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Table 1 Characteristics of the included systematic review reports

From: Synthesis methods used to combine observational studies and randomised trials in published meta-analyses

Characteristic

Studies

N = 132

n (%)

Journal of publication

 Specialty

119 (90)

 General

33 (10)

Country

 Europe

44 (33)

 North America

32 (24)

 Middle/South America

1 (1)

 Australia

7 (5)

 Asia

48 (37)

 Africa

0 (0)

Type of intervention

 Pharmacological

51 (39)

 Non-pharmacological

81 (61)

 Primary studies included (median [IQR])

14 [9.0–26.0]

 Randomised controlled trials included (median [IQR])

5.0 [2.0–8.0]

 OSs included (median [IQR])

9. 0 [5.0–18.0]

Specific OS designs included

 Prospective cohort studies

17 (13)

 Retrospective cohort studies

13 (10)

 Case control studies

9 (7)

Were the different types of OSs analysed differently?

 Yes

8 (6)

 No

120 (91)

 Unclear

4 (3)

Was an evaluation of the risk of bias for primary studies provided?

 yes, with different tools for OSs and RCTs

79 (65)

 yes, with same tool for OSs and RCTs

33 (27)

 yes, for OSs only

8 (6)

 yes, for RCTs only

1 (1)

 No

11 (8)

  1. MA Meta-analysis, OSs Observational studies, RCTs Randomised controlled trials, RoB Risk of bias