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  1. Antipsychotic drugs and especially the newer compounds are known to cause metabolic side effects. However, a comprehensive comparison of the different substances regarding their propensity to cause metabolic s...

    Authors: Johannes Schneider-Thoma, Angelika Kapfhammer, Dongfang Wang, Irene Bighelli, Spyridon Siafis, Hui Wu, Wulf-Peter Hansen, John M. Davis, Georgia Salanti and Stefan Leucht
    Citation: Systematic Reviews 2021 10:214
    Content type: Protocol Published on:

  2. Considerable disparities exist on the use of adipose tissue-derived stem cells (ADSCs) for treatment of spinal cord injury (SCI). Hence, the current systematic review aimed to investigate the efficacy of ADSCs...

    Authors: Seyedeh Niloufar Rafiei Alavi, Arian Madani Neishaboori, Hasti Hossein, Arash Sarveazad and Mahmoud Yousefifard
    Citation: Systematic Reviews 2021 10:213
    Content type: Systematic review update Published on:

  3. We aimed to perform a systematic review and meta-analysis of the association between obstructive sleep apnea (OSA) and cardiac as well as coronary impairment evaluated using imaging modalities. Finding of this...

    Authors: Mi Lu, Zhenjia Wang, Xiaojun Zhan and Yongxiang Wei
    Citation: Systematic Reviews 2021 10:212
    Content type: Systematic review update Published on:

  4. Chronic obstructive pulmonary disease (COPD) is a major cause of years of life lost globally. Acute exacerbations of COPD (AECOPD) drive disease progression, reduce quality of life and are a source of mortalit...

    Authors: Ruan Spies, Matthew Potter, Ruan Hollamby, Stefan van der Walt, Ameer Hohlfeld, Eleanor Ochodo and Richard N. van Zyl-Smit
    Citation: Systematic Reviews 2021 10:211
    Content type: Protocol Published on:

  5. There is abundant evidence for sex differences in the diagnosis, implantation, and outcomes for cardiac resynchronization therapy (CRT) devices. Controversial data suggesting women are less likely to receive t...

    Authors: Omar Dewidar, David Birnie, Irina Podinic, Vivian Welch and George A. Wells
    Citation: Systematic Reviews 2021 10:210
    Content type: Protocol Published on:

  6. It is well recognised that access and receipt of appropriate guideline recommended treatment with systemic anti-cancer therapies for secondary breast cancer is a key determinant in overall survival. Where ther...

    Authors: Sally Anne Pearson, Sally Taylor, Antonia Marsden and Janelle Yorke
    Citation: Systematic Reviews 2021 10:209
    Content type: Protocol Published on:

  7. There has been an exponential growth in the number of clinical research studies regarding exercise training in multiple sclerosis, and literature reviews and meta-analyses have documented the many benefits of ...

    Authors: Y. C. Learmonth, L. A. Pilutti, M. P. Herring, R. W. Motl, B. Chan and A. P. Metse
    Citation: Systematic Reviews 2021 10:208
    Content type: Protocol Published on:

  8. Children’s academic readiness has important implications for subsequent achievement and psychosocial functioning. A growing number of studies are utilizing randomized controlled trials (RCT) to examine whether...

    Authors: Heather Prime, Krysta Andrews, Andrea Gonzalez, Magdalena Janus, Andrea C. Tricco, Teresa Bennett and Leslie Atkinson
    Citation: Systematic Reviews 2021 10:207
    Content type: Protocol Published on:

  9. Ocular toxoplasmosis (OT) is the most common cause of posterior uveitis, which leads to visual impairment in a large proportion of patients. Antibiotics and corticosteroids lower the risk of permanent visual l...

    Authors: John E. Feliciano-Alfonso, Juliana Muñoz-Ortiz, María Alejandra Marín-Noriega, Andrés Vargas-Villanueva, Laura Triviño-Blanco, Natalia Carvajal-Saiz and Alejandra de-la-Torre
    Citation: Systematic Reviews 2021 10:206
    Content type: Systematic review update Published on:

  10. Biologic drugs such as adalimumab, etanercept, and infliximab represent major first-line and second-line treatments for rheumatoid arthritis (RA) patients. However, their high cost poses a massive burden on he...

