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  1. Clinical trials typically have a relatively short follow-up period, and may both underestimate potential benefits of treatments investigated, and fail to detect hazards, which can take much longer to emerge. P...

    Authors: Rebecca Llewellyn-Bennett, Louise Bowman and Richard Bulbulia
    Citation: Systematic Reviews 2016 5:214
  2. Colonic mural thickening is often a finding in standard computed tomography (CT) scans of the abdomen. It often presents clinician with a dilemma on when a further endoscopic evaluation is needed, especially i...

    Authors: Subashini Chandrapalan, Faraz Tahir, Rakesh Sinha and Ramesh Arasaradnam
    Citation: Systematic Reviews 2016 5:213
  3. As more complex meta-analytical techniques such as network and multivariate meta-analyses become increasingly common, further pressures are placed on reviewers to extract data in a systematic and consistent ma...

    Authors: Hugo Pedder, Grammati Sarri, Edna Keeney, Vanessa Nunes and Sofia Dias
    Citation: Systematic Reviews 2016 5:212
  4. The prevalence of delirium in intensive care unit (ICU) patients is high. Delirium has been associated with morbidity and mortality including more ventilator days, longer ICU stay, increased long-term mortalit...

    Authors: Marija Barbateskovic, Laura Krone Larsen, Marie Oxenbøll-Collet, Janus Christian Jakobsen, Anders Perner and Jørn Wetterslev
    Citation: Systematic Reviews 2016 5:211
  5. Synthesis of multiple randomized controlled trials (RCTs) in a systematic review can summarize the effects of individual outcomes and provide numerical answers about the effectiveness of interventions. Filteri...

    Authors: Mourad Ouzzani, Hossam Hammady, Zbys Fedorowicz and Ahmed Elmagarmid
    Citation: Systematic Reviews 2016 5:210
  6. Medication errors represent a noteworthy source of harm to patients. In recent years, several systematic reviews have assessed the frequency and causes of these events, as well as other factors such as commonl...

    Authors: Brian Hutton, Salmaan Kanji, Erika McDonald, Fatemeh Yazdi, Dianna Wolfe, Kednapa Thavorn, Sally Pepper, Laurie Chapman, Becky Skidmore and David Moher
    Citation: Systematic Reviews 2016 5:209
  7. In patients with intracranial large vessel arterial occlusion, ipsilateral extracranial carotid artery occlusions or near-occlusions pose a significant hurdle in endovascular management of acute ischaemic stro...

    Authors: Henrik Steglich-Arnholm, Markus Holtmannspötter, Christian Gluud and Derk Wolfgang Krieger
    Citation: Systematic Reviews 2016 5:208
  8. Behavioural support for smoking cessation in pregnancy can be effective; however, many pregnant women face barriers to seeking support to stop smoking. Some digital interventions have been found to be effectiv...

    Authors: Sarah Ellen Griffiths, Katherine E. Brown, Emily Anne Fulton, Ildiko Tombor and Felix Naughton
    Citation: Systematic Reviews 2016 5:207
  9. It is believed increasingly that patients with severe Crohn’s disease are best treated early with biological therapy, which may ameliorate subsequent disease course and diminish long-term complications. Howeve...

    Authors: Steve Halligan, Darren Boone, Gauraang Bhatnagar, Tariq Ahmad, Stuart Bloom, Manuel Rodriguez-Justo, Stuart A. Taylor and Susan Mallett
    Citation: Systematic Reviews 2016 5:206
  10. Converging evidence demonstrates the important role of the neuropeptide hormone oxytocin (OT) in human behaviour and cognition. Intranasal OT administration has been shown to improve several aspects of social ...

    Authors: Daniel S. Quintana, Tim Outhred, Lars T. Westlye, Gin S. Malhi and Ole A. Andreassen
    Citation: Systematic Reviews 2016 5:205
  11. Despite the growing international interest in patient safety as a discipline, there has been a lack of exploration of its application to mental health. It cannot be assumed that findings based upon physical he...

    Authors: Danielle D’Lima, Stephanie Archer, Bethan Ines Thibaut, Sonny Christian Ramtale, Lindsay H. Dewa and Ara Darzi
    Citation: Systematic Reviews 2016 5:203
  12. Mental contrasting is a self-regulation strategy that is required for strong goal commitment. In mental contrasting, individuals firstly imagine a desired future or health goal that contrasted with the reality...

