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  1. The comparative safety and efficacy between anti-vascular endothelial growth factor agents (anti-VEGFs) and between combined therapies for patients with neovascular age-related macular degeneration (nAMD) is u...

    Authors: Andrea C. Tricco, Sonia M. Thomas, Erin Lillie, Areti Angeliki Veroniki, Jemila S. Hamid, Ba’ Pham, Taehoon Lee, Arnav Agarwal, Jane P. Sharpe, Alistair Scott, Rachel Warren, Ronak Brahmbhatt, Erin Macdonald, Ghayath Janoudi, Rajeev H. Muni, Carolina L. M. Francisconi…
    Citation: Systematic Reviews 2021 10:315
    Content type: Research Published on:

  2. Dyspnea with bilateral pulmonary edema is common among patients in emergency departments (EDs) or intensive care units (ICUs). For the initial management of patients with this condition, cardiopulmonary edema ...

    Authors: Takero Terayama, Takuya Taniguchi, Ryosuke Imai, Keisuke Anan, Takuo Yoshida, Koichi Ando, Satoshi Okamori and Yohei Okada
    Citation: Systematic Reviews 2021 10:314
    Content type: Protocol Published on:

  3. The Extension for Community Healthcare Outcomes (ECHO) Model of continuing tele-education is an innovative guided-practice model aiming at amplifying healthcare professionals’ competencies in the management of...

    Authors: Gabrielle Chicoine, José Côté, Jacinthe Pepin, Guillaume Fontaine, Marc-André Maheu-Cadotte, Quan Nha Hong, Geneviève Rouleau, Daniela Ziegler and Didier Jutras-Aswad
    Citation: Systematic Reviews 2021 10:313
    Content type: Protocol Published on:

  4. Swallowing impairment (dysphagia) following brain injury can lead to life-threatening complications such as dehydration, aspiration pneumonia and acute choking episodes. In adult therapeutic practice, there is...

    Authors: Rhiannon Halfpenny, Alexandra Stewart, Paula Kelly, Eleanor Conway and Christina Smith
    Citation: Systematic Reviews 2021 10:312
    Content type: Protocol Published on:

  5. Urban health is a field of research and practice that has attracted the interest of various disciplines. While it is encouraged for diverse disciplines to contribute to a multidisciplinary field of study such ...

    Authors: Jinhee Kim, Ben Harris-Roxas, Evelyne de Leeuw, David Lilley, Alana Crimeen and Peter Sainsbury
    Citation: Systematic Reviews 2021 10:311
    Content type: Protocol Published on:

  7. Although systematic reviews are considered as central components in evidence-based practice, they currently face an important challenge to keep up with the exponential publication rate of clinical trials. Afte...

    Authors: S. Elbers, H. Wittink, U. Kaiser, J. Kleijnen, J. Pool, A. Köke and R. Smeets
    Citation: Systematic Reviews 2021 10:309
    Content type: Commentary Published on:

  8. Solitary pulmonary nodule (SPN) is a common finding in routine clinical practice when performing chest imaging tests. The vast majority of these nodules are benign, and only a small proportion are malignant. T...

    Authors: Marina Senent-Valero, Julián Librero and María Pastor-Valero
    Citation: Systematic Reviews 2021 10:308
    Content type: Research Published on:

  9. Home visiting services for older adults have been offered for decades to maintain and promote health and independent functioning, thus enhancing quality of life. Previous systematic reviews have provided a mix...

    Authors: Yea Lu Tay, Nurul Salwana Abu Bakar, Ruzimah Tumiran, Noor Hasidah Ab Rahman, Noor Areefa Ameera Mohd Ma’amor, Weng Keong Yau and Zalilah Abdullah
    Citation: Systematic Reviews 2021 10:307
    Content type: Protocol Published on:

  10. There are limited data on the clinical benefits of adding surgical resection in patients with recurrent or metastatic gastrointestinal stromal tumors (GISTs). This protocol outlines the planned scope and metho...

