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  1. Barriers to receiving optimal healthcare exist for Indigenous populations globally for a range of reasons. To overcome such barriers and enable greater access to basic and specialist care, developments in info...

    Authors: Rachel Reilly, Jacqueline Stephens, Jasmine Micklem, Catalin Tufanaru, Stephen Harfield, Ike Fisher, Odette Pearson and James Ward

    Citation: Systematic Reviews 2020 9:123

    Content type: Research

    Published on:

  2. With an increase in wildfire activity across the globe and growing numbers of personnel involved each year, it is necessary to explore the health impacts of occupational exposure to wildfires and the practices...

    Authors: Erica Koopmans, Trina Fyfe, Mike Eadie and Chelsea A. Pelletier

    Citation: Systematic Reviews 2020 9:119

    Content type: Protocol

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  3. Peripheral nerves are constant targets of traumatic injury which may result in neurotmesis and which invariably requires surgical treatment. In view of this, tissue engineering studies developed biomaterials w...

    Authors: Ana Camila Nobre de Lacerda Brito, Sara Emanuely Veríssimo Santos, Wilayane Alves Martins, Paulo César da Silva Queiroz, Wenddy Wyllie Damascena Sougey, Paula Ketilly Nascimento Alves, Kalline Lourenço Ribeiro, Maria Danielly Lima de Oliveira and Sílvia Regina Arruda de Moraes

    Citation: Systematic Reviews 2020 9:118

    Content type: Protocol

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  5. Meta-analysts rely on the availability of data from previously conducted studies. That is, they rely on primary study authors to register their outcome data, either in a study’s text or on publicly available w...

    Authors: Joshua R. Polanin, Dorothy L. Espelage, Jennifer K. Grotpeter, Alberto Valido, Katherine M. Ingram, Cagil Torgal, America El Sheikh and Luz E. Robinson

    Citation: Systematic Reviews 2020 9:116

    Content type: Methodology

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  6. This work aimed to identify studies of interventions seeking to address mental health inequalities, studies assessing the economic impact of such interventions and factors which act as barriers and those that ...

    Authors: Laura-Louise Arundell, Helen Greenwood, Helen Baldwin, Eleanor Kotas, Shubulade Smith, Kasia Trojanowska and Chris Cooper

    Citation: Systematic Reviews 2020 9:115

    Content type: Research

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  7. Neurotrauma is an important global health problem. The largest cause of neurotrauma worldwide is road traffic collisions (RTCs), particularly in low- and middle-income countries (LMICs). Neurotrauma and RTCs a...

    Authors: Santhani M Selveindran, Tamara Tango, Muhammad Mukhtar Khan, Daniel Martin Simadibrata, Peter J. A. Hutchinson, Carol Brayne, Christine Hill, Franco Servadei, Angelos G. Kolias, Andres M. Rubiano, Alexis J. Joannides and Hamisi K. Shabani

    Citation: Systematic Reviews 2020 9:114

    Content type: Research

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  8. Water, sanitation, and hygiene interventions often fail to show long-term impact on diarrhoeal and/or intestinal parasite risk in many low- and middle-income countries. Less attention has been paid to wider co...

    Authors: Benn Sartorius, Hugo Legge and Rachel Pullan

    Citation: Systematic Reviews 2020 9:113

    Content type: Protocol

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  9. The literature on the implementation of knowledge products is extensive. However, this literature is still difficult to interpret for policymakers and other stakeholders when faced with choosing implementation...

    Authors: Hervé Tchala Vignon Zomahoun, José Massougbodji, André Bussières, Aliki Thomas, Dahlia Kairy, Claude Bernard Uwizeye, Nathalie Rheault, Ali Ben Charif, Ella Diendéré, Léa Langlois, Sébastien Tchoubi, Serigne Abib Gaye and France Légaré

    Citation: Systematic Reviews 2020 9:112

    Content type: Protocol

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  11. To date multimorbidity has not received much attention in health policies, even though multiple chronic diseases put high demands on the health care system in industrial nations. Enormous costs of care and a p...

    Authors: Simone Schweda and Inga Krauss

    Citation: Systematic Reviews 2020 9:110

    Content type: Protocol

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  12. Environmental factors such as pollution, pesticide exposure and socio-demographic location have been implicated as a pressure capable of altering genetic make-up. Altered genetic sequence of genes encoding enz...

