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  1. The period following discharge from a pediatric emergency department (ED) can be a time of significant vulnerability for caregivers who provide ongoing care to their child when they return home. Discharge comm...

    Authors: Janet A Curran, Andrea Murphy, Mandi Newton, Roger Zemek, Lisa Hartling, Amy Plint, Jill Chorney, Shannon MacPhee, Samuel G Campbell, Mona Jabbour, Darlene Boliver, David Petrie, Randy Colwell, Kate MacWilliams and Alicia Nolan
    Citation: Systematic Reviews 2014 3:26
  2. The most important symptom as well as one of the major diagnostic criteria for eczema is itch. Although oral antihistamines continue to be prescribed for people with eczema, it is unclear if they are effective...

    Authors: Esther J van Zuuren, Christian J Apfelbacher, Zbys Fedorowicz, Aldrin Jupiter, Uwe Matterne and Elke Weisshaar
    Citation: Systematic Reviews 2014 3:25
  3. Cardiogenic shock is the leading cause of death in patients with acute myocardial infarction. Despite significant advancements in health technology and research, hospital mortality approaches 50%. The intra-ao...

    Authors: Sultan Altayyar, Bram Rochwerg, Sami Alnasser, Awad Al-omari, Bandar Baw, Alison Fox-Robichaud and Waleed Alhazzani
    Citation: Systematic Reviews 2014 3:24
  4. In pregnancies complicated by early-onset extreme fetal growth restriction, there is a high risk of preterm birth and an overall dismal fetal prognosis. Sildenafil has been suggested to improve this prognosis....

    Authors: Wessel Ganzevoort, Zarko Alfirevic, Peter von Dadelszen, Louise Kenny, Aris Papageorghiou, Aleid van Wassenaer-Leemhuis, Christian Gluud, Ben Willem Mol and Philip N Baker
    Citation: Systematic Reviews 2014 3:23
  5. To date no network meta-analysis (NMA) has accounted for baseline variations in viral load when assessing the relative efficacy of interventions for chronic hepatitis B (CHB). We undertook baseline-adjusted an...

    Authors: Stuart Mealing, Isabella Ghement, Neil Hawkins, David A Scott, Benedicte Lescrauwaet, Maureen Watt, Mark Thursz, Pietro Lampertico, Lorenzo Mantovani, Edith Morais, Bruno Bregman and Michel Cucherat
    Citation: Systematic Reviews 2014 3:21
  6. Resilience has been defined as the ability of individuals to manage and adapt to stress and life challenges. Training programs that develop and/or enhance resilience may have efficacy in improving health, well...

    Authors: Aaron L Leppin, Michael R Gionfriddo, Amit Sood, Victor M Montori, Patricia J Erwin, Claudia Zeballos-Palacios, Pavithra R Bora, Megan M Dulohery, Juan Pablo Brito, Kasey R Boehmer and Jon C Tilburt
    Citation: Systematic Reviews 2014 3:20
  7. Pediatric injury is highly prevalent and has significant impact both physically and emotionally. The majority of pediatric injuries are treated in emergency departments (EDs), where treatment of physical injur...

    Authors: Jeffrey Odenbach, Amanda Newton, Rebecca Gokiert, Cathy Falconer, Craig Courchesne, Sandra Campbell and Sarah J Curtis
    Citation: Systematic Reviews 2014 3:19
  8. Identifying patients with increased risk of suicidal behaviors is a constant challenge and concern for clinicians caring for patients with psychiatric conditions. We conducted a systematic review to assess the...

    Authors: Shaista Malik, Amrit Kanwar, Leslie A Sim, Larry J Prokop, Zhen Wang, Khalid Benkhadra and Mohammad Hassan Murad
    Citation: Systematic Reviews 2014 3:18
  9. Eating out of the home has been associated with higher intakes of energy and fat and lower micronutrient intakes, as well as the development of obesity. Out-of-home food outlets (OHFOs) and the foods obtained ...

