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Table 1 GRADE summary of VAS for all comparisons among trials included

From: The effects of manual therapy in pain and safety of patients with knee osteoarthritis: a systematic review and meta-analysis

Comparisons

Assessment time

Studies

Effect estimate* (95% CI)

Participants

I 2 (%)

Quality of evidence

MT vs usual care

At the end of the intervention

Abbott (2013) [30]

Fitzgerald (2016) [34]

Perlman (2006) [40]

Perlman (2012) [41]

Liu (2023) [53]

Guo (2022) [54]

2.04 (0.94, 3.14)

500

96.30

Low

MT vs exercise

At the end of the intervention

Abbott (2013) [30]

Fitzgerald (2016) [34]

Liu (2022) [53]

Guo (2022) [54]

1.56 (0.41, 2.71)

421

96.20

Low

MT vs herb application

At the end of the intervention

Chiranthanut (2014) [31]

Dong (2021) [32]

Liu (2019) [38]

Qu (2020) [42]

0.04 (− 0.49, 0.57)

410

83.50

Low

MT vs oral analgesics

At the end of the intervention

Chiranthanut (2014) [31]

Xu (2021) [44]

Yao (2018) [45]

0.55 (− 0.08, 1.18)

197

77.50

Very low

MT vs acupuncture

At the end of the intervention

Liang (2012) [36]

Zhang (2018) [48]

Yang (2022) [49]

 − 0.53 (− 1.38, 0.33)

568

92.20

Low

MT vs intra-articular injection

At the end of the intervention

Peng (2018) [39]

Ma (2022) [51]

0.47 (− 0.91, 1.86)

172

94.20

Very low

MT vs moxibustion

At the end of the intervention

Lai (2020) [35]

N/A

40

N/A

Very low

MT vs cupping

At the end of the intervention

Xu (2022) [50]

N/A

68

N/A

Very low

  1. MT manual therapy, N/A not applicable