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  1. Content type: Research

    Systematic reviews of qualitative and quantitative evidence can provide a rich understanding of complex phenomena. This type of review is increasingly popular, has been used to provide a landscape of existing ...

    Authors: Quan Nha Hong, Pierre Pluye, Mathieu Bujold and Maggy Wassef

    Citation: Systematic Reviews 2017 6:61

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  2. Content type: Protocol

    Frequently cited benefit-cost ratios suggest that interventions to improve neurodevelopment have high economic returns when implemented during pregnancy and early childhood. However, there are many challenges ...

    Authors: Karen M. Edmond, Natalie A. Strobel, Kimberley McAuley, Elizabeth Geelhoed and Lisa Hurt

    Citation: Systematic Reviews 2017 6:59

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  3. Content type: Protocol

    Suboptimal thyroid hormone therapy including under-replacement and over-replacement is common amongst patients with hypothyroidism. This is a significant health concern as affected patients are at risk of adve...

    Authors: Rosie Dew, Onyebuchi Okosieme, Colin Dayan, Vinay Eligar, Ishrat Khan, Salman Razvi, Simon Pearce and Scott Wilkes

    Citation: Systematic Reviews 2017 6:60

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  4. Content type: Protocol

    Dietary advice is one of the cornerstones in the management of type 2 diabetes mellitus. The American Diabetes Association recommended a hypocaloric diet for overweight or obese adults with type 2 diabetes in ...

    Authors: Lukas Schwingshackl, Anna Chaimani, Georg Hoffmann, Carolina Schwedhelm and Heiner Boeing

    Citation: Systematic Reviews 2017 6:57

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  5. Content type: Methodology

    Decision support tools build upon comprehensive and timely syntheses of literature. Rapid reviews may allow supporting their development by omitting certain components of traditional systematic reviews. We thu...

    Authors: Moulikatou Adouni Lawani, Béatriz Valéra, Émilie Fortier-Brochu, France Légaré, Pierre-Hugues Carmichael, Luc Côté, Philippe Voyer, Edeltraut Kröger, Holly Witteman, Charo Rodriguez and Anik M. C. Giguere

    Citation: Systematic Reviews 2017 6:56

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  6. Content type: Research

    Dysvascular partial foot amputation (PFA) is a common sequel to advanced peripheral vascular disease. Helping inform difficult discussions between patients and practitioners about the level of PFA, or the deci...

    Authors: Michael P. Dillon, Matthew Quigley and Stefania Fatone

    Citation: Systematic Reviews 2017 6:54

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  7. Content type: Research

    Physical frailty is a prevalent syndrome in older adults that increases vulnerability for a range of adverse outcomes including increased dependency and death. Caregivers of older adults experience significant...

    Authors: Thom Ringer, Afeez Abiola Hazzan, Arnav Agarwal, Adam Mutsaers and Alexandra Papaioannou

    Citation: Systematic Reviews 2017 6:55

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  8. Content type: Protocol

    Human papillomavirus (HPV) is the most prevalent genital infection, especially in young women of reproductive age. In vitro and animal model experiments provide compelling evidence of the harmful effect of HPV...

    Authors: Joseph Niyibizi, Nadège Zanré, Marie-Hélène Mayrand and Helen Trottier

    Citation: Systematic Reviews 2017 6:53

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  9. Content type: Protocol

    The aim of this individual participant data meta-analysis (IPDMA) is to evaluate the effects of dietary and lifestyle interventions among pregnant women who are overweight or obese on later maternal and early ...

    Authors: Jodie M. Dodd, Rosalie M. Grivell, Jennie Louise, Andrea R. Deussen, Lynne Giles, Ben W. Mol, Christina Vinter, Mette Tanvig, Dorte Moller Jensen, Annick Bogaerts, Roland Devlieger, Riitta Luoto, Fionnuala McAuliffe, Kristina Renault, Emma Carlsen, Nina Geiker…

    Citation: Systematic Reviews 2017 6:51

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  10. Content type: Protocol

    There is a lack of high-level evidence on the surgical management of cleft palate. An appreciation of the differences in the complication rates between different surgical techniques and timing of repair is ess...