    Authors: Nkosinathi Banhela, Pragalathan Naidoo and Saloshni Naidoo

    Citation: Systematic Reviews 2020 9:109

    Content type: Research

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  13. COVID-19 is a rapidly spreading virus infection that has quickly caused extensive burden to individual, families, countries, and the globe. No intervention has yet been proven effective for the treatment of CO...

    Authors: Sophie Juul, Niklas Nielsen, Peter Bentzer, Areti Angeliki Veroniki, Lehana Thabane, Adam Linder, Sarah Klingenberg, Christian Gluud and Janus Christian Jakobsen

    Citation: Systematic Reviews 2020 9:108

    Content type: Protocol

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  14. Endovascular therapy is a fundamental treatment for peripheral arterial disease. However, the success rate of endovascular therapy remains poor, as a third of patients with critical limb ischemia ultimately re...

    Authors: Mark Rockley, Prasad Jetty and George Wells

    Citation: Systematic Reviews 2020 9:107

    Content type: Protocol

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  15. Antibiotics are prescribed frequently for upper respiratory tract infections (URTIs) even though most URTIs do not require antibiotics. This over-prescription contributes to antibiotic resistance which is a ma...

    Authors: Sameh Mortazhejri, Patrick Jiho Hong, Ashley M. Yu, Brian Younho Hong, Dawn Stacey, R. Sacha Bhatia and Jeremy M. Grimshaw

    Citation: Systematic Reviews 2020 9:106

    Content type: Research

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  16. Despite recent improvements in the burden of cardiovascular disease (CVD) in the UK, deaths from CVD are relatively high compared with other high-income countries. An estimated 7 million people in the UK are l...

    Authors: Olalekan A. Uthman, Lena Al-Khudairy, Chidozie U. Nduka, Rachel Court, Hema Mistry, G . J. Melendez-Torres, Sian Taylor-Phillips and Aileen Clarke

    Citation: Systematic Reviews 2020 9:105

    Content type: Protocol

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  17. With technological advances, there has been increasing interest in developing contactless and/or non-invasive wearable technologies that continuously monitor vital signs in the clinical setting, and in particu...

    Authors: Peter Y. Chan, John McNeil, Tam Nguyen, Nicholas Ryan and Ingrid Hopper

    Citation: Systematic Reviews 2020 9:104

    Content type: Protocol

    Published on:

  18. Vascular endothelial growth factor (VEGF) is one of the angiogenesis regulators, which plays an important role in tumor angiogenesis and tumor progression. Current studies have found that VEGF plays an importa...

    Authors: Mingzhu Song, Huiping Wang and Qianling Ye

    Citation: Systematic Reviews 2020 9:103

    Content type: Systematic review update

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  19. A growing number of studies suggest that social isolation and loneliness are associated with premature mortality and are more prevalent among people with mental illness than in the general population, outlinin...

    Authors: Adriano Winterton, Linn Rødevand, Lars T. Westlye, Nils Eiel Steen, Ole A. Andreassen and Daniel S. Quintana

    Citation: Systematic Reviews 2020 9:102

    Content type: Protocol

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  20. Many epidemiological studies have investigated the prevalence of type 2 diabetes in individuals with a psychiatric disorder. In an umbrella review, we aim to systematically summarize existing systematic review...

    Authors: N. Lindekilde, S. Scheuer, F. Rutters, J. E. Henriksen, K. H. Rubin, M. Lasgaard, G. S. Andersen and F. Pouwer

    Citation: Systematic Reviews 2020 9:101

    Content type: Protocol

    Published on:

  21. The fourth meeting of the International Collaboration for Automation of Systematic Reviews (ICASR) was held 5–6 November 2019 in The Hague, the Netherlands. ICASR is an interdisciplinary group whose goal is to...

    Authors: Annette M. O’Connor, Paul Glasziou, Michele Taylor, James Thomas, René Spijker and Mary S. Wolfe

    Citation: Systematic Reviews 2020 9:100

    Content type: Commentary

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  22. Cotton workers are exposed to various hazards in the textile industry that might result in different ailments including hypertension (HTN). However, few attempts have been made to systematically review the pre...

