- Open Access
- Open Peer Review
Physical therapies as an adjunct to Botulinum toxin-A injection of the upper or lower limb in adults following neurological impairment
© Kinnear; licensee BioMed Central Ltd. 2012
- Received: 29 March 2012
- Accepted: 26 June 2012
- Published: 26 June 2012
Spasticity of muscles is a common consequence of central nervous system impairment. Traditionally, neurological rehabilitation for spasticity has involved occupational and physical therapy; however, increasingly Botulinum toxin–A injections may be provided. Injection effects are temporary. Consequently, understanding the effect of adjunct physical therapies will help inform multimodal rehabilitation decisions. Presently, these effects are not known. This systematic review will identify and summarize evidence on physical therapies used after Botulinum toxin-A injection to improve motor function in adults with neurological impairments.
Systematic searching of seven electronic databases will occur to identify relevant randomized trials. Available trial data will be extracted into a list of pre-defined primary outcomes, including range of movement, spasticity and functional limb use. Pre-defined secondary outcomes will also be reviewed where trials have these data available for reporting. Effects will be expressed as mean differences or standardized mean differences with 95% confidence intervals (CI). Where possible, comparable results will be meta-analyzed, and a summary of the available pool of evidence produced.
All randomized controlled trials will be rated using the PEDro methodological quality scale. Where possible, study data will be meta-analyzed using RevMan 5 Software. The protocol was registered in PROSPERO international prosepective register of systematic reviews (PROSPERO 2011:CRD42011001491).
Review results will be the most comprehensive answer available to the following question: Are physical therapies clinically effective after Botulinum toxin-A injections in adults with neurological spasticity? Results will inform healthcare providers and managers who determine who gets access to and provision of Botulinum toxin-A injection and whether this is done with or without physical therapies. Results will inform the clinicians who conduct physical therapy following injection. This protocol provides readers with the scope and depth of a search that will ultimately answer a complex and pressing treatment question. The variability of current practice and high level of expense associated with multimodal rehabilitation means review results will be more useful and less contestable if the protocol is revealed in full through advance publication.
- Physical Therapy
- Occupational Therapy
- Botulinum toxin-A
- Motor Disorder
Spasticity is one negative symptom which can occur following central nervous system impairment[1, 2]. Spasticity is defined as a velocity-dependent increase in stretch reflex with exaggerated tendon jerks. This motor disorder can have a profound impact on health outcomes and quality of life. It is associated with pain, and often has a negative impact on function, self-esteem and body image. General health can suffer as spasticity leads to difficulties in hygiene and maintaining skin integrity in affected limbs with consequent infection common. Treatment of spasticity and management of consequences of this motor disorder is an unending, expensive and time intensive task for health services and the people affected by it, with results recognized to be ‘less than satisfactory’. There is an urgent need to identify treatment that is safe, effective and efficient. In the past decade, traditional rehabilitation for this motor disorder, such as occupational and physical therapy, has been augmented by pharmacotherapy, such as Botulinum Toxin-A, which has been demonstrated to reduce spasticity. The effect from pharmacotherapy is temporary so there is interest in the adjunct effects of physical therapies, since the rehabilitation goals of patients are long term. Typical goals include: increasing range of motion (ROM), improving limb position and performance of activities, and ensuring skin integrity[9–11].
Following BoNT-A injection, physical therapies can be used, such as stretching, casting, strengthening exercises, splinting and movement training often in the context of functional activities where normal movement patterns are encouraged[2, 6, 12, 13]. These physical therapies post-BoNT-A injection are thought to improve ROM and function in patients with motor disorders following neurological impairment. Both BoNT-A and physical therapies have been shown, together and separately, to have an impact on health outcomes, such as walking ability[14, 15]. To date, however, no study has examined the cumulative evidence regarding combined BoNT-A and physical therapies for treatment of spasticity in upper or lower limbs of adult patients with neurological impairment. Given the cost and scale of the service provided, and the breadth and complexity of health and quality of life problems involved, a review that provides a comprehensive summary of evidence relating to this problem and intervention is urgently needed.