    Authors: Zach Zhang, Michael Stein, Nigel Mercer and Claudia Malic

    Citation: Systematic Reviews 2017 6:52

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  11. Content type: Protocol

    Tuberous sclerosis complex (TSC) is an autosomal dominant condition, caused by mutations in either the TSC1 or TSC2 gene. It has widespread systemic manifestations and is associated with significant neurologic...

    Authors: Rebecca Mitchell, Sarah Barton, A. Simon Harvey and Katrina Williams

    Citation: Systematic Reviews 2017 6:49

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  12. Content type: Research

    Transcranial magnetic stimulation (TMS) is a non-invasive means by which to assess the structure and function of the central nervous system. Current practices involve the administration of multiple stimuli ove...

    Authors: Rocco Cavaleri, Siobhan M. Schabrun and Lucy S. Chipchase

    Citation: Systematic Reviews 2017 6:48

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  13. Content type: Research

    Evidence suggests that newborn and child health systematic reviews and meta-analyses exhibit poor quality in reporting. The “Preferred Reporting Items in Systematic Review and Meta-Analysis” (PRISMA) and PRISM...

    Authors: Mufiza Farid-Kapadia, Kariym C. Joachim, Chrinna Balasingham, April Clyburne-Sherin and Martin Offringa

    Citation: Systematic Reviews 2017 6:31

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  14. Content type: Protocol

    Atrial fibrillation is the most common arrhythmia of the heart with a prevalence of approximately 2% in the western world. Atrial flutter, another arrhythmia, occurs less often with an incidence of approximate...

    Authors: Naqash J. Sethi, Sanam Safi, Emil E. Nielsen, Joshua Feinberg, Christian Gluud and Janus C. Jakobsen

    Citation: Systematic Reviews 2017 6:47

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  15. Content type: Protocol

    Freeman-Sheldon and Sheldon-Hall syndromes (FSS and SHS) and distal arthrogryposis types 1 and 3 (DA1 and DA3) are rare, often confused, congenital syndromes. Few studies exist. With reported diagnosis unrelia...

    Authors: Mikaela I. Poling, José Andrés Morales Corado and Robert L. Chamberlain

    Citation: Systematic Reviews 2017 6:46

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  16. Content type: Protocol

    Excess body weight and heavy alcohol consumption are two of the greatest contributors to global disease. Alcohol use peaks in early adulthood. Alcohol consumption can also exacerbate weight gain. A high body m...

    Authors: Stephanie Scott, Kathryn Parkinson, Eileen Kaner, Shannon Robalino, Martine Stead, Christine Power, Niamh Fitzgerald, Wendy Wrieden and Ashley Adamson

    Citation: Systematic Reviews 2017 6:42

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  17. Content type: Protocol

    As eHealth interventions prove both efficacious and practical, and as they arguably overcome certain barriers encountered by traditional face-to-face treatment for chronic pain, their number has increased dram...

    Authors: Brian W. Slattery, Stephanie Haugh, Kady Francis, Laura O’Connor, Katie Barrett, Christopher P. Dwyer, Siobhan O’Higgins, Jonathan Egan and Brian E. McGuire

    Citation: Systematic Reviews 2017 6:45

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  18. Content type: Protocol

    Overweight and obesity are well-known risk factors for cardiometabolic diseases including hypertension, myocardial infarction, stroke, and type 2 diabetes in the general population. Survivors of childhood brai...

    Authors: Kuan-Wen Wang, Adam Fleming, Sheila K. Singh, Laura Banfield, Russell J. de Souza, Lehana Thabane and M. Constantine Samaan

    Citation: Systematic Reviews 2017 6:43

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  19. Content type: Research

    The Cochrane risk of bias tool is commonly criticized for having a low reliability. We aimed to investigate whether training of raters, with objective and standardized instructions on how to assess risk of bia...