    Authors: Ainslea Cross and David Sheffield
    Citation: Systematic Reviews 2016 5:201
  13. Delirium is a syndrome characterized by acute fluctuations and alterations in attention and arousal. Critically ill patients are at particularly high risk, and those that develop delirium are more likely to ex...

    Authors: Jennifer Foster, Lisa D. Burry, Lehana Thabane, Karen Choong, Kusum Menon, Mark Duffett, Alexandra Cheung, Melanie Guenette, Timothy Chimunda and Louise Rose
    Citation: Systematic Reviews 2016 5:199
  14. Systematic reviews offer the most reliable and valid support for health policy decision-making, patient information, and guideline development. However, they are labor intensive and frequently take longer than...

    Authors: Barbara Nussbaumer-Streit, Irma Klerings, Gernot Wagner, Viktoria Titscher and Gerald Gartlehner
    Citation: Systematic Reviews 2016 5:197
  15. Data abstraction, a critical systematic review step, is time-consuming and prone to errors. Current standards for approaches to data abstraction rest on a weak evidence base. We developed the Data Abstraction ...

    Authors: Ian J. Saldanha, Christopher H. Schmid, Joseph Lau, Kay Dickersin, Jesse A. Berlin, Jens Jap, Bryant T. Smith, Simona Carini, Wiley Chan, Berry De Bruijn, Byron C. Wallace, Susan M. Hutfless, Ida Sim, M. Hassan Murad, Sandra A. Walsh, Elizabeth J. Whamond…
    Citation: Systematic Reviews 2016 5:196
  16. Novel psychoactive substances (NPS) are new narcotic or psychotropic drugs that are not controlled by the United Nations drug convention that may pose a serious public health threat due to their wide availabil...

    Authors: Salma M. Khaled, Elizabeth Hughes, Dan Bressington, Monica Zolezzi, Ahmed Radwan, Ashish Badnapurkar and Richard Gray
    Citation: Systematic Reviews 2016 5:195
  17. Critically ill patients frequently experience severe agitation placing them at risk of harm. Physical restraint is common in intensive care units (ICUs) for clinician concerns about safety. However, physical r...

    Authors: Louise Rose, Craig Dale, Orla M. Smith, Lisa Burry, Glenn Enright, Dean Fergusson, Samir Sinha, Lesley Wiesenfeld, Tasnim Sinuff and Sangeeta Mehta
    Citation: Systematic Reviews 2016 5:194
  18. Traumatic brain injury (TBI) is a worldwide leading cause of mortality and disability. Among TBI complications, agitation is a frequent behavioural problem. Agitation causes potential harm to patients and care...

    Authors: David R. Williamson, Anne Julie Frenette, Lisa Burry, Marc M. Perreault, Emmanuel Charbonney, François Lamontagne, Marie-Julie Potvin, Jean-François Giguère, Sangeeta Mehta and Francis Bernard
    Citation: Systematic Reviews 2016 5:193
  19. Complex or heterogeneous data pose challenges for systematic review and meta-analysis. In recent years, a number of new methods have been developed to meet these challenges. This qualitative interview study ai...

    Authors: Theo Lorenc, Lambert Felix, Mark Petticrew, G J Melendez-Torres, James Thomas, Sian Thomas, Alison O’Mara-Eves and Michelle Richardson
    Citation: Systematic Reviews 2016 5:192
  20. Websites and online resources outside academic bibliographic databases can be significant sources for identifying literature, though there are challenges in searching and managing the results. These are pertin...

    Authors: Claire Stansfield, Kelly Dickson and Mukdarut Bangpan
    Citation: Systematic Reviews 2016 5:191
  21. Overviews of reviews (overviews) compile data from multiple systematic reviews to provide a single synthesis of relevant evidence for decision-making. Despite their increasing popularity, there is limited meth...

    Authors: Michelle Pollock, Ricardo M. Fernandes, Lorne A. Becker, Robin Featherstone and Lisa Hartling
    Citation: Systematic Reviews 2016 5:190
  22. Amphetamine and methamphetamine use disorders are associated with severe health and social consequences. No pharmacological therapy has been approved for the treatment of these disorders. Psychostimulants can ...

    Authors: Meha Bhatt, Laura Zielinski, Lola Baker-Beal, Neera Bhatnagar, Natalia Mouravska, Phillip Laplante, Andrew Worster, Lehana Thabane and Zainab Samaan
    Citation: Systematic Reviews 2016 5:189
  23. In the absence of existing data, the present review intends to determine the incidence, prevalence and/or genetic determinants of neonatal diabetes mellitus (NDM), with expected contribution to disease charact...

