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  1. The clinical presentation of panic disorder and panic attack overlaps many symptoms typically experienced in coronary heart disease (CHD). Etiological links between panic disorder and CHD are controversial and...

    Authors: Phillip J Tully, Gary A Wittert, Deborah A Turnbull, John F Beltrame, John D Horowitz, Suzanne Cosh and Harald Baumeister

    Citation: Systematic Reviews 2015 4:33

    Content type: Protocol

    Published on:

  2. Recognition that ascending infection leads to preterm birth has led to a number of studies that have evaluated the treatment of vaginal infections in pregnancy to reduce preterm birth rates. However, the role ...

    Authors: Christine L Roberts, Charles S Algert, Kristen L Rickard and Jonathan M Morris

    Citation: Systematic Reviews 2015 4:31

    Content type: Research

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  3. A myocardial infarction (MI) (‘heart attack’) can be intensely stressful, and the impact of this event can leave patients with clinically significant post-MI stress symptoms. Untreated stress can make heart di...

    Authors: Jenny Jones, Paul Kane, Rob Polson, Stephen J Leslie, Nicholas J Hulbert-Williams, Sébastien Simard, Gozde Ozakinci and Gill Hubbard

    Citation: Systematic Reviews 2015 4:10

    Content type: Protocol

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  4. Chiropractic care is a common treatment for low back pain (LBP). Previous studies have failed to clarify the relative cost-effectiveness of chiropractic care in comparison with other commonly used approaches b...

    Authors: Marc-André Blanchette, André Bussières, Mette Jensen Stochkendahl, Jill Boruff and Pamela Harrison

    Citation: Systematic Reviews 2015 4:30

    Content type: Protocol

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  5. Preoperative anemia is a common and potentially serious hematological problem in elective surgery and increases the risk for perioperative red blood cell (RBC) transfusion. Transfusion is associated with posto...

    Authors: Abdelsalam M Elhenawy, Steven R Meyer, Sean M Bagshaw, Roderick G MacArthur and Linda J Carroll

    Citation: Systematic Reviews 2015 4:29

    Content type: Protocol

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  6. Individuals with chronic diseases may have difficulty optimizing their health and getting the care they need due to a combination of patient, provider, and health system level barriers. Patient navigator progr...

    Authors: Elizabeth Kelly, Noah Ivers, Rami Zawi, Lianne Barnieh, Braden Manns, Diane L Lorenzetti, David Nicholas, Marcello Tonelli, Brenda Hemmelgarn, Richard Lewanczuk, Alun Edwards, Ted Braun and Kerry A McBrien

    Citation: Systematic Reviews 2015 4:28

    Content type: Protocol

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  7. Many parents consider fever a disease in itself and feel disempowered when their child is ill. Numerous guidelines have been produced; however, their target audience remains healthcare professionals and not ca...

    Authors: Maria Kelly, Laura J Sahm, Frances Shiely, Ronan O’Sullivan, Maria Brenner, Philip Larkin and Suzanne McCarthy

    Citation: Systematic Reviews 2015 4:27

    Content type: Protocol

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  8. Health care decision makers often need to make decisions in limited timeframes and cannot await the completion of a full evidence review. Rapid reviews (RRs), utilizing streamlined systematic review methods, a...

    Authors: Julie Polisena, Chantelle Garritty, Chris Kamel, Adrienne Stevens and Ahmed M Abou-Setta

    Citation: Systematic Reviews 2015 4:26

    Content type: Research

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  9. There is currently no mechanism in place outside of government to provide rapid syntheses of the best available research evidence about problems, options and/or implementation considerations related to a speci...

    Authors: Michael G Wilson, John N Lavis and Francois-Pierre Gauvin

    Citation: Systematic Reviews 2015 4:25

    Content type: Research

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  10. Indoor air pollution (IAP) interventions are widely promoted as a means of reducing indoor air pollution/health from solid fuel use; and research addressing impact of these interventions has increased substant...

