Fig. 1

Trials and treatments included in the primary analysis from which an indirect comparison of AAP+ADT vs Doc+ADT may be obtained. Note: Reviews are ordered by earliest known date of submission, acceptance or publication (online or print). Conference abstracts were assumed to be accepted as of the publicised submission deadline. For visual clarity, trials are clustered by included treatments rather than placed in strict order of publication. See Additional files 3, 4 and 5 for details and references for the reviews and trials. Green = docetaxel (Doc); blue = zoledronic acid (ZA); maroon = celecoxib (Cel); amber = abiraterone (AAP); purple = other. Split colours = treatment combinations, as above. Light shading = included in sensitivity/exploratory analysis only