brubaker, Shannon L. Mihalko, Adrienne R. Hill and Clancy J. Clark

    Citation: Systematic Reviews 2018 7:103

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  31. Content type: Protocol

    The Sustainable Development Goals (SDGs) emphasize the need for strengthening the capacity of all developing countries in the early warning, risk reduction and management of national as well as global health r...

    Authors: Neusa Fernanda Torres, Buyisile Chibi, Lyn E. Middleton, Vernon P. Solomon and Tivani Mashamba-Thompson

    Citation: Systematic Reviews 2018 7:102

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  32. Content type: Protocol

    Patient-Oriented Research (POR) is a Canadian initiative for health research that refers to research processes informed by full and active patient involvement in all aspects of the research. Ideally, POR resul...

    Authors: Anastasia A. Mallidou, Noreen Frisch, Mary M. Doyle-Waters, Martha L. P. MacLeod, John Ward and Pat Atherton

    Citation: Systematic Reviews 2018 7:101

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  33. Content type: Protocol

    When patients have been on opioid therapy for more than 90 days, more than half of them continue using opioids years later. Knowing that long-term opioid consumption could lead to harmful side effects includin...

    Authors: M. Gabrielle Pagé, Irina Kudrina, Hervé Tchala Vignon Zomahoun, Daniela Ziegler, Pierre Beaulieu, Céline Charbonneau, Jennifer Cogan, Raoul Daoust, Marc O. Martel, Andrée Néron, Philippe Richebé and Hance Clarke

    Citation: Systematic Reviews 2018 7:97

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  34. Content type: Research

    There is considerable interest in the impact of increased flavan-3-ol intake on cardiovascular disease (CVD) and diabetes outcomes. Through evidence mapping, we determined the extent of the evidence base to in...

    Authors: Gowri Raman, Marissa Shams-White, Esther E. Avendano, Fan Chen, Janet A. Novotny and Aedin Cassidy

    Citation: Systematic Reviews 2018 7:100

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  35. Content type: Protocol

    Systematic review (SR) guidelines recommend extending literature search to gray literature in order to identify all available data related to the review topic. We aim to conduct an overview of SRs on populatio...

    Authors: Karima Chaabna, Sohaila Cheema, Amit Abraham, Hekmat Alrouh, Ravinder Mamtani and Javaid I. Sheikh

    Citation: Systematic Reviews 2018 7:94

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  36. Content type: Protocol

    Diabetes mellitus (DM) in women of childbearing age may affect the fetus, thereby accelerating the intergenerational risk of DM. The Middle East and North Africa (MENA) region is experiencing a growing epidemi...

    Authors: Rami H. Al-Rifai and Faisal Aziz

    Citation: Systematic Reviews 2018 7:96

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  37. Content type: Protocol

    Glucose abnormalities in cystic fibrosis (CF) are common, but there is limited evidence to guide their dietary management. Progressive impaired glucose tolerance eventually leads to cystic fibrosis-related dia...

    Authors: Laura Birch, Fiona E. Lithander, Simon Langton Hewer, Katie Harriman, Julian Hamilton-Shield and Rachel Perry

    Citation: Systematic Reviews 2018 7:98

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  38. Content type: Protocol

    Pediatric epilepsy, including treatment-resistant forms, has a major effect on the quality of life, morbidity, and mortality of affected children. Interest has been growing in the use of medical cannabis as a ...

    Authors: Jesse Elliott, Deirdre DeJean, Tammy Clifford, Doug Coyle, Beth Potter, Becky Skidmore, Christine Alexander, Alexander E. Repetski, Bláthnaid McCoy and George A. Wells

    Citation: Systematic Reviews 2018 7:95

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  39. Content type: Protocol

    ‘Pain rewarded’ is a hypothesis wherein acute pain sufferers are exposed to reinforcers and punishers from their environment that shape their behaviour, i.e. pain responses. Such a point of view has been taken...

    Authors: Wacław M. Adamczyk, Kerstin Luedtke, Ewa Buglewicz and Przemysław Bąbel

    Citation: Systematic Reviews 2018 7:93

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  40. Content type: Protocol

    As general population life expectancy has increased, the need to investigate the quality of life has arisen, especially because it is important that people have a healthy long life and with good quality. Studi...

    Authors: Janete Capel Hernandes, Viviane Cruvinel Di Castro, Mauro Elias Mendonça and Celmo Celeno Porto

    Citation: Systematic Reviews 2018 7:92

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  41. Content type: Protocol

    Neoadjuvant chemotherapy (NACT), a standard of care for locally advanced breast cancer patients, is widely used for early breast cancer patients also. The varying role of regimens used as NACT needs to be inve...

    Authors: Mona Pathak, Sada Nand Dwivedi, S. V. S. Deo, Bhaskar Thakur, Vishnubhatla Sreenivas and G. K. Rath

    Citation: Systematic Reviews 2018 7:89

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  42. Content type: Protocol

    Individuals with substance use and addictive disorders often display greater risk-taking behaviour, higher impulsivity, and altered reward processing compared to individuals without these disorders. While it i...

    Authors: Katherine R. Naish, Lana Vedelago, James MacKillop and Michael Amlung

    Citation: Systematic Reviews 2018 7:90

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  43. Content type: Protocol

    Dementia is a globally prevalent disease that requires ongoing and increasing levels of care, often provided in the first instance by informal caregivers. Supporting transitions in informal caregiving in demen...

    Authors: Marianne Cranwell, Anna Gavine, Linda McSwiggan and Timothy B. Kelly

    Citation: Systematic Reviews 2018 7:91

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  44. Content type: Protocol

    Menu labelling is continuing to gather public and legislative support as one of the potential environmental strategies for addressing the obesity pandemic. However, issues relating to implementation have been ...

    Authors: Claire Kerins, Jennifer McSharry, Catherine Hayes, Ivan J. Perry, Fiona Geaney and Colette Kelly

    Citation: Systematic Reviews 2018 7:88

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  45. Content type: Editorial

    The journal recently celebrated its fifth anniversary. Like systematic reviews themselves, the journal is thriving and publishing a variety of protocols, reviews, and methods papers. We have also had success i...

    Authors: David Moher, Lesley A. Stewart and Paul Shekelle

    Citation: Systematic Reviews 2018 7:87

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  46. Content type: Protocol

    Meningococcal disease (MD) is notoriously difficult to diagnose in the early stages of the illness and presents similarly to many self-limiting viral infections. This mandates a cautious approach to diagnosis ...

    Authors: Thomas Waterfield, Derek Fairley, Fiona Lynn, Bronagh Blackwood and Michael D. Shields

    Citation: Systematic Reviews 2018 7:86

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  47. Content type: Research

    Self-management support interventions may potentially delay kidney function decline and associated complications in patients with comorbid diabetes and chronic kidney disease. However, the effectiveness of the...

    Authors: Edward Zimbudzi, Clement Lo, Marie L. Misso, Sanjeeva Ranasinha, Peter G. Kerr, Helena J. Teede and Sophia Zoungas

    Citation: Systematic Reviews 2018 7:84

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  48. Content type: Protocol

    Systematic reviews (SRs) of randomised controlled trials (RCTs) can provide the best evidence to inform decision-making, but their methodological and reporting quality varies. Tools exist to guide the critical...

    Authors: Allison Gates, Michelle Gates, Gonçalo Duarte, Maria Cary, Monika Becker, Barbara Prediger, Ben Vandermeer, Ricardo M. Fernandes, Dawid Pieper and Lisa Hartling

    Citation: Systematic Reviews 2018 7:85

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