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  1. Antidepressant medicines are used to manage symptoms of low back pain. The efficacy, acceptability, and safety of antidepressant medicines for low back pain (LBP) are not clear. We aimed to evaluate the effica...

    Authors: Michael C. Ferraro, Matthew K. Bagg, Michael A. Wewege, Aidan G. Cashin, Hayley B. Leake, Rodrigo R. N. Rizzo, Matthew D. Jones, Sylvia M. Gustin, Richard Day, Colleen K. Loo and James H. McAuley
    Citation: Systematic Reviews 2021 10:62
  2. Childhood hypertension is a growing public health problem. Simultaneously, hypovitaminosis D is widespread in this population and could be associated with hypertension. This study systematically reviewed the l...

    Authors: Myriam Abboud, Fatme Al Anouti, Dimitrios Papandreou, Rana Rizk, Nadine Mahboub and Suzan Haidar
    Citation: Systematic Reviews 2021 10:60
  3. Globally, very preterm birth is a health concern leading to various developmental difficulties such as poor motor and/or cognitive function. For infants born very preterm, family-centered care (FCC) might prom...

    Authors: Manasa Kolibylu Raghupathy, Bhamini Krishna Rao, Shubha R. Nayak, Alicia J. Spittle and Shradha S. Parsekar
    Citation: Systematic Reviews 2021 10:59
  4. The relationship between cancer with overweight and obesity has been extensively reported. However, the association between urinary cancers with these risk factors remains unclear, with existing reports showin...

    Authors: Jiyuan Shi, Liang Zhao, Ya Gao, Mingming Niu, Meili Yan, Yamin Chen, Ziwei Song, Xueni Ma, Peng Wang and Jinhui Tian
    Citation: Systematic Reviews 2021 10:58
  5. Obstructed labor accounted for 22% of obstetrical complications and 9% of all maternal deaths in low- and middle-income countries. Even though there are separate studies regarding obstructed labor and its comp...

    Authors: Yordanos Gizachew Yeshitila, Melaku Desta and Abraham Kebede
    Citation: Systematic Reviews 2021 10:57
  6. High tibial osteotomy (HTO) has been used for over 60 years in clinical practice and mainly comprises two major techniques: closed wedge high tibial osteotomy (CWHTO) and open wedge high tibial osteotomy (OWHT...

    Authors: Mingliang He, Xihong Zhong, Zhong Li, Kun Shen and Wen Zeng
    Citation: Systematic Reviews 2021 10:56
  7. The scale-up of evidence-based innovations is required to reduce waste and inequities in health and social services (HSS). However, it often tends to be a top-down process initiated by policy makers, and the v...

    Authors: Ali Ben Charif, Karine V. Plourde, Sabrina Guay-Bélanger, Hervé Tchala Vignon Zomahoun, Amédé Gogovor, Sharon Straus, Ron Beleno, Kathy Kastner, Robert K. D. McLean, Andrew J. Milat, Luke Wolfenden, Jean-Sébastien Paquette, Friedemann Geiger and France Légaré
    Citation: Systematic Reviews 2021 10:55
  8. People living with human immunodeficiency virus (PLHIV) struggle with the challenges of living with a chronic disease and integrating antiretroviral treatment (ART) and care into their daily lives. The aims of...

    Authors: Lynn Hendricks, Ingrid Eshun-Wilson and Anke Rohwer
    Citation: Systematic Reviews 2021 10:54
  9. Chronic pain is a common public health problem with negative consequences for individuals and societies. Fortunately, interdisciplinary chronic pain management has been shown to be effective for improving pati...

    Authors: Hervé Tchala Vignon Zomahoun, Regina Visca, Nicole George and Sara Ahmed
    Citation: Systematic Reviews 2021 10:53
  10. Physical inactivity is one of the major risk factors for non-communicable diseases. This systematic review and meta-analysis aimed to assess the effects of educational interventions on promoting regular physic...

