Skip to main content

Impact of interventions to reduce sugar-sweetened beverage intake in children and adults: a protocol for a systematic review and meta-analysis



Sugar-sweetened beverages (SSBs) have been stressed as relevant targets of public health interventions considering the negative outcomes derived from their excessive intake. Though the evidence from published literature grows to support a cause-and-effect association of SSBs with obesity and other diseases, little is known on the effectiveness that strategies alone or as part of multi-component programmes have had to influence this particular dietary behaviour across all ages. Therefore, this review and meta-analysis aim to evaluate the effect that interventions have had to decrease their consumption or increase water intake in children and adults so as to guide the design of future programmes and inform policy making.


Included studies in this review will be randomised controlled trials and quasi-experimental interventions (with a control group) that have reported baseline and post-intervention intakes of SSBs or water and that have been published from 1990 in any language. A thorough search will be performed in MEDLINE, EMBASE, Scopus, Web of Science, Cochrane’s central register of controlled trials, and the Global Health Library. Two independent reviewers will conduct initial screening of potentially included articles and will later extract data to analyse domains of intervention design and delivery (with emphasis on behaviour change techniques used as rationale), as well as results in changes on consumption patterns and behavioural determinants. Internal and external validity of each study will also be appraised. A meta-analysis will be performed if a sufficient number of studies are available, and if not, a narrative review will be conducted instead.


The results from this review aim to strengthen public health initiatives tackling obesity through improvements in non-alcoholic drinking patterns. As a subject of growing attention globally, this review will help determine which strategies available are the most effective in different contexts. Knowledge gained from this work will also aid resource allocation in future research and government agendas.

Systematic review registration

PROSPERO: CRD42014013436.

Peer Review reports


Obesity represents one of the most important public health challenges of the modern era. Projections for 2030 have estimated that up to 2.16 billion and 1.12 billion adults will be overweight and obese, respectively [1]. Yet, it has been recognised that the economic, social and health consequences will be greater for low- and lower-middle-income countries facing nutritional transitions such as those in Northern Africa, the Middle East, Asia and Latin America [2].

Several responses have been undertaken to counteract this problem mainly through interventions that have addressed modifiable factors - such as healthy eating and physical activity [3-6]. Results nevertheless have been inconsistent in the long term, partly due to a lack of commitment and allocated resources from national levels for evaluation and to guarantee their sustainability [7].

In the majority of obesity prevention programmes, strategies have focused on discouraging high intakes of fat (mainly saturated and trans) and added sugars in food and beverages. Evidence has additionally supported the potential to target individual dietary elements that contribute to higher energy intakes and that increase the risk of developing obesity [8,9]. This is the case with sugar-sweetened beverages (SSBs), which are high sources of energy with poor nutritional and satiating values [9,10]. SSBs are made up of naturally occurring caloric sweeteners such as sucrose (50% glucose and 50% fructose), fruit juice concentrates or more frequently high fructose corn syrup (45% glucose and 55% fructose) [11]. The latter, in particular, has been attributed as one of the main contributors to the adverse health effects from SSBs due to the metabolic pathways of fructose degradation (exacerbating triglyceride synthesis, insulin resistance and uric acid production) [12]. However, as the use of any caloric sweetener in beverages appears to have similar acute responses in the body, more robust study designs and data are warranted to determine detrimental health outcomes in the longer term [13-17].

Soft drinks are the leading source of added sugars in the American diet, accounting for 9.5% of total energy intake in adolescents and young adults and up to 6.2% in children from 6 to 11 years old [18]. Data from consumption patterns in the United Kingdom (UK) indicates that non-alcoholic beverages contribute to approximately 6% of daily total energy intake in boys and girls (4 to 18 years old), 4% in men and women (19 to 64 years old) and 2% in older adults [19]. On the other hand, soft drinks (carbonated and noncarbonated beverages containing sugar as well as fruit drinks) account for approximately 10% of total daily energy intake in Mexican children and adults [20-22]. A similar trend of consumption has been also reported for Taiwan, although the most popular sweetened drinks in that country include ice-based beverages and processed juice [23]. Figures on purchasing trends in China and Brazil have shown a steep rise in SSB sales per capita of 269% and 147%, respectively, for The Coca Cola Company over the last decade [24]. Brazil household surveys have identified that 2.1% of total calories consumed come from soft drinks exclusively, whereas in Chile, SSBs are amongst the three main products of food expenditure within the poorest sectors of society [25,26]. The former highlights that sugar-sweetened beverage intake is not a problem exclusively of the developed world but also one affecting developing countries [1]. Indeed, it has been emphasised that it is those on a lower income that have higher odds of engaging in unhealthier dietary patterns such as drinking SSBs - since access and availability to these is not limited to the least deprived [27].