    Authors: Jobert Richie N. Nansseu, Suzanne S. Ngo-Um and Eric V. Balti
    Citation: Systematic Reviews 2016 5:188
  24. Estimates of the burden of antimicrobial resistance (AMR) are needed to ascertain AMR impact, to evaluate interventions, and to allocate resources efficiently. Recent studies have estimated health, cost, and e...

    Authors: Nichola R. Naylor, Sachin Silva, Kavian Kulasabanathan, Rifat Atun, Nina Zhu, Gwenan M. Knight and Julie Robotham
    Citation: Systematic Reviews 2016 5:187
  25. The prevalence of knee osteoarthritis (OA)/degenerative joint disease (DJD) is increasing in the USA. Systematic reviews of treatment efficacy and adverse events (AEs) of hyaluronic acid (HA) injections report...

    Authors: Claire E. O’Hanlon, Sydne J. Newberry, Marika Booth, Sean Grant, Aneesa Motala, Margaret A. Maglione, John D. FitzGerald and Paul G. Shekelle
    Citation: Systematic Reviews 2016 5:186
  26. Policymakers and healthcare stakeholders are increasingly seeking evidence to inform the policymaking process, and often use existing or commissioned systematic reviews to inform decisions. However, the method...

    Authors: Chantelle Garritty, Adrienne Stevens, Gerald Gartlehner, Valerie King and Chris Kamel
    Citation: Systematic Reviews 2016 5:184
  27. The management of osteoarthritis (OA) is unsatisfactory, as most treatments are not clinically effective over placebo and most drugs have considerable side effects. On average, 75 % of the analgesic effect fro...

    Authors: Yu Fu, Monica S. M. Persson, Archan Bhattacharya, Siew-Li Goh, Joanne Stocks, Marienke van Middelkoop, Sita M. A. Bierma-Zeinstra, David Walsh, Michael Doherty and Weiya Zhang
    Citation: Systematic Reviews 2016 5:183
  28. Colorectal cancer represents the fourth most common cancer in England and Wales; survival is high for early stage disease but declines sharply with advanced stage. UK figures suggest that cancer survival rates...

    Authors: Ella Mozdiak, Alexander Tsertsvadze, Michael McFarlane, Monika Widlak, Maria Tabuso, Amber Dunlop and Ramesh Arasaradnam
    Citation: Systematic Reviews 2016 5:182
  29. Chinese herbal medicine has been used to treat hypertension in China and East Asia since centuries. In this study, we conduct an overview of systematic reviews of Chinese herbal medicine in the treatment of pr...

    Authors: Zhao Xinke, Li Yingdong, Feng Mingxia, Liu Kai, Chen Kaibing, Lu Yuqing, Sun Shaobo, Song Peng and Liu Bin
    Citation: Systematic Reviews 2016 5:180
  30. In 2013, there was a shortage of approximately 7.2 million health workers worldwide, which is larger among family physicians than among specialists. eLearning could provide a potential solution to some of thes...

    Authors: Živa Cotič, Rebecca Rees, Petra A. Wark and Josip Car
    Citation: Systematic Reviews 2016 5:179
  31. mLearning is increasingly presented as an attractive novel educational strategy for medical and nursing education. Yet, evidence base for its effectiveness or factors which influence use, success, implementati...

    Authors: Charmaine Krishnasamy, Sik Yin Ong, Yvonne Yock, Issac Lim, Rebecca Rees and Josip Car
    Citation: Systematic Reviews 2016 5:178
  32. Cluster randomised trials (CRTs) are a key instrument to evaluate public health interventions, particularly in low- and middle-income countries (LMICs). Fidelity assessment examines study processes to gauge wh...

    Authors: Myriam Cielo Pérez, Nanor Minoyan, Valéry Ridde, Marie-Pierre Sylvestre and Mira Johri
    Citation: Systematic Reviews 2016 5:177
  33. Telemedicine applications aim to address variance in clinical outcomes and increase access to specialist expertise. Despite widespread implementation, there is little robust evidence about cost-effectiveness, ...

    Authors: Nicola Mackintosh, Marius Terblanche, Ritesh Maharaj, Andreas Xyrichis, Karen Franklin, Jamie Keddie, Emily Larkins, Anna Maslen, James Skinner, Samuel Newman, Joana Hiew De Sousa Magalhaes and Jane Sandall
    Citation: Systematic Reviews 2016 5:176
  34. Resource and geographic barriers are the commonly cited constraints preventing the uptake of psychological treatment for chronic pain management. For adults, there is some evidence to support the use of inform...

