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  1. Content type: Protocol

    North America is in the midst of an unabated opioid overdose epidemic due to the increasing non-medical use of fentanyl and ultra-potent opioids. Naloxone is an effective antidote to opioid toxicity, yet its o...

    Authors: Lindsay Victoria Shaw, Jessica Moe, Roy Purssell, Jane A. Buxton, Jesse Godwin, Mary M. Doyle-Waters, Penelope M. A. Brasher, Jeffrey P. Hau, Jason Curran and Corinne M. Hohl

    Citation: Systematic Reviews 2019 8:138

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  2. Content type: Protocol

    Shared decision-making is an approach to making treatment-based decisions that rely on the patient encounter and clear discussions between the patient and the healthcare provider. Patients with arthritis of th...

    Authors: Daniel L. Riddle, Trisha Sando, Talicia Tarver, James Slover, Robert A. Perera, Rafael Sierra, Juan P. Brito and Victor M. Montori

    Citation: Systematic Reviews 2019 8:137

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  3. Content type: Protocol

    Despite the increased utilization of clinical pathways (CPWs) as a strategy to improve patient and system outcomes in hospitals, there remain ongoing challenges with their conceptualization, implementation, an...

    Authors: Adegboyega K. Lawal, Gary Groot, Donna Goodridge, Shannon Scott and Leigh Kinsman

    Citation: Systematic Reviews 2019 8:136

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  4. Content type: Protocol

    Telemedicine use is increasing in many specialties, but its impact on clinical outcomes in infectious diseases has not been systematically studied and reviewed. The proposed systematic review will evaluate the...

    Authors: Jason P. Burnham, Stephanie A. Fritz, Lauren H. Yaeger and Graham A. Colditz

    Citation: Systematic Reviews 2019 8:135

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  5. Content type: Research

    Living alone has become more common in today’s societies. Despite the high number of the population living alone, research directed towards the mental wellbeing issues related to living alone has been limited....

    Authors: Nina Tamminen, Tarja Kettunen, Tuija Martelin, Jaakko Reinikainen and Pia Solin

    Citation: Systematic Reviews 2019 8:134

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  6. Content type: Research

    Cervical cancer is a major public health issue in the world, especially in developing countries. It can be prevented through vaccination against HPV (primary prevention) and through screening and treatment of ...

    Authors: Alex Baleka Mutombo, Cindy Simoens, Rahma Tozin, Johannes Bogers, Jean-Pierre Van Geertruyden and Yves Jacquemyn

    Citation: Systematic Reviews 2019 8:132

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  7. Content type: Protocol

    Upon surviving the first year post-lung transplantation, recipients can expect a median survival of 8 years. Within the first year, graft failure and multi-organ failure (possibly secondary to graft failure) a...

    Authors: Farid Foroutan, Gordon Guyatt, Erik Friesen, Luis Enrique Colunga Lozano, Aman Sidhu and Maureen Meade

    Citation: Systematic Reviews 2019 8:131

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  8. Content type: Research

    Consuming whey protein supplements, along with physiotherapy and psychotherapy, have been recognised in sports performance. Whey protein supplements (WPS) is one of the commonly used supplements as ergogenic a...

    Authors: Fui-Ching Lam, Tahir Mehmood Khan, Hani Faidah, Abdul Haseeb and Amer Hayat Khan

    Citation: Systematic Reviews 2019 8:130

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  9. Content type: Protocol

    Estimation of the dietary requirements for vitamin D is crucial from a public health perspective in providing a framework for the prevention of vitamin D deficiency. It has been shown that pooling individual p...

    Authors: Kevin D. Cashman and Christian Ritz

    Citation: Systematic Reviews 2019 8:128

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  10. Content type: Protocol

    Physical attractiveness or unattractiveness wields a tremendous impact on the social and psychological components of life. Many individuals with facial deformities are treated more negatively than normal indiv...

    Authors: Mikaela I. Poling and Craig R. Dufresne

    Citation: Systematic Reviews 2019 8:127

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  11. Content type: Protocol

    Sensorineural hearing loss (SNHL) is the most common form of hearing impairment and is characterized by a loss of receptor hair cells and/or spiral ganglion neurons. Regenerative stem cell therapy could potent...

    Authors: Kevin T. Chorath, Matthew J. Willis, Nicolas Morton-Gonzaba, Walter J. Humann and Alvaro Moreira

    Citation: Systematic Reviews 2019 8:126

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  12. Content type: Protocol

    There is great interest in the possibility that ‘stage of illness’ moderates treatment outcomes in bipolar disorder (BD). Much remains unknown about the construct of stage of illness, but there is evidence tha...