Considering the burden of disease derived by obesity and the financial constraints posed to healthcare systems globally, policy makers and governments around the world have widely supported and joined efforts in improving low- or non-caloric beverage consumption patterns. Actions taken have encompassed interventions to decrease consumption of SSBs or/and increase water intake at community levels, through school policies and media coverage (health campaigns). Political measures like taxation and marketing restrictions have also been implemented.

Nevertheless, there is general recognition about the need for sufficient evidence to help decide the best public health action to decrease sugar-sweetened beverage consumption within populations [9,28]. Though literature has particularly highlighted the importance to address behaviour change in interventions so that effective and successful practice can be achieved both in clinical and public health sectors [29], to-date, there are no reviews available that have evaluated the content of interventions seeking to modify behaviour of SSB consumption. The reviews that are available have focused on the cause-and-effect association of SSB with obesity and other health outcomes and have advocated the need for successful initiatives to promote a change in SSB consumption [16,20,30-33].

As an issue of growing interest internationally, it is then necessary to inform intervention designers as well as higher levels of authority of the interventions that have most success in reducing SSB intake, in order to improve dietary guidelines and health outcomes and ensure better allocation of health resources.


The main purpose of this systematic review and meta-analysis is to evaluate the effect of public health interventions to reduce sugar-sweetened beverage intake or increase water intake in children and adults.

Primary objectives include

  • ▪ Evaluation of intervention elements or factors generating a change in SSB behaviour (either on their frequency of consumption or amount consumed) in children and adults.

  • ▪ Evaluation of intervention elements or factors generating a change in water intake in children and adults.

Secondary objectives

  • ▪ Identification and evaluation of the most effective behavioural change techniques targeting SSBs or water intake.

  • ▪ Evaluation of programmes' delivery processes and their contribution to achieving sustainable outcomes.

  • ▪ Identification of the effectiveness of interventions targeting SSBs or water intake to decrease health inequalities.


How the intervention might work

As portrayed in Figure 1, evidence surrounding the deleterious effects from increased intake of added sugars in the diet (such as those coming from SSBs) has encouraged different initiatives involving a wide range of stakeholders (from children to governmental authorities). By addressing SSB consumption, it is firstly desired to have an impact on participants’ awareness, knowledge and beliefs that could increase their motivation to change this dietary behaviour [34]. By successfully turning attempts at change into action, weight gain can be prevented, and further benefits on a larger scale can be achieved. It should be noted that the macro-environment or context per se may stand as a barrier at primary stages of interventions for enabling the development of desirable skills and behaviours particularly in those from disadvantaged backgrounds [29,34].

Figure 1
figure 1

Decreasing SSB and/or increasing water intake. Interventions and activities for decreasing SSB and/or increasing water intake in children and adults. SSB, sugar-sweetened beverage.

Research questions

  • Can public health interventions reduce the intake of sugar-sweetened beverages in children and adults?

  • Can public health interventions increase water intake in children and adults?

  • Which intervention components/elements are contributing to reducing SSB intake or increasing water intake in children and adults?

  • Which intervention components/elements are hindering or benefiting the implementation/delivery process of programmes targeting consumption of drinking water or SSB?

  • Which are the most potentially effective behavioural techniques underpinning changes in SSB or water intake?

  • What has been the impact of public health interventions targeting either a reduction in SSB consumption or increase in water intake on reducing health inequalities?

Description of the Condition/issue

What is a sugar-sweetened beverage?

The range of products that fall into such a category is broad as its characterisation and availability varies from country to country. Language discrepancies also pose a difficulty. The lack of a standard definition across different studies has been previously highlighted [35]. Yet, major presence of added sugars is the key element to judge or rate overall healthiness and their inclusion under such a term.

Operational definitions

Existing information mainly describes a sugar-sweetened beverage as a non-diet, non-alcoholic and non-dairy cold or warm drink (carbonated or still), with added sugars (derived from energy-yielding sweeteners/sources both natural and processed), including fruit drinks, nectars and cordials with less than 100% fruit juice as well as sports or energy drinks, ready-to-drink sweetened tea and ready-to-drink sweetened coffee [27,36].

In the case of drinking water, this will be considered as water that is intended to be ingested or for human consumption. Other terms frequently found in the literature are potable water, plain water or bottled water.

