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  2. Traumatic brain injury (TBI) is a leading cause of death and disability. Recently, a paradigm shift in our understanding of moderate-to-severe TBI has led to its reconceptualization as a progressive neurodegen...

    Authors: Bhanu Sharma, Alana Changoor, Leanne Monteiro, Brenda Colella and Robin Green

    Citation: Systematic Reviews 2020 9:23

    Content type: Protocol

    Published on:

  4. Stakeholder engagement has become widely accepted as a necessary component of guideline development and implementation. While frameworks for developing guidelines express the need for those potentially affecte...

    Authors: Jennifer Petkovic, Alison Riddle, Elie A. Akl, Joanne Khabsa, Lyubov Lytvyn, Pearl Atwere, Pauline Campbell, Kalipso Chalkidou, Stephanie M. Chang, Sally Crowe, Leonila Dans, Fadi El Jardali, Davina Ghersi, Ian D. Graham, Sean Grant, Regina Greer-Smith…

    Citation: Systematic Reviews 2020 9:21

    Content type: Protocol

    Published on:

  5. Two reviews and an overview were produced for the Canadian Task Force on Preventive Health Care guideline on screening for esophageal adenocarcinoma in patients with chronic gastroesophageal reflux disease (GE...

    Authors: Candyce Hamel, Nadera Ahmadzai, Andrew Beck, Micere Thuku, Becky Skidmore, Kusala Pussegoda, Lise Bjerre, Avijit Chatterjee, Kristopher Dennis, Lorenzo Ferri, Donna E. Maziak, Beverley J. Shea, Brian Hutton, Julian Little, David Moher and Adrienne Stevens

    Citation: Systematic Reviews 2020 9:20

    Content type: Research

    Published on:

  6. Products containing anthraquinones (AQ) are mainly used as laxatives and have several biological effects. Long-term use of AQ laxatives is associated with an increased risk of serious adverse events (AEs), suc...

    Authors: Niccolò Lombardi, Alessandra Bettiol, Giada Crescioli, Valentina Maggini, Eugenia Gallo, Francesco Sivelli, Francesco Sofi, Gian Franco Gensini, Alfredo Vannacci and Fabio Firenzuoli

    Citation: Systematic Reviews 2020 9:19

    Content type: Protocol

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  7. The importance of access to healthcare for all is internationally recognised as a global goal, high on the global agenda. Yet inequalities in health exist within and between countries which are exacerbated by ...

    Authors: Bryony Dawkins, Charlotte Renwick, Tim Ensor, Bethany Shinkins, David Jayne and David Meads

    Citation: Systematic Reviews 2020 9:18

    Content type: Protocol

    Published on:

  8. Major psychiatric disorders are growing public health concern that attributed 14% of the global burden of diseases. The management of major psychiatric disorders is challenging mainly due to medication non-adh...

    Authors: Agumasie Semahegn, Kwasi Torpey, Adom Manu, Nega Assefa, Gezahegn Tesfaye and Augustine Ankomah

    Citation: Systematic Reviews 2020 9:17

    Content type: Research

    Published on:

  9. Uncontrolled hypertension is the most important risk factor and leading cause of cardiovascular diseases. It is predicted that the number of people with hypertension will increase, and a large proportion of th...

    Authors: Shukri F. Mohamed, Olalekan A. Uthman, Rishi Caleyachetty, Ivy Chumo, Martin K. Mutua, Gershim Asiki and Paramjit Gill

    Citation: Systematic Reviews 2020 9:16

    Content type: Protocol

    Published on:

  10. Clinical practice guidelines for the management of complex chronic conditions in older adults encourage healthcare providers to engage patients in shared decision-making about self-management goals and actions...

    Authors: Michael T. Lawless, Phoebe Drioli-Phillips, Mandy M. Archibald and Alison L. Kitson

    Citation: Systematic Reviews 2020 9:15

    Content type: Protocol

    Published on:

  11. We systematically reviewed and chronicled exposures and outcomes measured in the maternal and birth cohort studies in the Gulf Cooperation Council (GCC) countries and quantitatively summarized the weighted eff...