This systematic review will identify and summarize evidence on physical therapies used after Botulinum toxin-A injection to improve motor function in adults with neurological impairments. In summarizing evidence, the review will evaluate the effectiveness of physical therapies used post-BoNT-A injection for improving motor function in this patient population. Inclusion criteria for studies in the review now follow.
Types of studies
Eligible studies will be randomizsed controlled trials and quasi-randomized controlled trials. Only the first arm of cross-over trials will be included.
Types of participants
Eligible participants will be aged 16 years and over with a neurological impairment (central nervous system damage) and have received BoNT-A injections in their limb muscles up to three months prior to study rehabilitation commencement for spasticity management.
Types of interventions
Physical rehabilitation interventions provided to patients who have received BoNT-A to the upper or lower limb, including casting, splinting, stretching, movement training, exercises, strengthening or electrical stimulation, are compared with sham or no physical therapy.
Types of outcome measures
Measures of range of movement, such as goniometry or torque-controlled range of movement.
Measures of improved functional limb use or active movement of the affected limb as measured on the Action Research Arm Test, the Motor Activity Log (assessment or self report), Wolf Motor Function Test, Fugl-Meyer assessment of motor function, Box and Blocks test, velocity of gait (meters/second) and step length.
Measures of reduced spasticity as measured by the Modified Ashworth Scale.
Health-related quality of life
Caregiver/attendant care time and/or number
Discharge destination/living situation
Rehabilitation length of stay
The study design investigated diagnostic or prognostic factors/relationships
Less than 50% of the interventions were applied to the upper or lower limb
Outcomes from physical therapies were not able to be differentiated from the outcomes of other therapies provided simultaneously to participants.
The following databases will be electronically searched for all available years: PEDro, CENTRAL, Pub Med, EMBASE, CINAHL, National Research Register, Meta Registry of Controlled Trials and Occupational Therapy Systematic Evaluation of Effectiveness database (OTseeker). The search will not be limited by date or publication status. We will check the reference lists of any eligible studies identified for further relevant studies. Unpublished, non-peer reviewed sources, such as conference abstracts, will not be included (refer to appendix 1.)
Two authors will independently review all potential studies for inclusion against the eligibility criteria. They will examine the title and abstract and, where necessary, the full text of studies to assess if they are eligible for inclusion. If they cannot reach agreement by discussion, a third author will make the final decision about eligibility.
Two authors will independently use a standard form to extract study characteristics and outcome data from the studies. Discrepancies will be checked against the original data. A third author will make the final decision if there is a disagreement. One author (BK) will enter data in Revman meta-analysis software (Review Manager (RevMan) [Computer program]. Version 5.1. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2011). Data will be reported during therapy as well as at end of therapy. Any outcomes measured after therapy has finished will be grouped as less than one month, one to six months, and over six months.
Methodological quality will be assessed using the PEDro scale by one reviewer (BK). The PEDro scale has established reliability and provides a score out of 10. Studies which attain a PEDro score of 7 or greater are considered ‘high quality’, those with a PEDro score of 5 or 6 are considered ‘moderate quality’ and those with a PEDro score of 4 or less are considered ‘poor quality’ in terms of study methods and susceptibility to bias. Adequacy of concealment will additionally be rated using the procedure outlined by Schulz. The methodological quality of included observational studies will be assessed independently by two raters using the MOOSE (Meta-analysis Of Observational Studies in Epidemiology) guidelines. Scores will be based on all information available from both the published version and the authors themselves. No trial will be excluded on the basis of poor quality.
Analysis of covariance-adjusted between-group means and standard deviations will be extracted in preference to between-group differences in change scores, and between-group differences in change scores will be extracted in preference to between group differences in final scores. If studies reported data as medians and interquartile ranges, medians will be used as a surrogate for means and standard deviations were estimated as 80% of the interquartile range (studies which do not report an interquartile range (IQR) will be excluded from the meta-analysis). For continuous outcome measures, a pooled estimate of treatment effect will be determined by calculating the mean difference and the corresponding 95% CIs. For dichotomous outcome measures, a pooled estimate of treatment effect will be calculated for each outcome across studies using risk ratio where appropriate and the corresponding 95% confidence intervals (CIs). Time-to-event data will be analyzed using the hazard ratio and 95% CIs as required. When conducting a meta-analysis combining results from crossover studies, the first-arm data only will be used. In the event of missing, incomplete or unclear data, the original investigators will be contacted. If it is not possible to obtain the necessary data for analysis, the study results will be described in the text and will not be included in the meta-analysis.
