Fig. 2

Reasons for non-adherence and non-persistence provided by patients identified in this review. Findings are sorted by patient-led, treatment-led, and other factors as provided by WHO MAM Model. In total, 937/409,215 provided patient-led reasons, out of which treatment dissatisfaction (29.9%), financial burden (19.0%) and old age/co-comorbidities (15.5%) were the most commonly occurring reasons provided. *Old age and co-morbidities were given as a single percentage of 15.5% due to the fact that these were combined in several of the papers. Aside from patient-associated factors given, several studies included physician-associated factors and external factors such as patient death and transfer of care elsewhere