    Authors: Frances C Hillier-Brown, Helen J Moore, Amelia A Lake, Ashley J Adamson, Martin White, Jean Adams, Vera Araujo-Soares, Charles Abraham and Carolyn D Summerbell
    Citation: Systematic Reviews 2014 3:17
  10. Patients undergoing renal transplant procedures require multi-agent immunosuppressive regimens both short term (induction phase) and long term (maintenance phase) to minimize the risk of organ rejection. There...

    Authors: Brian Hutton, Lawrence Joseph, Fatemeh Yazdi, Jennifer Tetzlaff, Mona Hersi, Madzouka Kokolo, Nicolas Fergusson, Alexandria Bennett, Chieny Buenaventura, Dean Fergusson, Andrea Tricco, Sharon Strauss, David Moher and Greg Knoll
    Citation: Systematic Reviews 2014 3:16
  11. Bariatric surgery is the only weight-loss treatment available that results in both sustained weight loss and improvements of obesity-related comorbidities. Individuals who meet the eligibility criteria for bar...

    Authors: Timothy D Jackson, Rujun Zhang, Dresden Glockler, Jason Pennington, Jacinta I Reddigan, Ori D Rotstein, Janet Smylie, Laure Perrier and Lesley Gotlib Conn
    Citation: Systematic Reviews 2014 3:15
  12. Studies suggest that expectations powerfully shape clinical outcomes. For subjective outcomes in adequately blinded trials, health improvements are substantial and largely explained by non-specific factors.

    Authors: Frederik Feys, Geertruida E Bekkering, Kavita Singh and Dirk Devroey
    Citation: Systematic Reviews 2014 3:14
  13. Systematic reviews are a cornerstone of evidence-based medicine but are useful only if up-to-date. Methods for detecting signals of when a systematic review needs updating have face validity, but no proposed m...

    Authors: Paul G Shekelle, Aneesa Motala, Breanne Johnsen and Sydne J Newberry
    Citation: Systematic Reviews 2014 3:13

    The Erratum to this article has been published in Systematic Reviews 2014 3:22

  14. The aims of antenatal education contain both outcomes related to pregnancy, birth and parenthood. Both content and methods of antenatal education have changed over time without evidence of effects on relevant ...

    Authors: Carina Sjöberg Brixval, Solveig Forberg Axelsen, Stig Krøger Andersen, Pernille Due and Vibeke Koushede
    Citation: Systematic Reviews 2014 3:12
  15. Human herpes virus 8 (HHV-8) is the underlying infectious cause of Kaposi sarcoma (KS) and other proliferative diseases; that is, primary effusion lymphoma and multicentric Castleman disease. In regions with h...

    Authors: Eliane Rohner, Natascha Wyss, Sven Trelle, Sam M Mbulaiteye, Matthias Egger, Urban Novak, Marcel Zwahlen and Julia Bohlius
    Citation: Systematic Reviews 2014 3:11
  16. Exercise programmes are frequently advocated for the management of musculoskeletal disorders; however, adherence is an important pre-requisite for their success. The assessment of exercise adherence requires t...

    Authors: Melanie A Holden, Kirstie L Haywood, Tanzila A Potia, Melanie Gee and Sionnadh McLean
    Citation: Systematic Reviews 2014 3:10
  17. Over 850 million people worldwide and 200 million adults in Sub-Saharan Africa suffer from malnutrition. Countries most affected by HIV are also stricken by elevated rates of food insecurity and malnutrition. ...

    Authors: Maryline Sicotte, Étienne V Langlois, Joséphine Aho, Daniela Ziegler and Maria Victoria Zunzunegui
    Citation: Systematic Reviews 2014 3:9
  18. A peer-reviewed journal would not survive without the generous time and insightful comments of the reviewers, whose efforts often go unrecognized. Systematic Reviews has been blessed by the support of highly-qual...

