Optimal drug regimens for improving ALP biochemical levels in patients with primary biliary cholangitis refractory to UDCA: a systematic review and Bayesian network meta-analysis

Table 1 Risk of bias assessment with ROBINS-I

Study	1	2	3	4	5	6	7	Overall
Cheung 2016	M	L	L	L	NI	L	M	M
Liberopoulos 2010	M	L	L	S	M	L	L	S
Wang 2022	M	L	L	NI	L	L	M	M
Dohmen 2013	M	L	L	S	M	L	L	S
Ding 2022	M	L	L	NI	L	L	M	M
Ding 2023	M	L	L	L	NI	L	M	M

Risk of bias options are L Low, M Moderate, S Serious, C Critical, and NI No information
1 bias due to confounding, 2 bias in the selection of participants into the study, 3 bias in classification of interventions, 4 bias due to deviations from intended interventions, 5 bias due to missing data, 6 bias in the measurement of outcomes, 7 bias in the selection of the reported result
The seven bias domains are individually assessed for each study

ISSN: 2046-4053