Description of the intervention

‘Intervention’ and ‘programme’ will be interchangeable terms used throughout this review. Public health intervention will be understood as a set of actions (within policy, regulatory initiatives, single strategy projects or multi-component programmes) with a coherent objective to bring about change or produce identifiable outcomes seeking to promote health or prevent disease in communities or populations [37].

Type of studies

This review will include

  • Randomised controlled trials (RCTs) reporting a change in sugar-sweetened beverage or water intake throughout the day as part of the intervention targets (even if they were not explicitly designed to address SSB or drinking water alone).

  • Quasi-experimental studies and pilot trials (considering the probable lack of RCTs available).

  • Studies that have been published from January 1990 in any language.

This review will exclude

  • Observational and small studies (for example, enrolling fewer than ten people in each arm) [38].

  • Studies looking at health outcomes (type 2 diabetes, cardiovascular disease and so on) as the primary outcome with no measure of intake of SSB or drinking water being reported.

  • Studies addressing gestational diabetes - if no randomisation took place.

  • Studies that do not provide an objective measure of SSB (describing frequency of consumption) derived from a standard assessment method (24-h recall, weighed or un-weighed food diary or food frequency questionnaire).

  • Studies that do not have baseline and post-intervention information on either primary outcomes (SSB or water consumption).

  • Studies that do not have a control group or that do not report any measure of variation such as standard deviation, standard error or 95% confidence intervals will not be included in the meta-analysis but may be considered for the review.

  • Alcohol interventions (those targeting reduction of alcohol intake).

  • Studies addressing sanitation or hygiene aspects.

  • Rehydration and subjective appetite trials (those looking at intake of SSB and acute changes in hormonal or appetite intake).

For the purpose of the present review, the control group will also be referred to as the comparison group which should be understood as the arm of a programme that did not receive the planned or active intervention (either no activity was given, a ‘usual care’ approach was taken or an alternative intervention was provided).

Type of participants

Participants to be included are subjects aged 3 years and over. For mixed-aged groups, only studies where more than 50% of the participants were 3 years or over will be included.

For interventions targeting individuals with morbid obesity (body mass index ≥40 kg/m2), metabolic syndrome and chronic diseases such as type 2 diabetes, they will only be reviewed if they were part of a RCT; as by already having a clinical condition or disease, randomisation would diminish or prevent a more favourable prognosis to one of the groups. This would warrant that they both started with the same opportunities for success or beneficial effects.

Participants suffering from a psychiatric condition (for example, binge eaters) will be excluded.

Type of interventions

This review will consider public health interventions addressing a reduction in SSB consumption or water increase that had a minimum length of 4 weeks of follow-up (from baseline data collection until the first assessment of outcomes) and that were provided mainly at community settings. Studies taking place at clinical locations (for example, a hospital) will only be reviewed if participants had been allocated into intervention or control groups by random methods.

Interventions addressing artificially sweetened drinks/diet beverages (those flavoured with non-energy-yielding sweeteners such as aspartame, sucralose, saccharin, acesulfame potassium, neotame or stevia) [39] will be included if these were used as alternatives for reducing intakes of SSB, and dietary patterns of consumption were reported. Interventions replacing SSB with 100% fruit juice (for a healthier substitution) will not be included as it may be difficult to determine the real concentration of naturally occurring sugars in such drinks which will bias our results. Interventions targeting an increase in fruit and vegetable juice consumption as the primary outcome will also be excluded.

Trials looking at effects of beverage replacement on hormonal response, appetite and subsequent energy intake will not be included.

Type of outcome measures

Primary outcomes

  • ▪ Change in SSB consumption (in millilitres/per day)

  • ▪ Change in water intake (in millilitres/per day)

Secondary outcomes

  • ▪ Presence or absence of specific intervention components such as behaviour change techniques (BCTs).

  • ▪ Change in knowledge/attitude/beliefs in regard to SSB and water consumption as measured by an existing taxonomy on BCTs.

  • ▪ Changes in physical environments and policies.

  • ▪ Changes in health inequalities as measured by interactions between socio-demographic characteristics of participants and interventions' effects/outcomes.

Search methods for identification of studies

Search strategy

The PICO framework (acronym for patient/intervention/comparator and outcome) was used as a first tool to identify pertinent terminology for inclusion in the search strategy. Considering the characteristics of this review ‘setting’ was used instead of the ‘comparator’ category. A combination of keywords relating mostly to interventions, settings and outcomes comprised the searching. Medical subheadings (MeSH) and other controlled vocabulary used in indexed journals were considered for the development of the strategy.

