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Table 3 MT treatment cycle and follow-up in pain

From: The effects of manual therapy in pain and safety of patients with knee osteoarthritis: a systematic review and meta-analysis

Author, year

Follow-up

Treatment (week)

Period

Effect

Description

Abbott, 2013 [30]

1 year

+

The improvements in pain and disability were evident at 9 weeks and sustained for a year.

9

Chiranthanut, 2014 [31]

NR

NR

NR

3

Dong, 2021 [32]

3-6 month

+-

Mild recurrence of symptoms and signs during follow-up time (22/105). No severe relapses seen

4

Feng, 2014 [33]

NR

NR

NR

4

Fitzgerald, 2016 [34]

1 year

-

MT may have some short term benefit.

9

Lai, 2020 [35]

NR

NR

NR

6

Liang, 2012 [36]

NR

NR

NR

3

Lin, 2018 [37]

1, 3 month

+

The 1-month and 3-month follow-ups were showed a more consistent treatment effect than after 4 weeks of treatment.

4

Liu, 2019 [38]

NR

NR

NR

8

Peng, 2018 [39]

6 month

+

At the 6-month follow-up after MT treatment, VAS scores were significantly lower compared with pre-treatment

4

Perlman, 2006 [40]

16 week

+

MT was largely sustained at the 16-week follow-up visit.

8

Perlman, 2012 [41]

16, 24week

+

MT showed improvements.

8

Qu, 2020 [42]

NR

NR

NR

4

Wu, 2015 [43]

NR

NR

NR

8

Xu, 2021 [44]

NR

NR

NR

4

Yao, 2018 [45]

NR

NR

NR

2

Yuan, 2018 [46]

NR

NR

NR

3

Zhang, 2014 [47]

NR

NR

NR

4

Zhang, 2018 [48]

NR

NR

NR

4

Yang, 2022 [49]

NR

NR

NR

1.5

Xu, 2022 [50]

NR

NR

NR

4

Ma, 2022 [51]

NR

NR

NR

4

Liu, 2022 [52]

NR

NR

NR

4

Liu, 2023 [53]

NR

NR

NR

4

Guo, 2022 [54]

16 week

NR

NR

8

  1. MT Manual therapy, NR Unreported; +: Satisfied; +-: Moderate; -: Not satisfied