    Authors: Naureen Akber Ali and Anam Shahil Feroz

    Citation: Systematic Reviews 2020 9:99

    Content type: Protocol

    Published on:

  23. Gasless laparoscopy, developed in the early 1990s, was a means to minimize the clinical and financial challenges of pneumoperitoneum and general anaesthesia. It has been used in a variety of procedures such as...

    Authors: Haitham Shoman, Simone Sandler, Alexander Peters, Ameer Farooq, Magdalen Gruendl, Shauna Trinh, James Little, Alex Woods, William Bolton, Abubakar Abioye and David Ljungman

    Citation: Systematic Reviews 2020 9:98

    Content type: Protocol

    Published on:

  24. Network meta-analysis (NMA) has rapidly grown in use during the past decade for the comparison of healthcare interventions. While its general use in the comparison of conventional medicines has been studied pr...

    Authors: Misty Pratt, Susan Wieland, Nadera Ahmadzai, Claire Butler, Dianna Wolfe, Kusala Pussagoda, Becky Skidmore, Argie Veroniki, Patricia Rios, Andrea C. Tricco and Brian Hutton

    Citation: Systematic Reviews 2020 9:97

    Content type: Research

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  25. In children and adolescents, anxiety disorders (ADs) are among the most prevalent mental disorders. While there is a solid empirical foundation to support CBT as an evidence-based treatment for childhood ADs, ...

    Authors: Kathrin Schopf, Cornelia Mohr, Michael W. Lippert, Katharina Sommer, Andrea Hans Meyer and Silvia Schneider

    Citation: Systematic Reviews 2020 9:96

    Content type: Protocol

    Published on:

  26. Acute hypoxemic respiratory failure is one of the leading causes of intensive care unit admission and is associated with high mortality. Noninvasive oxygenation strategies such as high-flow nasal cannula, stan...

    Authors: Bruno L. Ferreyro, Federico Angriman, Laveena Munshi, Lorenzo Del Sorbo, Niall D. Ferguson, Bram Rochwerg, Michelle J. Ryu, Refik Saskin, Hannah Wunsch, Bruno R. da Costa and Damon C. Scales

    Citation: Systematic Reviews 2020 9:95

    Content type: Protocol

    Published on:

  27. Recognising the influence of context and the context-sensitive nature of quality improvement (QI) interventions is crucial to implementing effective improvements and successfully replicating them in new settin...

    Authors: Emma Coles, Julie Anderson, Margaret Maxwell, Fiona M. Harris, Nicola M. Gray, Gill Milner and Stephen MacGillivray

    Citation: Systematic Reviews 2020 9:94

    Content type: Research

    Published on:

  28. Sub-Saharan Africa carries the greatest burden of HIV-infection with increasing drug resistance burden, which requires improved patient management and monitoring. Current WHO recommendations suggest transition...

    Authors: Ezechiel Ngoufack Jagni Semengue, Maria Mercedes Santoro, Valantine Ngum Ndze, Beatrice Dambaya, Desiré Takou, Georges Teto, Alex Durand Nka, Lavinia Fabeni, Alison Wiyeh, Francesca Ceccherini-Silberstein, Vittorio Colizzi, Carlo-Federico Perno and Joseph Fokam

    Citation: Systematic Reviews 2020 9:93

    Content type: Protocol

    Published on:

  29. Epilepsy affects nearly 50 million people worldwide. Self-management is critical for individuals with epilepsy in order to maintain optimal physical, cognitive, and emotional health. Implementing and adopting ...

    Authors: Allison A. Lewinski, Abigail Shapiro, Jennifer M. Gierisch, Karen M. Goldstein, Dan V. Blalock, Matthew W. Luedke, Adelaide M. Gordon, Hayden B. Bosworth, Connor Drake, Jeffrey D. Lewis, Saurabh R. Sinha, Aatif M. Husain, Tung T. Tran, Megan G. Van Noord and John W. Williams Jr

    Citation: Systematic Reviews 2020 9:92

    Content type: Research

    Published on:

  30. The importance of teaching the skills and practice of evidence-based medicine (EBM) for medical professionals has steadily grown in recent years. Alongside this growth is a need to evaluate the effectiveness o...

    Authors: Bharathy Kumaravel, Jasmine Heath Hearn, Leila Jahangiri, Rachel Pollard, Claire J. Stocker and David Nunan

    Citation: Systematic Reviews 2020 9:91

    Content type: Research

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  31. Globally, miniscule improvements have been implemented regarding equality, inclusion, access, and protection of people with diverse gender identities whilst accessing health care facilities of which transgende...

