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  1. The increasingly rapid rate of evidence publication has made it difficult for evidence synthesis—systematic reviews and health guidelines—to be continually kept up to date. One proposed solution for this is th...

    Authors: Anneliese Arno, Julian Elliott, Byron Wallace, Tari Turner and James Thomas

    Citation: Systematic Reviews 2021 10:16

    Content type: Research

    Published on:

  2. Sexual orientation and gender identity and expression change efforts (SOGIECE) are a set of scientifically discredited practices that aim to deny and suppress the sexual orientations, gender identities, and/or...

    Authors: David J. Kinitz, Travis Salway, Elisabeth Dromer, Dean Giustini, Florence Ashley, Trevor Goodyear, Olivier Ferlatte, Hannah Kia and Alex Abramovich

    Citation: Systematic Reviews 2021 10:14

    Content type: Protocol

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  3. Knowledge translation (KT) theories, frameworks, and models (TFMs) can help guide and explain KT processes, and facilitate the evaluation of implementation outcomes. They play a critical role in conducting KT ...

    Authors: Junqiang Zhao, Xuejing Li, Lijiao Yan, Yamei Yu, Jiale Hu, Shelly-Anne Li and Wenjun Chen

    Citation: Systematic Reviews 2021 10:13

    Content type: Protocol

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  4. Existing self-management and behavioural interventions for diabetes vary widely in their content, and their sustained long-term effectiveness is uncertain. Autonomy supporting interventions may be a prerequisi...

    Authors: Anne Sophie Mathiesen, Mette Juel Rothmann, Vibeke Zoffmann, Janus Christian Jakobsen, Christian Gluud, Jane Lindschou, Mette Due-Christensen, Bodil Rasmussen, Emilie Marqvorsen and Thordis Thomsen

    Citation: Systematic Reviews 2021 10:12

    Content type: Protocol

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  5. Cost-related nonadherence to medications (CRNA) is common in many countries and thought to be associated with adverse outcomes. The characteristics of CRNA in Canada, with its patchwork coverage of increasingl...

    Authors: Anne M. Holbrook, Mei Wang, Munil Lee, Zhiyuan Chen, Michael Garcia, Laura Nguyen, Angela Ford, Selina Manji and Michael R. Law

    Citation: Systematic Reviews 2021 10:11

    Content type: Research

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  6. Symptoms in multiple sclerosis (MS) can lead to different types and ranges of sexual dysfunction in MS patients. Studies in different parts of the world have reported a high range of sexual dysfunction in men ...

    Authors: Maryam Dastoorpoor, Maryam Zamanian, Rahmatollah Moradzadeh, Seyed Massood Nabavi and Raana Kousari

    Citation: Systematic Reviews 2021 10:10

    Content type: Systematic review update

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  7. Respiratory distress syndrome (RDS) is the most common cause of respiratory failure in preterm infants. Treatment consists of respiratory support and exogenous surfactant administration. Commonly, surfactant i...

    Authors: Vincent D. Gaertner, Dirk Bassler and Christoph M. Rüegger

    Citation: Systematic Reviews 2021 10:9

    Content type: Protocol

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  8. Total hip and knee arthroplasty are a highly performed surgery; however, patient satisfaction with surgery results and patient involvement in the decision-making process remains low. Patient decision aids (PtD...

    Authors: Lissa Pacheco-Brousseau, Marylène Charette, Dawn Stacey and Stéphane Poitras

    Citation: Systematic Reviews 2021 10:8

    Content type: Protocol

    Published on:

  9. Both cystic fibrosis (CF) and non-cystic fibrosis bronchiectasis are characterized by permanent bronchial dilation, impaired mucociliary clearance, and development of chronic colonization and infection. Althou...

    Authors: Salony Verma, Joseph L. Mathew and Pallab Ray

    Citation: Systematic Reviews 2021 10:7

    Content type: Protocol

    Published on:

  10. The growing societal and economic impact of Alzheimer’s disease (AD) is further compounded by the present lack of disease-modifying interventions. Non-pharmacological intervention approaches, such as exercise,...