    Authors: Babak Moeini, Forouzan Rezapur-Shahkolai, Saeed Bashirian, Amin Doosti-Irani, Maryam Afshari and Azam Geravandi
    Citation: Systematic Reviews 2021 10:52
  11. Coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 strain, was first identified in late 2019 in China. The outcomes of patients affected by the virus can worsen, deve...

    Authors: Marcela Larissa Costa, Carlos Adriano Santos Souza, Ana Caroline Cardoso Silva, Dayane Franciely Conceição Santos, Edilene Fernandes Nonato, Francismayne Batista Santana, Giselle dos Santos Dias, Jessyca Teles Barreto, Laís Santos Costa, Maria Carolina Barros Costa, Tamila das Neves Ferreira, Jeniffer Santos Santana, Raquel Simões Mendes-Netto, Tereza Virgínia Silva Bezerra do Nascimento, Marco Antônio Prado Nunes and Márcia Ferreira Cândido de Souza
    Citation: Systematic Reviews 2021 10:51
  12. Depression is one of the most prevalent mental disorders among an estimated 25.6 million people living with HIV (PLHIV) in sub-Saharan Africa (SSA). The depression rate is higher in HIV-seropositive men who ha...

    Authors: Delarise M. Mulqueeny, Senzelokuhle M. Nkabini and Manduleli H. Pokiya
    Citation: Systematic Reviews 2021 10:50
  13. Psychosocial health issues such as depression and social isolation are an important cause of morbidity and premature mortality for older adults and people with dementia. Social robots are promising technologic...

    Authors: Wei Qi Koh, Simone Anna Felding, Elaine Toomey and Dympna Casey
    Citation: Systematic Reviews 2021 10:49
  14. The COVID-19 pandemic is creating severe issues for healthcare and broad social structures, exposing societal vulnerabilities. Among the populations affected by COVID-19 are people engaged in substance use, su...

    Authors: Navin Kumar, Kamila Janmohamed, Kate Nyhan, Silvia S. Martins, Magdalena Cerda, Deborah Hasin, Jenny Scott, Richard Pates, Lilian Ghandour, Mayyada Wazaify and Kaveh Khoshnood
    Citation: Systematic Reviews 2021 10:48
  15. More than 75% of patients presenting to the Emergency Department are suffering symptoms of pain. Despite this, 67% will not receive any analgesia. Methoxyflurane is a fluorinated hydrocarbon gas which has anal...

    Authors: Michael M. Eager, Grant S. Nolan, Kathryn Tonks, Anoopama Ramjeeawon and Natalie Taylor
    Citation: Systematic Reviews 2021 10:47
  16. Of the 15–20% of youth in North America affected by a chronic health condition (e.g., type 1 diabetes, cystic fibrosis) and/or mental health or neurodevelopmental disorder (e.g., depression, eating disorder, A...

    Authors: Kyleigh Schraeder, Brooke Allemang, Cathie Scott, Kerry McBrien, Gina Dimitropoulos, Ashley Felske and Susan Samuel
    Citation: Systematic Reviews 2021 10:46
  17. Dental and oral health workers have direct contact with respiratory aerosols of patients during procedures. This study aimed to determine the main concerns of dental and oral health workers globally during COV...

    Authors: Peivand Bastani, Mohammadtaghi Mohammadpour, Arash Ghanbarzadegan, Kostas Kapellas and Loc Giang Do
    Citation: Systematic Reviews 2021 10:45
  18. In recent years, we have seen the incorporation of magnetic resonance imaging (MRI) simulators into radiotherapy centres and the emergence of the new technology of MR linacs. However, the significant health ca...

    Authors: Sarah Elliott, Alexandra Berlangieri, Jason Wasiak, Michael Chao and Farshad Foroudi
    Citation: Systematic Reviews 2021 10:44
  19. Cancer patients are particularly vulnerable to COVID-19, partially owing to their compromised immune systems and curbed or cut cancer healthcare services caused by the pandemic. As a result, cancer caregivers ...

    Authors: Zhaohui Su, Dean McDonnell, Bin Liang, Jennifer Kue, Xiaoshan Li, Sabina Šegalo, Shailesh Advani, Bertha E. Flores and Jing Wang
    Citation: Systematic Reviews 2021 10:43
  20. Healthcare settings are complex, and the decision-making process is usually complicated, too. Precise use of best evidence from different sources for increasing the desired outcomes is the result of EBM. There...