    Authors: Bruno R. da Costa, Brooke Beckett, Alison Diaz, Nina M. Resta, Bradley C. Johnston, Matthias Egger, Peter Jüni and Susan Armijo-Olivo

    Citation: Systematic Reviews 2017 6:44

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  20. Content type: Commentary

    Guideline developers and other users of systematic reviews need information about whether a medical or preventive intervention is likely to benefit or harm some patients more (or less) than the average in orde...

    Authors: Evelyn P. Whitlock, Michelle Eder, Jamie H. Thompson, Daniel E. Jonas, Corinne V. Evans, Janelle M. Guirguis-Blake and Jennifer S. Lin

    Citation: Systematic Reviews 2017 6:41

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  21. Content type: Research

    Stroke can lead to significant impairment of upper limb function which affects performance of activities of daily living (ADL). Functional electrical stimulation (FES) involves electrical stimulation of motor ...

    Authors: John Eraifej, William Clark, Benjamin France, Sebastian Desando and David Moore

    Citation: Systematic Reviews 2017 6:40

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  22. Content type: Protocol

    Diabetes has become a global health emergency affecting high-, middle- and low-income countries. Previous systematic reviews have either focused on patients’ adherence to diabetes self-care behaviours only or ...

    Authors: Victor Mogre, Natalie A. Johnson, Flora Tzelepis, Jonathan Shaw and Christine Paul

    Citation: Systematic Reviews 2017 6:39

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  23. Content type: Protocol

    Primary care electronic medical record (EMR) data are being used for research, surveillance, and clinical monitoring. To broaden the reach and usability of EMR data, case definitions must be specified to ident...

    Authors: Sepideh Souri, Nicola E. Symonds, Azin Rouhi, Brendan C. Lethebe, Stephanie Garies, Paul E. Ronksley, Tyler S. Williamson, Gabriel E. Fabreau, Richard Birtwhistle, Hude Quan and Kerry A. McBrien

    Citation: Systematic Reviews 2017 6:38

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  24. Content type: Protocol

    Chronic kidney disease (CKD) is associated with an increased risk of fracture and cardiovascular mortality. The risk of fracture in hemodialysis (HD), peritoneal dialysis (PD), and kidney transplantation (KT) ...

    Authors: Aboubacar Sidibé, Lynne Moore, Sonia Jean and Fabrice Mac-Way

    Citation: Systematic Reviews 2017 6:37

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  25. Content type: Protocol

    Colorectal cancer (CRC) is a common and important disease. There are different tests for diagnosis, one of which is computed tomographic colonography (CTC). No test is perfect, and patients with normal CTC may...

    Authors: Andrew A. Plumb, Anu Obaro, Thomas Fanshawe, Ulysses S. Torres, Rachel Baldwin-Cleland, Steve Halligan and David Burling

    Citation: Systematic Reviews 2017 6:36

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  26. Content type: Protocol

    There is limited information about how transgender, gender diverse, and Two-Spirit (trans) people have been represented and studied by researchers. The objectives of this study are to (1) map and describe tran...

    Authors: Zack Marshall, Vivian Welch, James Thomas, Fern Brunger, Michelle Swab, Ian Shemilt and Chris Kaposy

    Citation: Systematic Reviews 2017 6:35

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  27. Content type: Protocol

    Effective knowledge translation (KT) is critical to implementing program and policy changes that require shared understandings of knowledge systems, assumptions, and practices. Within mainstream research insti...

    Authors: Melody E. Morton Ninomiya, Donna Atkinson, Simon Brascoupé, Michelle Firestone, Nicole Robinson, Jeff Reading, Carolyn P. Ziegler, Raglan Maddox and Janet K. Smylie

    Citation: Systematic Reviews 2017 6:34

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  28. Content type: Protocol

    Despite limited evidence of effectiveness, withdrawal (discontinuation or dose reduction) of high risk medications known as “fall-risk increasing drugs” (FRIDs) is typically conducted as a fall prevention stra...

    Authors: Justin Yusen Lee and Anne Holbrook

    Citation: Systematic Reviews 2017 6:33

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  29. Content type: Research

    There is increasing demand for rapid reviews and timely evidence synthesis. The goal of this project was to understand end-user perspectives on the utility and limitations of rapid products including evidence ...