    Authors: Julie M. Faieta, Hannes Devos, Prasanna Vaduvathiriyan, Michele K. York, Kirk I. Erickson, Mark A. Hirsch, Brian G. Downer, Erwin E. H. van Wegen, Diana C. Wong, Elena Philippou, Ahmed Negm, Pedram Ahmadnezhad, Shilpa Krishnan, Melike Kahya, Pallavi Sood and Patricia C. Heyn

    Citation: Systematic Reviews 2021 10:6

    Content type: Protocol

    Published on:

  11. The antioxidant potential of vitamin C is useful in reducing oxidative stress, free radicals, and reactive oxygen species, which may assist in the improved outcomes of periodontal therapy. This systematic revi...

    Authors: Hytham N. Fageeh, Hammam I. Fageeh, Ashwin Prabhu, Shilpa Bhandi, Shahrukh Khan and Shankargouda Patil

    Citation: Systematic Reviews 2021 10:5

    Content type: Systematic review update

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  12. Diabetic retinopathy is the most common ocular complication of diabetes and a cause of vision loss in adults. Diabetic retinopathy screening leading to early identification of the disease followed by timely tr...

    Authors: Covadonga Bascaran, Nyawira Mwangi, Fabrizio D’Esposito, Iris Gordon, Juan Alberto Lopez Ulloa, Shaffi Mdala, Jacqueline Ramke, Jennifer R. Evans and Matthew Burton

    Citation: Systematic Reviews 2021 10:4

    Content type: Protocol

    Published on:

  13. Climate change is a defining issue and grand challenge for the health sector in North America. Synthesizing evidence on climate change impacts, climate-health adaptation, and climate-health mitigation is cruci...

    Authors: Sherilee L. Harper, Ashlee Cunsolo, Amreen Babujee, Shaugn Coggins, Mauricio Domínguez Aguilar and Carlee J. Wright

    Citation: Systematic Reviews 2021 10:3

    Content type: Protocol

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  14. To inform recommendations by the Canadian Task Force on Preventive Health Care on screening in primary care for the prevention and early detection of cervical cancer by systematically reviewing evidence of (a)...

    Authors: Allison Gates, Jennifer Pillay, Donna Reynolds, Rob Stirling, Gregory Traversy, Christina Korownyk, Ainsley Moore, Guylène Thériault, Brett D. Thombs, Julian Little, Catherine Popadiuk, Dirk van Niekerk, Diana Keto-Lambert, Ben Vandermeer and Lisa Hartling

    Citation: Systematic Reviews 2021 10:2

    Content type: Protocol

    Published on:

  15. Population health (PH) research capacity and performance are essential pillars of evidence-based practice to help address health inequalities. Best evidence is provided by systematic reviews (SRs). None of the...

    Authors: Karima Chaabna, Sohaila Cheema, Amit Abraham, Patrick Maisonneuve, Albert B. Lowenfels and Ravinder Mamtani

    Citation: Systematic Reviews 2021 10:1

    Content type: Research

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  16. Despite existing research on text mining and machine learning for title and abstract screening, the role of machine learning within systematic literature reviews (SLRs) for health technology assessment (HTA) r...

    Authors: E. Popoff, M. Besada, J. P. Jansen, S. Cope and S. Kanters

    Citation: Systematic Reviews 2020 9:293

    Content type: Methodology

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  17. Despite the increase in the number of people accessing antiretroviral therapy (ART), there is limited data regarding treatment failure and its related factors among HIV-positive individuals enrolled in HIV car...

    Authors: Yishak Lailulo, Marcel Kitenge, Shahista Jaffer, Omololu Aluko and Peter Suwirakwenda Nyasulu

    Citation: Systematic Reviews 2020 9:292

    Content type: Research

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  18. Bone is a plastic tissue that is responsive to its physical environment. As a result, exercise interventions represent a potential means to influence the bone. However, little is currently known about how vari...