    Authors: Tahereh Shafaghat, Mohammad Hasan Imani Nasab, Mohammad Amin Bahrami, Zahra Kavosi, Mahsa Roozrokh Arshadi Montazer, Mohammad Kazem Rahimi Zarchi and Peivand Bastani
    Citation: Systematic Reviews 2021 10:42
  21. Mental health problems are common in the working population and represent a growing concern internationally, with potential impacts on workers, organisations, workplace health and compensation authorities, lab...

    Authors: Charlotte Paterson, Caleb Leduc, Margaret Maxwell, Birgit Aust, Benedikt L. Amann, Arlinda Cerga-Pashoja, Evelien Coppens, Chrisje Couwenbergh, Cliodhna O’Connor, Ella Arensman and Birgit A. Greiner
    Citation: Systematic Reviews 2021 10:41
  22. Inflammation scores based on general inflammation markers as leucocyte count or C-reactive protein have been evaluated as prognostic markers of inferior survival in several cancers. In small cell lung cancer (...

    Authors: Anne Winther-Larsen, Ninna Aggerholm-Pedersen and Birgitte Sandfeld-Paulsen
    Citation: Systematic Reviews 2021 10:40
  23. Literature searches underlie the foundations of systematic reviews and related review types. Yet, the literature searching component of systematic reviews and related review types is often poorly reported. Gui...

    Authors: Melissa L. Rethlefsen, Shona Kirtley, Siw Waffenschmidt, Ana Patricia Ayala, David Moher, Matthew J. Page and Jonathan B. Koffel
    Citation: Systematic Reviews 2021 10:39
  24. Systematic reviews involve searching multiple bibliographic databases to identify eligible studies. As this type of evidence synthesis is increasingly pursued, the use of various electronic platforms can help ...

    Authors: Sandra McKeown and Zuhaib M. Mir
    Citation: Systematic Reviews 2021 10:38
  25. Global responses to the COVID-19 pandemic have exposed and exacerbated existing socioeconomic and health inequities that disproportionately affect the sexual health and well-being of many populations, includin...

    Authors: Navin Kumar, Kamila Janmohamed, Kate Nyhan, Laura Forastiere, Wei-Hong Zhang, Anna Kågesten, Maximiliane Uhlich, Sarah M. Van de Velde, Joel M. Francis, Jennifer T. Erausquin, Elin C. Larsson, Denton Callander, John Scott, Victor Minichiello and Joseph D. Tucker
    Citation: Systematic Reviews 2021 10:37
  26. Preoperative anemia is a common comorbidity that often necessitates allogeneic blood transfusion (ABT). As there is a risk associated with blood transfusions, preoperative intravenous iron (IV) has been propos...

    Authors: Abdelsalam M. Elhenawy, Steven R. Meyer, Sean M. Bagshaw, Roderick G. MacArthur and Linda J. Carroll
    Citation: Systematic Reviews 2021 10:36
  27. Chimeric antigen receptor (CAR) T cell therapy has had great success in treating patients with relapsed or refractory B cell malignancies, with CD19-targeting therapies now approved in many countries. However,...

    Authors: Komal Adeel, Nathan J. Fergusson, Risa Shorr, Harold Atkins and Kevin A. Hay
    Citation: Systematic Reviews 2021 10:35
  28. All individuals should have the right to engage meaningfully in occupations that meet their aspirations and life goals as well as promote their health and well-being. For individuals with disability, meaningfu...

    Authors: Jacqueline Nhu Quynh Pho, Aidan Christopher Tan, Katrina Chaudhary, Sonia Hines, Caroline Ellison, Vivian Isaac and David Lim
    Citation: Systematic Reviews 2021 10:34
  29. A variety of public health interventions have been undertaken in low- and middle-income countries (LMICs) to prevent morbidity and mortality associated with household air pollution (HAP) due to cooking, heatin...