    Authors: Zhaolun Cai, Chunyu Xin, Zhiyuan Jiang, Chunyu Liu, Chaoyong Shen, Guozhen Zhao, Yuan Yin, Xiaonan Yin, Zhou Zhao, Mingchun Mu and Bo Zhang
    Citation: Systematic Reviews 2021 10:306
    Content type: Protocol Published on:

  11. Early onset fetal growth restriction secondary to placental insufficiency can lead to severe maternal and neonatal morbidity and mortality. Pre-clinical studies and a few small randomised clinical trials have ...

    Authors: Jessica Liauw, Katie Groom, Wessel Ganzevoort, Christian Gluud, Christopher J. D. McKinlay, Andrew Sharp, Laura Mackay, Chirag Kariya, Ken Lim, Peter von Dadelszen, Jacqueline Limpens and Janus C. Jakobsen
    Citation: Systematic Reviews 2021 10:305
    Content type: Protocol Published on:

  12. Several resources have been developed (e.g., reporting guidelines) to promote high-standard practices in health research. However, there was no continuous and systematic assessment of recommended practices in ...

    Authors: Nórton Luís Oliveira, Cíntia Ehlers Botton, Angélica Trevisan De Nardi and Daniel Umpierre
    Citation: Systematic Reviews 2021 10:304
    Content type: Research Published on:

  13. Autism spectrum disorder (ASD) is a neurodevelopmental disorder defined by persistent deficits in social functioning and the presence of restricted and repetitive behaviours (RRBs). RRBs refer to four subtypes...

    Authors: Tegan Sellick, Alexandra Ure and Katrina Williams
    Citation: Systematic Reviews 2021 10:303
    Content type: Protocol Published on:

  14. The prevalence of type 2 diabetes mellitus (T2DM) is growing in China. Depression is a significant complication of T2DM, leading to poor management of T2DM. Thus, early detection and treatment of depression in...

    Authors: Xiaobo Liu, Chao Dong, Hong Jiang, Dongling Zhong, Yuxi Li, Huiling Zhang, Jun Zhang, Jin Fan, Juan Li, Li Guan and Rongjiang Jin
    Citation: Systematic Reviews 2021 10:302
    Content type: Protocol Published on:

  15. The global prevalence of diabetes is nearly 9%, with an upward trend in type 2 diabetes mellitus (T2DM) and gestational diabetes (GDM). Although evidence shows that vulnerable groups are affected disproportion...

    Authors: Jessica Breuing, Christine Joisten, Annika Lena Neuhaus, Simone Heß, Lena Kusche, Fabiola Haas, Mark Spiller and Dawid Pieper
    Citation: Systematic Reviews 2021 10:301
    Content type: Research Published on:

  16. To the best of our knowledge, a scoping review of the published literature investigating the determinants of adult stroke survivors’ reintegration to normal living has not been conducted. This scoping review a...

    Authors: Michael Opeoluwa Ogunlana, Pragashnie Govender, Olufemi Oyeleye Oyewole and Ifeoma Blessing Nwosu
    Citation: Systematic Reviews 2021 10:300
    Content type: Protocol Published on:

  17. The COVID-19 pandemic has devastated the global community with nearly 4.9 million deaths as of October 2021. While organ transplant (OT) recipients (OTr) may be at increased risk for severe COVID-19 due to the...

    Authors: Alexis H. Lerner, Elizabeth J. Klein, Anna Hardesty, Orestis A. Panagiotou, Chelsea Misquith and Dimitrios Farmakiotis
    Citation: Systematic Reviews 2021 10:299
    Content type: Protocol Published on:

  18. The North American opioid crisis is driven by opioid-related mortality and morbidity, including opioid use-associated infections (OUAIs), resulting in a substantial burden for society. Users of legal and illeg...

    Authors: Irina Kudrina, Svetlana Puzhko, Kristian B. Filion, Genevieve Gore, Elena Paraskevopoulos, Sarah Windle, Marc O. Martel and Mark J. Eisenberg
    Citation: Systematic Reviews 2021 10:298
    Content type: Protocol Published on:

  19. Idiopathic pulmonary fibrosis (IPF) is one of the common types of interstitial lung disease having high prevalence and mortality worldwide. As a result of patient-centred hindering factors of adherence to cent...