    Authors: Reginald Quansah, Caroline A Ochieng, Sean Semple, Sanjar Juvekar, Jacques Emina, Frederick Ato Armah and Isaac Luginaah

    Citation: Systematic Reviews 2015 4:22

    Content type: Protocol

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  11. Vortioxetine is the first mixed serotonin agonist and antagonist antidepressant approved in the US. We sought to evaluate all published and unpublished data available to determine the efficacy and harms of vor...

    Authors: Amanda S Meeker, Megan C Herink, Dean G Haxby and Daniel M Hartung

    Citation: Systematic Reviews 2015 4:21

    Content type: Research

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  12. The aims of antenatal education are broad and encompass outcomes related to pregnancy, birth, and parenthood. Both form and content of antenatal education have changed over time without evidence of effects on ...

    Authors: Carina Sjöberg Brixval, Solveig Forberg Axelsen, Stine Glenstrup Lauemøller, Stig Krøger Andersen, Pernille Due and Vibeke Koushede

    Citation: Systematic Reviews 2015 4:20

    Content type: Research

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  13. Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders of children and adolescents, with a significant impact on health services and the community in terms of ec...

    Authors: Ferrán Catalá-López, Brian Hutton, Amparo Núñez-Beltrán, Alain D Mayhew, Matthew J Page, Manuel Ridao, Aurelio Tobías, Miguel A Catalá, Rafael Tabarés-Seisdedos and David Moher

    Citation: Systematic Reviews 2015 4:19

    Content type: Protocol

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  14. The prevalence of vitamin D deficiency in hemodialysis patients is high. While most hemodialysis patients are treated with activated vitamin D (1,25[OH]2D) to prevent renal osteodystrophy, clinical practices of t...

    Authors: Anita Mehrotra, Wai-Yin Leung and Tannia Joson

    Citation: Systematic Reviews 2015 4:115

    Content type: Protocol

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    The Erratum to this article has been published in Systematic Reviews 2015 4:106

  15. A peer-reviewed journal would not survive without the generous time and insightful comments of the reviewers, whose efforts often go unrecognized. Although final decisions are always editorial, they are greatl...

    Authors: David Moher, Paul Shekelle and Lesley A Stewart

    Citation: Systematic Reviews 2015 4:94

    Content type: Reviewer acknowledgement

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    The Erratum to this article has been published in Systematic Reviews 2015 4:100

  16. Worldwide, approximately 12% of children under the age of 5 are either overweight or obese. As many young children spend 30 h or more per week in childcare centres with childcare educators. Targeting childcare...

    Authors: Stéphanie Ward, Mathieu Bélanger, Denise Donovan, Amanda Horsman and Natalie Carrier

    Citation: Systematic Reviews 2015 4:18

    Content type: Protocol

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  17. Sugar-sweetened beverages (SSBs) have been stressed as relevant targets of public health interventions considering the negative outcomes derived from their excessive intake. Though the evidence from published ...

    Authors: Elisa J Vargas-Garcia, Charlotte EL Evans and Janet E Cade

    Citation: Systematic Reviews 2015 4:17

    Content type: Protocol

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  18. Mentorship is perceived as vital to attracting, training, and retaining nursing faculty members and to maintaining high-quality education programs. While there is emerging evidence to support the value of ment...

    Authors: Lorelli Nowell, Deborah E White, Kelly Mrklas and Jill M Norris

    Citation: Systematic Reviews 2015 4:16

    Content type: Protocol

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  19. People with diabetic retinopathy tend to have lower levels of health-related quality of life than individuals with no retinopathy. Strategies for screening and treatment have been shown to be cost-effective. I...

    Authors: Christopher J Sampson, Jonathan C Tosh, Christopher P Cheyne, Deborah Broadbent and Marilyn James

    Citation: Systematic Reviews 2015 4:15

    Content type: PROTOCOL

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  20. Canada’s diverse society and its statutory commitment to multiculturalism means that a synthesis of knowledge related to the healthcare experiences of immigrants is essential to realise the health potential fo...