    Authors: Rami H. Al-Rifai, Nasloon Ali, Esther T. Barigye, Amal H. I. Al Haddad, Fatima Al-Maskari, Tom Loney and Luai A. Ahmed

    Citation: Systematic Reviews 2020 9:14

    Content type: Research

    Published on:

  12. Small/kiddie cigarette packs consist of less than 20 cigarette sticks. Kiddie packs were recently proposed to be reintroduced by the tobacco industry with an excuse to prevent consumers from buying illicit cig...

    Authors: Halizah Mat Rifin, Wan Shakira Rodzlan Hasani, Miaw Yn Jane Ling, Tania Gayle Robert Lourdes, Thamil Arasu Saminathan, Nur Liana Ab Majid, Ahzairin Ahmad, Hasimah Ismail and Muhammad Fadhli Mohd Yusoff

    Citation: Systematic Reviews 2020 9:13

    Content type: Protocol

    Published on:

  13. The Cochrane Bias Methods Group recently developed the “Risk of Bias (ROB) in Non-randomized Studies of Interventions” (ROBINS-I) tool to assess ROB for non-randomized studies of interventions (NRSI). It is im...

    Authors: Maya M. Jeyaraman, Rasheda Rabbani, Nameer Al-Yousif, Reid C. Robson, Leslie Copstein, Jun Xia, Michelle Pollock, Samer Mansour, Mohammed T. Ansari, Andrea C. Tricco and Ahmed M. Abou-Setta

    Citation: Systematic Reviews 2020 9:12

    Content type: Protocol

    Published on:

  14. The lack of a reporting guideline for scaling of evidence-based practices (EBPs) studies has prompted the registration of the Standards for reporting studies assessing the impact of scaling strategies of EBPs ...

    Authors: Amédé Gogovor, Hervé Tchala Vignon Zomahoun, Ali Ben Charif, Robert K. D. McLean, David Moher, Andrew Milat, Luke Wolfenden, Karina Prévost, Emmanuelle Aubin, Paula Rochon, Giraud Ekanmian, Jasmine Sawadogo, Nathalie Rheault and France Légaré

    Citation: Systematic Reviews 2020 9:11

    Content type: Protocol

    Published on:

  15. The workplace environment potentially provides access to a large population who are employed, and it is an employer's responsibility to provide appropriate conditions for its employees. Whilst the aetiology of...

    Authors: Paige M. Hulls, Rebecca C. Richmond, Richard M. Martin and Frank de Vocht

    Citation: Systematic Reviews 2020 9:10

    Content type: Protocol

    Published on:

  16. Systematic reviews should specify all outcomes at the protocol stage. Pre-specification helps prevent outcome choice from being influenced by knowledge of included study results. Completely specified outcomes ...

    Authors: Solange Durão, Marianne Visser, Tamara Kredo and Ian J. Saldanha

    Citation: Systematic Reviews 2020 9:9

    Content type: Protocol

    Published on:

  17. Obsessive compulsive disorder (OCD) is a chronic mental health condition recognized as one of the most serious causes of disability and impaired quality of life. In the literature, there is no review about sex...

    Authors: Andrea Pozza, David Veale, Donatella Marazziti, Jaime Delgadillo, Umberto Albert, Giacomo Grassi, Davide Prestia and Davide Dèttore

    Citation: Systematic Reviews 2020 9:8

    Content type: Protocol

    Published on:

  18. Studies on several preclinical models of type 2 diabetes mellitus have been conducted to establish the hypoglycemic activity of Momordica charantia L. Concerned with appropriateness of these models, we designed a...

    Authors: Emanuel L. Peter, Andrew G. Mtewa, Prakash B. Nagendrappa, Anita Kaligirwa and Crispin Duncan Sesaazi

    Citation: Systematic Reviews 2020 9:7

    Content type: Protocol

    Published on:

  19. Equity in health has become an important policy agenda around the world, prompting health economists to advance methods to enable the inclusion of equity in economic evaluations. Among the methods that have be...

    Authors: Hafizah Besar Sa’aid, Sharon Mathew, Marina Richardson, Joanna M. Bielecki and Beate Sander

    Citation: Systematic Reviews 2020 9:6

    Content type: Protocol

    Published on:

  20. Health education programs (HEPs) have been documented to increase individuals’ awareness toward their health and improve health outcomes. Given the reported poor health seeking behavior among men in low- to mi...

