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Table 3 Included studies which reported access to treatment defined as treatment receipt and utilisation (n = 15)

From: Geographic and sociodemographic access to systemic anticancer therapies for secondary breast cancer: a systematic review

Author (year)

Outcome of interest

Type of SACT treatment

Main finding(s)

Accordino et al. (2017) [26]

Receipt of EOL care which included receipt of IV chemotherapy within the last 14 days of life

IV chemotherapy as treatment within the last 14 days of life

60% receipt of IV chemotherapy as treatment within the last 14 days of life

Alves et al. (2022) [33]

Receipt of no SACT treatment

Unspecified SACT

60% of women received no first-course treatment

Cole et al. (2019) [34]

Receipt of specialist palliative care (SPC) which included non-curative systemic chemotherapy

Non-curative systemic chemotherapy

18.5% received specialist palliative care (SPC) which included non-curative systemic chemotherapy

Falchook et al. (2017) [35]

Receipt of chemotherapy within the last 14 days of life

Chemotherapy within the last 14 days of life

14.1% received chemotherapy within the last 14 days of life

Giap et al. (2023) [27]

Receipt of palliative care which included non-curative systemic therapy

Non-curative systemic chemotherapy

21.4% received non-curative systemic chemotherapy

Sathe et al. (2023) [28]

Receipt of cyclin-dependent kinase 4 and 6 (CDK4 and CDK6) inhibitors following secondary (metastatic) breast cancer diagnosis

Cyclin-dependent kinase 4 and 6 (CDK4 and CDK6) inhibitors

76.3% received CDK4/6i

Shih et al. (2009) [39]

Receipt of immunotherapy post diagnosis

Immunotherapy

4% received immunotherapy post diagnosis

Shiovitz et al. (2015) [40]

Utilisation of cancer-directed therapy which included chemotherapy

Chemotherapy

61% received SACT

Skinner et al. (2021) [32]

Receipt of systemic anticancer therapy

Unspecified SACT

83% received SACT

Small et al. (2012) [41]

Receipt of no first course anticancer therapy

Unspecified SACT—no first-course therapy

12.8% received no first-course SACT therapy

Statler et al. (2019) [30]

First-line treatment with chemotherapy and/or hormone therapy

First-line treatment with chemotherapy and/or hormone therapy

60% received first-line treatment with hormone therapy, 39% received chemotherapy, and 42% of patients received anti-HER2 therapy

Vyas et al. (2021) [5]

Receipt of initial systemic therapy within 6 months of secondary (metastatic) breast cancer diagnosis

Unspecified systemic anticancer therapy

72.3% received initial (guideline concordant) systemic therapy within 6 months of secondary (metastatic) breast cancer diagnosis

Wan & Jubelirer (2015) [35]

Receipt of chemotherapy within 6 months of diagnosis

Chemotherapy

30.2% received chemotherapy

Wang & Du (2015) [42]

Receipt of hormone therapy 1 year post initiation (stratified by chemotherapy use)

Hormone (endocrine) therapy

70.8% received hormone therapy

Wolfson et al. (2015) [43]

Receipt of care which included un specified SACT

SACT at a National Cancer Institute Comprehensive Cancer Centre (NCI CCC)

Nonspecified SACT

**22–39 years

9.7%

40–65 years 90.3%