Table 1 Characteristics of the systematic reviews included
Authors, year of publication | Nb of primary articles retained for the OvSR | Design of the studies included | Population | Purpose of the review | ROBIS assessment |
|---|---|---|---|---|---|
Begaz et al., 2006 [44] | 7/11 | Prospective cohort studies | Adults with mTBI | Assess the predictive ability and potential clinical utility of known serum biochemical markers on the outcome of PCS in patients with closed head injury and mild TBI | HR |
Belanger et al., 2005 [45] | 39/39 | Not specified | Adults and adolescents with mTBI | Determine the magnitude of impairment in mTBI participants across multiple cognitive domains | HR |
Belanger et al., 2010 [46] | 8/8 | Not specified | Adult and adolescent athletes with mTBI | Determine the magnitude of impairment in those participants with multiple concussions across multiple cognitive domains | HR |
Biagianti et al., 2020 [47] | 9/9 | Longitudinal cohort and case-control studies | Adults with mTBI | Integrate findings from longitudinal studies that investigated across the spectrum of neuroimaging modalities the changes within the first twelve months following a mTBI, with the goal of identifying possible predictors or biomarkers of persistent PCS | HR |
Boyle et al., 2014 [17] | 3/3 | Retrospective cohort studies | Military with mTBI | Synthesize the best available evidence on the course and prognosis of mTBI in the military population | LR |
Cancelliere et al., 2014 [48] | 4/4 | Cohort studies | Workers with mTBI | Synthesize the best available evidence on RTW after mTBI | LR |
Cancelliere et al., 2016 [18] | 12/16 | Control trials, cohort, and case-control studies | Adults and children with mTBI | Determine sex differences in the recovery and prognosis after mTBI in adults and children | HR |
Carroll et al., 2004 [19] | 53/120a | Cohort studies, randomized control trials, systematic reviews, cross-sectional studies, and case series or variant designs | Adults and children with mTBI | Produce a best-evidence synthesis on the epidemiology (incidence, risk, and prevention), diagnosis, treatment, and prognosis of mTBI | LR |
Carroll et al., 2014 [5] | 20/21 | Randomized control trials, cohort, and case-control studies | Adults with mTBI | Synthesize the best available evidence on objective outcomes after adult mTBI | LR |
Cassidy et al., 2014 [2] | 20/23 | Cohort and non-randomized experimental studies | Adults with mTBI (excluding sport/military injuries) | Update the WHO findings on course and prognosis in adults with respect to self-reported outcomes | LR |
Finkbeiner et al., 2016 [49] | 15/23 | Retrospective studies and qualitative studies | Adult athletes with concussion | Summarize the current literature addressing chronic (> 3 months) psychiatric changes, including emotional and behavioral domains (depression, anxiety, substance abuse, and challenging behaviors) with sport concussion in adults | HR |
Godbolt et al., 2014 [22] | 2/8 | Cohort studies and randomized control trials | Adults and children with mTBI | Synthesize the best available evidence regarding the risk of dementia and chronic cognitive impairment after mTBI | LR |
Khong et al., (2016) [50] | 9/10 | Case-control | Adults and children with mTBI | Review the evidence for the use of DTI parameters in the human brain as a diagnostic tool for and predictor of PCS after a mTBI | HR |
King, 2014a [24] | 20/20 | Retrospective studies, prevalence studies of risk factors, and outcome with/without matched controls | Adults with mTBI (16–65 years old) | Review the studies which have examined working age mTBI patients at 18+ months post-injury and examined the relationship between age or gender and permanent PCS | HR |
King, 2014b [25] | 16/16 | Prevalence, prospective follow-up, explorative follow-up, and epidemiological studies | Adults with mTBI (16–65 years old) | Systematically review the literature to identify and examine those studies which have investigated working-age patients with prolonged PCS (i.e., at 12–18 months post-injury) | HR |
Ludwig et al., 2020 [51] | 2/4 | Prospective longitudinal study and longitudinal cohort study | > 16 years old individuals with mTBI | Examine the association between sleep during the acute stage (< 2 weeks) of a concussion and long-term post-concussive outcomes | LR |
Manley et al., 2017 [52] | 47/47 | Retrospective, case series, case-control, cross-sectional, cross-sectional surveys, cohort studies, and surveys | Adults with sport-related concussion | Address the current state of the scientific evidence about the prevalence, risk factors, and causation of possible long-term sequelae like chronic traumatic encephalopathy and other neurodegenerative diseases, with respect to sports concussion | LR |
Mercier et al., 2018a [27] | 21/29 | Retrospective, prospective cohort studies, and randomized control trials | Adults with mTBI | Determine the prognostic value of S-100b protein to identify patients with post-concussion symptoms after a mTBI | LR |
Mercier et al., 2018b [26] | 7/10 | Cohort studies | Adults with mTBI | Determine the prognostic value of neuron-specific enolase to predict post-concussion symptoms following mTBI | LR |
Merritt et al., 2019 [53] | 10/37 | Cross-sectional, epidemiology, repeated measures, retrospective and case series studies, systematic review, and meta-analysis | Adults with mTBI | Examine sex differences in concussion, or mTBI outcome, updating previous critical reviews of the literature | HR |
Ofoghi et al., 2020 [54] | 14/19 | Retrospective or prospective, observational, case-cohort, cohort, non-randomized studies | Individuals with mTBI | Evaluated the current literature examining the structural and functional neuroimaging correlates and pain processing network differences that could contribute to the persistence of pain following mTBI | HR |
Puig et al., 2020 [55] | 10/14 | Prospective or retrospective cohort studies | Individuals > 16 years old with mTBI | Evaluate the current literature examining the use of MRI-based brain-connectivity mapping techniques including DTI and/or rs-fMRI to predict clinical outcomes following acute mTBI | LR |
Silverberg et al., 2015 [56] | 18/26 | Prospective inception cohort studies | Adults and children with mTBI | Identify and evaluate multivariable prognostic models for mTBI and determine which pre-, peri-, and early post-injury variables have independent prognostic value in the context of multivariable models | LR |
Sullivan et al., 2016 [57] | 4/5 | Cohort and cross-sectional studies | Adults with mTBI | Determine how the term resilience has been used in adult mTBI research | HR |
Zhu et al., 2019 [58] | 6/9 | Cohort and case-control studies | Adults with mTBI | Explore the association between DTI findings and cognitive function following mTBI using a meta-analysis | HR |