The following databases will be used to search for relevant articles published from January 1990 in any language:

  • ▪ OVID Medline

  • ▪ Cochrane central register of controlled trials (CENTRAL)

  • ▪ EMBASE

  • ▪ Scopus

  • ▪ Web of Science

  • ▪ The Global Health Library

  • ▪ Database of Abstracts of Reviews of Effects (DARE)

  • ▪

  • ▪ The Trials Register of Promoting Health Interventions (TRoPHI)

  • ▪ International Clinical Trials Registry Platform (ICTRP)

  • ▪ metaRegister of Controlled Trials (mRCT)

Reference lists will also be scanned in order to include missing relevant papers. Selected articles will be imported to an EndNote library. An example of the searching strategy designed and executed in Medline (OVID) can be seen elsewhere [see Additional file 1].

Data collection and analysis

Selection of studies

Two trained reviewers will independently perform an initial screening based on title and abstract. Any disagreements found at this stage will be discussed by them and - if required - resolved by discussion and consultation with a third review author.

A copy of full articles will be obtained for all potentially relevant studies. For unavailable articles at the University of Leeds, authors will be contacted electronically, and papers will be also ordered from the British Library. Any discrepancies that could arise at this stage will also be resolved by consulting a third reviewer.

Agreement between responses will be verified through Cohen’s kappa index of inter-rater reliability. A kappa of 0.7 will be considered as a good level of agreement.

The process of inclusion and exclusion of records at each stage will be guided, documented and described using the preferred reporting items of systematic reviews and meta-analyses (PRISMA) flow chart which is a recognised tool from a group of reviewers, clinicians, editors and consumers seeking to enhance transparency in published systematic reviews [40].

Data extraction and management

Data from the studies meeting the inclusion criteria will be entered into Review Manager 5 software in duplicate. Characteristics regarding type of study, allocation concealment, sample size, intervention targets, setting, population’s age, country and year of study, length of the intervention, primary and secondary outcomes, statistical measures, results as well as attrition rates will be fully extracted by two members of the team using an adapted spreadsheet form available from the Cochrane Collaboration [41] and then managed with the aforementioned software.

The following characteristics will be summarised and presented in tables from studies meeting inclusion criteria: study details (author, year of publication, trial design, place of study), study objective and aims, study duration, setting of intervention, content, delivery (frequency, duration and intensity of activities), duration of intervention and follow-up, participants’ characteristics (mean age, sex and other socio-demographic features available), outcome definition and overall main results on primary outcomes.

Authors will be contacted if no definition or description of serving sizes is available within the information of a study. If no response is provided, then a standardised portion or serving of SSB will be imputed, that being 8 fluid oz or approximately 240 mL.

When studies have measured intakes of SSB or drinking water at several points across a given intervention, baseline and the longest follow-up measurement will be used for analysis. If this was not the case, then baseline and post-intervention measurements will be considered. Frequency of consumption of SSBs or water will be analysed and transformed - if necessary - into ‘times per day’. For studies reporting more than one group or category of SSBs without the total, in the first instance the authors will be contacted to determine whether results for total intake are available. If this is not possible then most important type of SSB will be entered into the analysis used in the meta-analysis. This will be determined by agreement within the review team.

Additional information-when available-on equity will be analysed using the PROGRESS framework (which stands for place of residence, race or ethnicity, occupation, gender, religion, education, socioeconomic status, social status) to identify if the intervention had more positive effects in certain participants or groups.

As one of the main objectives of this review is to identify the behaviour change techniques that explain intervention effectiveness, two independent reviewers will judge and code these (both in the intervention and control groups) with help of an existing reliable taxonomy of 26 techniques that has characterised the content of interventions addressing healthy eating amongst obese populations [42]. Description and examples of techniques can be found in the Additional file 2 [43].

Statistical analysis

Random-effects meta-analysis will be carried out to produce a pooled estimate of the difference in millilitres (mL) of SSB and drinking water between the intervention and control arms in the studies included in the review. The data will be displayed in forest plots, firstly of all studies in the review and secondly in subgroups according to the following age stages of childhood development and adulthood: 3 to 5 years old, 6 to 12 years old, 13 to 18 years old and 19 and above [5]. If the whole family was targeted, the intervention will be allocated under the latter subgroup. The I2 test will be used to check for heterogeneity across studies. Results of heterogeneity denoted by I2 between 25 and 50% will be indicative of moderate heterogeneity, from 50 to 75% of substantial and above 75% of considerable heterogeneity, respectively [41]. If there are sufficient studies available - more than ten studies [41] - a meta-regression will be conducted to explore whether heterogeneity is explained by the BCTs used in the intervention. This will determine whether the use of certain techniques is associated with more effective interventions. Potential confounders will also be taken into account in the analysis such as age, gender, setting of intervention and randomisation. Mean differences and 95% confidence intervals will be used in the analysis of the primary outcome (change in mL of SSBs or water intakes). Reported means together with standard errors will be used to determine this. Odds ratios and 95% confidence intervals will be used for pooling binary outcomes.