    Authors: Tafadzwa Dzinamarira, Desmond Kuupiel and Tivani Phosa Mashamba-Thompson

    Citation: Systematic Reviews 2020 9:5

    Content type: Protocol

    Published on:

  21. The use of survey instruments to measure women’s experiences of their maternity care is regarded internationally as an indicator of the quality of care received. To ensure the credibility of the data arising f...

    Authors: Claire Beecher, Richard Greene, Laura O’Dwyer, Ethel Ryan, Mark White, Michelle Beattie and Declan Devane

    Citation: Systematic Reviews 2020 9:4

    Content type: Protocol

    Published on:

  22. Reducing meat consumption may improve human health, curb environmental damage and greenhouse gas emissions, and limit the large-scale suffering of animals raised in factory farms. Previous work has begun to de...

    Authors: Maya B. Mathur, Thomas N. Robinson, David B. Reichling, Christopher D. Gardner, Janice Nadler, Paul A. Bain and Jacob Peacock

    Citation: Systematic Reviews 2020 9:3

    Content type: Protocol

    Published on:

  23. Globally, breast cancer is the most common malignant condition in women. Breast self-examination practice following correct procedure potentially can lead to early detection of breast abnormalities. We propose...

    Authors: Roseline H. Udoh, Monica Ansu-Mensah, Mohammed Tahiru, Vitalis Bawontuo and Desmond Kuupiel

    Citation: Systematic Reviews 2020 9:2

    Content type: Protocol

    Published on:

  24. An inadequate combination of prescription drugs with food or medicinal plants could cause adverse effects in patients or produce negative therapeutic results. Therefore, this generic systematic review protocol...

    Authors: Adriana Orellana-Paucar and Daniela Vintimilla-Rojas

    Citation: Systematic Reviews 2020 9:1

    Content type: Protocol

    Published on:

  25. Hearing loss is one of the leading causes of disability in Canada and worldwide, with more than one million Canadians enduring a hearing-related disability. Meniere’s disease (MD) is a chronic condition of the...

    Authors: Nadera Ahmadzai, Wei Cheng, Dianna Wolfe, Jamie Bonaparte, David Schramm, Elizabeth Fitzpatrick, Vincent Lin, Becky Skidmore, Leila Esmaeilisaraji, Shaun Kilty and Brian Hutton

    Citation: Systematic Reviews 2019 8:341

    Content type: Protocol

    Published on:

  26. The UK National Screening Committee (UK NSC) reviews evidence about existing or potential population screening programmes using rapid review products called evidence summaries. We provide a case report as an e...

    Authors: Saoirse Leonard, Amy Buchanan-Hughes, Anna Bobrowska, Cristina Visintin and John Marshall

    Citation: Systematic Reviews 2019 8:340

    Content type: Methodology

    Published on:

  27. White spot lesions (WSLs) are common adverse effects in fixed orthodontic treatment. Remineralising agents are widely used to prevent WSLs formation and are the first-line treatment for existing WSLs. Previous...

    Authors: Huimin Hu, Chong Feng, Zhaowei Jiang, Lufei Wang, Sonu Shrestha, Xiaoming Su, Yu Shu, Long Ge, Wenli Lai, Fang Hua and Hu Long

    Citation: Systematic Reviews 2019 8:339

    Content type: Protocol

    Published on:

  28. Chronic pain is pain greater than 3 months duration that may result from disease, trauma, surgery, or unknown origin. The overlap between the psychological, behavioural, and management aspects of pain suggest ...

    Authors: Kirk J. Levins, Thomas Drago, Elena Roman, Anna Martin, Roisin King, Paul Murphy, Hugh Gallagher, Denis Barry, Erik O’Hanlon and Darren William Roddy

    Citation: Systematic Reviews 2019 8:338

    Content type: Protocol

    Published on:

  29. Studies have indicated that Plantago major L. (P. major) has therapeutic properties, such as anti-inflammatory, antioxidant, antifungal, immunostimulatory, and tissue regeneration. This plant species is assumed t...

    Authors: Fernanda de Cássia Israel Cardoso, Priscila Peruzzo Apolinário, Jéssica da Silva Cunha Breder, Thalita Paranhos, Henrique Ceretta Oliveira, Ariane Dini Polidoro, Ana Railka Souza Oliveira Kumakura and Maria Helena Melo Lima

    Citation: Systematic Reviews 2019 8:337

    Content type: Protocol

    Published on:

  30. A large number of children living with chronic conditions such as HIV experience impairments and disabilities. Current sub-Saharan African healthcare systems are challenged with paediatric care that does not i...