    Authors: Hailey Tremain, Kathryn Fletcher, Jan Scott, Carla McEnery, Michael Berk and Greg Murray

    Citation: Systematic Reviews 2019 8:125

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  13. Content type: Protocol

    Many people who have common mental disorders, such as depression and anxiety, also have some psychotic experiences. These experiences are associated with higher clinical complexity, poor treatment response, an...

    Authors: Emma Soneson, Debra Russo, Clare Knight, Louise Lafortune, Margaret Heslin, Jan Stochl, Alex Georgiadis, Julieta Galante, Robbie Duschinsky, Nick Grey, Leticia Gonzalez-Blanco, Juliet Couche, Michelle Griffiths, Hannah Murray, Nesta Reeve, Joanne Hodgekins…

    Citation: Systematic Reviews 2019 8:124

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  14. Content type: Protocol

    Improving the quality of primary healthcare services is one of the global health priorities. Literature shows that the incompetency of healthcare providers has the potential to negatively affect the quality of...

    Authors: Nkosinothando Chamane, Desmond Kuupiel and Tivani Phosa Mashamba-Thompson

    Citation: Systematic Reviews 2019 8:123

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  15. Content type: Protocol

    Better characterisation of the epidemiological data on respiratory viral infections among people with acute respiratory tract infection (ARTI) can help to implement efficient strategies to curb the burden of A...

    Authors: Sebastien Kenmoe, Jean Joel Bigna, Abdou Fatawou Modiyinji, Fredy Brice N. Simo and Richard Njouom

    Citation: Systematic Reviews 2019 8:122

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  16. Content type: Research

    Shared decision making (SDM) is a patient-centered approach in which clinicians and patients work together to find and choose the best course of action for each patient’s particular situation. Six SDM key elem...

    Authors: Thomas H. Wieringa, Rene Rodriguez-Gutierrez, Gabriela Spencer-Bonilla, Maartje de Wit, Oscar J. Ponce, Manuel F. Sanchez-Herrera, Nataly R. Espinoza, Yaara Zisman-Ilani, Marleen Kunneman, Linda J. Schoonmade, Victor M. Montori and Frank J. Snoek

    Citation: Systematic Reviews 2019 8:121

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  17. Content type: Protocol

    Hepatitis E virus (HEV) is one of the major causes of acute hepatitis in humans worldwide with a case-fatality rate of 1–4% in the general population that might reach 30% in pregnant women. In the past decade ...

    Authors: Abdou Fatawou Modiyinji, Jean Joel Bigna, Fredy Brice N. Simo, Moise Nola, Marie S. Ndangang, Sebastien Kenmoe and Richard Njouom

    Citation: Systematic Reviews 2019 8:120

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  18. Content type: Protocol

    Experiential peers are increasingly involved in the development and delivery of interventions for individuals who are engaged in delinquent behavior. Experiential peer support, which is the provision of suppor...

    Authors: Margriet Lenkens, Frank J. van Lenthe, Loïs Schenk, Tessa Magnée, Miranda Sentse, Sabine Severiens, Godfried Engbersen and Gera E. Nagelhout

    Citation: Systematic Reviews 2019 8:119

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  19. Content type: Protocol

    Behavioral and psychological symptoms of dementia (BPSD) are present in a majority of patients with dementia contributing to increased morbidity, health care costs, and caregiver burden. While there are no Uni...

    Authors: Sophiya Benjamin, John W. Williams Jr, Cecilia Cotton, Jennifer Tung, Howard An, Stephanie Sanger and Joanne Man-Wai Ho

    Citation: Systematic Reviews 2019 8:118

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  20. Content type: Protocol

    Due to a growing reliance on mobile phone technology and decreasing mobile phone costs, the use of mobile phones is on the rise, especially among the youth population. Young people are responsive and enthusias...

    Authors: Anam Feroz, Farina Abrejo, Sumera Aziz Ali, Rozina Nuruddin and Sarah Saleem

    Citation: Systematic Reviews 2019 8:117

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  21. Content type: Protocol

    Polycystic ovary syndrome (PCOS) is the most common endocrinopathy, affecting 4–12% of reproductive-aged women. Women with PCOS often exhibit many metabolic abnormalities that are associated with an increased ...

    Authors: Amie Woodward, Markos Klonizakis, Ian Lahart, Anouska Carter, Caroline Dalton, Mostafa Metwally and David Broom

    Citation: Systematic Reviews 2019 8:116

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  22. Content type: Protocol

    The lifetime risk of suicide in patients with substance use disorder is five to ten times the risk in the general population. Critically, up to 19% of patients continue to think about and attempt suicide even ...

