Table 3 Subgroup analysis of different ages

ORR at 3m

< 18 years old

6

167/281

1.72

[1.14, 2.59]

0.01

0.239

0

0.82

≥ 18 years old

2

78/78

2.90

[1.21, 6.99]

0.02

12

0.29

Unlimited

2

133/175

2.23

[0.96, 5.20]

0.06

66

0.08

ORR at 6 months

< 18 years old

7

176/297

1.49

[0.97, 2.28]

0.07

0.071

0

0.44

≥ 18 years old

3

126/112

2.39

[0.67, 8.46]

0.18

75

0.02

Unlimited

5

532/562

2.61

[1.97, 3.46]

< 0.00001

0

0.80

ORR at 12 months

< 18 years old

5

144/229

0.94

[0.60, 1.48]

0.79

0.260

0

0.82

≥ 18 years old

2

102/101

1.81

[0.49, 6.64]

0.37

70

0.07

Unlimited

0

–

–

–

–

–

–

CRR at 3 months

< 18 years old

6

167/281

2.55

[1.50, 4.35]

0.0006

0.639

0

0.89

≥ 18 years old

1

54/67

2.48

[0.78, 7.90]

–

–

0.12

Unlimited

2

133/175

3.72

[1.25, 11.07]

0.02

39

0.20

CRR at 6 months

< 18 years old

7

176/297

2.92

[1.51, 5.67]

0.002

0.841

50

0.06

≥ 18 years old

2

102/101

2.69

[1.29, 5.59]

0.008

0

0.78

Unlimited

5

532/562

2.87

[2.04, 4.04]

< 0.00001

23

0.27

CRR at 12 months

< 18 years old

5

144/229

1.22

[0.77, 1.94]

0.39

0.546

4

0.38

≥ 18 years old

2

102/101

1.92

[0.43, 8.52]

0.39

81

0.02

Unlimited

0

–

–

–

–

–

–