    Authors: Daniel Shanahan
    Citation: Systematic Reviews 2014 3:6
  19. Advances in surgical technique, prosthetic heart valve design, and anticoagulation have contributed to an overall improvement in morbidity and mortality in women with heart valve prostheses as well as increase...

    Authors: Claire M Lawley, Samantha J Lain, Charles S Algert, Jane B Ford, Gemma A Figtree and Christine L Roberts
    Citation: Systematic Reviews 2014 3:8
  20. Globally, the incidence of sexually transmitted infections (STI) is rising, posing a challenge to its control and appropriate management. Text messaging has become the most common mode of communication among a...

    Authors: Carole Lunny, Darlene Taylor, Jasmina Memetovic, Orion Wärje, Richard Lester, Tom Wong, Kendall Ho, Mark Gilbert and Gina Ogilvie
    Citation: Systematic Reviews 2014 3:7
  21. Depression is common in people with long term conditions (LTCs) and is associated with worse medical outcomes. Understanding the mechanisms underpinning this relationship could help predict who is at increased...

    Authors: Leanne Trick, Edward Watkins and Chris Dickens
    Citation: Systematic Reviews 2014 3:5
  22. Improving and sustaining the quality of care in hospitals is an intractable and persistent challenge. The patients’ experience of the quality of hospital care can provide insightful feedback to enable clinical...

    Authors: Michelle Beattie, William Lauder, Iain Atherton and Douglas J Murphy
    Citation: Systematic Reviews 2014 3:4
  23. Although health care providers utilize classically described signs and symptoms to diagnose tension pneumothorax, available literature sources differ in their descriptions of its clinical manifestations. Moreo...

    Authors: Derek J Roberts, Simon Leigh-Smith, Peter D Faris, Chad G Ball, Helen Lee Robertson, Christopher Blackmore, Elijah Dixon, Andrew W Kirkpatrick, John B Kortbeek and Henry Thomas Stelfox
    Citation: Systematic Reviews 2014 3:3
  24. Almost all patients under general anesthesia for surgery need mechanical ventilation. The harmful effects of short-term intra-operative ventilation on pulmonary integrity are increasingly recognized. Recent in...

    Authors: Ary Serpa Neto, Sabrine NT Hemmes, Marcelo Gama de Abreu, Paolo Pelosi and Marcus J Schultz
    Citation: Systematic Reviews 2014 3:2
  25. Consensus has not been reached on safe alcohol consumption recommendations during pregnancy. The National Institutes for Care and Health Excellence (NICE) in the UK suggest that one to two drinks not more than...

    Authors: Linda M O’Keeffe, Richard A Greene and Patricia M Kearney
    Citation: Systematic Reviews 2014 3:1
  26. Individuals with major psychotic and/or affective disorders are at increased risk for developing metabolic syndrome due to lifestyle- and treatment-related factors. Numerous pharmacological and non-pharmacolog...

    Authors: Cynthia Nover and Sarah S Jackson
    Citation: Systematic Reviews 2013 2:116
  27. The usefulness of Google Scholar (GS) as a bibliographic database for biomedical systematic review (SR) searching is a subject of current interest and debate in research circles. Recent research has suggested ...

    Authors: Wichor M Bramer, Dean Giustini, Bianca MR Kramer and PF Anderson
    Citation: Systematic Reviews 2013 2:115
  28. Previous studies have been limited in reporting the association between chocolate consumption, measured by interviewer-administered questionnaire or serum theobromine, a biomarker for cocoa, and risk of preecl...

    Authors: Jaime Andres Mogollon, Catherine Boivin, Kadhel Philippe, Stéphane Turcotte, Simone Lemieux, Claudine Blanchet, Emmanuel Bujold and Sylvie Dodin
    Citation: Systematic Reviews 2013 2:114
  29. Clinicians, providers and guideline panels use absolute effects to weigh the advantages and downsides of treatment alternatives. Relative measures have the potential to mislead readers. However, little is know...

