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  1. Acute diarrhea and acute gastroenteritis (AD/AGE) are common among children in low- and middle-income countries (LMIC) and high-income countries (HIC). Supportive therapy including maintaining feeding, prevent...

    Authors: Ivan D. Florez, Reem Al-Khalifah, Javier M. Sierra, Claudia M. Granados, Juan J. Yepes-Nuñez, Carlos Cuello-Garcia, Giordano Perez-Gaxiola, Adriana M. Zea, Gilma N. Hernandez, Areti-Angeliki Veroniki, Gordon H. Guyatt and Lehana Thabane
    Citation: Systematic Reviews 2016 5:14
  2. Systematic reviews seek to bring together research evidence to answer the question for the review. The reviewers usually wish to compare, contrast and, if appropriate, combine the findings of the existing rese...

    Authors: Mike Clarke and Paula R. Williamson
    Citation: Systematic Reviews 2016 5:11
  3. Traumatic brain injury (TBI) is a devastating condition with significant long-term mortality and morbidity. Despite current need for objective indicators to guide initial decision-making, few reliable acute ph...

    Authors: Hourmazd Haghbayan, Amélie Boutin, Mathieu Laflamme, François Lauzier, Michèle Shemilt, Lynne Moore, Ryan Zarychanski, Dean Fergusson and Alexis F. Turgeon
    Citation: Systematic Reviews 2016 5:10
  4. Overweight and obesity in children and adults is a major public health concern. Emerging evidence suggests dietary sodium intake may be associated with obesity. This systematic review and meta-analysis will ai...

    Authors: Carley A. Grimes, Dieuwerke P. Bolhuis, Feng J. He and Caryl A. Nowson
    Citation: Systematic Reviews 2016 5:7
  5. Cost-effectiveness analysis has been recognized as an important tool to determine the efficiency of healthcare interventions and services. There is a need for evaluating the reporting of methods and results of...

    Authors: Ferrán Catalá-López, Manuel Ridao, Adolfo Alonso-Arroyo, Anna García-Altés, Chris Cameron, Diana González-Bermejo, Rafael Aleixandre-Benavent, Enrique Bernal-Delgado, Salvador Peiró, Rafael Tabarés-Seisdedos and Brian Hutton
    Citation: Systematic Reviews 2016 5:6
  6. Worldwide, the prevalences of diabetes and dementia are both increasing, particularly in older people. Rates of diabetes in people with dementia are between 13 and 20 %. Diabetes management and diabetic self-c...

    Authors: Frances Bunn, Claire Goodman, Jo Rycroft Malone, Peter Reece Jones, Chris Burton, Greta Rait, Daksha Trivedi, Antony Bayer and Alan Sinclair
    Citation: Systematic Reviews 2016 5:5
  7. Overviews of systematic reviews attempt to systematically retrieve and summarise the results of multiple systematic reviews into a single document. Methods for conducting, interpreting and reporting overviews ...

    Authors: Carole Lunny, Sue E. Brennan, Steve McDonald and Joanne E. McKenzie
    Citation: Systematic Reviews 2016 5:4
  8. Chronic kidney disease-mineral and bone disorders (CKD-MBD) have been associated with poor health outcomes, including diminished quality and length of life. Standard management for CKD-MBD includes phosphate-r...

    Authors: Nigar Sekercioglu, Jason W. Busse, Reem A. Mustafa, Gordon H. Guyatt and Lehana Thabane
    Citation: Systematic Reviews 2016 5:2
  9. Research with a focus on Aboriginal and Torres Strait Islander Australian’s (hereafter referred to as Indigenous1) needs is crucial to ensure culturally appropriate evidence-based strategies are developed to impr...

    Authors: Sara Farnbach, Anne-Marie Eades and Maree Lisa Hackett
    Citation: Systematic Reviews 2015 4:189
  10. Up to 90 % of people with scleroderma have gastrointestinal (GI) problems such as constipation, bloating, diarrhea, and malabsorption. These problems significantly impair quality of life. Our objective was to ...