    Authors: Lisa Hartling, Jeanne-Marie Guise, Susanne Hempel, Robin Featherstone, Matthew D. Mitchell, Makalapua L. Motu’apuaka, Karen A. Robinson, Karen Schoelles, Annette Totten, Evelyn Whitlock, Timothy J. Wilt, Johanna Anderson, Elise Berliner, Aysegul Gozu, Elisabeth Kato, Robin Paynter…

    Citation: Systematic Reviews 2017 6:32

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  30. Content type: Research

    It is uncertain whether the replication of systematic reviews, particularly those with the same objectives and resources, would employ similar methods and/or arrive at identical findings. We compared the resul...

    Authors: Jeffrey Low, Joseph S. Ross, Jessica D. Ritchie, Cary P. Gross, Richard Lehman, Haiqun Lin, Rongwei Fu, Lesley A. Stewart and Harlan M. Krumholz

    Citation: Systematic Reviews 2017 6:28

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  31. Content type: Protocol

    Little is known about the mechanisms that influence the success or failure of programs to facilitate re-engagement with health and social services for formerly incarcerated persons with HIV. This review aims t...

    Authors: Jenkin Tsang, Sharmistha Mishra, Janet Rowe, Patricia O’Campo, Carolyn Ziegler, Fiona G. Kouyoumdjian, Flora I. Matheson, Ahmed M. Bayoumi, Shatabdy Zahid and Tony Antoniou

    Citation: Systematic Reviews 2017 6:29

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  32. Content type: Protocol

    Perinatal morbidity and mortality remain significant public health issues globally, with enduring impact on the health and well-being of women and their families. Pregnant women who adopt, practice and maintai...

    Authors: Lisa M. Daly, Dell Horey, Philippa F. Middleton, Frances M. Boyle and Vicki Flenady

    Citation: Systematic Reviews 2017 6:26

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  33. Content type: Protocol

    Muslims comprise 4.8% of the national population in the UK and also form a significant proportion of its ethnic minority population, with trends set to continue for the foreseeable future. With ethnic minority...

    Authors: Yassar Mustafa, Diya Baker, Preeti Puligari, Teresa Melody, Joyce Yeung and Fang Gao-Smith

    Citation: Systematic Reviews 2017 6:25

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  34. Content type: Protocol

    Despite the surge of research and development in assistive products for older adults and/or people living with disabilities, policies on access and procurement have lagged in responding to the growing demand f...

    Authors: Winnie Sun, Michael G. Wilson, Daphne Schreiber and Rosalie H. Wang

    Citation: Systematic Reviews 2017 6:24

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  35. Content type: Research

    Rapid reviews are increasingly being used to help policy makers access research in short time frames. A clear articulation of the review’s purpose, questions, scope, methods and reporting format is thought to ...

    Authors: Gabriel Moore, Sally Redman, Catherine D’Este, Steve Makkar and Tari Turner

    Citation: Systematic Reviews 2017 6:23

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  36. Content type: Protocol

    Chronic low back pain (LBP) is the leading cause of pain and disability, resulting in a major socioeconomic impact. The Cochrane Review which examined the effect of spinal manipulative therapy (SMT) for chroni...

    Authors: A. de Zoete, M. R. de Boer, M. W. van Tulder, S. M. Rubinstein, M. Underwood, J. A. Hayden, J. Kalter and R. Ostelo

    Citation: Systematic Reviews 2017 6:21

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  37. Content type: Protocol

    Acute respiratory infections (ARI) are a leading cause of morbidity and mortality globally, and are often linked to seasonal and/or meteorological conditions. Globally, Indigenous peoples may experience a diff...

    Authors: Katherine E. Bishop-Williams, Jan M. Sargeant, Lea Berrang-Ford, Victoria L. Edge, Ashlee Cunsolo and Sherilee L. Harper

    Citation: Systematic Reviews 2017 6:19

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  38. Content type: Protocol

    Chewing and masticatory function constitutes one of the most important oral health factors that affect quality of life, especially in older individuals. Little consensus currently exists regarding ways to obje...