    Authors: Stacy Maddocks, Saul Cobbing, Jill Hanass-Hancock and Verusia Chetty

    Citation: Systematic Reviews 2019 8:336

    Content type: Protocol

    Published on:

  31. Overviews of reviews (i.e., overviews) compile information from multiple systematic reviews to provide a single synthesis of relevant evidence for healthcare decision-making. Despite their increasing popularit...

    Authors: Michelle Pollock, Ricardo M. Fernandes, Dawid Pieper, Andrea C. Tricco, Michelle Gates, Allison Gates and Lisa Hartling

    Citation: Systematic Reviews 2019 8:335

    Content type: Protocol

    Published on:

  32. Conducting systematic reviews (“reviews”) requires a great deal of effort and resources. Making data extracted during reviews available publicly could offer many benefits, including reducing unnecessary duplic...

    Authors: Ian J. Saldanha, Bryant T. Smith, Evangelia Ntzani, Jens Jap, Ethan M. Balk and Joseph Lau

    Citation: Systematic Reviews 2019 8:334

    Content type: Research

    Published on:

  33. Lower respiratory tract infection (LRTI) caused by respiratory syncytial virus (RSV) has been associated with greater risk of recurrent wheezing and subsequent asthma. However, it is still unclear whether this...

    Authors: Lauren Alexandra Quinn, Michael D. Shields and Helen E. Groves

    Citation: Systematic Reviews 2019 8:333

    Content type: Protocol

    Published on:

  34. Our understanding of recovery after moderate-to-severe traumatic brain injury (TBI) has shifted. Until recently, it was presumed that following a period of acute neurological vulnerability, the brain remained ...

    Authors: Bhanu Sharma, Alana T. Changoor, Leanne Monteiro, Brenda Colella and Robin E. A. Green

    Citation: Systematic Reviews 2019 8:332

    Content type: Protocol

    Published on:

  35. Stroke is a leading cause of death and disability worldwide. Identifying the aetiology of ischaemic stroke is essential in order to initiate appropriate and timely secondary prevention measures to reduce the r...

    Authors: Emma P. Bray, Naoimh E. McMahon, Munirah Bangee, A. Hakam Al-Khalidi, Valerio Benedetto, Umesh Chauhan, Andrew J. Clegg, Rachel F. Georgiou, Josephine Gibson, Deirdre A. Lane, Gregory Y. H. Lip, Elizabeth Lightbody, Alakendu Sekhar, Kausik Chatterjee and Caroline L. Watkins

    Citation: Systematic Reviews 2019 8:331

    Content type: Protocol

    Published on:

  36. Hypertension, type 2 diabetes mellitus and cardiovascular disease are among the leading causes of mortality globally. Exercise is one of the commonly recommended interventions/preventions for hypertension, typ...

    Authors: Anupa Rijal, Emil Eik Nielsen, Bianca Hemmingsen, Dinesh Neupane, Peter Haulund Gæde, Michael Hecht Olsen and Janus Christian Jakobsen

    Citation: Systematic Reviews 2019 8:330

    Content type: Protocol

    Published on:

  37. Pyrazinamide (PZA) is a key component of current and future regimens for tuberculosis (TB). Inclusion of PZA at higher doses and for longer durations may improve efficacy outcomes but must be balanced against ...

    Authors: James D. Millard, Elizabeth A. Mackay, Laura J. Bonnett and Geraint R. Davies

    Citation: Systematic Reviews 2019 8:329

    Content type: Protocol

    Published on:

  38. Research shows that there are inadequate interventions in resource-limited settings that could enable women of reproductive age to access and use health services in those settings. The main objective of this s...

    Authors: Joyce T. Shatilwe and Tivani P. Mashamba-Thompson

    Citation: Systematic Reviews 2019 8:328

    Content type: Protocol

    Published on:

  39. Over the past decades, there has been an increase in overweight and obesity in women of childbearing age, as well as the general population. Overweight and obesity are related to a later, increased risk of typ...