    Authors: Brian Younho Hong, Raymond Giang, Lawrence Mbuagbaw, Maggie Larche and Lehana Thabane
    Citation: Systematic Reviews 2015 4:188
  11. Suicidal behaviour is a complex phenomenon with a multitude of risk factors. Brain-derived neurotrophic factor (BDNF), a protein crucial to nervous system function, may be involved in suicide risk. The objecti...

    Authors: Rebecca B. Eisen, Stefan Perera, Laura Banfield, Rebecca Anglin, Luciano Minuzzi and Zainab Samaan
    Citation: Systematic Reviews 2015 4:187
  12. The mental health of children and adolescents is a key area of health concern internationally. Previous empirical studies suggest that resilience may act as a protective mechanism towards the development of me...

    Authors: Julia Dray, Jenny Bowman, Luke Wolfenden, Elizabeth Campbell, Megan Freund, Rebecca Hodder and John Wiggers
    Citation: Systematic Reviews 2015 4:186
  13. The long-term management of chronic diseases requires adoption of complex dietary recommendations, which can be facilitated by regular coaching to support sustained behaviour change. Telehealth interventions c...

    Authors: Jaimon T. Kelly, Dianne P. Reidlinger, Tammy C. Hoffmann and Katrina L. Campbell
    Citation: Systematic Reviews 2015 4:185
  14. Tobacco and alcohol are recognised as the major risk factors for both oral cavity (mouth) and oropharyngeal (throat) cancers, with increasing acceptance of the role of human papillomavirus (HPV) in the aetiolo...

    Authors: Sweta Mathur, David I. Conway, Heather Worlledge-Andrew, Lorna M.D. Macpherson and Alastair J. Ross
    Citation: Systematic Reviews 2015 4:184
  15. Testicular cancer is primarily treated with the surgical removal of the affected testis. About 50 % of testicular cancer patients present with a stage I seminoma. If no chemo- or radiotherapy as adjuvant treat...

    Authors: Frank Kunath, Annabel Spek, Katrin Jensen, Friedemann Zengerling and Stefanie Schmidt
    Citation: Systematic Reviews 2015 4:182
  16. Improving health-care outcomes for people living with dementia when they are admitted to hospital is a policy priority. Dementia friendly interventions in health care promote inclusion of patients and carers i...

    Authors: Melanie Handley, Frances Bunn and Claire Goodman
    Citation: Systematic Reviews 2015 4:180
  17. Whilst nutrition is vital to survival in health, the precise role of nutrition during critical illness is controversial. More specifically, the exact amount of energy that is required during critical illness t...

    Authors: Emma J. Ridley, Andrew R. Davies, Carol Hodgson, Adam Deane, Michael Bailey and D. James Cooper
    Citation: Systematic Reviews 2015 4:179
  18. A physically active lifestyle plays a preventative role in the development of various chronic diseases and mental health conditions. Unfortunately, few adults achieve the minimum amount of physical activity an...

    Authors: Christina C. Loitz, Robert J. Potter, Jessica L. Walker, Nicole C. McLeod and Nora J. Johnston
    Citation: Systematic Reviews 2015 4:178
  19. The risk of developing cardiovascular disease is directly correlated to one’s resting blood pressure (BP), age, and biological sex. Resting BP can be reduced using handgrip exercise training, but the impact of...

    Authors: Danielle C. Bentley, Cindy H. Nguyen and Scott G. Thomas
    Citation: Systematic Reviews 2015 4:176
  20. Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder. While abdominal pain is a dominant symptom of IBS, many sufferers also report widespread hypersensitivity and present with other...

    Authors: Rosemary J. Chakiath, Philip J. Siddall, John E. Kellow, Julia M. Hush, Mike P. Jones, Anna Marcuzzi and Paul J. Wrigley
    Citation: Systematic Reviews 2015 4:175
  21. Fatigue is a common symptom in cancer patients that can persist beyond the curative treatment phase. Some evidence has been reported for interventions for fatigue during active treatment. However, to date, the...

    Authors: Teresa Corbett, Declan Devane, Jane C. Walsh, AnnMarie Groarke and Brian E. McGuire
    Citation: Systematic Reviews 2015 4:174
  22. Helping people make well-informed decisions about dysvascular partial foot amputation is becoming increasingly important as improvements in diabetes care and vascular surgery make more distal amputations incre...