When there are at least two clinically homogenous studies (studies which investigated the effect of similar interventions on similar populations and reported similar outcomes) meta-analysis will be considered. In such circumstances, the I2 statistic will be used to quantify the heterogeneity of outcomes and informed decisions about whether to pool data. Where I2 is greater than 30% in the presence of significant chi-squared test result (P-value < 0.10), this will be interpreted as indicating heterogeneity. If there is significant heterogeneity (over 50%), data will not be pooled.
We will enter data extracted from included studies into RevMan software. Meta-analyses of clinically homogenous therapies will be conducted using a fixed-effects model. Where heterogeneity is substantial (I2 > 50%), the possible causes of heterogeneity will be explored in sensitivity analyses in which individual studies will be omitted one at a time. Should heterogeneity not be able to be explained, a random-effects model will be used.
The robustness of our results will be tested through sensitivity analyses excluding unpublished studies, small studies and studies with a PEDro score less than 5.
Spasticity can be a significant causal factor in patients’ decreasing functional limb use and mobility, often compounding the difficulties faced in rehabilitation by patients with motor weakness and impairment. Reviewing the effectiveness of therapies provided after BoNT-A and the effects on spasticity, movement and function will provide much needed guidance to therapists, as well as policy and funding guidance to health departments in how to provide the most effective interventions.
There are currently no evidence-based guidelines for the physical rehabilitation that should be provided to adults with neurological impairment who have received Botulinum toxin–A injections in the upper or lower limb. Recent European international consensus guidelines and national treatment guidelines do not recommend a protocol for physical rehabilitation when provided as an adjunct to Botulinum toxin injection. Instead, evidence is available from completed and ongoing trials in the area of stroke rehabilitation where different post Botulinum toxin injection physical rehabilitation interventions are compared with each other, other forms of therapy or no therapy. Internationally, Botulinum toxin-A has regulatory approval for upper and lower limb injection in adults with neurological conditions. This review considers whether physical rehabilitation following such injection has an effect on functional outcomes.
A.1. PEDro Search Strategy
A.2. CENTRAL Search Strategy
Spasticity (key word, title, abstract)
Botulinum toxin (key word, title, abstract)
Therapy (key word, title, abstract)
Adults (key word, title, abstract)
A.3. PubMed Search Strategy
((muscle* or muscular) adj3 (spasm* or cramp or spastic* or clonus).ab, ti.
exp brain ischemia
brain/or exp intracranial arterial diseases
exp “intracranial embolism and thrombosis”
exp intracranial haemorrhages/
((stroke$ or post stroke$ or post- stroke$ or cva$).tw.)
((cerebrovascular cerebral vascular) adj3 (accident? or insult?).tw.)
(((cerebral or brain$ or vertebrobasilar) adj5 (infarc$ or isch?emi$ or thrombo$ or apoplexy or emboli$)).t.w.)
((cerebral or brain or subarachnoid) adj5 (haemorrhage or hemorrhage or haematoma or hematoma or bleed)).tw.)
(((trauma$ or acquired) adj5 brain injur$).tw.)
(exp brain injuries/)
brain damage, chronic/or brain injury, chronic/)
(exp craniocerebral trauma/or head injuries, closed/or intracranial hemorrhage, traumatic/)
(exp encephalitis/or exp meningitis, viral/or brain abscess/or exp central nervous system infections)
((encephalitis or meningitis or brain abscess or brain infection$ or cerebral infection$).tw.)
(exp Brain Neoplasms/)
(((brain or cerebr$) adj5 (neoplasm$ or lesion$ or tumor$)).tw.)
