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Table 2 Characteristics of NIBS treatment

From: Efficacy of non-invasive brain stimulation combined with antidepressant medications for depression: a systematic review and meta-analysis of randomized controlled trials

Authors, Years

Type of NIBS

Cortical target

mA /Hz (%MT)

NIBS treatment protocol

N session (weeks)

Burkhardt 2023 [16]

tDCS

Anode:LDLPFC Cathode: RDLPFC

2 mA

A current with an intensity 2 mA and a 30 s ramp­down phase delivered for 30 min

24 (6w)

Kumari 2023 [15]

tDCS

Anode:LDLPFC Cathode: RDLPFC

2 mA

A current with an intensity of 2 mA and ramp time of 20 s was delivered for 20 min

10 (2w)

Li 2022 [29]

tDCS

Anode:LDLPFC Cathode: RDLPFC

2 mA

A current with an intensity 2 mA and a 30 s ramp­down phase delivered for 30 min

10 (2w)

Pavlova 2018a [30]

tDCS

Anode:LDLPFC Cathode: RDLPFC

5 mA

A current with an intensity reduced 1 mA to 0.5 mA to compensate for smaller electrode size to keep current density constant delivered for 20 min

10 (2w)

Pavlova 2018b [30]

tDCS

Anode:LDLPFC Cathode: RDLPFC

5 mA

A current with an intensity reduced 1 mA to 0.5 mA to compensate for smaller electrode size to keep current density constant delivered for 30 min

10 (2w)

Zhang 2020 [31]

tDCS

Anode:LDLPFC Cathode: RDLPFC

2 mA

A current with an intensity 2 mA delivered for 20 min

48 (8w)

Bennabi 2014 [32]

tDCS

Anode:LDLPFC Cathode:contralateral supraorbital area

2 mA

A current with an intensity 2 mA delivered for 30 min

10 (1w)

Brunoni 2013 [33]

tDCS

Anode:LDLPFC Cathode: RDLPFC

2 mA

A current with an intensity 2 mA delivered for 30 min

12 (6w)

Pu 2023 [34]

rTMS

left DLPFC

10 Hz (120%)

Each train lastedasted 8 s with a 26s inter-train pause (800 pulses)

20 (8w)

Ma 2023 [35]

rTMS

left DLPFC

20 Hz

Each train lastedasted 2 s with a 30s inter-train pause (800 pulses)

30 (6w)

Akpinar 2022 [21]

rTMS

left DLPFC

10 Hz (110%)

Each train lastedasted 2.5 s with a 20s inter-train pause (2000 pulses)

10 (2w)

Zhang 2019 [36]

rTMS

left DLPFC

10 Hz (80%)

NR

40 (8w)

Wang 2017 [37]

rTMS

left DLPFC

10 Hz (80%)

Each train lasted 2 s with a 28-s inter-train pause (800 pulses)

20 (4w)

Ullrich 2012 [38]

rTMS

left DLPFC

30 Hz (110%)

Each train lastedasted 3 s with a 57s inter-train pause (1800 pulses)

15 (3w)

Huang 2012 [39]

rTMS

left DLPFC

10 Hz (90%)

Each train lastedasted 4 s with a 56s inter-train pause (800 pulses)

10 (2w)

Bretlau 2008 [40]

rTMS

left DLPFC

10 Hz (90%)

Each train lastedasted 8 s with a 52s inter-train pause (1289 pulses)

15 (3w)

Herwig 2007 [41]

rTMS

left DLPFC

10 Hz (110%)

Each train lastedasted 2s with a 8s inter-train pause (2000 pulses)

15 (3w)

Rossini 2005 [42]

rTMS

left DLPFC

10 Hz (100%)

Each train lastedasted 2 s with a 28s inter-train pause (900 pulses)

10 (2w)

Rumi 2005 [43]

rTMS

left DLPFC

10 Hz (120%)

Each train lasting 10 s, with 20-s interval (1250 pulses)

20 (4w)

  1. NR Not report, DLPFC The dorsolateral prefrontal cortex, MT Motor threshold, rTMS Repetitive transcranial magnetic stimulation, tDCS transcranial direct currentstimulation