Table 2 Quality of evidence
Certainty assessment | No. of patients | Effect | Certainty | Importance | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | PACK-CXL + SAT | SAT | Relative (95% CI) | Absolute (95% CI) | ||
The duration of corneal healing performed | ||||||||||||
2 | Randomized trials | Seriousa | Not serious | Not serious | Seriousb | None | 27 | 25 | - | MD 1.13 lower (0.183 lower to 0.42 lower) | ⨁⨁◯◯ Low | Critical |
Adverse events in fungal keratitis | ||||||||||||
4 | Randomized trials | Seriousa | Not serious | Not serious | Seriousb | None | 21/91 (23.1%) | 32/94 (34.0%) | RR 0.78 (0.38 to 1.60) | 75 fewer per 1000 (from 211 fewer to 204 more) | ⨁⨁◯◯ Low | Critical |
Adverse events in bacterial keratitis | ||||||||||||
2 | Randomized trials | Seriousa | Not serious | Not serious | Seriousb | None | 2/33 (6.1%) | 6/35 (17.1%) | RR 0.36 (0.08 to 1.71) | 110 fewer per 1000 (from 158 fewer to 122 more) | ⨁⨁◯◯ Low | Critical |