    Authors: Michael P Dillon, Stefania Fatone and Matthew Quigley
    Citation: Systematic Reviews 2015 4:173

    The Erratum to this article has been published in Systematic Reviews 2016 5:1

  23. The recent Ebola epidemic in western Africa developed into an acute public health emergency of unprecedented level in modern times. The treatment provided in most cases has been limited to supportive care, as ...

    Authors: Hussein Sweiti, Obinna Ekwunife, Thomas Jaschinski and Stefan K. Lhachimi
    Citation: Systematic Reviews 2015 4:171
  24. Probiotics may prevent antibiotic-associated and Clostridium difficile-associated diarrhoea (AAD/CDAD). Many spinal cord injury centre (SCIC) practitioners consider probiotics generically and may not realise that...

    Authors: Samford Wong, Ali Jamous, Jean O’Driscoll, Ravi Sekhar, Mofid Saif, Steve O’Driscoll, Sarah Lewis, Eamonn McKeown and Shashi P. Hirani
    Citation: Systematic Reviews 2015 4:170
  25. The objective of the study is to conduct a systematic review to compare the effects of high-dose chemotherapy (HDCT) with autologous haematopoietic stem cell transplantation (HSCT) versus standard-dose chemoth...

    Authors: Caroline Main, Jayne S. Wilson, Simon P. Stevens, Aimee E. Houlton, Martin English, Pamela R. Kearns, Bob Phillips, Barry Pizer, Sophie Wilne and Keith Wheatley
    Citation: Systematic Reviews 2015 4:168
  26. Transplantation improves survival and the quality of life of patients with end-stage organ failure. Infection, due to surgical issues, host factors such as diabetes, immunosuppression, and hypogammaglobulinemi...

    Authors: Juthaporn Cowan, Brian Hutton, Nicholas Fergusson, Alexandria Bennett, Jason Tay, D. William Cameron and Greg A. Knoll
    Citation: Systematic Reviews 2015 4:167
  27. Several options are available for the treatment of chronic rhinosinusitis (CRS), but disease control remains elusive for many patients. Recently, literature has emerged describing anti-IgE monoclonal antibody ...

    Authors: Chris J. Hong, Adrian C. Tsang, Jason G. Quinn, James P. Bonaparte, Adrienne Stevens and Shaun J. Kilty
    Citation: Systematic Reviews 2015 4:166
  28. Head injury represents an extremely common presentation to emergency departments (ED), but not all patients present immediately after injury. There is evidence that clinical deterioration following head injury...

    Authors: Carl Marincowitz, Christopher M. Smith and William Townend
    Citation: Systematic Reviews 2015 4:165
  29. Cardiovascular diseases (CVDs), including myocardial infarction, heart failure, peripheral arterial disease and strokes, are highly prevalent conditions and are associated with high morbidity and mortality. Ca...

    Authors: Neil Heron, Frank Kee, Michael Donnelly, Mark A. Tully and Margaret E. Cupples
    Citation: Systematic Reviews 2015 4:164
  30. Many randomised trials have count outcomes, such as the number of falls or the number of asthma exacerbations. These outcomes have been treated as counts, continuous outcomes or dichotomised and analysed using...

    Authors: Peter Herbison, M. Clare Robertson and Joanne E. McKenzie
    Citation: Systematic Reviews 2015 4:163
  31. Fluid administration to critically ill patients remains the subject of considerable controversy. While intravenous fluid given for resuscitation may be life-saving, a positive fluid balance over time is associ...

    Authors: Jonathan A. Silversides, Andrew J. Ferguson, Daniel F. McAuley, Bronagh Blackwood, John C. Marshall and Eddy Fan
    Citation: Systematic Reviews 2015 4:162
  32. Non-union of fractured bone is a major cause of morbidity in the orthopaedic population. Despite this, optimal management of non-union is still unclear and remains a significant clinical challenge. Research co...

    Authors: Sarah K. Stewart, Philippa M. Bennett, Sarah A. Stapley, Janine Dretzke, Danai Bem and Jowan G. Penn-Barwell
    Citation: Systematic Reviews 2015 4:161
  33. Healthcare consumers, researchers, patients and policy makers increasingly use systematic reviews (SRs) to aid their decision-making process. However, the conduct of SRs can be a time-consuming and resource-in...

