Skip to main content

Table 3 Tumor outcome information

From: Prognostic impact of tumor budding in rectal cancer after neoadjuvant therapy: a systematic review and meta-analysis

Authors

Year

Outcome

TB-1

TB-0

P-value

HR

HR_LI

HR_UI

C. Du

2012

5-year DFS

55.6%

87.5%

 < 0.001

1.45

0.13

15.71

M. Huebner

2012

5-year CSS

73.8%

88.4%

–

6.73

1.56

28.96

A. C. Rogers

2013

5-year DFS

33.3%

77.5%

 ≤ 0.001

3.49

0.73

16.60

5-year CSS

61.1%

87.3%

0.021

5.79

0.44

76.62

LR

33%

10%

0.012

–

–

–

DR*

44%

15%

0.007

–

–

–

5-year CSD

39%

13%

0.01

3.51

1.03

11.93

J. W. Huh

2016

5-year DFS

–

–

–

1.109

0.593

2.073

LR

–

–

–

2.040

0.766

5.429

T. Jäger

2018

5-year RFS

71%

90%

0.02

3.44

1.23

9.63

5-year OS

80%

90%

0.09

–

–

–

LR

7%

0%

0.27

–

–

–

DR

12%

2%

0.03

–

–

–

M. Swets

2018

5-year DFS

–

–

–

1.54

1.00

2.37

5-year OS

–

–

–

1.54

1.09

3.03

DR

–

–

–

1.60

1.00

2.57

A. Demir

2019

1-year DFS

86%

93%

0.01

–

–

–

3-year DFS

24%

61%

0.01

–

–

–

J. W. Huh

2019

5-year OS

–

–

–

1.48

0.535

4.094

I. Trotsyuk

2019

5-year DFSa

39%

75%

 < 0.001

2.34

1.14

4.79

5-year OSa

53%

84%

0.001

2.72

1.15

6.44

5-year DFSb

44%

87%

 < 0.001

4.59

1.79

11.72

5-year OSb

59%

92%

 < 0.001

5.19

1.62

16.61

L. Farchoukh

2021

5-year DFS

39%

87%

0.001

3.35

1.25

8.99

LR

4%

2%

–

–

–

–

DR

31%

7%

–

–

–

–

J. K. Shin

2021

5-year DFS

65.4%

80.5%

 < 0.001

1.665

1.108

2.504

5-year OS

82.1%

94.7%

 < 0.001

2.102

1.111

9.979

  1. Methods of pathological staining of the specimen
  2. NA not applicable
  3. *Distant recurrence (DR): also known as distant metastasis (DM), refers to the tumor involving the peritoneum, liver, lung sites, and other distant organs
  4. aHematoxylin and eosin (H&E) staining
  5. bImmunohistochemical (IHC) staining