    Authors: E. Dolan, A. Dumas, K. M. Keane, G. Bestetti, L. H. M. Freitas, B. Gualano, W. Kohrt, G. A. Kelley, R. M. R. Pereira, C. Sale and P. Swinton

    Citation: Systematic Reviews 2020 9:291

    Content type: Protocol

    Published on:

  20. Economic evaluations help decision-makers faced with tough decisions on how to allocate resources. Systematic reviews of economic evaluations are useful as they allow readers to assess whether interventions ha...

    Authors: Gemma E. Shields and Jamie Elvidge

    Citation: Systematic Reviews 2020 9:289

    Content type: Commentary

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  21. The disease burden caused by type 2 diabetes mellitus is a prime public health concern. The prevalence and rate of deaths from diabetes mellitus in low- and middle-income countries (LMICs) are higher than the ...

    Authors: Anupam Sarker, Rina Das, Saraban Ether and K. M. Saif-Ur-Rahman

    Citation: Systematic Reviews 2020 9:288

    Content type: Protocol

    Published on:

  22. Critically ill patients receiving invasive ventilation are at risk of sputum retention. Mechanical insufflation-exsufflation (MI-E) is a technique used to mobilise sputum and optimise airway clearance. Recentl...

    Authors: Ema Swingwood, Willemke Stilma, Lyvonne Tume, Fiona Cramp, Frederique Paulus, Marcus Schultz, Wilma Scholte op Reimer and Louise Rose

    Citation: Systematic Reviews 2020 9:287

    Content type: Protocol

    Published on:

  23. Although mindfulness-based interventions (MBIs) are becoming increasingly popular, the application of MBIs with children and adolescents is still in its infancy. Mapping the existing literature is necessary to...

    Authors: Marie-France Perrier, Nalia Gurgel-Juarez, Heather Leslie Flowers, Anna McCormick and Sarah J. Short

    Citation: Systematic Reviews 2020 9:286

    Content type: Protocol

    Published on:

  24. FMS-like tyrosine kinase 3 (FLT3) is the most frequent mutation in AML. With two FLT3 inhibitors recently approved by the FDA (midostaurin and gilteritinib), there is a need to evaluate these targeted agents.

    Authors: S. Majothi, D. Adams, J. Loke, S. P. Stevens, K. Wheatley and J. S. Wilson

    Citation: Systematic Reviews 2020 9:285

    Content type: Research

    Published on:

  25. Loneliness is a highly prevalent, harmful, and aversive experience which is fundamentally subjective: social isolation alone cannot account for loneliness, and people can experience loneliness even with ample ...

    Authors: Phoebe E. McKenna-Plumley, Jenny M. Groarke, Rhiannon N. Turner and Keming Yang

    Citation: Systematic Reviews 2020 9:284

    Content type: Protocol

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  26. Young people’s use of pornography and participation in sexting are commonly viewed as harmful behaviours. This paper reports findings from a ‘review of reviews’, which aimed to systematically identify and synt...

    Authors: Gary Raine, Claire Khouja, Rachel Scott, Kath Wright and Amanda J. Sowden

    Citation: Systematic Reviews 2020 9:283

    Content type: Research

    Published on:

  27. Diabetes is a major public health issue and there is a need to develop low-cost, novel interventions to prevent or reduce disease progression. Growing evidence shows that supplementation with carnosine, or its...

    Authors: Joseph J. Matthews, Eimear Dolan, Paul A. Swinton, Livia Santos, Guilherme G. Artioli, Mark D. Turner, Kirsty J. Elliott-Sale and Craig Sale

    Citation: Systematic Reviews 2020 9:282

    Content type: Protocol

    Published on:

  28. Professionalism is a core competency of medical residents in residency programs. Unprofessional behavior has a negative influence on patient safety, quality of care, and interpersonal relationships. The object...