    Authors: Bruna O. Ascef, Matheus O. Almeida, Ana Cristina de Medeiros Ribeiro, Danieli C. O. Andrade, Haliton A. de Oliveira Júnior, Tiago V. Pereira and Patrícia C. de Soárez
    Citation: Systematic Reviews 2021 10:205
    Content type: Protocol Published on:

  11. Adolescence is a period of rapid physical growth and transition between childhood to adulthood. However, in many developing countries, nutritional and epidemiological transitions are contributing to surging ov...

    Authors: Sachin Shinde, Dongqing Wang and Wafaie W Fawzi
    Citation: Systematic Reviews 2021 10:204
    Content type: Protocol Published on:

  12. Infectious diseases such as tuberculosis (TB), malaria and soil-transmitted helminthiasis continue to impose a significant global health burden and socio-economic impact. Globally, minority indigenous people a...

    Authors: Beth Gilmour, Kefyalew Addis Alene, Naomi E. Clarke and Archie C. A. Clements
    Citation: Systematic Reviews 2021 10:203
    Content type: Protocol Published on:

  13. The pharmacological treatment of cardiovascular diseases and type 2 diabetes mellitus reduces the risk of cardiovascular events.; however, most patients do not adhere to the treatment. There are several self-r...

    Authors: Henrique Ceretta Oliveira, Daisuke Hayashi Neto, Samantha Dalbosco Lins Carvalho, Rita de Cássia Lopes Barros, Mayza Luzia dos Santos Neves, Carla Renata Silva Andrechuk, Neusa Maria Costa Alexandre and Roberta Cunha Matheus Rodrigues
    Citation: Systematic Reviews 2021 10:202
    Content type: Protocol Published on:

  14. Non-steroidal anti-inflammatory drugs (NSAID) have excellent anti-inflammatory and analgesic properties and are extensively used to treat post-traumatic or surgical musculoskeletal pain. Although an extensive ...

    Authors: Haider Al-Waeli, Ana Paula Reboucas, Alaa Mansour, Martin Morris, Faleh Tamimi and Belinda Nicolau
    Citation: Systematic Reviews 2021 10:201
    Content type: Research Published on:

  15. Rheumatic heart disease is preventable, yet associated with significant health burden, mostly in low-resourced settings. It is prevalent among children and young adults living in impoverished areas. Primordial...

    Authors: Panduleni Penipawa Shimanda, Tonderai Washington Shumba, Mattias Brunström, Stefan Söderberg, Lars Lindholm, Scholastika Ndatinda Iipinge and Fredrik Norström
    Citation: Systematic Reviews 2021 10:200
    Content type: Protocol Published on:

  16. People living with dementia (PLWD) are at significant risk of developing urinary and/or faecal incontinence and are also at risk of functional incontinence or being labelled as being incontinent. Despite the g...

    Authors: Deborah Edwards, Jane Harden, Aled Jones and Katie Featherstone
    Citation: Systematic Reviews 2021 10:199
    Content type: Research Published on:

  17. Polypharmacy, often defined as the concomitant use of ≥ 5 medications, has been identified as a significant global public health threat. Aging and multimorbidity are key drivers of polypharmacy and have been l...

    Authors: Ikechi G. Okpechi, Mohammed M. Tinwala, Shezel Muneer, Deenaz Zaidi, Feng Ye, Laura N. Hamonic, Maryam Khan, Naima Sultana, Scott Brimble, Allan Grill, Scott Klarenbach, Cliff Lindeman, Amber Molnar, Dorothea Nitsch, Paul Ronksley, Soroush Shojai…
    Citation: Systematic Reviews 2021 10:198
    Content type: Protocol Published on:

  18. Obesity has become a major driver in the burden of chronic diseases. The Canadian Clinical Practice Guidelines recommend a lifestyle intervention for the management and prevention of obesity. This includes beh...