    Authors: Pernille Kjaergaard Christiansen, Mette Maria Skjøth, Mette Juel Rothmann, Christina Anne Vinter, Ronald Francis Lamont and Eva Draborg

    Citation: Systematic Reviews 2019 8:327

    Content type: Research

    Published on:

  40. The use of substances is a growing concern in Ethiopia, and their impacts on younger generation have been a concern of different professionals. Even though students are at high-risk of substance abuse, there i...

    Authors: Hirbo Shore Roba, Addisu Shunu Beyene, Asnake Ararsa Irenso and Berhe Gebremichael

    Citation: Systematic Reviews 2019 8:326

    Content type: Research

    Published on:

  41. Living systematic reviews (LSRs) offer an approach to keeping high-quality evidence synthesis continually up to date, so the most recent, relevant and reliable evidence can be used to inform policy and practic...

    Authors: Tanya Millard, Anneliese Synnot, Julian Elliott, Sally Green, Steve McDonald and Tari Turner

    Citation: Systematic Reviews 2019 8:325

    Content type: Research

    Published on:

  42. Fatigue is a common symptom in cancer patients that can persist beyond the curative treatment phase. This systematic review evaluated the effectiveness of psychological interventions for cancer-related fatigue...

    Authors: T. K. Corbett, A. Groarke, D. Devane, E. Carr, J. C. Walsh and B. E. McGuire

    Citation: Systematic Reviews 2019 8:324

    Content type: Research

    Published on:

  43. Severe acute malnutrition affects more than 20 million children. Africa is pointed out as a region where the problem is highly prevalent. There were individual studies on the recovery rate and its determinants...

    Authors: Kassahun Gebeyehu Yazew, Chanyalew Worku Kassahun, Amare Wondim Ewnetie, Habtamu Kerebih Mekonen and Endalamaw Salilew Abagez

    Citation: Systematic Reviews 2019 8:323

    Content type: Systematic review update

    Published on:

  44. Over the past decade, mesenchymal stromal cells have been increasingly investigated for their therapeutic potential in several different illnesses. However, cell therapy can be limited by potentially serious a...

    Authors: Alvin Tieu, Mitchell Slobodian, Dean A. Fergusson, Joshua Montroy, Dylan Burger, Duncan J. Stewart, Risa Shorr, David S. Allan and Manoj M. Lalu

    Citation: Systematic Reviews 2019 8:322

    Content type: Protocol

    Published on:

  45. Trastuzumab is a monoclonal antibody for patients with HER2 (human epidermal growth factor receptor 2)-positive breast cancer, which is added to regular treatment and reduces mortality. Originally, trastuzumab...

    Authors: Miriam Van den Nest, Anna Glechner, Maria Gold and Gerald Gartlehner

    Citation: Systematic Reviews 2019 8:321

    Content type: Research

    Published on:

  46. There has been increased interest in the role of cannabis for treating medical conditions. The availability of different cannabis-based products can make the side effects of exposure unpredictable. We sought t...

    Authors: Misty Pratt, Adrienne Stevens, Micere Thuku, Claire Butler, Becky Skidmore, L. Susan Wieland, Mark Clemons, Salmaan Kanji and Brian Hutton

    Citation: Systematic Reviews 2019 8:320

    Content type: Research

    Published on:

  48. The World Health Organization describes the perpetuation of human rights violations against people with mental health problems as a global emergency. Despite this observation, recent studies suggest that coerc...

    Authors: Pierre Pariseau-Legault, Sandrine Vallée-Ouimet, Marie-Hélène Goulet and Jean-Daniel Jacob

    Citation: Systematic Reviews 2019 8:318

    Content type: Protocol

    Published on:

  49. The growing number of medical literature and textual data in online repositories led to an exponential increase in the workload of researchers involved in citation screening for systematic reviews. This work a...

    Authors: Corrado Lanera, Paola Berchialla, Abhinav Sharma, Clara Minto, Dario Gregori and Ileana Baldi

    Citation: Systematic Reviews 2019 8:317

    Content type: Methodology

    Published on:

  50. Smoking remains a major public health concern. School-based social networks influence uptake of smoking among peers. During the past two decades, the UK macro-systemic context within which schools are nested a...

    Authors: H. J. Littlecott, J. Hawkins, M. Mann, G. J. Melendez-Torres, F. Dobbie and G. Moore

    Citation: Systematic Reviews 2019 8:313

    Content type: Protocol

    Published on:

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