Cochrane’s tool of risk of bias will be used to assess quality of studies (both in randomised, non-randomised and cluster-randomised controlled trials) with regard to allocation concealment, sequence generation, blinding, treatment of completers versus non-completers, selective reporting and other biases [44]. Cluster RCTs will be assessed as low risk of bias if the unit of analysis was considered at the same level as the allocation (either by school, classes or community), and allocation was carried out on all entities before the intervention had started. In the case of studies that had not accounted for this, then effect estimates and their standard errors from correct analyses of cluster-randomised trials may be meta-analysed using the generic inverse-variance method in RevMan. In addition, intra-cluster correlation coefficients (ICC) will be used to assess variability between and within clusters. Reporting bias will be identified in studies that included outcomes throughout the methodology but were not presented in the results section or referenced in other peer reviewed publications.

Quantitative synthesis will be the desired approach, yet if very small numbers of studies were available and do not allow this or if heterogeneity was found to be too high or unexplained, then a narrative synthesis will be performed instead or the forest plot will be presented without the pooled estimate provided.


The magnitude of the obesity epidemic in both children and adults worldwide urgently demands action and better approaches. Both observational and experimental evidence have successfully demonstrated a link between SSB intake, weight gain and its related comorbidities (that mainly being obesity, metabolic syndrome, CVD and type 2 diabetes). As a result, research has suggested that SSB are a feasible target for public health initiatives in order to reduce the obesity prevalence and other negative consequences [9,28].

There has been a growing debate in regard to a causative link between sugar-sweetened beverages and weight gain in recent years [9,35,45]. Nevertheless, much of the attention given has focused solely on the longer health outcomes related to morbidity rather than those related to behaviour change. The former could be the result of the multi-factorial context in which health-related behaviours lie, which pose one of the greatest challenges when seeking to tackle unhealthy dietary patterns [46].

Despite the fact that the complexity of a problem like obesity does not rely on the reduced consumption of a single food item (in this case, sugar-sweetened beverages), it should be recognised that their nutritional composition is poor as they do not provide any real health benefit nor appear to have protective effects in any published study so far. Thus, considering the documented parallel increase in consumption trends and obesity rates in many countries, there is much expectation to know the feasibility of generating a change in SSB intake and whether current resources should be kept or placed elsewhere.

The findings derived from this systematic review and meta-analysis will therefore help in the development of improved public health initiatives tackling obesity, particularly in countries with a magnified consumption of SSB. It will also help identify the pathways and discriminate amongst the array of possibilities available to generate a desirable and sustainable change towards healthier drinking patterns.

While it is likely that the number of papers available addressing the intended research questions will be limited - as it is a topic that has gained recent momentum - this review will particularly be benefited by including literature in any language. Consequently, it will be possible to detect useful, innovative strategies or elements that could be integrated in upcoming interventions or programmes for future research and policy making.



behaviour change technique


cardiovascular disease


Food Agriculture Organisation

I 2 :





non-government organisation




randomised controlled trial


sugar-sweetened beverage


United Kingdom


World Health Organisation


  1. Kelly T, Yang W, Chen CS, Reynolds K, He J. Global burden of obesity in 2005 and projections to 2030. Int J Obes (Lond). 2008;32(9):1431–7. doi:10.1038/ijo.2008.102.

    CAS  Google Scholar 

  2. Popkin BM. Nutrition in transition: the changing global nutrition challenge. Asia Pac J Clin Nutr. 2001;10(Suppl):S13–8.

    PubMed  Google Scholar 

  3. Shaw K, Gennat H, O’Rourke P, Del Mar C. Exercise for overweight or obesity. Cochrane Database Syst Rev. 2006;4:CD003817. doi:10.1002/14651858.CD003817.pub3.

    PubMed  Google Scholar 

  4. Ho M, Garnett SP, Baur LA, Burrows T, Stewart L, Neve M, et al. Impact of dietary and exercise interventions on weight change and metabolic outcomes in obese children and adolescents: a systematic review and meta-analysis of randomized trials. JAMA Pediatr. 2013;167(8):759–68. doi:10.1001/jamapediatrics.2013.1453.