    Authors: Revati Amin, K. Vaishali, G. Arun Maiya, Aswini Kumar Mohapatra, Uday Narayan Yadav and Shradha S. Parsekar
    Citation: Systematic Reviews 2021 10:297
    Content type: Protocol Published on:

  20. Peer-support programs are a useful social support strategy for populations trying to quit smoking who are willing to maintain smoking abstinence. This study is a protocol for a systematic review and meta-analy...

    Authors: Hyun-Ju Seo, Soo Young Kim, Dongah Park, Seung-Soo Sheen, Miyoung Choi, Bo-Hyoung Jang, Su Jung Lee and Youngju Cha
    Citation: Systematic Reviews 2021 10:296
    Content type: Protocol Published on:

  21. In many countries, children who are diagnosed with autism during the first 5 years of life are offered a range of early intervention options. These options vary considerably in the theoretical approaches and t...

    Authors: Katherine Pye, Hannah Jackson, Teresa Iacono and Alan Shiell
    Citation: Systematic Reviews 2021 10:295
    Content type: Protocol Published on:

  22. Despite the expectations regarding the effectiveness of chloroquine (CQ) and hydroxychloroquine (HCQ) for coronavirus disease (COVID-19) management, concerns about their adverse events have remained.

    Authors: Mayra Souza Botelho, Fernanda Bolfi, Renata Giacomini Occhiuto Ferreira Leite, Mauro Salles Ferreira Leite, Luisa Rocco Banzato, Luiza Teixeira Soares, Thaina Oliveira Felicio Olivatti, Amanda Sampaio Mangolim, Flávia Ramos Kazan Oliveira, Luciana Patrícia Fernandes Abbade, Joelcio Francisco Abbade, Ricardo Augusto Monteiro de Barros Almeida, Julia Simões Corrêa Galendi, Lehana Thabane and Vania dos Santos Nunes-Nogueira
    Citation: Systematic Reviews 2021 10:294
    Content type: Research Published on:

  23. Low levels of physical activity are common during the hospital stay and have been associated with negative health outcomes. Understanding barriers and enablers to physical activity during a hospital stay can i...

    Authors: Sven Jacobus Gertruda Geelen, Hanneke Corine van Dijk - Huisman, Robert Adriaan de Bie, Cindy Veenhof, Raoul Engelbert, Marike van der Schaaf and Antoine François Lenssen
    Citation: Systematic Reviews 2021 10:293
    Content type: Research Published on:

  26. Subclinical hypothyroidism is a thyroid disorder diagnosed from the laboratory blood test results of otherwise asymptomatic patients. It has been associated with poor cardiovascular outcomes, mortality and pro...

    Authors: Brenda S. Bauer, Amaya Azcoaga-Lorenzo, Utkarsh Agrawal and Colin McCowan
    Citation: Systematic Reviews 2021 10:290
    Content type: Protocol Published on:

  27. The coronavirus disease 19 (covid-19) pandemic has underscored the need to expedite clinical research, which may lead investigators to shift away from measuring patient-important outcomes (PIO), limiting resea...

    Authors: Mario A. Jimenez-Mora, Andrea Ramírez Varela, Jose F. Meneses-Echavez, Julia Bidonde, Adriana Angarita-Fonseca, Reed A. C. Siemieniuk, Dena Zeraatkar, Jessica J. Bartoszko, Romina Brignardello-Petersen, Kimia Honarmand, Bram Rochwerg, Gordon Guyatt and Juan José Yepes-Nuñez
    Citation: Systematic Reviews 2021 10:289
    Content type: Protocol Published on:

  28. Many prognostic models of diabetic microvascular complications have been developed, but their performances still varies. Therefore, we conducted a systematic review and meta-analysis to summarise the performan...

    Authors: Sigit Ari Saputro, Oraluck Pattanaprateep, Anuchate Pattanateepapon, Swekshya Karmacharya and Ammarin Thakkinstian
    Citation: Systematic Reviews 2021 10:288
    Content type: Research Published on:

  29. Though cervical cancer is largely preventable, it is still the second most common female cancer globally and the leading cause of cancer deaths among females in African. Though many efforts have been done to s...

