Fig. 3
From: Multivariable prediction models of caries increment: a systematic review and critical appraisal
A caries process model with 6 levels. Each level holds a set of variables used as predictors in included studies. The horizontal line CAUSALITY LOST indicates that the 3 top levels do not commute with the other levels. Protons in dental plaque (H+) are the driving force in the caries process in development of dysbiosis as well as demineralisation of dental tissues. Acid tolerant bacteria in dental plaque are proposed as novel candidate predictors