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Table 1 Information on the basic characteristics of the included studies

From: Prognostic impact of tumor budding in rectal cancer after neoadjuvant therapy: a systematic review and meta-analysis

Authors

Year

Country

Number of cases

Age*

Gender (male and proportion,%)

Distance from anal edge (cm)a

Follow-up monthsb

Type of studyc

Stars of NOS

TB-1

TB-0

TB-1

TB-0

TB-1

TB-0

TB-1

TB-0

C. Du [18]

2012

China

36

48

 < 60: ≥ 60 = 25: 11

 < 60: ≥ 60 = 25: 23

18 (50)

31 (64.6)

 ≤ 5: ≥ 5 = 13: 23

 ≤ 5: ≥ 5 = 15: 34

71

Case–control

5

M. Huebner [25]

2012

America

24

210

60.0 (12.49)

160 (67.5)

NA

42

Cohort

7

A. C. Rogers [20]

2013

Ireland

18

71

59.3 (8.6)

62.3 (12.8)

12 (67)

45 (63)

NA

49

Cohort

7

J. W. Huh [28]

2016

Korea

44

165

56 (27–81)

136 (65)

 ≤ 10

44

Cohort

6

T. Jäger [21]

2018

Switzerland

81

47

64 (10)

63 (10)

57 (66)

30 (34)

NA

84a

Cohort

7

M. Swets [24]

2018

Holland

99

199

59.8 (9.7)

136 (61.5)

 ≤ 10: > 10 = 130:85

64.8

Cohort

7

A. Demir [26]

2019

Turkey

46

29

56 (19–77)

31 (68)

20 (69)

P: 21; M: 19; D: 44

P: 7; M: 11; D: 11

35

Cohort

6

J. W. Huh [22]

2019

Korea

43

452

56 (24–80)

437 (68.4)

4.0

4.0

56.7

Cohort

6

I. Trotsyuk [23]

2019

Germany

38

65

67.1 (10.8)

62.5 (9.2)

25 (65.8)

48 (73.8)

NA

54.7d

Cohort

6

L. Farchoukh [13]

2021

America

26

91

65 (20)

60 (17)

17 (65)

52 (57)

M: 10 D: 16

M: 43 D: 48

29

Cohort

7

J. K. Shin [27]

2021

Korea

209

209

 < 65: ≥ 65 = 154: 55

 < 65: ≥ 65 = 146: 63

147 (70.3)

146 (69.9)

NA

NA

Cohort

7

  1. NA not applicable
  2. *Age: mean and SD; median and range
  3. aFollow-up month: mean month (day); other was a median month
  4. bMedian distance from the anal edge: P proxima, M middle or mid-rectum, D distal or distal rectum
  5. cType of study: all included studies were retrospective study