Traumatic brain injury*
exp Spinal cord injuries
(spinal cord adj3 (injur* or damage* or contusion* or lacerat* or trauma*)).ab,ti.
28 or 29 or 30
Cerebral palsy or CP
Multiple sclerosis or MS
((((“Multiple Sclerosis”[mh]) OR (“Myelitis, Transverse”[mh:noexp]) OR (“Demyelinating Diseases”[mh:noexp]) OR (“Encephalomyelitis, Acute Disseminated”[mh:noexp]) OR (“Optic Neuritis”[mh])) OR (((“multiple sclerosis”) OR (“neuromyelitis optica”) OR (“transverse myelitis”) OR (encephalomyelitis) OR (devic) OR (“optic neuritis”)) OR (“demyelinating disease*”) OR (“acute disseminated encephalomyelitis”)))
exp Botulinum Toxins/
Botulinum toxin type a/
Muscle spasticity/dt [Drug therapy]
Muscle tonus/de [Drug effects]
Physical therapy modalities/
Exercise movement techniques/
controlled clinical trial.pt.
clinical trials as topic.sh.
randomized controlled trial.pt
6 and 41 and 49 and 60 and 68 and 69
A.4. CINAHL Search Strategy
Intracranial arterial diseases
Intracranial embolism and thrombosis
Brain damage, chronic
Spinal cord injuries
Spinal cord neoplasms
Encephalomyelitis, acute disseminated
Demyelinating autoimmune diseases, CNS
Physical therapy assessment
Physical therapy service
Occupational Therapy assessment
53 or 54
6 and 36 and 40 and 52 and 55
The author acknowledges scholarly and project support from Associate Professor Natasha Lannin, Professor Anne Cusick and Associate Professor Lisa Harvey. Acknowledgement is also given to Dr. Barry Rawicki for guidance regarding medical considerations in the data base search strategies.
- Lance JW: In Spasticity: Disordered Motor Control. Symposium synopsis. Edited by: Feldman RG, Young RR, Koella WP. 1980, Miami: Symposia Specialists, 485-494.Google Scholar
- Sheean G, Lannin N, Turner-Stokes L, Rawicki B, Snow BJ, Cerebral Palsy Institute: Botulinum toxin assessment, intervention and after care for upper limb hypertonicity in adults: international consensus statement. Eur J Neurol. 2010, 17: 74-93.View ArticlePubMedGoogle Scholar
- Yelnik AP, Colle FM, Bonan IV, Vicaut E: Treatment of shoulder pain in spastic hemiplegia by reducing spasticity of the subscapular muscle: a randomised, double blind, placebo controlled study of botulinum toxin A. J Neurol Neurosurg Psychiatry. 2007, 78: 845-848. 10.1136/jnnp.2006.103341.View ArticlePubMedGoogle Scholar
- Cardoso E, Rodrigues B, Lucena R, de Reis Oliveira I, Pedreira G, Melo A: Botulinum toxin type A for the treatment of the upper limb spasticity after stroke: a meta- analysis. Arq Neuropsiquiatr. 2005, 63: 30-33. 10.1590/S0004-282X2005000100006.View ArticlePubMedGoogle Scholar
- Bhakta BB, Cozens JA, Chamberlain MA, Bamford JM: Impact of botulinum toxin type A on disability and carer burden due to arm spasticity after stroke: a randomised double blind placebo controlled trial. J Neurol Neurosurg Psychiatry. 2000, 69: 217-221. 10.1136/jnnp.69.2.217.View ArticlePubMedPubMed CentralGoogle Scholar
- Chin TY, Graham HK: Botulinum toxin A in the management of upper limb spasticity in cerebral palsy. Hand Clin. 2005, 19: 591-600.View ArticleGoogle Scholar
- National Stroke Foundation: Clinical guidelines for stroke management. 2010, Available fromhttp://www.strokefoundation.com.au/clinical-guidelines,Google Scholar
- Simpson DM, Gracies JM, Graham HK, Miyasaki JM, Naumann M, Russman B, Simpson LL, So Y, Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology: Assessment: botulinum neurotoxin for the treatment of spasticity (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology. 2008, 70: 1691-1698. 10.1212/01.wnl.0000311391.00944.c4.View ArticlePubMedGoogle Scholar
