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Table 2 Outcome variables and predictors in the selected studies

From: Clinical prediction models for the early diagnosis of obstructive sleep apnea in stroke patients: a systematic review

Author/year

Outcome variables

Candidate predictors

Predictors in the final model

Time of assessment

Measurement method/definition

N

Variables

Time of assessment

N

Variables

Sico/2017 [23]

Within 30 days

PSG, AHI ≥ 5/h

19

Age, race, gender, height, weight, BMI, large neck circumference, waist circumference, medical history, smoking, cocaine use or used, Charlson comorbidity score, modified Rankin, PHQ-8, NIHSS score, ESS, BQ, SACS, STOP-BANG

No stated

7

Female, weight, large neck, congestive heart failure, diabetes,

ESS, NIHSS

Brown/2020 [25]

Within 14 days from stroke

HSAT, REI ≥ 10/h

19

Age, race, hypertension, sex, diabetes, atrial fibrillation, smoking, history of TIA/stroke, excessive alcohol consumption,

congestive heart failure, coronary artery disease, hyper cholesterol,

BMI, NIHSS, neck circumference, waist circumference, BQ, Friedman palate position

After stroke onset

6

Neck circumference, BMI, waist circumference, age, NIHSS, daytime sleepiness

Boulos/2019 [29]

   

STOP-BAG (snoring, tired, observed, high blood pressure, BMI, age, neck circumference, gender)

After stroke diagnosis

8

STOP-BAG-O (snoring, tired observed, high blood pressure, BMI, age, neck circumference, gender, oximetry)

Katzan/2016 [27]

   

STOP (snoring, tired, observed, high blood pressure), BMI, age, race, neck circumference, married status, sex, history of coronary artery disease, sleep time, smoking

No stated

7

STOP-BAG2- (STOP, sex, BMI, age)

Bernardini/2021 [21]

No stated

PSG, AHI ≥ 5/h

No stated

No stated

No stated

 

ECG, peripheral oxygen saturation (SpO2)

Zhang/2019 [22]

No mentioned

PSG, AHI ≥ 10/h

11

Age, gender, BMI, neck circumference, smoking, alcohol consumption, medical history (hypertension, diabetes, AF, CHD, stroke, wake up stroke, progressive stroke, TIA, Ischemic stroke), NIHSS, homocysteine, CRP, hemoglobin A1c

With 1 week from stroke

4

Modified 4 V (sex, neck, blood pressure, snoring)

Boulos/2016 [24]

180 days after stroke

HSAT, AHI ≥ 10/h

10

4 V (sex, BMI, blood pressure, and snoring), STOP-BAG (snoring, tired, observed, high blood pressure, BMI, age, gender), Berlin Questionnaire, and

ESS, stroke location, atrial fibrillation, diabetes, smoking, hyperlipidemia, NIHSS

Within 72 h of sleep testing

4

4 V (sex, BMI, blood pressure, snoring)

Petrie/2021 [26]

64 days after stroke

PSG, AHI ≥ 5/h

No fit

Not fit

After admission

/

/

Šiarnik/2020 [31]

Within 7 days after the stroke onset

PSG, AHI ≥ 15/h

12

Age, gender, BMI, neck, past medical history (arterial hypertension, diabetes mellitus, ischemic heart disease, atrial fibrillation, heart failure, chronic kidney disease), NIHSS, ESS

Within 7 days from stroke onset

3

SLAPS (BMI, wake-up stroke onset, diastolic dysfunction in echocardiography)

Camilo/2014 [28]

Within 24 h after stroke

PSG, AHI ≥ 10/h

13

Age, male, hypertension, diabetes, dyslipidemia, smoking, alcohol consumption, BMI, neck, BQ, CT, ESS, NIHSS

No stated

2

SOS score (BQ and ESS)

Srijithesh/2011 [30]

28 days after stroke onset

PSG, AHI ≥ 5/h

No stated

BQ

No stated

/

BQ and combination of ESS and BQ

  1. PSG polysomnography, HSAT home sleep apnea test, BMI body mass index, ESS Epworth Sleepiness Scale, NIHSS National Institute of Health stroke scale, PHQ-8 Patient Health Questionnaire, CHD coronary heart disease, TIA transient ischemic attack, BQ Berlin Questionnaire, SACS sleep apnea clinical score, CT brain computed tomography, SOS sleep obstructive apnea score, AF atrial fibrillation, CRP C-reactive protein, 4 V the four-variable screening tool