    Authors: Katrina Cachero, Matthew Granger, Rebecca C. Mollard, Nicole Askin, George N. Okoli, Ahmed M. Abou-Setta and Dylan MacKay
    Citation: Systematic Reviews 2021 10:197
    Content type: Protocol Published on:

  19. The COVID-19 pandemic caused by SARS-CoV-2 has highlighted consistent inequities in incidence, disease severity, and mortality across racial and ethnic minority populations in the United States (US) and beyond...

    Authors: Neia Prata Menezes, Jowanna Malone, Carrie Lyons, Kechna Cadet, Lorraine Dean, Gregorio Millett and Stefan Baral
    Citation: Systematic Reviews 2021 10:196
    Content type: Protocol Published on:

  20. Precarious employment is a significant determinant of population health and health inequities and has complex public health consequences both for a given nation and internationally. Precarious employment is co...

    Authors: Virginia Gunn, Carin Håkansta, Emilia Vignola, Nuria Matilla-Santander, Bertina Kreshpaj, David H. Wegman, Christer Hogstedt, Emily Q. Ahonen, Carles Muntaner, Sherry Baron and Theo Bodin
    Citation: Systematic Reviews 2021 10:195
    Content type: Protocol Published on:

  21. Comprehensive evidence synthesis on the associations between comorbidities and behavioural factors with hospitalisation, intensive care unit (ICU) admission, and death due to COVID-19 is required for deriving ...

    Authors: Nathalie Verónica Fernández Villalobos, Jördis Jennifer Ott, Carolina Judith Klett-Tammen, Annabelle Bockey, Patrizio Vanella, Gérard Krause and Berit Lange
    Citation: Systematic Reviews 2021 10:194
    Content type: Systematic review update Published on:

  22. Social media has been used to disseminate the contents of scientific articles. To measure the impact of this, a new tool called Altmetric was created. Altmetric aims to quantify the impact of each article through...

    Authors: Amanda Costa Araujo, Adriane Aver Vanin, Dafne Port Nascimento, Gabrielle Zoldan Gonzalez and Leonardo Oliveira Pena Costa
    Citation: Systematic Reviews 2021 10:193
    Content type: Research Published on:

  24. An assessment of the validity of individual diagnostic accuracy studies in systematic reviews is necessary to guide the analysis and the interpretation of results. Such an assessment is performed for each incl...

    Authors: Yasaman Vali, Mariska M. G. Leeflang and Patrick M. M. Bossuyt
    Citation: Systematic Reviews 2021 10:191
    Content type: Methodology Published on:

  25. Improving evidence-informed policy dialogue to support the development and implementation of national health policies is vital, but there is limited evidence on researchers’ roles in policy dialogue processes ...

    Authors: Doris Yimgang, Georges Danhoundo, Elizabeth Kusi-Appiah, Vijit Sunder, Sandra Campbell and Sanni Yaya
    Citation: Systematic Reviews 2021 10:190
    Content type: Systematic review update Published on:

  26. Healthcare and human services increasingly rely on teams of individuals to deliver services. Implementation of evidence-based practices and other innovations in these settings requires teams to work together t...

    Authors: Elizabeth A. McGuier, David J. Kolko, Mary Lou Klem, Jamie Feldman, Grace Kinkler, Matthew A. Diabes, Laurie R. Weingart and Courtney Benjamin Wolk
    Citation: Systematic Reviews 2021 10:189
    Content type: Protocol Published on:

  27. Parkinson’s disease (PD) is the second most common age-dependent neurodegenerative disease that causes motor and cognitive disabilities. This disease is associated with a loss of dopamine content within the pu...

    Authors: Aliasghar Karimi, Mitra Elmi, Zahra Shiri and Hossein Baharvand
    Citation: Systematic Reviews 2021 10:188
    Content type: Protocol Published on:

  28. Many studies have evaluated the effects that a lack of resources has in children’s physical and cognitive development. Although there are reviews that have focused on applied interventions from different persp...

