Table 2 Adverse effects of antibiotic therapy

Penicillin

Jarisch–Herxheimer reaction [25]

1

38

2.6%

Rash [30]

1

87

1.1%

Asthenia [32]

70

112

62.5%

Dark urine [32]

66

112

58.9%

Abdominal pain [32]

71

112

63.4%

Epigastric pain [32]

27

112

24.1%

Hypotension [32]

22

112

19.6%

Malaise [32]

14

112

12.5%

Nausea [32]

40

112

35.7%

Oliguria [32]

42

112

37.5%

Pallor [32]

52

112

46.4%

Conjunctival suffusion [32]

25

112

22.3%

Dizziness [32]

23

112

20.5%

Cough [32]

41

112

36.9%

Doxycycline

Nausea [31]

3

145

2.1%

Vomiting [31]

22

145

15.2%

Nausea and vomiting [31]

10

145

6.9%

Diarrhea [31]

1

145

0.7%

Abdominal pain [31]

1

145

0.7%

Rash [31]

1

145

0.7%

Dizziness [31]

2

145

1.4%

Adverse effects or Jarisch–Herxheimer reaction [23]

0

14

0%

Azithromycin

Nausea [31]

1

151

0.7%

Vomiting [31]

10

151

6.6%

Nausea and vomiting [31]

1

151

0.7%

Diarrhea [31]

1

151

0.7%

Rash [31]

3

151

2.0%