    Authors: Ayele Semachew Kasa, Tadesse Dagget, Yeshiwork Beyene, Getnet Dessie, Aklilu Endalamaw, Yinager Workineh, Emiru Ayalew, Balew Zeleke, Sitotaw Kerie, Getasew Mulat and Worku Animaw
    Citation: Systematic Reviews 2021 10:287
    Content type: Research Published on:

  30. Approaches for rapid reviews that focus on streamlining systematic review methods are not always suitable for exploring complex policy questions, as developing and testing theories to explain these complexitie...

    Authors: Michael G. Wilson, Sandy Oliver, G. J. Melendez-Torres, John N. Lavis, Kerry Waddell and Kelly Dickson
    Citation: Systematic Reviews 2021 10:286
    Content type: Research Published on:

  32. Hemodynamic assessment in patients with pulmonary arterial hypertension (PAH) is essential for risk stratification and pharmacological management. However, the prognostic value of the hemodynamic changes after...

    Authors: Shih-Hsien Sung, Wan-Yu Yeh, Chern-En Chiang, Chi-Jung Huang, Wei-Ming Huang, Chen-Huan Chen and Hao-Min Cheng
    Citation: Systematic Reviews 2021 10:284
    Content type: Research Published on:

  33. Burnout is a syndrome caused by chronic stress in the workplace that has not been successfully managed. Although prevalence of burnout is well documented in different fields, little is known about this syndrom...

    Authors: Sharareh Azedi Tehrani, Abbasali Keshtkar, Akilesh Ramasamy and Majid Fadaei
    Citation: Systematic Reviews 2021 10:283
    Content type: Protocol Published on:

  34. Non-traumatic coma is a common acute childhood presentation to healthcare facilities in Africa and is associated with high morbidity and mortality. Historically, the majority of cases were attributed to cerebr...

    Authors: Stephen T. J. Ray, Charlotte Fuller, Alexandra Boubour, Laura J. Bonnett, David G. Lalloo, Karl B. Seydel and Michael J. Griffiths
    Citation: Systematic Reviews 2021 10:282
    Content type: Protocol Published on:

  35. The primary objective of this study is twofold: (1) to examine the effect of COVID-19 safety measures, enacted to prevent transmission of SARS-nCOV-2, on total physical activity in the adult general population...

    Authors: Fabian Schwendinger, Denis Infanger, Elena Pocecco, Joséphine Gander, Timo Hinrichs and Arno Schmidt-Trucksäss
    Citation: Systematic Reviews 2021 10:281
    Content type: Protocol Published on:

  36. The aim of this study was to review the scientific evidence and describe the ocular treatment-emergent adverse events (TEAEs) related to pharmacological treatment in patients with multiple sclerosis.

    Authors: Juliana Muñoz-Ortiz, Juliana Reyes-Guanes, Estefanía Zapata-Bravo, Laura Mora-Muñoz, Juan Antonio Reyes-Hurtado, Luis Octavio Tierradentro-García, William Rojas-Carabali, Marcela Gómez-Suarez and Alejandra de-la-Torre
    Citation: Systematic Reviews 2021 10:280
    Content type: Systematic review update Published on:

  37. People with disabilities (PWDs) remain among the poorest and least empowered population. They experience limited access to basic services, especially in low- and middle-income countries (LMIC). The infringemen...

    Authors: Sithembiso Blose, Saul Cobbing and Verusia Chetty
    Citation: Systematic Reviews 2021 10:279
    Content type: Protocol Published on:

  38. Rapid and accurate diagnosis of paediatric tuberculosis (TB) is key to manage the disease and to control and prevent its transmission. Collection of quality sputum samples without invasion methods from paediat...

    Authors: Emmanuel Oladipo Babafemi, Benny P. Cherian, Beatrice Ouma and Gilbert Mangua Mogoko
    Citation: Systematic Reviews 2021 10:278
    Content type: Research Published on:

  39. Men who have sex with men (MSM) are disproportionately affected by HIV in China. Globally, younger MSM are at higher risk for incident HIV infections, but there has been substantial variation in the estimates ...

    Authors: Wenting Huang, Liming Wang, Mi Guodong, Ryan J. Zahn, Jennifer Taussig, Shenita R. Peterson, Stefan Baral, Renee H. Moore, Xiaojie Huang, Jianhua Hou, Patrick S. Sullivan and Aaron J. Siegler
    Citation: Systematic Reviews 2021 10:277
    Content type: Protocol Published on:

  40. Evidence suggests that there are substantial inconsistencies in the practice of anesthesia. There has not yet been a comprehensive summary of the anesthesia literature that can guide future knowledge translati...