    Authors: S. Espinet, T. Corrin, D. Baliunas, L. Quilty, L. Zawertailo, S. J. Rizvi, W. deRuiter, S. Bonato, V. De Luca, S. Kennedy and P. Selby

    Citation: Systematic Reviews 2019 8:115

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  23. Content type: Protocol

    Despite a considerable amount of epidemiological research for identification of risk factors involved in the development of colorectal cancer, the current understanding of the etiology of this disease remains ...

    Authors: Amal Idrissi Janati, Igor Karp, Hisham Sabri and Elham Emami

    Citation: Systematic Reviews 2019 8:114

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  24. Content type: Protocol

    Recent studies have observed low levels of physical activity in children and adolescents worldwide. Physical activity interventions are increasingly carried out to counteract this development. The school envir...

    Authors: Yolanda Demetriou, Anne K. Reimers, Marianna Alesi, Lidia Scifo, Carla Chicau Borrego, Diogo Monteiro and Anne Kelso

    Citation: Systematic Reviews 2019 8:113

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  25. Content type: Protocol

    Despite policies for universal HIV testing and treatment (UTT) regardless of CD4 count, there are still 1.8 million new HIV infections and 1 million AIDS-related deaths annually. The UNAIDS 90-90-90 goals targ...

    Authors: Dylan Green, Brenda Kharono, Diana M. Tordoff, Adam Akullian, Anna Bershteyn, Michelle Morrison, Geoff Garnett, Ann Duerr and Paul Drain

    Citation: Systematic Reviews 2019 8:110

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  26. Content type: Protocol

    Acute myeloid leukaemia is the most common type of acute leukaemia in the world. Thus, the study of genetic alterations, such as single-nucleotide polymorphisms (SNPs), has contributed to a better understandin...

    Authors: Taynah Cascaes Puty, Jonathan Souza Sarraf, Tabata Cristina Do Carmo Almeida, Valter Cordeiro Barbosa Filho, Luis Eduardo Werneck de Carvalho, Fernando Luiz Affonso Fonseca and Fernando Adami

    Citation: Systematic Reviews 2019 8:109

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  27. Content type: Protocol

    Schools can play a vital role in the resettlement of refugee children and their families. Yet, the body of research examining school environmental factors that support the mental health and acculturation of re...

    Authors: Deserae Horswood, Jess Baker, Mina Fazel, Susan Rees, Linda Heslop and Derrick Silove

    Citation: Systematic Reviews 2019 8:107

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  28. Content type: Correction

    Following publication of the original article [1], the authors reported an error in Fig. 4 in the PDF version. Figure 4 is the duplicate image of Fig. 3 and the correct figure is missing. The authors would lik...

    Authors: Mapa Mudiyanselage Prabhath Nishantha Piyasena, Gudlavalleti Venkata S. Murthy, Jennifer L. Y. Yip, Clare Gilbert, Tunde Peto, Iris Gordon, Suwin Hewage and Sureshkumar Kamalakannan

    Citation: Systematic Reviews 2019 8:106

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    The original article was published in Systematic Reviews 2018 7:182

  29. Content type: Protocol

    The main objective of this review is to assess the effects of aerobic, resistance, and meditative movement exercise on sleep quality in patients with unipolar depression. A secondary goal is to ascertain the e...

    Authors: Gavin Brupbacher, Heike Gerger, Monika Wechsler, Thea Zander-Schellenberg, Doris Straus, Hildburg Porschke, Markus Gerber, Roland von Känel and Arno Schmidt-Trucksäss

    Citation: Systematic Reviews 2019 8:105

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  30. Content type: Protocol

    Recent estimates suggest that one in ten young people worldwide experiences a diagnosable mental health disorder, with many more suffering subsyndromal levels of psychological distress. As young people spend m...

    Authors: Thomas King and Mina Fazel

    Citation: Systematic Reviews 2019 8:104

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  31. Content type: Protocol

    A child’s risk of dying is highest in the neonatal period, i.e. the first 28 days of life. Newborn death accounts for nearly half of under-five death. More than 80% of newborn deaths are the result of preventa...

    Authors: Tesfalidet Tekelab, Mohammed Akibu, Negash Tagesse, Temesgen Tilhaun, Yosef Yohanes and Smriti Nepal

    Citation: Systematic Reviews 2019 8:103

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  32. Content type: Protocol

    Rare cancers comprise almost a quarter of all cancers in Europe, and patients generally have poorer outcomes than those suffering from more common cancers. This is attributed in part to a general lack of knowl...