    PubMed  Google Scholar 

  5. Waters E, de Silva-Sanigorski A, Hall BJ, Brown T, Campbell KJ, Gao Y, et al. Interventions for preventing obesity in children. Cochrane Database Syst Rev. 2011;12:CD001871. doi:10.1002/14651858.CD001871.pub3.

    PubMed  Google Scholar 

  6. Wadden TA, Webb VL, Moran CH, Bailer BA. Lifestyle modification for obesity: new developments in diet, physical activity, and behavior therapy. Circulation. 2012;125(9):1157–70. doi:10.1161/circulationaha.111.039453.

    PubMed  PubMed Central  Google Scholar 

  7. WHO. 2008-2013 Action plan for the global strategy for the prevention and control of noncommunicable diseases. Geneva: World Health Organization; 2008.

    Google Scholar 

  8. Mozaffarian D, Hao T, Rimm EB, Willett WC, Hu FB. Changes in diet and lifestyle and long-term weight gain in women and men. N Engl J Med. 2011;364(25):2392–404. doi:10.1056/NEJMoa1014296.

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Hu FB. Resolved: there is sufficient scientific evidence that decreasing sugar-sweetened beverage consumption will reduce the prevalence of obesity and obesity-related diseases. Obes Rev. 2013;14(8):606–19. doi:10.1111/obr.12040.

    CAS  PubMed  Google Scholar 

  10. Stull AJ, Apolzan JW, Thalacker-Mercer AE, Iglay HB, Campbell WW. Liquid and solid meal replacement products differentially affect postprandial appetite and food intake in older adults. J Am Diet Assoc. 2008;108(7):1226–30. doi:10.1016/j.jada.2008.04.014.

    PubMed  PubMed Central  Google Scholar 

  11. Malik VS, Hu FB. Sweeteners and risk of obesity and type 2 diabetes: the role of sugar-sweetened beverages. Curr Diab Rep. 2012. doi:10.1007/s11892-012-0259-6

  12. Bray GA. Energy and fructose from beverages sweetened with sugar or high-fructose corn syrup pose a health risk for some people. Adv Nutr. 2013;4(2):220–5. doi:10.3945/an.112.002816.

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Teff KL, Grudziak J, Townsend RR, Dunn TN, Grant RW, Adams SH, et al. Endocrine and metabolic effects of consuming fructose- and glucose-sweetened beverages with meals in obese men and women: influence of insulin resistance on plasma triglyceride responses. J Clin Endocrinol Metab. 2009;94(5):1562–9. doi:10.1210/jc.2008-2192.

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Wiebe N, Padwal R, Field C, Marks S, Jacobs R, Tonelli M. A systematic review on the effect of sweeteners on glycemic response and clinically relevant outcomes. BMC Med. 2011;9:123. doi:10.1186/1741-7015-9-123.

    CAS  PubMed  PubMed Central  Google Scholar 

  15. Rippe JM, Angelopoulos TJ. Sucrose, high-fructose corn syrup, and fructose, their metabolism and potential health effects: what do we really know? Advances Nutr. 2013;4(2):236–45. doi:10.3945/an.112.002824.

    CAS  Google Scholar 

  16. Greenwood DC, Threapleton DE, Evans CE, Cleghorn CL, Nykjaer C, Woodhead C et al. Association between sugar-sweetened and artificially sweetened soft drinks and type 2 diabetes: systematic review and dose-response meta-analysis of prospective studies. Brit J Nutr. 2014:1-10. doi:10.1017/s0007114514001329

  17. Maersk M, Belza A, Stodkilde-Jorgensen H, Ringgaard S, Chabanova E, Thomsen H, et al. Sucrose-sweetened beverages increase fat storage in the liver, muscle, and visceral fat depot: a 6-mo randomized intervention study. Am J Clin Nutr. 2012;95(2):283–9. doi:10.3945/ajcn.111.022533.

    CAS  PubMed  Google Scholar 

  18. Welsh JA, Sharma AJ, Grellinger L, Vos MB. Consumption of added sugars is decreasing in the United States. Am J Clin Nutr. 2011;94(3):726–34. doi:10.3945/ajcn.111.018366.

    CAS  PubMed  PubMed Central  Google Scholar 

  19. Bates BLA, Bates C, Swan G. National diet and nutrition survey: headline results from years 1 and 2 (combined) of the Rolling Programme (2008/2009–2009/10). In: Agency DoHatFS. UK: Department of Health; 2011.

    Google Scholar 

  20. Malik VS, Popkin BM, Bray GA, Despres JP, Hu FB. Sugar-sweetened beverages, obesity, type 2 diabetes mellitus, and cardiovascular disease risk. Circulation. 2010;121(11):1356–64. doi:10.1161/circulationaha.109.876185.