    Authors: Gina MA Higginbottom, Myfanwy Morgan, Mirande Alexandre, Yvonne Chiu, Joan Forgeron, Deb Kocay and Rubina Barolia

    Citation: Systematic Reviews 2015 4:13

    Content type: Research

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  21. Primary studies examining the accuracy of a continuous test evaluate its sensitivity and specificity at one or more thresholds. Meta-analysts then usually perform a separate meta-analysis for each threshold. H...

    Authors: Richard D Riley, Ikhlaaq Ahmed, Joie Ensor, Yemisi Takwoingi, Amanda Kirkham, R Katie Morris, J Pieter Noordzij and Jonathan J Deeks

    Citation: Systematic Reviews 2015 4:12

    Content type: Methodology

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  22. Providing patient-centered care requires that patients partner in their personal health-care decisions to the full extent desired. Patient decision aids facilitate processes of shared decision-making between p...

    Authors: Holly O Witteman, Selma Chipenda Dansokho, Heather Colquhoun, Angela Coulter, Michèle Dugas, Angela Fagerlin, Anik MC Giguere, Sholom Glouberman, Lynne Haslett, Aubri Hoffman, Noah Ivers, France Légaré, Jean Légaré, Carrie Levin, Karli Lopez, Victor M Montori…

    Citation: Systematic Reviews 2015 4:11

    Content type: Protocol

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  23. Strawberry diseases are a major limiting factor that severely impact plant agronomic performance. Regarding limitations of traditional techniques for detection of pathogens, researchers have developed specific...

    Authors: Seyed Mahyar Mirmajlessi, Marialaura Destefanis, Richard Alexander Gottsberger, Marika Mänd and Evelin Loit

    Citation: Systematic Reviews 2015 4:9

    Content type: Research

    Published on:

  24. Despite criticism, quality improvement (QI) continues to drive political and educational priorities within health care. Until recently, QI educational interventions have varied, targeting mainly postgraduates,...

    Authors: Lorraine Armstrong, William Lauder and Ashley Shepherd

    Citation: Systematic Reviews 2015 4:8

    Content type: Protocol

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  25. The aim of this rapid knowledge synthesis was to provide relevant research evidence to inform the implementation of a new health service in Nova Scotia, Canada: Collaborative Emergency Centres (CECs). CECs pro...

    Authors: Jill A Hayden, Lara Killian, Austin Zygmunt, Jessica Babineau, Ruth Martin-Misener, Jan L Jensen and Alix J Carter

    Citation: Systematic Reviews 2015 4:7

    Content type: Methodology

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  26. A major problem arising from searching across bibliographic databases is the retrieval of duplicate citations. Removing such duplicates is an essential task to ensure systematic reviewers do not waste time scr...

    Authors: John Rathbone, Matt Carter, Tammy Hoffmann and Paul Glasziou

    Citation: Systematic Reviews 2015 4:6

    Content type: Research

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  27. The large and growing number of published studies, and their increasing rate of publication, makes the task of identifying relevant studies in an unbiased way for inclusion in systematic reviews both complex a...

    Authors: Alison O’Mara-Eves, James Thomas, John McNaught, Makoto Miwa and Sophia Ananiadou

    Citation: Systematic Reviews 2015 4:5

    Content type: Research

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    The Erratum to this article has been published in Systematic Reviews 2015 4:59

  28. The rapid pace of modern life requires working-age women to juggle occupational, family, and social demands. Despite the large numbers of working-age women in developed countries and the proven benefits of reg...

    Authors: Jennifer L Reed, Stephanie A Prince, Christie A Cole, Kara A Nerenberg, Swapnil Hiremath, Heather E Tulloch, J George Fodor, Agnieszka Szczotka, Lisa A McDonnell, Kerri-Anne Mullen, Andrew L Pipe and Robert D Reid

    Citation: Systematic Reviews 2015 4:3

    Content type: Protocol

    Published on:

  29. Overweight and obesity, which have a substantial impact on health in the general population, have similar prevalence in solid organ transplant recipients but carry even more serious ramifications. As this grou...

