Skip to main content
Fig. 2 | Systematic Reviews

Fig. 2

From: Resuscitation-associated endotheliopathy (RAsE): a conceptual framework based on a systematic review and meta-analysis

Fig. 2

a Forest plot showing meta-analysis of eight studies that described syndecan-1 release post-resuscitation. Despite the high heterogeneity index, I2 = 75.87%, resuscitation caused a statistically significant release of syndecan-1 (pooled effect size; mean = 0.27; 95% CI - 0.07 to 0.60; p = 0.12). b Forest plot showing meta-analysis of four studies that described thrombomodulin release post-resuscitation. There was a high heterogeneity index between the studies with no significant effect of resuscitation on thrombomodulin release (I2 = 78.93%; mean = 0.41; 95% CI − 0.10 to 0.92; p = 0.12). c Forest plot of e-selectin release post-resuscitation. Only three studies described e-selectin release with high homogeneity but no significant effect of resuscitation on e-selectin release (I2 = 50.29%; mean =  − 0.15; 95% CI − 0.64 to 0.33; p = 0.53). d Forest plot of microvascular flow index (MFI) post-resuscitation. Only two-studies described MFI with high homogeneity but showed resuscitation significantly reduced the MFI (I.2 = 0%; mean =  − 0.80; 95% CI − 1.37 to − 0.24; p < 0.01)

Back to article page