    Authors: Per Elgestad Stjernfeldt, Inger Wårdh, Mats Trulsson, Gerd Faxén Irving and Anne-Marie Boström

    Citation: Systematic Reviews 2017 6:20

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  39. Content type: Protocol

    Dementia and cognitive impairment could severely impact patients’ life and bring heavy burden to patients, caregivers and societies. Some interventions are suggested for the older patients with these condition...

    Authors: Fan Yang, Piers Dawes, Iracema Leroi and Brenda Gannon

    Citation: Systematic Reviews 2017 6:22

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  40. Content type: Protocol

    Pregnancy and childbirth are important risk factors for urinary incontinence (UI) in women. Pelvic floor muscle exercises (PFME) are effective for prevention of UI. Guidelines for the management of UI recommen...

    Authors: Victoria E. Salmon, E. Jean C. Hay-Smith, Rachel Jarvie, Sarah Dean, Eivor Oborn, Susan E. Bayliss, Debra Bick, Clare Davenport, Khaled M. Ismail, Christine MacArthur and Mark Pearson

    Citation: Systematic Reviews 2017 6:18

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  41. Content type: Research

    Youth comprise 40% of the world’s unemployed, a status associated with adverse wellbeing and social, health, and economic costs. This systematic review and meta-analysis review synthesises the literature on th...

    Authors: Lauren Mawn, Emily J. Oliver, Nasima Akhter, Clare L. Bambra, Carole Torgerson, Chris Bridle and Helen J. Stain

    Citation: Systematic Reviews 2017 6:16

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  42. Content type: Protocol

    Sexually transmitted infection with high-risk, oncogenic strains of human papillomavirus (HPV) still induces a relevant burden of diseases on both men and women. Although vaccines appear to be highly efficacio...

    Authors: Giampiero Favato, Emmanouil Noikokyris and Riccardo Vecchiato

    Citation: Systematic Reviews 2017 6:17

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  43. Content type: Protocol

    Chronic non-healing wounds present a substantial economic burden to healthcare system; significant reductions in quality of life for those affected, and precede often serious events such as limp amputations or...

    Authors: Krister Järbrink, Gao Ni, Henrik Sönnergren, Artur Schmidtchen, Caroline Pang, Ram Bajpai and Josip Car

    Citation: Systematic Reviews 2017 6:15

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  44. Content type: Protocol

    Good patient-pharmacist communication improves health outcomes. There is, however, room for improving pharmacists’ communication skills. These develop through complex interactions during undergraduate pharmacy...

    Authors: Aisling Kerr, Judith Strawbridge, Caroline Kelleher, Fien Mertens, Peter Pype, Myriam Deveugele and Teresa Pawlikowska

    Citation: Systematic Reviews 2017 6:14

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  45. Content type: Protocol

    Celebrities are highly influential people whose actions and decisions are watched and often emulated by wide audiences. Many celebrities have used their prominent social standing to offer medical advice or end...

    Authors: Steven J. Hoffman, Yasmeen Mansoor, Navneet Natt, Lathika Sritharan, Julia Belluz, Timothy Caulfield, Yoni Freedhoff, John N. Lavis and Arya M. Sharma

    Citation: Systematic Reviews 2017 6:13

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  46. Content type: Protocol

    Injury represents one of the greatest public health challenges of our time with over 5 million deaths and 100 million people temporarily or permanently disabled every year worldwide. The effectiveness of traum...

    Authors: Lynne Moore, Howard Champion, Gerard O’Reilly, Ari Leppaniemi, Peter Cameron, Cameron Palmer, Fikri M. Abu-Zidan, Belinda Gabbe, Christine Gaarder, Natalie Yanchar, Henry Thomas Stelfox, Raul Coimbra, John Kortbeek, Vanessa Noonan, Amy Gunning, Luke Leenan…

    Citation: Systematic Reviews 2017 6:12

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