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Table 2 Association between prognostic factors and outcomes described in the reviews

From: Prognostic factors for persistent symptoms in adults with mild traumatic brain injury: an overview of systematic reviews

Prognostic factors

(+)

(+/−)

(−)

Total number of reviews

Biomarkers

3 (50, 54, 58)

9 (2, 5, 26, 27, 44, 47, 52, 55, 56)

 

12

Sex

3 (24, 25, 53)

4 (5, 18, 19, 56)

1 (48)

8

Age

3 (2, 24, 25)

3 (19, 48, 56)

 

6

Multiple concussions

2 (46, 49)

3 (19, 52, 56)

1 (22)

6

Negative perceptions/expectations

3 (2, 5, 22)

1 (56)

 

4

Somatic complaints

2 (2, 48)

2 (19, 56)

 

4

Litigation/financial compensation

2 (2, 19)

1 (45)

 

3

Mental health (pre-injury)

2 (2, 56)

1 (19)

 

3

Extracranial injuries

2 (17, 48)

1 (56)

 

3

Level of education

2 (2, 48)

1 (56)

 

3

Anxiety/depression

2 (2, 56)

 

1 (5)

3

PTSD

2 (17, 19)

 

1 (5)

3

LOC

 

1 (5)

2 (2, 56)

3

Nausea/vomiting

1 (48)

1 (19)

 

2

Marital status

1 (2)

1 (19)

 

2

Memory of the injury event

1 (2)

1 (5)

 

2

Physical health (pre-injury)

1 (56)

1 (19)

 

2

PTA

 

2 (2, 56)

 

2

Mechanism of injury

 

1 (19)

1 (56)

2

Acute stress disorder (ASD)

1 (19)

  

1

Baseline mental/physical health

1 (2)

  

1

Degree of trait of resilience

1 (57)

  

1

Baseline noise sensitivity

1 (2)

  

1

Job independence/decision-making latitude at work

1 (48)

  

1

Gross national product of the country

1 (2)

  

1

Pre-injury fatigue

1 (2)

  

1

Being a student

 

1 (19)

 

1

Being sober/intoxicated in ED

 

1 (56)

 

1

Quality of sleep

 

1 (51)

 

1

Prior neurological problems

 

1 (19)

 

1

Life stressors

 

1 (19)

 

1

Complicated mTBI

 

1 (19)

 

1

Sensory motor test

 

1 (56)

 

1

Cognitive/neuropsychological tests

 

1 (56)

 

1

Glasgow Coma Scale score

  

1 (56)

1

  1. ED Emergency department, LOC Loss of consciousness, mTBI Mild traumatic brain injury, PTA Post-traumatic amnesia, PTSD Post-traumatic stress disorder