Optimal drug regimens for improving ALP biochemical levels in patients with primary biliary cholangitis refractory to UDCA: a systematic review and Bayesian network meta-analysis

Lin, Wei; Wang, Jun-xi; Liu, Yi-juan

doi:10.1186/s13643-024-02460-0

Systematic Reviews

Table 2 Characteristics of included studies

From: Optimal drug regimens for improving ALP biochemical levels in patients with primary biliary cholangitis refractory to UDCA: a systematic review and Bayesian network meta-analysis

Study	Design	Treatment/control	Dose	ALP baseline levels (U/L)	Duration	Size
Corpechot 2018	RCT	BEF plus UDCA/UDCA	BEF: 400 mg per day; UDCA: 900–1500 mg per day	244/242	24 months	100
Hosonuma 2015	RCT	BEF plus UDCA/UDCA	BEF: 400 mg per day; UDCA: 600–900 mg per day	423/454	96 months	27
Takeuchi 2011	RCT	BEF plus UDCA/UDCA	BEF: 400 mg per day; UDCA: 600 mg per day	411/602	24 months	37
Iwasaki 2008	RCT	BEF plus UDCA/UDCA	BEF: 400 mg per day; UDCA: 600 mg per day	643/608	12 months	22
Itakura 2004	RCT	BEF plus UDCA/UDCA	BEF: 400 mg per day; UDCA: 600 mg per day	618/463	6 months	16
Kanda 2003	RCT	BEF plus UDCA/UDCA	BEF: 400 mg per day; UDCA: 600 mg per day	700/550	6 months	22
Nakai 2000	RCT	BEF plus UDCA/UDCA	BEF: 400 mg per day; UDCA: 600 mg per day	NA	12 months	23
Mayo 2018	RCT	Aldafermin plus UDCA/UDCA	NGM 282:0.3 mg or 3 mg per day; UDCA: 15 mg/kg per day	244/242	1 month	45
Nevens 2016	RCT	OCA plus UDCA/UDCA	OCA: 5 mg or 10 mg or per day; UDCA: 13–15 mg/kg per day	423/454	12 months	217
Hirschfield 2015	RCT	OCA plus UDCA/UDCA	OCA: 10 mg or 25 mg or 50 mg per day; UDCA: 15.6–16.3 mg/kg per day	294.4/290/286.9/275.2	3 months	165
Kjærgaard 2021	RCT	OCA + UDCA/UDCA	OCA: 5 mg or 10 mg per day; UDCA: Not mentioned	216	3 months	8
Cheung 2016	CS	FEF + UDCA/UDCA	FEF:200 mg per day; UDCA: 13–15 mg/kg per day	302/318	11 months	120
Liberopoulos 2010	CCS	FEF + UDCA/UDCA	FEF: 200 mg per day; UDCA: 600 mg per day	195/232	2 months	10
Li 2022	RCT	FEF + UDCA/UDCA	FEF: 200 mg per day; UDCA: 13–15 mg/kg per day	189.2/217.96	3 months	48
Wang 2022	CS	FEF + UDCA/UDCA	FEF: 200 mg per day; UDCA: 13–15 mg/kg per day	321.3/333.08	12 months	106
Dohmen 2013	CCS	BEF + UDCA/FEF + UDCA	BEF: 400 mg per day; FEF: 80 mg per day;	595.9/522.5	12 months	21
Hirschfield 2021	RCT	Budesonide + UDCA/UDCA	Budesonide: 9 mg per day; UDCA: 12–16 mg/kg per day	262/256	36 months	62
Vuppalanchi 2022	RCT	Saroglitazar + UDCA/UDCA	Saroglitazar: 2 mg or 4 mg per day UDCA: 13 mg/kg per day	351.3/323.2/294.9	4 months	37
Schattenberg 2021	RCT	Elafibranor + UDCA/UDCA	Elafifibranor: 80 mg or 120 mg per day UDCA: 13–15 mg/kg per day	350.6/263.7/296.2	3 months	45
Kowdley 2023	RCT	Elafibranor + UDCA/UDCA	Elafifibranor: 80 mg per day UDCA:13–15 mg/kg per day	321.3/ 321.9	13 months	161
Ding 2022	CS	FEF + UDCA/UDCA	FEF: 200 mg per day; UDCA: 13–15 mg/kg per day	328.9/309.4	12 months	59
Ding 2023	CS	FEF + UDCA/UDCA	FEF: 200 mg per day; UDCA: 13–15 mg/kg per day	365.3/330.2	12 months	118
Hirschfield 2023	RCT	Seladelpar + UDCA/UDCA	Seladelpar: 5 mg or 10 mg per day UDCA: 13–15 mg/kg per day	290.5/290.8/293.4	3 months	265

RCT Randomized controlled trial, CS Cohort study, CCS Case–control study, UDCA Ursodeoxycholic acid, OCA Obeticholic acid, BEF Bezafibrate, FEF Fenofibrate, ALP Alkaline phosphatase, NA Not available

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ISSN: 2046-4053

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