    Authors: Rosalba Company-Córdoba, Antonio Sianes, Ian Craig Simpson and Joaquín A. Ibáñez-Alfonso
    Citation: Systematic Reviews 2021 10:187
    Content type: Protocol Published on:

  29. Low birth weight might affect adverse health outcomes during a lifetime. Our study analyzes the association between low birth weight and negative health outcomes during adulthood in twin populations.

    Authors: Sapha Hassan, Shayesteh Jahanfar, Joseph Inungu and Jeffrey M. Craig
    Citation: Systematic Reviews 2021 10:186
    Content type: Systematic review update Published on:

  30. Polypharmacy is inevitable and appropriate for many conditions, but in some cases, it can be problematic resulting in an increased risk of harm and reduced quality of life. There has been an increasing interes...

    Authors: Rik S. van der Veen, Joseph J. Lee, Richard J. McManus, Richard F. D. Hobbs, Kamal R. Mahtani, Constantinos Koshiaris and James P. Sheppard
    Citation: Systematic Reviews 2021 10:185
    Content type: Protocol Published on:

  31. Health promotion efforts among African American men have been met with significant challenges and have produced limited results. Interventions that do not align with the values, perspectives, and preferences o...

    Authors: Guillermo M. Wippold, Sarah Grace Frary, Demetrius Abshire and Dawn K. Wilson
    Citation: Systematic Reviews 2021 10:184
    Content type: Protocol Published on:

  33. Separately, mental and musculoskeletal disorders (MSDs) are prevalent across the life course and are leading contributors to disability worldwide. While people with personality disorder (PD) have been shown to...

    Authors: Shae E. Quirk, Heli Koivumaa-Honkanen, Risto Honkanen, Jeremi Heikkinen, Bianca E. Kavanagh and Lana J. Williams
    Citation: Systematic Reviews 2021 10:182
    Content type: Protocol Published on:

  34. Obesity is a prevalent, complex, progressive and relapsing chronic disease characterised by abnormal or excessive body fat that impairs health and quality of life. It affects more than 650 million adults world...

    Authors: Emma Farrell, Marta Bustillo, Carel W. le Roux, Joe Nadglowski, Eva Hollmann and Deirdre McGillicuddy
    Citation: Systematic Reviews 2021 10:181
    Content type: Protocol Published on:

  35. Cancer is a non-communicable disease and is the number 2 leading cause of death globally. Among all cancers, cervical cancer is the number 1 killer of women in low-income countries (LICs). Cervical cancer is a...

    Authors: Petmore Zibako, Mbuzeleni Hlongwa, Nomsa Tsikai, Sarah Manyame and Themba G. Ginindza
    Citation: Systematic Reviews 2021 10:180
    Content type: Protocol Published on:

  36. People living with all stages of dementia should have the opportunity to participate in meaningful occupations. For those living in care homes, this may not always occur and residents may spend significant par...

    Authors: Nicholas Luscombe, Sarah Morgan-Trimmer, Sharon Savage and Louise Allan
    Citation: Systematic Reviews 2021 10:179
    Content type: Protocol Published on:

  37. The aspects of marriage and relationship and their effect on couples’ satisfaction are essential and critical aspects to be explored in this globalized and contemporary world. Since there are no reported meta-...

    Authors: Zeinab Javadivala, Hamid Allahverdipour, Mohammad Asghari Jafarabadi, Somaye Azimi, Neda Gilani and Vijay Kumar Chattu
    Citation: Systematic Reviews 2021 10:178
    Content type: Research Published on:

  38. Anemia is common in neurocritically ill patients. Considering the limited clinical evidence in this population, preclinical data may provide some understanding of the potential impact of anemia and of red bloo...

    Authors: Mathieu Laflamme, Hourmazd Haghbayan, Manoj M. Lalu, Ryan Zarychanski, François Lauzier, Amélie Boutin, Malcolm R. Macleod, Dean A. Fergusson, Lynne Moore, Olivier Costerousse, Jacques Lacroix, Cheryl Wellington, Jamie Hutchison and Alexis F. Turgeon
    Citation: Systematic Reviews 2021 10:177
    Content type: Protocol Published on:

  39. Caesarean sections often have no urgent indication and are electively planned. Research showed that elective caesarean section should not be performed until 39 + (0–6) weeks of gestation to ensure best neonata...