- Hagedorn R: Foundations for Practice in Occupational Therapy. 2009, New York: Churchill Livingstone, 2Google Scholar
- Hesse S, Brandi-Hesse B, Bardeleben A, Werner C, Funk M: Botulinum toxin A treatment of adult upper and lower limb spasticity. Drugs Aging. 2001, 18: 255-262. 10.2165/00002512-200118040-00003.View ArticlePubMedGoogle Scholar
- Kinnear B, Lannin N, Cusick A: The promise and potential of botulinum toxin-A: national survey of therapy practices. Int J Stroke. 2011, 6 (Suppl. 1): 17-Google Scholar
- Hoare B, Imms C: Upper-limb injections of botulinum toxin-A in children with cerebral palsy: a critical review of the literature and clinical implications for Occupational Therapists. Am J Occup Ther. 2004, 58: 389-397. 10.5014/ajot.58.4.389.View ArticlePubMedGoogle Scholar
- Sun SF, Hsu CW, Sun HP, Hwang CW, Yang CL, Wang JL: Combined botulinum toxin type A with modified constraint-induced movement therapy for chronic stroke patients with upper extremity spasticity: a randomized controlled study. Neurorehabil Neural Repair. 2010, 24: 34-41. 10.1177/1545968309341060.View ArticlePubMedGoogle Scholar
- Caty GD, Detrembleur C, Bleyenheuft C, Deltombe T, Lejeune TM: Effect of simultaneous botulinum toxin injections into several muscles on impairment, activity, participation, and quality of life among stroke patients presenting with a stiff knee gait. Stroke. 2008, 39: 2803-2808. 10.1161/STROKEAHA.108.516153.View ArticlePubMedGoogle Scholar
- Karadag-Saygi E, Cubukcu-Aydoseli K, Kablan N, Ofluoqlu D: The role of kinesiotaping combined with botulinum toxin to reduce plantar flexors spasticity after stroke. Top Stroke Rehabil. 2010, 17: 318-322. 10.1310/tsr1704-318.View ArticlePubMedGoogle Scholar
- The Nordic Cochrane Centre: Review Manager (RevMan). 5.0. The Cochrane Collaboration. 2008, Copenhagen: The Nordic Cochrane Centre, The Cochrane CollaborationGoogle Scholar
- Maher CG, Sherrington C, Herbert RD, Moseley AM, Elkins M: Reliability of the PEDro scale for rating quality of randomized controlled trials. Phys Ther. 2003, 83: 713-715.PubMedGoogle Scholar
- Harvey L, Herbert R, Crosbie J: Does stretching induce lasting increases in joint ROM? A systematic review. Physiother Res Int. 2002, 7: 1-13. 10.1002/pri.236.View ArticlePubMedGoogle Scholar
- Schultz KF, Chalmers I, Hayes RJ, Aitman DG: Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA. 1995, 273: 408-412. 10.1001/jama.1995.03520290060030.View ArticleGoogle Scholar
- Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA, Thacker SB: Meta-analysis of observational studies in epidemiology: a proposal for reporting. JAMA. 2000, 283: 2008-2012. 10.1001/jama.283.15.2008.View ArticlePubMedGoogle Scholar
- Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. Edited by: Higgins JPT, Green S. 2011, The Cochrane Collaboration, Available fromwww.cochrane-handbook.org,Google Scholar
- Wissel J, Ward AB, Ertzgaard P, Bensmail B, Hecht MJ, Lejeune TM, Schnider P: European consensus table on the use of botulinum toxin type A in adult spasticity. J Rehabil Med. 2009, 41: 13-25. 10.2340/16501977-0303.View ArticlePubMedGoogle Scholar
- Royal College of Physicians London: National Guidelines Spasticity in Adults: Management Using Botlulinum Toxin. 2009, Aberystwyth: Cambrian Printers LtdGoogle Scholar
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