    Authors: Angeline Traynor, Eimear Morrissey, Jonathan Egan and Brian E. McGuire
    Citation: Systematic Reviews 2016 5:175
  35. Journal abstracts including those reporting systematic reviews (SR) should contain sufficiently clear and accurate information for adequate comprehension and interpretation. The aim was to compare the quality ...

    Authors: Jean Joel R. Bigna, Lewis N. Um and Jobert Richie N. Nansseu
    Citation: Systematic Reviews 2016 5:174
  36. Failure to successfully implement and sustain change over the long term continues to be a major problem in health and social care. Translating evidence into routine clinical practice is notoriously complex, an...

    Authors: Stephan U. Dombrowski, Pauline Campbell, Helen Frost, Alex Pollock, Julie McLellan, Steve MacGillivray, Anna Gavine, Margaret Maxwell, Ronan O’Carroll, Helen Cheyne, Justin Presseau and Brian Williams
    Citation: Systematic Reviews 2016 5:173
  37. Overviews of methods are potentially useful means to increase clarity and enhance collective understanding of specific methods topics that may be characterized by ambiguity, inconsistency, or a lack of compreh...

    Authors: Stephen J. Gentles, Cathy Charles, David B. Nicholas, Jenny Ploeg and K. Ann McKibbon
    Citation: Systematic Reviews 2016 5:172
  38. Given limited resources and time constraints, the use of existing systematic reviews (SR) for the development of evidence-based public health recommendations has become increasingly important. Recently, a five...

    Authors: Thomas Harder, Cornelius Remschmidt, Sebastian Haller, Tim Eckmanns and Ole Wichmann
    Citation: Systematic Reviews 2016 5:171
  39. Western publicly funded health care systems increasingly rely on interdisciplinary teams to support primary care delivery and management of chronic conditions. This knowledge synthesis focuses on what is known...

    Authors: W. Dominika Wranik, Jill A. Hayden, Sheri Price, Robin M.N. Parker, Susan M. Haydt, Jeanette M. Edwards, Esther Suter, Alan Katz, Liesl L. Gambold and Adrian R. Levy
    Citation: Systematic Reviews 2016 5:170
  40. Distinguishing hydatidiform moles (HMs) from non-molar specimens and the subclassification of HM are important because complete hydatidiform mole (CHM) is associated with an increased risk of gestational troph...

    Authors: Jose Mauro Madi, Antonio Rodrigues Braga, Machline Paim Paganella, Isnard Elman Litvin and Eliana Márcia Da Ros Wendland
    Citation: Systematic Reviews 2016 5:169
  41. Approximately half of new invasive breast cancer cases diagnosed each year in the United States occur among women aged 65 years and older. The increasing life expectancy coupled with the attendant rise in brea...

    Authors: Joshua Demb, Isabel Allen and Dejana Braithwaite
    Citation: Systematic Reviews 2016 5:168
  42. NHS England’s Five Year Forward View (NHS England, Five Year Forward View, 2014) formally introduced a strategy for new models of care driven by simultaneous pressures to contain costs, improve care and delive...

    Authors: Alison Turner, Abeda Mulla, Andrew Booth, Shiona Aldridge, Sharon Stevens, Fraser Battye and Peter Spilsbury
    Citation: Systematic Reviews 2016 5:167
  43. Life-long specialized care is of the utmost importance to safeguard longevity as well as the quality of life in children diagnosed with a chronic condition (CC). Provision of life-long care, however, infers tr...

    Authors: Mariela Acuña Mora, Philip Moons, Carina Sparud-Lundin, Ewa-Lena Bratt and Eva Goossens
    Citation: Systematic Reviews 2016 5:166
  44. Pain is the most troubling issue to patients with osteoarthritis (OA), yet current pharmacological treatments offer only small-to-moderate pain reduction. Current guidelines therefore emphasise the need to ide...

    Authors: Monica S. M. Persson, Yu Fu, Archan Bhattacharya, Siew-Li Goh, Marienke van Middelkoop, Sita M. A. Bierma-Zeinstra, David Walsh, Michael Doherty and Weiya Zhang
    Citation: Systematic Reviews 2016 5:165

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    Journal Impact Factor: 6.3
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    Source Normalized Impact per Paper (SNIP): 1.919
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