    Authors: Delarise M. Mulqueeny, Senzelokuhle M. Nkabini and Tivani P. Mashamba-Thompson

    Citation: Systematic Reviews 2020 9:90

    Content type: Protocol

    Published on:

  32. The necessity of antibiotic prophylaxis for postoperative urinary tract infections (UTIs) after transurethral resection of bladder tumours is controversial. This potentially leads to the overuse of antibiotic ...

    Authors: Kathrin Bausch, Soheila Aghlmandi, Sarah Ursula Sutter, Linda Maria Stamm, Hannah Ewald, Christian Appenzeller-Herzog, Jan Adam Roth, Andreas F. Widmer and Hans-Helge Seifert

    Citation: Systematic Reviews 2020 9:89

    Content type: Protocol

    Published on:

  33. People living with HIV (PLHIV) are at a high risk of developing HPV-related cancers. HPV-related malignancies occur frequently and/or are high among PLHIV, with cervical cancer as a designated AIDS-defining co...

    Authors: Kabelo Matjie Bridget Lekoane, Desmond Kuupiel, Tivani P. Mashamba-Thompson and Themba G. Ginindza

    Citation: Systematic Reviews 2020 9:88

    Content type: Research

    Published on:

  34. Food and nutrition literacy is a newly emerged concept to connect food-related knowledge and skills to healthy diets. Its promotion is important to protect children as they eat too many low-nutrient, high-ener...

    Authors: Azam Doustmohammadian, Nasrin Omidvar and Elham Shakibazadeh

    Citation: Systematic Reviews 2020 9:87

    Content type: Protocol

    Published on:

  35. Tobacco consumption is the leading cause of preventable death globally. The global mortality burden of tobacco use lies predominantly in low- to middle-income countries (LMICs). There is much evidence on the e...

    Authors: Navin Kumar, Jessica Ainooson, Ameera Billings, Grace Chen, Lauren Cueto, Kamila Janmohamed, Jeannette Jiang, Raymond Niaura and Amy Zhang

    Citation: Systematic Reviews 2020 9:86

    Content type: Protocol

    Published on:

  36. Surgical interventions for the treatment of stress urinary incontinence (SUI) in women are commonly employed following the failure of minimally invasive therapies. Due to the limited information available on t...

    Authors: Mehdi Javanbakht, Eoin Moloney, Miriam Brazzelli, Sheila Wallace, Muhammad Imran Omar, Ash Monga, Lucky Saraswat, Phil Mackie, Mari Imamura, Jemma Hudson, Michal Shimonovich, Graeme MacLennan, Luke Vale and Dawn Craig

    Citation: Systematic Reviews 2020 9:85

    Content type: Research

    Published on:

  37. Most of the major cities in the developed western countries are characterized by an increasing multiculturalism brought by the immigrant population. The immigrant communities face challenges in the new environ...

    Authors: Tanvir C. Turin, Nashit Chowdhury, Mahzabin Ferdous, Marcus Vaska, Nahid Rumana, Rudra Dahal, Nafiza Rahman and Mohammad Z. I. Chowdhury

    Citation: Systematic Reviews 2020 9:84

    Content type: Protocol

    Published on:

  38. Non-melanoma skin cancer, which includes basal cell carcinoma and cutaneous squamous cell carcinoma, is the commonest malignancy worldwide. The mainstay of treatment is surgical excision. Despite this being an...

    Authors: Grant S. Nolan, Justin C. R. Wormald, Ailbhe L. Kiely, Joshua P. Totty and Abhilash Jain

    Citation: Systematic Reviews 2020 9:83

    Content type: Protocol

    Published on:

  39. Emergency telehealth has been used to improve accessibility of rural and remote patients to specialist care. Evidence to date has demonstrated effectiveness and cost-effectiveness of telehealth in rural and re...

    Authors: Christina Tsou, Suzanne Robinson, James Boyd, Andrew Jamieson, Robert Blakeman, Kylie Bosich, Justin Yeung, Stephanie Waters and Delia Hendrie

    Citation: Systematic Reviews 2020 9:82

    Content type: Protocol

    Published on:

  40. So far, only one meta-analysis has estimated the prevalence of rheumatoid arthritis (RA) in Africa. Out of 10 studies included in that meta-analysis, nine came from sub-Saharan African countries and had been p...