    Authors: Katherine E. Woolley, Emma Dickinson-Craig, Suzanne E. Bartington, Tosin Oludotun, Bruce Kirenga, Shelton T. Mariga, Telesphore Kabera, April Coombe, Francis D. Pope, Ajit Singh, William R. Avis, Rosie Day, David Warburton, Semira Manaseki-Holland, David J. Moore and G. Neil Thomas
    Citation: Systematic Reviews 2021 10:33
  30. Progressive language difficulties arise in many neurodegenerative conditions, causing significant impact upon patients and families. This occurs most obviously in primary progressive aphasia (PPA) but can also...

    Authors: Sharon A. Savage, Aida Suárez-González, Alice Cassani, Ragaviveka Gopalan and Joshua Stott
    Citation: Systematic Reviews 2021 10:32
  31. Malaria is the most common vector-borne disease transmitted to humans by Anopheles mosquitoes. Endectocides and especially ivermectin will be available as a vector control tool soon. The current review could be v...

    Authors: Fereshteh Ghahvechi Khaligh, Abbas Jafari, Elena Silivanova, Mikhail Levchenko, Bahlol Rahimi and Saber Gholizadeh
    Citation: Systematic Reviews 2021 10:30
  32. Despite the extensive research that has been conducted to date, practice often differs from established guidelines and will vary between individuals and organisations. It has been noted that the global uptake ...

    Authors: Sarah Hassan, Vincent Chan, Julie Stevens and Ieva Stupans
    Citation: Systematic Reviews 2021 10:29
  33. Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. To decrease the high case fatality rates and morbidity for sepsis and septic shock, there is a need to increa...

    Authors: Ivana Pepic, Robert Feldt, Lars Ljungström, Richard Torkar, Daniel Dalevi, Hanna Maurin Söderholm, Lars-Magnus Andersson, Marina Axelson-Fisk, Katarina Bohm, Bengt Arne Sjöqvist and Stefan Candefjord
    Citation: Systematic Reviews 2021 10:28
  34. Vision loss due to diabetic retinopathy can largely be prevented or delayed through treatment. Patients with vision-threatening diabetic retinopathy are typically offered laser or intravitreal injections which...

    Authors: Covadonga Bascaran, Nyawira Mwangi, Fabrizio D’Esposito, Charles Cleland, Iris Gordon, Juan Alberto Lopez Ulloa, Ranad Maswadi, Shaffi Mdala, Jacqueline Ramke, Jennifer R. Evans and Matthew Burton
    Citation: Systematic Reviews 2021 10:27
  35. Phantom limb pain (PLP) is a prevalent problem for children after amputation because of the chemotherapy treatment. Gabapentin is a potential option to manage PLP after amputation in pediatric oncology. Howeve...

    Authors: Shuang Jiang, Meng-meng Zhou, Rong Xia, Jing-hui Bai and Li-hui Yan
    Citation: Systematic Reviews 2021 10:26
  36. Telephone-based digital triage is widely used by services that provide urgent care. This involves a call handler or clinician using a digital triage tool to generate algorithm-based care advice, based on a pat...

    Authors: Vanashree Sexton, Jeremy Dale and Helen Atherton
    Citation: Systematic Reviews 2021 10:25
  37. Major depressive disorder is common, debilitating, and affects feelings, thoughts, mood, and behaviors. Childhood and adolescence are critical periods for the development of depression and adolescence is marke...

    Authors: Andrew Beck, John C. LeBlanc, Kate Morissette, Candyce Hamel, Becky Skidmore, Heather Colquhoun, Eddy Lang, Ainsley Moore, John J. Riva, Brett D. Thombs, Scott Patten, Heather Bragg, Ian Colman, Gary S. Goldfield, Stuart Gordon Nicholls, Kathleen Pajer…
    Citation: Systematic Reviews 2021 10:24
  38. Structural stigma in health systems experienced by consumers diagnosed with Borderline Personality Disorder (BPD) is a widespread phenomenon that causes major health inequities and harm for this population. St...