    Authors: Alexander Tsertsvadze, Yen-Fu Chen, David Moher, Paul Sutcliffe and Noel McCarthy
    Citation: Systematic Reviews 2015 4:160
  34. Landmark studies in adult-onset type 1 diabetes (T1D) populations indicate that improved glycaemic control through use of intensive insulin therapy is strongly associated with reduced risk for the development ...

    Authors: Veena Mazarello Paes, Dimitrios Charalampopoulos, Amal R. Khanolkar, David Taylor-Robinson, Russell Viner, Julie Edge, Terence Stephenson and Rakesh Amin
    Citation: Systematic Reviews 2015 4:159
  35. The matching of critical care service supply with demand is fundamental for the efficient delivery of advanced life support to patients in urgent need. Mismatch in this supply/demand relationship contributes t...

    Authors: S. Abolfazi Soltani, Armann Ingolfsson, David A. Zygun, Henry T. Stelfox, Lisa Hartling, Robin Featherstone, Dawn Opgenorth and Sean M. Bagshaw
    Citation: Systematic Reviews 2015 4:158
  36. Smoking cessation before surgery reduces postoperative complications, and the benefit is positively associated with the duration of being abstinent before a surgical procedure. A key issue in providing preoper...

    Authors: Fujian Song, Tracey J. Brown, Annie Blyth, Vivienne Maskrey, Iain McNamara and Simon Donell
    Citation: Systematic Reviews 2015 4:157
  37. The reach, effectiveness, adoption, implementation, and maintenance (RE-AIM) framework was developed to determine potential public health impact of interventions (i.e., programs, policy, and practice). The pur...

    Authors: Samantha M. Harden, Bridget Gaglio, Jo Ann Shoup, Kimberlee A. Kinney, Sallie Beth Johnson, Fabiana Brito, Kacie C. A. Blackman, Jamie M. Zoellner, Jennie L. Hill, Fabio A. Almeida, Russell E. Glasgow and Paul A. Estabrooks
    Citation: Systematic Reviews 2015 4:155
  38. Nebulised dornase alfa is used off-label in critically ill patients. We aimed to assess the benefits and harms of nebulised dornase alfa versus placebo, no prophylaxis, or hypertonic saline on patient-importan...

    Authors: Casper Claudius, Anders Perner and Morten Hylander Møller
    Citation: Systematic Reviews 2015 4:153
  39. Current health and social care systems are providing suboptimal and fragmented care to the growing dementia population. Interventions aiming to coordinate care services for individuals with dementia and their ...

    Authors: Amy Backhouse, Chris Dickens, David Richards and Rose McCabe
    Citation: Systematic Reviews 2015 4:156
  40. Though often used to control outbreaks, the efficacy of ward closure is unclear. This systematic review sought to identify studies defining and describing ward closure in outbreak control and to determine impa...

    Authors: Holly Wong, Katherine Eso, Ada Ip, Jessica Jones, Yoojin Kwon, Susan Powelson, Jill de Grood, Rose Geransar, Maria Santana, A. Mark Joffe, Geoffrey Taylor, Bayan Missaghi, Craig Pearce, William A. Ghali and John Conly
    Citation: Systematic Reviews 2015 4:152
  41. Management and choice of sedation is important during critical illness in order to reduce patient suffering and to facilitate the delivery of care. Unfortunately, medications traditionally used for sedation in...

    Authors: Gennie Jing Wang, Emilie Belley-Coté, Lisa Burry, Mark Duffett, Timothy Karachi, Dan Perri, Waleed Alhazzani, Frederick D’Aragon, Hannah Wunsch and Bram Rochwerg
    Citation: Systematic Reviews 2015 4:154
  42. Sepsis from burn injuries can result from colonisation of burn wounds, especially in large surface area burns. Reducing bacterial infection will reduce morbidity and mortality, and mortality for severe burns c...

    Authors: Johnny Kwei, Fenella D. Halstead, Janine Dretzke, Beryl A. Oppenheim and Naiem S. Moiemen
    Citation: Systematic Reviews 2015 4:150

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