    Authors: Mickael Essouma, Jan René Nkeck, Francky Teddy Endomba, Jean Joel Bigna and Stéphane Ralandison

    Citation: Systematic Reviews 2020 9:81

    Content type: Protocol

    Published on:

  41. Cancer predominates in adults over age 65. Cancer treatments are known to create physical and psychosocial challenges, which may be amplified for older adults with cancer.

    Authors: Kristen R. Haase, Martine Puts, Schroder Sattar, Mikaela Gray, Cindy Kenis, Valentina Donison, Steven Hall, Bianca McLean, Aria Wills and Doris Howell

    Citation: Systematic Reviews 2020 9:80

    Content type: Protocol

    Published on:

  42. Cervical cancer has become a major public health challenge in developing countries with a reported age-standardised incidence rate of about 17.9/100,000/year and lifetime risks approaching 1 in 20 in some sett...

    Authors: Witness Mapanga, Elvira Singh, Shingairai A. Feresu and Brendan Girdler-Brown

    Citation: Systematic Reviews 2020 9:79

    Content type: Systematic review update

    Published on:

  43. Pre-eclampsia and being born small for gestational age are associated with significant maternal and neonatal morbidity and mortality. Placental dysfunction is a key pathological process underpinning these cond...

    Authors: Melanie Griffin, Alexander E. P. Heazell, Lucy C. Chappell, Jian Zhao and Deborah A. Lawlor

    Citation: Systematic Reviews 2020 9:78

    Content type: Protocol

    Published on:

  44. A previous study found that 2 of 29 (6.9%) meta-analyses published in high-impact journals in 2009 reported included drug trials’ funding sources, and none reported trial authors’ financial conflicts of intere...

    Authors: Carla Benea, Kimberly A. Turner, Michelle Roseman, Lisa A. Bero, Joel Lexchin, Erick H. Turner and Brett D. Thombs

    Citation: Systematic Reviews 2020 9:77

    Content type: Research

    Published on:

  46. A new type of coronavirus, novel coronavirus (COVID-19), is causing an increasing number of cases of pneumonia and was declared a Public Health Emergency of International Concern by the World Health Organizati...

    Authors: Yuxi Li, Xiaobo Liu, Liuxue Guo, Juan Li, Dongling Zhong, Yonggang Zhang, Mike Clarke and Rongjiang Jin

    Citation: Systematic Reviews 2020 9:75

    Content type: Protocol

    Published on:

  47. Autogenic training is a relaxation technique that uses systematic exercises to induce a general disconnection of the organism. It is used in conjunction with conventional medical care as part of disease manage...

    Authors: Maria Pilar Ramirez-Garcia, Jérôme Leclerc-Loiselle, Christine Genest, Renaud Lussier and Golsa Dehghan

    Citation: Systematic Reviews 2020 9:74

    Content type: Protocol

    Published on:

  48. Dedicated air ambulance services provide a vital link for critically ill and injured patients to higher levels of care. The recent developments of pre-hospital and retrieval medicine create an opportunity for ...

    Authors: Kristin H. Edwards, Gerard FitzGerald, Richard C. Franklin and Mark Terrell Edwards

    Citation: Systematic Reviews 2020 9:72

    Content type: Protocol

    Published on:

  49. Alzheimer’s disease (AD) is a neurodegenerative disorder commonly associated with deficits of cognition and changes in behavior. Mild cognitive impairment (MCI) is the prodromal stage of AD that is defined by ...

    Authors: Maryam Ahmadzadeh, Gregory J. Christie, Theodore D. Cosco and Sylvain Moreno

    Citation: Systematic Reviews 2020 9:71

    Content type: Protocol

    Published on:

  50. Occlusive atherosclerotic disease of the anterior cerebral circulation is one of the most common causes of anterior circulation ischemia and stroke. Treatment options include medical therapies (including antip...

    Authors: Xuesong Bai, Yao Feng, Kun Yang, Tao Wang, Jichang Luo, Xue Wang, Feng Ling, Yan Ma and Liqun Jiao

    Citation: Systematic Reviews 2020 9:70

    Content type: Protocol

    Published on:

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