    Authors: Saeideh Ghaffarifar, Azam Asghari-Khatooni, Amirhossein Akbarzadeh, Ahmad Pourabbas, Mehran Seif Farshad, Rasoul Masoomi and Fariborz Akbarzadeh

    Citation: Systematic Reviews 2020 9:281

    Content type: Protocol

    Published on:

  29. People aged ≥ 65 years comprise around 1 in 5 emergency department (ED) presentations. Many of these presentations occur due to complications associated with chronic diseases and frailty. This review aims to p...

    Authors: Ya-Ling Huang, Megan McGonagle, Rebecca Shaw, Julie Eastham, Nemat Alsaba and Julia Crilly

    Citation: Systematic Reviews 2020 9:280

    Content type: Protocol

    Published on:

  30. Liver resection (LR) in patients with liver metastasis from colorectal cancer remains the only curative treatment. Perioperative chemotherapy improves prognosis of these patients. However, there are concerns r...

    Authors: Mihai-Calin Pavel, Raquel Casanova, Laia Estalella, Robert Memba, Erik Llàcer-Millán, Mar Achalandabaso, Elisabet Julià, Justin Geoghegan and Rosa Jorba

    Citation: Systematic Reviews 2020 9:279

    Content type: Protocol

    Published on:

  31. Sub-Saharan Africa (SSA) homes most of the people living with HIV/AIDS in the world. Adolescents/young people are a vulnerable population and at high risk of HIV infection. Identifying and bridging the researc...

    Authors: Patience Adzordor, Clement Avoka, Vitalis Bawontuo, Silas Agbesi and Desmond Kuupiel

    Citation: Systematic Reviews 2020 9:278

    Content type: Protocol

    Published on:

  32. The challenge of implementing evidence-based innovations within practice settings is a significant public health issue that the field of implementation research (IR) is focused on addressing. Significant amoun...

    Authors: Bryan R. Garner, Sheila V. Patel and M. Alexis Kirk

    Citation: Systematic Reviews 2020 9:277

    Content type: Protocol

    Published on:

  33. Colorectal cancer (CRC) is a major cause of cancer deaths worldwide. Accumulating evidence suggests a potentially important role of colorectal infection with Fusobacterium nucleatum (F. nucleatum) in colorectal c...

    Authors: Amal Idrissi Janati, Igor Karp, Claudie Laprise, Hisham Sabri and Elham Emami

    Citation: Systematic Reviews 2020 9:276

    Content type: Research

    Published on:

  34. Health information technology (HIT) is known to reduce prescribing errors but may also cause new types of technology-generated errors (TGE) related to data entry, duplicate prescribing, and prescriber alert fa...

    Authors: Joan Devin, Brian J. Cleary and Shane Cullinan

    Citation: Systematic Reviews 2020 9:275

    Content type: Research

    Published on:

  37. We evaluated the benefits and risks of using the Abstrackr machine learning (ML) tool to semi-automate title-abstract screening and explored whether Abstrackr’s predictions varied by review or study-level char...

    Authors: Allison Gates, Michelle Gates, Daniel DaRosa, Sarah A. Elliott, Jennifer Pillay, Sholeh Rahman, Ben Vandermeer and Lisa Hartling

    Citation: Systematic Reviews 2020 9:272

    Content type: Research

    Published on:

  38. Robust diagnosis of dementia requires an understanding of the accuracy of the available diagnostic tests. Informant questionnaires are frequently used to assess for dementia in clinical practice. Recent system...

    Authors: Martin Taylor-Rowan, Sara Nafisi, Amit Patel, Jennifer K. Burton and Terry J. Quinn

    Citation: Systematic Reviews 2020 9:271

    Content type: Protocol

    Published on:

  39. The knowledge about the experience of informal caregivers who provide care to people with moderate to advanced dementia in a domestic home setting is limited. A consequence of long hours of caregiving in addit...

    Authors: Charles James, Catherine Walshe and Katherine Froggatt

    Citation: Systematic Reviews 2020 9:270

    Content type: Protocol

    Published on:

  40. Acute bronchiolitis caused by respiratory syncytial virus (RSV) has been associated with greater risk of recurrent wheezing and asthma. However, it is unclear whether this association is causal. RSV-specific m...