    Authors: Pablo Alonso-Coello, Alonso Carrasco-Labra, Romina Brignardello-Petersen, Ignacio Neumann, Elie A Akl, Xin Sun, Bradley C Johnston, Matthias Briel, Jason W Busse, Demián Glujovsky, Carlos E Granados, Alfonso Iorio, Affan Irfan, Laura M García, Reem A Mustafa, Anggie Ramirez-Morera…
    Citation: Systematic Reviews 2013 2:113

    The Erratum to this article has been published in Systematic Reviews 2014 3:76

  30. Reports from Africa have suggested that pneumocystis pneumonia (PCP) is a less important cause of morbidity than in the developed world. However, more recent studies have shown high seroprevalence rates of P. jir...

    Authors: Sean Wasserman, Mark E Engel and Marc Mendelson
    Citation: Systematic Reviews 2013 2:112
  31. PROSPERO is an international database of prospectively registered systematic reviews in health and social care. Between July 2012 and June 2013, 1,106 registrations were added, bringing the total since launch ...

    Authors: Alison Booth
    Citation: Systematic Reviews 2013 2:111
  32. Although it is often performed in clinical practice, the diagnostic value of a screening physical examination to detect maltreatment in children without prior suspicion has not been reviewed. This article aims...

    Authors: Eva MM Hoytema van Konijnenburg, Arianne H Teeuw, Tessa Sieswerda-Hoogendoorn, Arnold G E Leenders and Johanna H van der Lee
    Citation: Systematic Reviews 2013 2:109
  33. Permanent childhood hearing loss affects 1 to 3 per 1000 children and frequently disrupts typical spoken language acquisition. Early identification of hearing loss through universal newborn hearing screening a...

    Authors: Elizabeth M Fitzpatrick, Adrienne Stevens, Chantelle Garritty and David Moher
    Citation: Systematic Reviews 2013 2:108
  34. There are both theoretical and empirical reasons to believe that design and execution factors are associated with bias in controlled trials. Statistically significant moderator effects, such as the effect of t...

    Authors: Susanne Hempel, Jeremy NV Miles, Marika J Booth, Zhen Wang, Sally C Morton and Paul G Shekelle
    Citation: Systematic Reviews 2013 2:107
  35. The Statistical Methods Group has played a pivotal role in The Cochrane Collaboration over the past 20 years. The Statistical Methods Group has determined the direction of statistical methods used within Cochr...

    Authors: Joanne E McKenzie, Georgia Salanti, Steff C Lewis and Douglas G Altman
    Citation: Systematic Reviews 2013 2:80
  36. Virtually all low- and middle-income countries are dependent on the World Health Organization’s Expanded Program on Immunization for delivery of vaccines to children. The Expanded Program on Immunization deliv...

    Authors: Shingai Machingaidze, Eva Rehfuess, Rüdiger von Kries, Gregory D Hussey and Charles S Wiysonge
    Citation: Systematic Reviews 2013 2:106
  37. Depression is common in people with chronic physical illness and is associated with worse medical outcomes. Cognitive behavioural therapy and problem-solving improve depression, although usually have small to ...

    Authors: Sarah Harris, Paul Farrand and Chris Dickens
    Citation: Systematic Reviews 2013 2:105
  38. Systematic reviews (SRs) can become outdated as new evidence emerges over time. Organizations that produce SRs need a surveillance method to determine when reviews are likely to require updating. This report d...

    Authors: Nadera Ahmadzai, Sydne J Newberry, Margaret A Maglione, Alexander Tsertsvadze, Mohammed T Ansari, Susanne Hempel, Aneesa Motala, Sophia Tsouros, Jennifer J Schneider Chafen, Roberta Shanman, David Moher and Paul G Shekelle
    Citation: Systematic Reviews 2013 2:104
  39. Dapagliflozin is a first-in-class oral sodium glucose co-transporter 2 (SGLT2) inhibitor. It is often used in combination with conventional anti-diabetic drugs such as metformin, glimepiride, and insulin in tr...