    PubMed  PubMed Central  Google Scholar 

  21. Barquera S, Hernandez-Barrera L, Tolentino ML, Espinosa J, Ng SW, Rivera JA, et al. Energy intake from beverages is increasing among Mexican adolescents and adults. J Nutr. 2008;138(12):2454–61. doi:10.3945/jn.108.092163.

    CAS  PubMed  Google Scholar 

  22. Barquera S, Campirano F, Bonvecchio A, Hernandez-Barrera L, Rivera JA, Popkin BM. Caloric beverage consumption patterns in Mexican children. Nutr J. 2010;9:47. doi:10.1186/1475-2891-9-47.

    PubMed  PubMed Central  Google Scholar 

  23. Pan WH, Wu HJ, Yeh CJ, Chuang SY, Chang HY, Yeh NH, et al. Diet and health trends in Taiwan: comparison of two nutrition and health surveys from 1993-1996 and 2005-2008. Asia Pac J Clin Nutr. 2011;20(2):238–50.

    PubMed  Google Scholar 

  24. Kleiman S, Ng SW, Popkin B. Drinking to our health: can beverage companies cut calories while maintaining profits? Obes Rev. 2012;13(3):258–74. doi:10.1111/j.1467-789X.2011.00949.x.

    CAS  PubMed  Google Scholar 

  25. Albala C, Vio F, Kain J, Uauy R. Nutrition transition in Chile: determinants and consequences. Public Health Nutr. 2002;5(1A):123–8. doi:10.1079/phn2001283.

    PubMed  Google Scholar 

  26. Levy-Costa RB, Sichieri R, dos Santos Pontes N, Monteiro CA. Household food availability in Brazil: distribution and trends (1974-2003). Disponibilidade domiciliar de alimentos no Brasil: Distribuição e evolução (1974-2003). 2005;39(4):530-40. doi:Export Date 28 February 2014 Source Scopus.

  27. Han E, Powell LM. Consumption patterns of sugar-sweetened beverages in the United States. J Acad Nutr Diet. 2013;113(1):43–53. doi:10.1016/j.jand.2012.09.016.

    PubMed  PubMed Central  Google Scholar 

  28. Malik VS, Willett WC, Hu FB. Global obesity: trends, risk factors and policy implications. Nat Rev Endocrinol. 2013;9(1):13–27. doi:10.1038/nrendo.2012.199.

    PubMed  Google Scholar 

  29. Michie S, van Stralen MM, West R. The behaviour change wheel: a new method for characterising and designing behaviour change interventions. Implement Sci. 2011;6:42. doi:10.1186/1748-5908-6-42.

    PubMed  PubMed Central  Google Scholar 

  30. Malik VS, Schulze MB, Hu FB. Intake of sugar-sweetened beverages and weight gain: a systematic review123. Am J Clin Nutr. 2006;84(2):274–88.

    CAS  PubMed  PubMed Central  Google Scholar 

  31. Schulze MB, Manson JE, Ludwig DS, Colditz GA, Stampfer MJ, Willett WC, et al. Sugar-sweetened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged women. JAMA. 2004;292(8):927–34. doi:10.1001/jama.292.8.927.

    CAS  PubMed  Google Scholar 

  32. Forshee RA, Anderson PA, Storey ML. Sugar-sweetened beverages and body mass index in children and adolescents: a meta-analysis. Am J Clin Nutr. 2008;87(6):1662–71.

    CAS  PubMed  Google Scholar 

  33. Malik VS, Pan A, Willett WC, Hu FB. Sugar-sweetened beverages and weight gain in children and adults: a systematic review and meta-analysis. Am J Clin Nutr. 2013;98(4):1084–102. doi:10.3945/ajcn.113.058362.

    CAS  PubMed  PubMed Central  Google Scholar 

  34. Michie S, Jochelson K, Markham WA, Bridle C. Low-income groups and behaviour change interventions: a review of intervention content, effectiveness and theoretical frameworks. J Epidemiol Community Health. 2009;63(8):610–22. doi:10.1136/jech.2008.078725.

    CAS  PubMed  Google Scholar 

  35. Althuis MD, Weed DL. Evidence mapping: methodologic foundations and application to intervention and observational research on sugar-sweetened beverages and health outcomes. Am J Clin Nutr. 2013;98(3):755–68. doi:10.3945/ajcn.113.058917.