    Authors: Lauren Alexandra Quinn, Michael D. Shields, Ian Sinha and Helen E. Groves

    Citation: Systematic Reviews 2020 9:269

    Content type: Research

    Published on:

  41. Rehabilitation research does not always improve patient outcomes because of difficulties implementing complex health interventions. Identifying barriers and facilitators to implementation fidelity is critical....

    Authors: Jain Anne Holmes, Philippa Logan, Richard Morris and Kathryn Radford

    Citation: Systematic Reviews 2020 9:268

    Content type: Research

    Published on:

  42. Descriptive norms messaging interventions are used to motivate people to adopt or maintain desirable behaviors. Such interventions provide people with information that describes an undesirable behavior as unco...

    Authors: Jinyi Kuang, Maryann G. Delea, Erik Thulin and Cristina Bicchieri

    Citation: Systematic Reviews 2020 9:267

    Content type: Protocol

    Published on:

  43. Human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) continue to be a major public health issue, especially in sub-Sahara Africa (SSA). Literature shows significant HIV st...

    Authors: Clement Avoka, Patience Adzordor, Vitalis Bawontuo, Diana A. Akila and Desmond Kuupiel

    Citation: Systematic Reviews 2020 9:266

    Content type: Protocol

    Published on:

  44. The prevalence of type-2 diabetes mellitus (T2DM) has been increasing globally. Without proper management, T2DM can develop into serious complications and even death. Diet modification is one of the most effec...

    Authors: Lew Leong Chen, Arimi Fitri Mat Ludin, Suzana Shahar, Zahara Abdul Manaf and Noorlaili Mohd Tohit

    Citation: Systematic Reviews 2020 9:265

    Content type: Protocol

    Published on:

  45. Flexor tendon injuries most commonly occur following a penetrating injury to the hand or wrist. These are challenging injuries and the standard treatment is surgical repair under general or regional anaesthesia.

    Authors: Grant S. Nolan, Ailbhe L. Kiely, Tomas Madura and Alexia Karantana

    Citation: Systematic Reviews 2020 9:264

    Content type: Protocol

    Published on:

  47. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) which has rapidly spread worldwide. Several human randomized clinical trials assessing potential vaccines...

    Authors: Steven Kwasi Korang, Sophie Juul, Emil Eik Nielsen, Joshua Feinberg, Faiza Siddiqui, Giok Ong, Sarah Klingenberg, Areti Angeliki Veroniki, Fanlong Bu, Lehana Thabane, Allan Randrup Thomsen, Janus C. Jakobsen and Christian Gluud

    Citation: Systematic Reviews 2020 9:262

    Content type: Protocol

    Published on:

  48. Early identification of patients at risk for postoperative delirium is essential because adequate well-timed interventions could reduce the occurrence of delirium and the related detrimental outcomes.

    Authors: Tayler A. Buchan, Behnam Sadeghirad, Nayeli Schmutz, Nicolai Goettel, Farid Foroutan, Rachel Couban, Lawrence Mbuagbaw and Benjamin T. Dodsworth

    Citation: Systematic Reviews 2020 9:261

    Content type: Protocol

    Published on:

  49. Integrated care is a people-centered health delivery approach that ensures the comprehensiveness, quality, and continuity of service across the settings and levels of health systems. The World Health Organizat...

    Authors: Md Zabir Hasan, Shalini Singh, Dinesh Arora, Nishant Jain and Shivam Gupta

    Citation: Systematic Reviews 2020 9:260

    Content type: Protocol

    Published on:

  50. Physical activity (PA) is a complex multidimensional human behaviour. Currently, there is no standardised approach for measuring PA using wearable accelerometers in health research. The total volume of PA is a...

    Authors: Tripti Rastogi, Anne Backes, Susanne Schmitz, Guy Fagherazzi, Vincent van Hees and Laurent Malisoux

    Citation: Systematic Reviews 2020 9:259

    Content type: Protocol

    Published on:

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