    Authors: Sonja Beckmann, Nataša Ivanović, Gerda Drent, Todd Ruppar and Sabina De Geest

    Citation: Systematic Reviews 2015 4:2

    Content type: Protocol

    Published on:

  30. Systematic reviews should build on a protocol that describes the rationale, hypothesis, and planned methods of the review; few reviews report whether a protocol exists. Detailed, well-described protocols can f...

    Authors: David Moher, Larissa Shamseer, Mike Clarke, Davina Ghersi, Alessandro Liberati, Mark Petticrew, Paul Shekelle and Lesley A Stewart

    Citation: Systematic Reviews 2015 4:1

    Content type: Research

    Published on:

  31. Researchers often wish to carry out additional calculations or analyses using the survival data from one or more studies of other authors. When it is not possible to obtain the raw data directly, reconstructio...

    Authors: Zhihui Liu, Benjamin Rich and James A Hanley

    Citation: Systematic Reviews 2014 3:151

    Content type: Methodology

    Published on:

  32. Pharmacological thromboprophylaxis in the peri-operative period involves a trade-off between reduction in venous thromboembolism (VTE) and an increase in bleeding. Baseline risks, in the absence of prophylaxis...

    Authors: Kari AO Tikkinen, Arnav Agarwal, Samantha Craigie, Rufus Cartwright, Michael K Gould, Jari Haukka, Richard Naspro, Giacomo Novara, Per Morten Sandset, Reed A Siemieniuk, Philippe D Violette and Gordon H Guyatt

    Citation: Systematic Reviews 2014 3:150

    Content type: Protocol

    Published on:

  33. Experimental designs for evaluating knowledge translation (KT) interventions for professional behavior change can provide strong estimates of intervention effectiveness but offer limited insight how the interv...

    Authors: Shannon D Scott, Thomas Rotter, Lisa Hartling, Thane Chambers and Katherine H Bannar-Martin

    Citation: Systematic Reviews 2014 3:149

    Content type: Protocol

    Published on:

  34. Dietary interventions are considered an important aspect of clinical practice, more so in the face of the rising prevalence of obesity, diabetes and cardiovascular diseases globally. Routinely, most doctors do...

    Authors: Victor Mogre, Albert Scherpbier, Tim Dornan, Fred Stevens, Paul Armah Aryee and Mary Gemma Cherry

    Citation: Systematic Reviews 2014 3:148

    Content type: Protocol

    Published on:

  35. The rapid pace of modern life requires working-age women to juggle occupational, family and social demands. This modern lifestyle has been shown to have a detrimental effect on health, often associated with in...

    Authors: Jennifer L Reed, Stephanie A Prince, Christie A Cole, J George Fodor, Swapnil Hiremath, Kerri-Anne Mullen, Heather E Tulloch, Erica Wright and Robert D Reid

    Citation: Systematic Reviews 2014 3:147

    Content type: Protocol

    Published on:

  36. In the Middle East and North Africa (MENA), hepatitis C virus (HCV) distribution appears to present a wide range of prevalence. The scale and nature of HCV disease burden is poorly known in the Horn of Africa ...

    Authors: Karima Chaabna, Yousra A Mohamoud, Hiam Chemaitelly, Ghina R Mumtaz and Laith J Abu-Raddad

    Citation: Systematic Reviews 2014 3:146

    Content type: Protocol

    Published on:

  37. Suicide is a major public health problem and globally is the second leading cause of death in young adults. Globally, there are 164,000 suicides per year in young people under 25 years. Depression is a strong ...

    Authors: Lynda Tait and Maria Michail

    Citation: Systematic Reviews 2014 3:145

    Content type: Protocol

    Published on:

  38. The Cochrane risk of bias (RoB) tool has been widely embraced by the systematic review community, but several studies have reported that its reliability is low. We aim to investigate whether training of raters...

    Authors: Bruno R da Costa, Nina M Resta, Brooke Beckett, Nicholas Israel-Stahre, Alison Diaz, Bradley C Johnston, Matthias Egger, Peter Jüni and Susan Armijo-Olivo

    Citation: Systematic Reviews 2014 3:144

    Content type: Protocol

    Published on:

  39. Practical solutions are needed to support the appropriate use of available health system resources as countries are continually pressured to ‘do more with less’ in health care. Increasingly, health systems and...

    Authors: Michael G Wilson, Moriah E Ellen, John N Lavis, Jeremy M Grimshaw, Kaelan A Moat, Joshua Shemer, Terry Sullivan, Sarah Garner, Ron Goeree, Roberto Grilli, Justin Peffer and Kevin Samra

    Citation: Systematic Reviews 2014 3:143

    Content type: Protocol

    Published on:

  40. A rigorous and focused systematic review and meta-analysis of randomised controlled trials (RCTs) of individualised homeopathic treatment has not previously been undertaken. We tested the hypothesis that the o...

    Authors: Robert T Mathie, Suzanne M Lloyd, Lynn A Legg, Jürgen Clausen, Sian Moss, Jonathan RT Davidson and Ian Ford

    Citation: Systematic Reviews 2014 3:142

    Content type: Research

    Published on:

  41. Participation in leisure-time physical activity benefits health and is thought to be more prevalent in higher socioeconomic groups. Evidence indicates that childhood socioeconomic circumstances may have long-t...

    Authors: Ahmed Elhakeem, Rachel Cooper, David Bann and Rebecca Hardy

    Citation: Systematic Reviews 2014 3:141

    Content type: Protocol

    Published on:

  42. Prognostic factors are associated with the risk of future health outcomes in individuals with a particular health condition. The prognostic ability of such factors is increasingly being assessed in both primar...

    Authors: Janine Dretzke, Joie Ensor, Sue Bayliss, James Hodgkinson, Marie Lordkipanidzé, Richard D Riley, David Fitzmaurice and David Moore

    Citation: Systematic Reviews 2014 3:140

    Content type: Methodology

    Published on:

  43. There are more than 100,000 asylum seekers registered in Germany, who are granted limited access to health services. This study aims to provide a systematic overview of the empirical literature on the health s...

    Authors: Christine Schneider, Amir Mohsenpour, Stefanie Joos and Kayvan Bozorgmehr

    Citation: Systematic Reviews 2014 3:139

    Content type: Protocol

    Published on:

  44. Industry sponsorship has been identified as a factor correlating with positive research findings in several fields of medical science. To date, the influence of industry sponsorship in general and abdominal su...

    Authors: Pascal Probst, Kathrin Grummich, Alexis Ulrich, Markus W Büchler, Phillip Knebel and Markus K Diener

    Citation: Systematic Reviews 2014 3:138

    Content type: Protocol

    Published on:

  45. There is no consensus on how authors conducting meta-analysis should deal with trial participants with missing outcome data. The objectives of this study are to assess in Cochrane and non-Cochrane systematic r...

    Authors: Elie A Akl, Lara A Kahale, Arnav Agarwal, Nada Al-Matari, Shanil Ebrahim, Paul Elias Alexander, Matthias Briel, Romina Brignardello-Petersen, Jason W Busse, Batoul Diab, Alfonso Iorio, Joey Kwong, Ling Li, Luciane Cruz Lopes, Reem Mustafa, Ignacio Neumann…

    Citation: Systematic Reviews 2014 3:137

    Content type: Protocol

    Published on:

  46. Although abbreviated surgery with planned reoperation (damage control surgery) is now widely used to manage major trauma patients, the procedure and its component interventions have not been evaluated in rando...

    Authors: Nela Cosic, Derek J Roberts and Henry T Stelfox

    Citation: Systematic Reviews 2014 3:136

    Content type: Protocol

    Published on:

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