Efficacy of non-invasive brain stimulation combined with antidepressant medications for depression: a systematic review and meta-analysis of randomized controlled trials

Table 3 Meta-regression results

Variable	depression score
Variable	Coef (B)	95% CL	p
Clinical characteristics
Type of NIBS	0.79	-0.26 to 1.84	0.14
Total session	0.00	-0.05 to 0.05	0.92
Severity of depression
Major depression	-0.63	-2.55 to 1.27	0.51
Mild to moderate depressive	-0.15	-2.32 to 2.01	0.89
Moderate to severe depression	0.36	-2.67 to 3.38	0.82
Baseline score ^a	-0.03	-0.12 to 0.06	0.50
Class of antidepressant
SNRIs	-0.35	-2.60 to 189	0.76
SNRIs and NaSSAs	0.30	-2.51 to 312	0.83
SSRIs	-0.24	-2.36 to 1.89	0.83
SSRIs and SNRIs	-1.30	-3.78 to 1.18	0.31
TCAs	-3.97	-6.99 to -0.96	0.01*
Demographics
Sample size	0.00	-1.01 to 0.01	0.51
Age	0.00	-0.06 to 0.06	0.97
Female rate	-4.45	-8.37 to -0.6	0.02*

SNRIs Serotonin-norepinephrine reuptake inhibitors, NaSSAs Noradrenergic and specific serotonergic antidepressants TCAs Tricyclic Anti-depressive Agents
^aBaseline score was calculated by the weighted arithmetic mean of depression scores of NIBS and control groups. Each variable was analyzed separately in a meta-regression model, Coef (B) represents the regression coefficient of each linear regression, representing the slope of each model, 95% CI is the 95% confidence interval of the beta coefficient values
^*p < 0.05

ISSN: 2046-4053