    CAS  PubMed  Google Scholar 

  36. Gibson S. Sugar-sweetened soft drinks and obesity: a systematic review of the evidence from observational studies and interventions. Nutr Res Rev. 2008;21(2):134–47. doi:10.1017/s0954422408110976.

    PubMed  Google Scholar 

  37. Rychetnik L, Frommer M, Hawe P, Shiell A. Criteria for evaluating evidence on public health interventions. J Epidemiol Community Health. 2002;56(2):119–27.

    CAS  PubMed  PubMed Central  Google Scholar 

  38. Evans CE, Christian MS, Cleghorn CL, Greenwood DC, Cade JE. Systematic review and meta-analysis of school-based interventions to improve daily fruit and vegetable intake in children aged 5 to 12 y. Am J Clin Nutr. 2012;96(4):889–901. doi:10.3945/ajcn.111.030270.

    CAS  PubMed  Google Scholar 

  39. Mattes RD, Popkin BM. Nonnutritive sweetener consumption in humans: effects on appetite and food intake and their putative mechanisms. Am J Clin Nutr. 2009;89(1):1–14. doi:10.3945/ajcn.2008.26792.

    CAS  PubMed  Google Scholar 

  40. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol. 2009;62(10):1006–12. doi:10.1016/j.jclinepi.2009.06.005.

    PubMed  Google Scholar 

  41. Higgins JPT GS. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. The Cochrane Collaboration. 2011.

  42. Michie S, Abraham C, Whittington C, McAteer J, Gupta S. Effective techniques in healthy eating and physical activity interventions: a meta-regression. Health Psychol. 2009;28(6):690–701. doi:10.1037/a0016136.

    PubMed  Google Scholar 

  43. Michie S, Ashford S, Sniehotta FF, Dombrowski SU, Bishop A, French DP. A refined taxonomy of behaviour change techniques to help people change their physical activity and healthy eating behaviours: the CALO-RE taxonomy. Psychol Health. 2011;26(11):1479–98. doi:10.1080/08870446.2010.540664.

    PubMed  Google Scholar 

  44. Higgins JP, Altman DG, Gotzsche PC, Juni P, Moher D, Oxman AD, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928. doi:10.1136/bmj.d5928.

    PubMed  PubMed Central  Google Scholar 

  45. Kaiser KA, Shikany JM, Keating KD, Allison DB. Will reducing sugar-sweetened beverage consumption reduce obesity? Evidence supporting conjecture is strong, but evidence when testing effect is weak. Obes Rev. 2013;14(8):620–33. doi:10.1111/obr.12048.

    CAS  PubMed  PubMed Central  Google Scholar 

  46. WHO. Behaviour change strategies and health: the role of health systems. Tbilisi, Georgia: World Health Organization; 2008. Contract No.: EUR/RC58/10.

    Google Scholar 

Download references


EJVG is supported by a scholarship from the National Council of Science and Technology (CONACyT) and the Ministry of Public Education (SEP) in Mexico. No further funding has been given to finance this review. The authors would like to thank MSc student Jozef Hooson for his input in the initial stages of screening and acquirement of papers used in the protocol. We would also like to thank Dr. Judy Wright for her assistance in the development of the searching strategy and Dr. Andrew Prestwich for his involvement and critical views on the manuscript as well as the guidance provided towards the BCTs that will be used in the protocol.

Author information

Authors and Affiliations


Corresponding author

Correspondence to Elisa J Vargas-Garcia.

Additional information

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

EJVG, CELE and JEC all contributed to the original idea and research questions to be reviewed. EJVG has led the research approach and drafted relevant sections regarding the literature review and the searching strategy (both development and execution). CELE has led the development of the statistical analysis. CELE and JEC have shared responsibility in the research approach and have assisted in drafting the protocol and writing up the manuscript. All authors have read and approved the final manuscript.

Authors’ information

Elisa J Vargas-Garcia is a Doctoral Student, Charlotte E.L. Evans is a Lecturer in Nutritional Epidemiology and Janet E. Cade is a Professor in Nutritional Epidemiology.

Additional files

Additional file 1:

Example searching strategy: Medline (Ovid). This document displays an example of a searching strategy designed and executed in Medline (OVID).

Additional file 2:

Behaviour change techniques used in interventions targeting healthy eating. This document shows the list and description of each of the techniques that will be used to characterise the intervention’s components. Certain health examples have been also provided.

Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Vargas-Garcia, E.J., EL Evans, C. & Cade, J.E. Impact of interventions to reduce sugar-sweetened beverage intake in children and adults: a protocol for a systematic review and meta-analysis. Syst Rev 4, 17 (2015).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: