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  2. Exosomes may have critical roles in the maternal-embryo cross-talk for the recognition and maintenance of pregnancy during maternal aging. Exosomes have the capability to carry developmental signaling molecule...

    Authors: Halimeh Mobarak, Reza Rahbarghazi, Francesca Lolicato, Mohammad Heidarpour, Fariba Pashazadeh, Mohammad Nouri and Mahdi Mahdipour

    Citation: Systematic Reviews 2019 8:293

    Content type: Protocol

    Published on:

  3. The implementation of trauma systems in many high-income countries over the last 50 years has led to important reductions in injury mortality and disability in many healthcare jurisdictions. Injury organizatio...

    Authors: Brice Batomen, Lynne Moore, Mabel Carabali, Pier-Alexandre Tardif, Howard Champion and Arijit Nandi

    Citation: Systematic Reviews 2019 8:292

    Content type: Protocol

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  4. Nutritional therapy practice guidelines are designed to improve nutritional practices and thus the delivery of nutritional therapy in critically ill patients. However, they are not implemented despite the stro...

    Authors: Nomaxabiso M. Mooi and Busisiwe P. Ncama

    Citation: Systematic Reviews 2019 8:291

    Content type: Protocol

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  5. Childhood adiposity has increased dramatically in the last few decades and is an important predictor of adulthood chronic disease. Later eating rhythm, termed night eating (NE), is increasingly prevalent in ad...

    Authors: Mengxuan Zou, Kate Northstone, Rachel Perry, Laura Johnson and Sam Leary

    Citation: Systematic Reviews 2019 8:290

    Content type: Protocol

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  6. Since the deinstitutionalization policy, in psychiatric hospitals, the care of patients with schizophrenia was left to their families which has been imposing a heavy burden on them. Family caregiver burden cou...

    Authors: Zahra Tamizi, Masoud Fallahi-Khoshknab, Asghar Dalvandi, Farahnaz Mohammadi-Shahboulaghi, Eesa Mohammadi and Enayatollah Bakhshi

    Citation: Systematic Reviews 2019 8:289

    Content type: Protocol

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  7. Obesity and its consequences are worldwide epidemic problem; therefore, studies with strategies and mechanisms that favor weight loss to improve outcomes in health are necessary. Effects of mushrooms on body w...

    Authors: Denise Grotto, Isabella Ferreira Camargo, Katia Kodaira, Lauren Giustti Mazzei, Juliana Castro, Raquel Andrade Leite Vieira, Cristiane de Cásia Bergamaschi and Luciane Cruz Lopes

    Citation: Systematic Reviews 2019 8:288

    Content type: Protocol

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  8. Inflammation in anterior uveitis is characterised by breakdown of the blood-ocular barrier, which allows leakage of blood constituents of higher molecular weight into the aqueous humour. In routine clinical ca...

    Authors: Thomas W. McNally, Xiaoxuan Liu, Sophie Beese, Pearse A. Keane, David J. Moore and Alastair K. Denniston

    Citation: Systematic Reviews 2019 8:287

    Content type: Protocol

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  9. Despite advances in resuscitation care, mortality rates following cardiac arrest (CA) remain high. Between one-quarter (in-hospital CA) and two-thirds (out of hospital CA) of patients admitted comatose to inte...

    Authors: Alex Monk and Shashank Patil

    Citation: Systematic Reviews 2019 8:286

    Content type: Protocol

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  10. Despite existing best practice care recommendations for addressing tobacco smoking, alcohol consumption and weight management in preconception and antenatal care, such recommendations are often not implemented...

    Authors: Emma Doherty, Melanie Kingsland, Luke Wolfenden, John Wiggers, Julia Dray, Jenna Hollis, Elizabeth J. Elliott, Justine B. Daly, Kylie A. Bailey, John Attia, Mandy Hunter, Ian Symonds, Belinda Tully, Danika Tremain and Rebecca K. Hodder

    Citation: Systematic Reviews 2019 8:285

    Content type: Protocol

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  11. Obsessive-compulsive disorder (OCD) is a chronic mental health disorder characterized by recurring obsessions and compulsions affecting 1–3% of children and adolescents. Current treatment options are limited b...

    Authors: Lucía Babiano-Espinosa, Lidewij H. Wolters, Bernhard Weidle, Vivian op de Beek, Sindre A. Pedersen, Scott Compton and Norbert Skokauskas

    Citation: Systematic Reviews 2019 8:284

    Content type: Research

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  12. Oropharyngeal dysphagia or swallowing difficulties are common in acute care and critical care, affecting 47% of hospitalised frail elderly, 50% of acute stroke patients and approximately 62% of critically ill ...

    Authors: Sallyanne Duncan, Jennifer Mc Gaughey, Richard Fallis, Daniel F. McAuley, Margaret Walshe and Bronagh Blackwood

    Citation: Systematic Reviews 2019 8:283

    Content type: Protocol

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  13. The relative scale adjusts for baseline variability and therefore may lead to findings that can be generalized more widely. It is routinely used for the analysis of binary outcomes but only rarely for continuo...

    Authors: Harri Hemilä and Jan O. Friedrich

    Citation: Systematic Reviews 2019 8:282

    Content type: Methodology

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  14. This systematic review was conducted to inform the Canadian Task Force on Preventive Health Care recommendations on screening for thyroid dysfunction (TD). The review sought to answer key questions on the bene...

    Authors: Francesca Reyes Domingo, Marc T. Avey and Marion Doull

    Citation: Systematic Reviews 2019 8:260

    Content type: Research

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  15. This review aimed to assess the existing evidence regarding the clinical effectiveness and safety of pharmacological and non-pharmacological interventions in adults with insomnia and identify where research or...

    Authors: Patricia Rios, Roberta Cardoso, Deanna Morra, Vera Nincic, Zahra Goodarzi, Bechara Farah, Sharada Harricharan, Charles M. Morin, Judith Leech, Sharon E. Straus and Andrea C. Tricco

    Citation: Systematic Reviews 2019 8:281

    Content type: Research

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  16. Systematic reviews of health interventions are increasingly incorporating evidence outside of randomized controlled trials (RCT). While non-randomized study (NRS) types may be more prone to bias compared to RC...

    Authors: Kelly Farrah, Kelsey Young, Matthew C. Tunis and Linlu Zhao

    Citation: Systematic Reviews 2019 8:280

    Content type: Research

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  17. We explored the performance of three machine learning tools designed to facilitate title and abstract screening in systematic reviews (SRs) when used to (a) eliminate irrelevant records (automated simulation) ...

    Authors: Allison Gates, Samantha Guitard, Jennifer Pillay, Sarah A. Elliott, Michele P. Dyson, Amanda S. Newton and Lisa Hartling

    Citation: Systematic Reviews 2019 8:278

    Content type: Research

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  18. Web applications that employ natural language processing technologies to support systematic reviewers during abstract screening have become more common. The goal of our project was to conduct a case study to e...

    Authors: Gerald Gartlehner, Gernot Wagner, Linda Lux, Lisa Affengruber, Andreea Dobrescu, Angela Kaminski-Hartenthaler and Meera Viswanathan

    Citation: Systematic Reviews 2019 8:277

    Content type: Research

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  19. Compromised natural killer (NK) cell cytotoxic function is a well-documented and consistent feature of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Other outcomes evaluated in NK cells of ME/CF...

    Authors: Natalie Eaton-Fitch, Stanley du Preez, Hélène Cabanas, Donald Staines and Sonya Marshall-Gradisnik

    Citation: Systematic Reviews 2019 8:279

    Content type: Systematic review update

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  21. Alcohol use disorder (AUD) is highly prevalent and accounts globally for 1.6% of disability-adjusted life years (DALYs) among females and 6.0% of DALYs among males. Effective treatments for AUDs are available ...

    Authors: Susan A. Rombouts, James Conigrave, Eva Louie, Paul Haber and Kirsten C. Morley

    Citation: Systematic Reviews 2019 8:275

    Content type: Protocol

    Published on:

  22. Obesity in childhood is associated with adverse health outcomes and complications throughout the life-span of a child. Available evidence suggests a dramatic increase in childhood obesity in sub-Saharan Africa...

    Authors: Frederick I. Danquah, Matilda Yeboah, Vitalis Bawontuo and Desmond Kuupiel

    Citation: Systematic Reviews 2019 8:274

    Content type: Protocol

    Published on:

  23. Peripheral nerve block is a single injection that inhibits the transmission of peripheral nerve impulses to the central nervous system. The inhibition of the nociceptive impulse may decrease the occurrence of ...

    Authors: Jennifer Héroux, Emilie Belley-Côté, Pablo Echavé, Marie-Josée Loignon, Pierre-Olivier Bessette, Nicolas Patenaude, Jean-Patrice Baillargeon and Frédérick D’Aragon

    Citation: Systematic Reviews 2019 8:273

    Content type: Protocol

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  24. Pharmacy interventions are a subset of public health interventions and its research is usually performed within the scope of a trial. The economic evaluation of pharmacy interventions requires certain consider...

    Authors: Suzete Costa, Maria Cary, Dennis K. Helling, João Pereira and Céu Mateus

    Citation: Systematic Reviews 2019 8:272

    Content type: Research

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  26. Gestational diabetes (GDM) is increasingly common and has significant implications during pregnancy and for the long-term health of the mother and offspring. However, it is a heterogeneous condition with inter...

    Authors: Shamil D. Cooray, Jacqueline A. Boyle, Georgia Soldatos, Lihini A. Wijeyaratne and Helena J. Teede

    Citation: Systematic Reviews 2019 8:270

    Content type: Protocol

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  27. Chronic primary musculoskeletal pain (CPMP) is one subcategory of the new classification of chronic primary pain for the upcoming ICD-11, defined as chronic pain in the muscles, bones, joints, or tendons that ...

    Authors: Helen Koechlin, Ben Whalley, Nicky J. Welton and Cosima Locher

    Citation: Systematic Reviews 2019 8:269

    Content type: Protocol

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  28. Investing in women’s health is an inevitable investment in our future. We systematically reviewed the available evidence and summarized the weighted prevalence of type 2 diabetes (T2DM) and pre-diabetes mellit...

    Authors: Rami H. Al-Rifai, Maria Majeed, Maryam A. Qambar, Ayesha Ibrahim, Khawla M. AlYammahi and Faisal Aziz

    Citation: Systematic Reviews 2019 8:268

    Content type: Research

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  29. A considerable proportion of adults with low back pain (LBP) suffer from depressive symptoms or depression. Those with depressive symptoms or depression may be at risk of poorer LBP recovery and require more h...

    Authors: Jessica J. Wong, Andrea C. Tricco, Pierre Côté and Laura C. Rosella

    Citation: Systematic Reviews 2019 8:267

    Content type: Protocol

    Published on:

  30. Experimental designs for evaluating knowledge translation (KT) interventions can provide strong estimates of effectiveness but offer limited insight into how the intervention worked. Consequently, process evaluat...

    Authors: Shannon D. Scott, Thomas Rotter, Rachel Flynn, Hannah M. Brooks, Tabatha Plesuk, Katherine H. Bannar-Martin, Thane Chambers and Lisa Hartling

    Citation: Systematic Reviews 2019 8:266

    Content type: Research

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  31. While Internet- and mobile-based interventions (IMIs) might possess the potential to increase access to evidence-based therapies for post-traumatic stress disorder (PTSD), comprehensive knowledge on active int...

    Authors: Lena Steubl, Cedric Sachser, Harald Baumeister and Matthias Domhardt

    Citation: Systematic Reviews 2019 8:265

    Content type: Protocol

    Published on:

  33. The relation between socioeconomic position (SEP) and obesity measured by body mass index (BMI) has been extensively reviewed, but there is less research on the association between SEP and body composition. Fa...

    Authors: Charis Bridger Staatz, Yvonne Kelly, Rebecca Lacey and Rebecca Hardy

    Citation: Systematic Reviews 2019 8:263

    Content type: Protocol

    Published on:

  34. Paediatric cancers account for a minor fraction of deaths and hence receive little attention from policymakers. In low-income countries, the absence of comprehensive national paediatric strategies results in a...

    Authors: Sehlisiwe R. Ndlovu, Desmond Kuupiel and Themba G. Ginindza

    Citation: Systematic Reviews 2019 8:262

    Content type: Protocol

    Published on:

  35. This systematic review aims to inform the development of a screening tool which pre-operatively predicts which children are likely to develop velopharyngeal insufficiency, one of the causes of poor speech outc...

    Authors: David Sainsbury, Caroline Williams, Catherine de Blacam, Joanne Mullen, Ambika Chadha, Yvonne Wren and Peter Hodgkinson

    Citation: Systematic Reviews 2019 8:261

    Content type: Protocol

    Published on:

  36. Optimal type 1 diabetes mellitus (T1D) care requires lifelong appropriate insulin treatment, which can be provided either by multiple daily injections (MDI) of insulin or by continuous subcutaneous insulin inf...

    Authors: Tiago Jeronimo Dos Santos, Juan de Mata Donado Campos, Cristina Alexandra Fraga Medin, Jesús Argente and Fernando Rodríguez-Artalejo

    Citation: Systematic Reviews 2019 8:259

    Content type: Protocol

    Published on:

  37. The widespread implementation of interventions is often hindered by a decline and variability in effectiveness across implementation sites. It is anticipated that variations in the characteristics of the exter...

    Authors: Alexandra Ziemann, Louise Brown, Euan Sadler, Josephine Ocloo, Annette Boaz and Jane Sandall

    Citation: Systematic Reviews 2019 8:258

    Content type: Protocol

    Published on:

  38. Population mail-out bowel screening programs are a convenient, cost-effective and sensitive method of detecting colorectal cancer (CRC). Despite the increased survival rates associated with early detection of ...

    Authors: Belinda C. Goodwin, Michael J. Ireland, Sonja March, Larry Myers, Fiona Crawford-Williams, Suzanne K. Chambers, Joanne F. Aitken and Jeff Dunn

    Citation: Systematic Reviews 2019 8:257

    Content type: Research

    Published on:

  39. Patient-based assessment of health services is becoming popular in measuring the standard of care. Both quantitative and qualitative methods are available. Patient satisfaction surveys are commonly used to rec...

    Authors: Maureen O. Akunne, Mathew J. Okonta, Chinwe V. Ukwe, Thomas L. Heise and Obinna I. Ekwunife

    Citation: Systematic Reviews 2019 8:256

    Content type: Protocol

    Published on:

  40. Epilepsy is one of the most common and serious brain conditions, characterised by recurrent unprovoked seizures. It affects about 1% of the population worldwide. Despite a range of antiepileptic drugs being av...

    Authors: Naomi Dvir, Muhammad S. Javaid, Nigel C. Jones, Kim L. Powell, Patrick Kwan, Terence J. O’Brien and Ana Antonic-Baker

    Citation: Systematic Reviews 2019 8:255

    Content type: Protocol

    Published on:

  42. Direct supplementation or food fortification with iron are two public health initiatives intended to reduce the prevalence of iron deficiency (ID) and iron deficiency anaemia (IDA) in 4–24-month-old infants. I...

    Authors: Dominic J. Hare, Sabine Braat, Bárbara R. Cardoso, Christopher Morgan, Ewa A. Szymlek-Gay and Beverley-Ann Biggs

    Citation: Systematic Reviews 2019 8:253

    Content type: Protocol

    Published on:

  43. There is an increasing recognition that health intervention research requires methods and approaches that can engage with the complexity of systems, interventions, and the relations between systems and interve...

    Authors: Benjamin Hanckel, Mark Petticrew, James Thomas and Judith Green

    Citation: Systematic Reviews 2019 8:252

    Content type: Protocol

    Published on:

  44. Heart failure is a highly prevalent disease with a global prevalence of 37 million, and the prevalence is increasing. Patients with heart failure are at an increased risk of death and morbidity. Traditionally,...

    Authors: Emil Eik Nielsen, Joshua Feinberg, Ilan Raymond, Michael Hecht Olsen, Frank Victor Steensgaard-Hansen and Janus Christian Jakobsen

    Citation: Systematic Reviews 2019 8:251

    Content type: Protocol

    Published on:

  45. Chronic musculoskeletal pain affects the quality of life of older adults by interfering in their ability to perform activities of daily living. Aerobic exercise programs have been used in the treatment of vari...

    Authors: Naiane Teixeira Bastos de Oliveira, Irlei dos Santos, Gisela Cristiane Miyamoto and Cristina Maria Nunes Cabral

    Citation: Systematic Reviews 2019 8:250

    Content type: Protocol

    Published on:

  46. Venous thromboembolism (VTE) is a common postoperative complication associated with significant morbidity and mortality. The use of prophylactic heparin postoperatively reduces this risk, and the use of extend...

    Authors: Bridget Heijkoop, Natalie Parker, George Kiroff and Daniel Spernat

    Citation: Systematic Reviews 2019 8:249

    Content type: Protocol

    Published on:

  47. Interpersonal psychotherapy (IPT) is an intervention that has established efficacy in the prevention and treatment of depressive disorders. Previous systematic reviews have not evaluated the effectiveness of I...

    Authors: Katherine S. Bright, Elyse M. Charrois, Muhammad Kashif Mughal, Abdul Wajid, Deborah McNeil, Scott Stuart, K. Alix Hayden and Dawn Kingston

    Citation: Systematic Reviews 2019 8:248

    Content type: Protocol

    Published on:

  48. Musculoskeletal injuries are the most common non-fatal injury from road traffic crashes. Even when the injuries are mild, they can cause pain which can affect return to work rates and work ability post-crash. ...

    Authors: Charlotte L. Brakenridge, Elise M. Gane, Esther J. Smits, Nicole E. Andrews and Venerina Johnston

    Citation: Systematic Reviews 2019 8:247

    Content type: Protocol

    Published on:

  49. The optimal duration of anticoagulation after a first unprovoked venous thromboembolism (VTE) remains controversial. Deciding to stop or continue anticoagulant therapy indefinitely after completing 3 to 6 mont...

    Authors: Faizan Khan, Miriam Kimpton, Tobias Tritschler, Grégoire Le Gal, Brian Hutton, Dean A. Fergusson and Marc A. Rodger

    Citation: Systematic Reviews 2019 8:245

    Content type: Protocol

    Published on:

  50. New onset atrial fibrillation is the most commonly encountered arrhythmia in critically unwell patients with a reported incidence of 4% to 29%. The occurrence of new onset atrial fibrillation may precipitate a...

    Authors: Brian W. Johnston, Ruaraidh Hill, Rui Duarte, Chung Shen Chean, Danny F. McAuley, Bronagh Blackwood, Nathan Pace and Ingeborg D. Welters

    Citation: Systematic Reviews 2019 8:242

    Content type: Protocol

    Published on:

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