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Table 1 Main characteristics of included studies of multivariable prediction models of caries increment. A detailed description of included studies is presented in Additional file 4

From: Multivariable prediction models of caries increment: a systematic review and critical appraisal

First author and year [ref]

Country Year

Age (years) at baseline

Outcome (caries increment)

Method for measurement

Sample size

Number of events (E)

Events per variable (EPV)

Studies of model development

  Coronal caries

Angulo

1995 [13]

Uruguay

1988–1990

12–13

DS ˃ 1 cavity

Visual-tactile examination

69

19

6.33

Demers

1992 [14]

Canada

1988

Mean 5

dmfs ˃ 0 dentine

Visual-tactile examination

302

143

15.9

Disney

1992 [15]

USA

1986–1989

6 and 10

- DMFS ≥ 2 dentine

- DMFS ≥ 4 dentine

Visual-tactile examination

965–1099

204–234

5.2–5.6

Fontana

2011 [16]

Puerto Rico

2007

5–13

- ICDAS ≥ 1enamel

- ICDAS ≥ 3 cavity

Visual-tactile examination and bitewing radiography

395

239–35

5.8–8.7

Gao

2010 [17]

Singapore

2009–2010

3–6

dmft ˃ 0 dentine

Visual-tactile examination

1576

689

57–114.8

Hänsel Petersson

2002 [18]

Sweden

1998

10–11

DMFS/DMFT > 0 dentine

Dental records with bitewing radiography

392

121

10

Pang

2021 [19]

China

2018–2020

13–14

ICDAS ≥ 3 cavity

Visual-tactile examination

633

365

7.7

Sánchez-Pérez 

2009 [20]

Mexico

2001–2007

6

dmfs/DMFS ≥ 1 dentine

Visual-tactile examination

95

56

5.1

  Coronal and root caries

Powell

1991 [21]

USA

NR

66–95

 ≥ 1 coronal and/or root lesion

Visual-tactile examination

21

16

0.7

  Root caries

Ritter

2016 [22]

USA

2007–2008

Mean 52

Any incident root caries

Visual-tactile examination

155

76

5.8–9.5

Sánchez-García

2011 [23]

Mexico

2004–2005

Mean 73

 ≥ 1 root surfaces

Visual-tactile examination

531

115

3.7

Studies of model validation

  Coronal caries

Beck

1992 [24]

USA

1986–1989

6, 10

- DMFS ≥ 2 dentine

- DMFS ≥ 4 dentine

Visual-tactile examination

965–1099

338–642

8.7–14.6

Birpou

2019 [25]

Greece

NR

2–5

“Sound to non-cavitated” + “non-cavitated to cavitated”

Visual-tactile examination

140–147

74–77

8.2–10.1

Campus

2012 [26]

Italy

2007–2009

7–9

DFS ˃ 0 cavity

Visual-tactile examination

861

469

67

Christian

2020 [27]

Australia

NR

1.5

ICDAS-II ˃ 0 cavity

Visual examination

214

39–75

3.0–5.8

Dolic

2020 [28]

Bosnia and

Herzegovina

2007–2011

Mean 27

DMFT ˃ 1 cavity

Visual-tactile examination

80

5

6

Gao

2013 [29]

Hong Kong

NR

3

dmft ˃ 0 cavity

Visual-tactile examination

485

178

16.2–35.6

Hänsel Petersson

2015 [30]

Sweden

2006–2007

19

DFS ≥ 1 dentine

Visual-tactile examination, bitewing radiography

982

344

4.1–13.66

Hänsel Petersson

2010 [31]

Sweden

1998–2000

10–11

DMFS ˃ 0 dentine

Dental records and bitewing radiography

392

122

13.5–20.3

Lif Holgerson

2009 [32]

Sweden

2002–2007

2

dmfs/DMFS > 0 enamel and dentine

Visual-tactile examination and bitewing radiography

55

20

2.9

Pang

2020 [19]

China

2018–2020

13–14

ICDAS ≥ 3 cavity

Visual-tactile examination

320

202

4.4

  Root caries

Hayes

2018 [33]

Ireland

2012–2015

 ≥ 65

 ≥ 1 root surface with cavity

Visual-tactile examination

280

70

7.8–11.7

  1. Abbreviations: DMFT decayed missing filled teeth (permanent), DMFS decayed missing filled surfaces (permanent), DS decayed surfaces (permanent), dmft decayed missing filled teeth (primary), dmfs decayed missing filled surfaces (primary), NR not reported