    Authors: Sylvain Boet, Joseph K. Burns, Olivia Cheng-Boivin, Hira Khan, Kendra Derry, Deric Diep, Abdul Hadi Djokhdem, Sung Wook Um, Johnny W. Huang, Danica Paré, Mimi Deng, Liza Begunova, Linda Yi Ning Fei, Maryam Bezzahou, Pium Sonali Andrahennadi, Elysia Grose…
    Citation: Systematic Reviews 2021 10:276
    Content type: Research Published on:

    The Correction to this article has been published in Systematic Reviews 2022 11:24

  41. Historically, eating disorders were not identified in older populations and it is only in more recent times that there is greater recognition of the existence of eating disorders among the elderly. This is des...

    Authors: Megha Mulchandani, Namrata Shetty, Agatha Conrad, Petra Muir and Beth Mah
    Citation: Systematic Reviews 2021 10:275
    Content type: Systematic review update Published on:

  42. Early pregnancy loss (unintended pregnancy loss before 20 completed weeks of gestation) is a common adverse pregnancy outcome, with previous evidence reporting incidence ranging from 10 to 30% of detected preg...

    Authors: L. Schummers, N. Oveisi, M. S. Ohtsuka, J. A. Hutcheon, K. A. Ahrens, J. Liauw and W. V. Norman
    Citation: Systematic Reviews 2021 10:274
    Content type: Protocol Published on:

  44. Multimorbidity, defined as the co-existence of two or more chronic conditions, presents significant challenges to patients, healthcare providers and health systems. Despite this, there is ongoing uncertainty a...

    Authors: Susan M. Smith, Emma Wallace, Barbara Clyne, Fiona Boland and Martin Fortin
    Citation: Systematic Reviews 2021 10:271
    Content type: Research Published on:

  45. Numerous studies report changes in neuromuscular control in people with low back pain (LBP). However, the relationship between pain and altered neuromuscular control is challenging to unravel given the heterog...

    Authors: Valter Devecchi, Deborah Falla, Hélio V. Cabral and Alessio Gallina
    Citation: Systematic Reviews 2021 10:270
    Content type: Protocol Published on:

  46. Intrapartum mistreatment of women is an ubiquitous public health and human rights challenge. The issue reportedly has severe maternal and neonatal outcomes including mortality, and generally leads to a decreas...

    Authors: Helen H. Habib, Jefferson Mwaisaka, Kwasi Torpey, Ernest Tei Maya and Augustine Ankomah
    Citation: Systematic Reviews 2021 10:269
    Content type: Protocol Published on:

  47. Complex interventions in health care are characterized by multiple interacting components as well as by numerous nonlinear interactions with the social systems within which they are being implemented. The proc...

    Authors: Tina Quasdorf, Lauren Clack, Franziska Laporte Uribe, Daniela Holle, Martin Berwig, Daniel Purwins, Marie-Therese Schultes and Martina Roes
    Citation: Systematic Reviews 2021 10:268
    Content type: Protocol Published on:

  49. Cardiopulmonary arrest (CPA) is an urgency, which is associated with high mortality. This systematic review evaluated the relationship between baseline cortisol level and the outcome of resuscitated CPA patients.

    Authors: Adeleh Sahebnasagh, Paria Soltani Nejad, Amin Salehi-Abargouei, Mohammad Hossein Dehghani and Fatemeh Saghafi
    Citation: Systematic Reviews 2021 10:266
    Content type: Research Published on:

  50. Scoping reviews are an increasingly common approach to evidence synthesis with a growing suite of methodological guidance and resources to assist review authors with their planning, conduct and reporting. The ...

    Authors: Micah D. J. Peters, Casey Marnie, Heather Colquhoun, Chantelle M. Garritty, Susanne Hempel, Tanya Horsley, Etienne V. Langlois, Erin Lillie, Kelly K. O’Brien, Ӧzge Tunçalp, Michael G. Wilson, Wasifa Zarin and Andrea C. Tricco
    Citation: Systematic Reviews 2021 10:263
    Content type: Commentary Published on:
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