    Authors: Catherine Bell, Katie Kerr, Kerry Moore, Charlene McShane, Lesley Anderson, Amy Jayne McKnight and Helen McAneney

    Citation: Systematic Reviews 2019 8:102

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  33. Content type: Protocol

    Aerobic exercise programs have been used for various health conditions, including musculoskeletal disorders. However, the literature is still limited regarding the effect of aerobic exercise on pain and disabi...

    Authors: Irlei dos Santos, Adriana Claudia Lunardi, Naiane Teixeira Bastos de Oliveira, Matheus Oliveira de Almeida and Leonardo Oliveira Pena Costa

    Citation: Systematic Reviews 2019 8:101

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  34. Content type: Protocol

    Diabetes is a chronic medical condition that requires patients to be actively engaged in intensive self-management to achieve optimal clinical outcomes. Unfortunately, individuals who are experiencing homeless...

    Authors: David J. T. Campbell, Rachel B. Campbell, Carolyn Ziegler, Kerry A. McBrien, Stephen W. Hwang and Gillian L. Booth

    Citation: Systematic Reviews 2019 8:100

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  35. Content type: Protocol

    Cerebral venous thrombosis causes disability from venous infarct and hemorrhage and potential mortality. Anticoagulation improves survival and disability outcomes, yet direct oral anticoagulants are currently ...

    Authors: Gauruv Bose, Justin Graveline, Vignan Yogendrakumar, Dean Fergusson and Dar Dowlatshahi

    Citation: Systematic Reviews 2019 8:99

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  36. Content type: Protocol

    The global prevalence of diabetes mellitus is nearly 9%, with an upward trend in type 2 and gestational diabetes mellitus (T2DM/GDM). Evidence shows that vulnerable groups are affected disproportionally. There...

    Authors: Jessica Breuing, Christine Graf, Annika Lena Neuhaus, Simone Heß, Lena Lütkemeier, Fabiola Haas, Mark Spiller and Dawid Pieper

    Citation: Systematic Reviews 2019 8:98

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  37. Content type: Research

    With healthcare striving to shift to a more person-centered delivery model, patient and family involvement must have a bigger role in shaping this. While many initiatives involving patients and family members ...

    Authors: Tamara L. McCarron, Karen Moffat, Gloria Wilkinson, Sandra Zelinsky, Jamie M. Boyd, Deborah White, Derek Hassay, Diane L. Lorenzetti, Nancy J. Marlett and Thomas Noseworthy

    Citation: Systematic Reviews 2019 8:97

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  38. Content type: Methodology

    This study aimed at applying the restricted mean survival time difference (rmstD) as an absolute outcome measure in a network meta-analysis and comparing the results with those obtained using hazard ratios (HR...

    Authors: C. Petit, P. Blanchard, JP. Pignon and B. Lueza

    Citation: Systematic Reviews 2019 8:96

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  39. Content type: Protocol

    Development of fistula-in-ano following incision and drainage (I&D) of anorectal abscesses occurs in over 30% of patients. It is associated with significant patient morbidity and societal cost. The use of anti...

    Authors: Laura Baker, Lara Williams, Remington Winter, Caitlin Cahill, Alexandra Davis and Dean Fergusson

    Citation: Systematic Reviews 2019 8:95

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  40. Content type: Methodology

    Efforts to improve health equity should be informed by the best available evidence. However, equity-related research is inconsistently indexed, and uses a variety of terms to describe key concepts, making it d...

    Authors: Jamie Hosking, Alexandra Macmillan, Rhys Jones, Shanthi Ameratunga and Alistair Woodward

    Citation: Systematic Reviews 2019 8:94

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  41. Content type: Protocol

    Low back pain is the greatest contributor to the global burden of disease and can result in work disability. Previous literature has examined the influence of personal factors, the healthcare system, workplace...

    Authors: Michael Di Donato, Ross Iles, Tyler Lane and Alex Collie

    Citation: Systematic Reviews 2019 8:92

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  42. Content type: Protocol

    Despite the introduction of rapid response systems and early warning scores, clinical deterioration that is not recognised or responded to early enough prevails in acute care areas. One intervention that aims ...

    Authors: Aidín McKinney, Donna Fitzsimons, Bronagh Blackwood and Jennifer McGaughey

    Citation: Systematic Reviews 2019 8:91

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  43. Content type: Protocol

    Before implementing healthcare interventions, clinicians need to weigh the beneficial and adverse effects of interventions. However, a large body of evidence has demonstrated that seeking and reporting of adve...

    Authors: Pauline A. J. Steegmans, Shandra Bipat and Reint A. Meursinge Reynders

    Citation: Systematic Reviews 2019 8:89

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