    Authors: Pauline Klein, Alicia Kate Fairweather, Sharon Lawn, Helen Margaret Stallman and Paul Cammell
    Citation: Systematic Reviews 2021 10:23
  39. Cardiac surgery is becoming increasingly common in older, more vulnerable adults. A focus on timely and complete medical and functional recovery has led to the development of enhanced recovery protocols (ERPs)...

    Authors: Nebojša Oravec, Rakesh C. Arora, Brian Bjorklund, April Gregora, Caroline Monnin, Todd A. Duhamel, David E. Kent, Annette S. H. Schultz and Anna M. Chudyk
    Citation: Systematic Reviews 2021 10:22
  40. Sexual risk, substance use, and mental ill health constitute a syndemic of co-occurring, mutually reinforcing epidemics amongst men who have sex with men (MSM). Developed since 1995, e-health interventions off...

    Authors: Rebecca Meiksin, G. J. Melendez-Torres, Jane Falconer, T. Charles Witzel, Peter Weatherburn and Chris Bonell
    Citation: Systematic Reviews 2021 10:21
  41. Chronic obstructive pulmonary disease (COPD) is increasingly contributing to the disease burden in South Asia. This review will summarize the prevalence and risk factors of COPD in South Asia and the intervent...

    Authors: Rafiqul Islam, Md. Tarek Hossain, Nantu Chakma, Afroza Khanom, Tapas Mazumder and Md. Tauhidul Islam
    Citation: Systematic Reviews 2021 10:20
  42. Culture influences nurses’ attitudes towards caring for older adults. Additionally, nursing students’ perceptions and attitudes towards older adults affect their behavior, possibly their career choices and/or ...

    Authors: Esther L. Wanko Keutchafo, Jane Kerr, Mary A. Jarvis and Desmond Kuupiel
    Citation: Systematic Reviews 2021 10:19
  43. An estimated 20–30% of community-dwelling Canadian adults aged 65 years or older experience one or more falls each year. Fall-related injuries are a leading cause of hospitalization and can lead to functional ...

    Authors: Jennifer Pillay, John J. Riva, Laure A. Tessier, Heather Colquhoun, Eddy Lang, Ainsley E. Moore, Brett D. Thombs, Brenda J. Wilson, Amanda Tzenov, Catherine Donnelly, Marcel Émond, Jayna Holroyd-Leduc, Jamie Milligan, Diana Keto-Lambert, Sholeh Rahman, Ben Vandermeer…
    Citation: Systematic Reviews 2021 10:18
  44. The purpose of this study was to comprehensively assess the heterogeneity of procedures in the diagnostic guidelines for acute pancreatitis and to identify gaps limiting knowledge in diagnosing this disease.

    Authors: Ke-Qian Yi, Ting Yang, Yan-Min Yang, Guo-Li Lan, Li-Ya An, Yu-Xing Qi, Hong-Bo Fan, Yong-Qing Duan and Da-Li Sun
    Citation: Systematic Reviews 2021 10:17
  45. The increasingly rapid rate of evidence publication has made it difficult for evidence synthesis—systematic reviews and health guidelines—to be continually kept up to date. One proposed solution for this is th...

    Authors: Anneliese Arno, Julian Elliott, Byron Wallace, Tari Turner and James Thomas
    Citation: Systematic Reviews 2021 10:16
  46. Sexual orientation and gender identity and expression change efforts (SOGIECE) are a set of scientifically discredited practices that aim to deny and suppress the sexual orientations, gender identities, and/or...

    Authors: David J. Kinitz, Travis Salway, Elisabeth Dromer, Dean Giustini, Florence Ashley, Trevor Goodyear, Olivier Ferlatte, Hannah Kia and Alex Abramovich
    Citation: Systematic Reviews 2021 10:14
  47. Knowledge translation (KT) theories, frameworks, and models (TFMs) can help guide and explain KT processes, and facilitate the evaluation of implementation outcomes. They play a critical role in conducting KT ...

    Authors: Junqiang Zhao, Xuejing Li, Lijiao Yan, Yamei Yu, Jiale Hu, Shelly-Anne Li and Wenjun Chen
    Citation: Systematic Reviews 2021 10:13

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