    Authors: Yu-nan Sun, Yi Zhou, Xi Chen, Wen-si Che and Siu-wai Leung
    Citation: Systematic Reviews 2013 2:103
  40. Although healthcare administrative data are commonly used for traumatic brain injury research, there is currently no consensus or consistency on using the International Classification of Diseases version 10 co...

    Authors: Vincy Chan, Pravheen Thurairajah and Angela Colantonio
    Citation: Systematic Reviews 2013 2:102
  41. Healthcare worker hand hygiene is thought to be one of the most important strategies to prevent healthcare-associated infections, but compliance is generally poor. Hand hygiene improvement interventions must i...

    Authors: Jocelyn A Srigley, David Lightfoot, Geoff Fernie, Michael Gardam and Matthew P Muller
    Citation: Systematic Reviews 2013 2:101
  42. The essential clinical diagnostic components of brain death must include evidence for an established etiology capable of causing brain death, two independent clinical confirmations of the absence of all brains...

    Authors: Michaël Chassé, Peter Glen, Mary-Anne Doyle, Lauralyn McIntyre, Shane W English, Greg Knoll, Jean-François Lizé, Sam D Shemie, Claudio Martin, Alexis F Turgeon, François Lauzier and Dean A Fergusson
    Citation: Systematic Reviews 2013 2:100
  43. Somatoform-type disorders and functional medically unexplained symptoms are extremely common in primary care settings. These disorders, however, are consistently underdiagnosed and under-recognised which precl...

    Authors: Alexandra M Murray, Anne Toussaint, Astrid Althaus and Bernd Löwe
    Citation: Systematic Reviews 2013 2:99
  44. Accountability has center stage in the current post-Millennium Development Goals (MDG) debate. One of the effective strategies for building equitable health systems and providing quality health services is the...

    Authors: Elsbet Lodenstein, Marjolein Dieleman, Barend Gerretsen and Jacqueline EW Broerse
    Citation: Systematic Reviews 2013 2:98
  45. Google Translate offers free Web-based translation, but it is unknown whether its translation accuracy is sufficient to use in systematic reviews to mitigate concerns about language bias.

    Authors: Ethan M Balk, Mei Chung, Minghua L Chen, Lina Kong Win Chang and Thomas A Trikalinos
    Citation: Systematic Reviews 2013 2:97
  46. The prognostic accuracy of 1H (proton) magnetic resonance spectroscopy (MRS) in neonatal hypoxic-ischemic encephalopathy has been assessed by a criticized study-based meta-analysis. An individual patient data met...

    Authors: Pieter LJ Degraeuwe, Gerald J Jaspers, Nicola J Robertson and Alfons GH Kessels
    Citation: Systematic Reviews 2013 2:96
  47. There is considerable unexplained heterogeneity in previous meta-analyses of randomized controlled trials (RCTs) evaluating the effects of patient decision aids on the accuracy of knowledge of outcome probabil...

    Authors: Stephen J Gentles, Dawn Stacey, Carol Bennett, Mohamad Alshurafa and Stephen D Walter
    Citation: Systematic Reviews 2013 2:95
  48. Cochrane systematic reviews have proven to be beneficial for decision making processes, both on a practitioner and a policy level, and there are current initiatives to extend the types of evidence used by them...

    Authors: Karin Hannes, Andrew Booth, Janet Harris and Jane Noyes
    Citation: Systematic Reviews 2013 2:84
  49. Three meta-analyses and one systematic review have been conducted on the question of whether self-collected specimens are as accurate as clinician-collected specimens for STI screening. However, these reviews ...

    Authors: Darlene Taylor, Carole Lunny, Tom Wong, Mark Gilbert, Neville Li, Richard Lester, Mel Krajden, Linda Hoang and Gina Ogilvie
    Citation: Systematic Reviews 2013 2:93

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