    Authors: Barbara Prediger, Anahieta Heu-Parvaresch, Stephanie Polus, Stefanie Bühn, Edmund A. M. Neugebauer and Pieper Dawid
    Citation: Systematic Reviews 2021 10:176
    Content type: Research Published on:

  41. Tuberculosis (TB) is still one of the leading causes of death worldwide. Genetic studies have pointed to the relevance of the NOD2 and CD14 polymorphic alleles in association with the risk of diseases caused by M...

    Authors: Juan M. Cubillos-Angulo, Catarina D. Fernandes, Davi N. Araújo, Cristinna A. Carmo, María B. Arriaga and Bruno B. Andrade
    Citation: Systematic Reviews 2021 10:174
    Content type: Research Published on:

  42. Current clinical guidelines recommend conservative management including non-pharmacologic therapy prior to considering surgery for knee OA. There is a paucity of clinical trials investigating the use of biomec...

    Authors: Michael J. Callaghan, Elizabeth Palmer and Terence O’Neill
    Citation: Systematic Reviews 2021 10:173
    Content type: Research Published on:

  43. Utilization of post-abortion family planning is very critical to reduce high levels of unintended pregnancy, which is the root cause of induced abortion. In Eastern Africa, it is estimated that as many as 95% ...

    Authors: Asmamaw Demis Bizuneh and Getnet Gedefaw Azeze
    Citation: Systematic Reviews 2021 10:172
    Content type: Research Published on:

  44. Major depression significantly impairs quality of life, increases the risk of suicide, and poses tremendous economic burden on individuals and societies. Duloxetine, a serotonin norepinephrine reuptake inhibit...

    Authors: Faiza Siddiqui, Marija Barbateskovic, Sophie Juul, Kiran Kumar Katakam, Klaus Munkholm, Christian Gluud and Janus Christian Jakobsen
    Citation: Systematic Reviews 2021 10:171
    Content type: Protocol Published on:

  46. Substantial literature has highlighted the importance of patient-reported outcome and experience measures (PROMs and PREMs, respectively) to collect clinically relevant information to better understand and add...

    Authors: Angela C. Wolff, Andrea Dresselhuis, Samar Hejazi, Duncan Dixon, Deborah Gibson, A. Fuchsia Howard, Sarah Liva, Barbara Astle, Sheryl Reimer-Kirkham, Vanessa K. Noonan and Lisa Edwards
    Citation: Systematic Reviews 2021 10:169
    Content type: Protocol Published on:

  48. Cancer diagnosis in childhood or adolescence impacts significantly on school attendance, experience and educational outcomes. While there is longstanding recognition in clinical practice that these effects spa...

    Authors: Gemma Bryan, Paula Kelly, Heather Chesters, Jayne Franklin, Helen Griffiths, Loveday Langton, Luke Langton, Claire E. Wakefield and Faith Gibson
    Citation: Systematic Reviews 2021 10:167
    Content type: Protocol Published on:

  49. Sleep disturbances constitute a common complication in pediatric cancer patients and survivors and are frequently severe enough to warrant treatment. Suboptimal sleep has been associated with decreased emotion...

    Authors: Peter L. Stavinoha, Ineke M. Olsthoorn, Maria C. Swartz, Sara Nowakowski, Stephanie J. Wells, Rachel S. Hicklen, Irtiza Sheikh and Hannah J. Jang
    Citation: Systematic Reviews 2021 10:166
    Content type: Protocol Published on:

  50. People with intellectual disabilities have been historically excluded from decision-making processes. Previous literature indicates that increasing social participation may be an effective way to address this ...

    Authors: Andrés Aparicio, Paulina Arango, Rosario Espinoza, Vicente Villate and Marcela Tenorio
    Citation: Systematic Reviews 2021 10:165
    Content type: Protocol Published on:
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