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Table 1 Characteristics of eligible studies

From: Ethnic differences between South Asians and White Caucasians in cardiovascular disease-related mortality in developed countries: a systematic literature review

Author, year

Country

Study time period

Design

Study population

Sample size

CVD, type

Outcome

Total in study

Number (%) South Asian

CVD related

All cause

Adil, 2013 [30]

USA

2000–2009

Cross-sectional

Stroke-related deaths in the USA between 2000 and 2009

152,736

1,220

Stroke/TIA

Yes

No

Albarak, 2012 [31]

Canada

04/1995–03/2002

Retrospective

Patients with AMI between aged 20–55 years

7,135

487

AMI

No

Yes

Bansal, 2013 [32]

UK

05/2001–04/2008

Retrospective

All residents in Scotland during the 2001 census

39,317

103

MI

Yes

No

Bellary, 2010 [33]

UK

2004–2007

Prospective

Patients with type 2 diabetes mellitus from 25 general practices from Birmingham, UK

1,978

1,486

CHD

Yes

No

Blackledge, 2003 [34]

UK

04/1998–03/2001

Retrospective

Patients hospitalised with heart failure

5,393

336

HF

No

Yes

Chaturvedi, 1996 [35]

UK

1985–1989

Retrospective

Deaths in people aged 45+ years where diabetes was mentioned on the death certificate

NR

NR

CVD, CHD, stroke/TIA

Yes

Yes

Deb, 2016 [36]

Canada

04/1996–03/2007

Retrospective

Adults who underwent isolated coronary artery bypass grafting

4,946

2,473

CHD

No

Yes

Elahi, 2005 [37]

UK

10/1999–10/2004

Retrospective

Patients who underwent isolated first-time CABG surgery on cardiopulmonary bypass

7,876

650

CHD

No

Yes

Feder, 2002 [38]

UK

04/1996–04/1997

Prospective

Patients undergoing coronary angiography in the ACRE study

3,476

502

CHD

No

Yes

Fischbacher, 2007 [39]

UK

04/2001–12/2003

Retrospective

Linked death data registry to 2001 Census of Scotland

4,624,528

47,811

MI

Yes

No

Forouhi, 2006 [40]

UK

1998–1990

Prospective

Patients who were a part of the Southall and Brent population-based studies

3,207

1,420

CHD

Yes

No

Gahungu, 2020 [41]

Canada

2006–2013

Prospective

Patients identified from the Institutional Cardiac CCTA Registry

144

72

CAD

Yes

Yes

Gasevic, 2013 [42]

Canada

04/1999–03/2003

Retrospective

Patients who underwent percutaneous coronary intervention and coronary artery bypass grafting surgery after AMI

4729, 1687

371, 137

MI

No

Yes

George, 2017 [17]

UK

01/1997–03/2010

Prospective

Patients registered from 225 GPs across England submitting data to CPRD

1,068,318

38,292

Various

Yes

No

Gholap, 2015 [43]

UK

10/2002–09/2008

Retrospective

Hospitalised patients with AMI from two coronary care units

4,111

730

AMI

No

Yes

Gray, 2007 [44]

Australia

1998–2002

Cross-sectional

Anonymous individual death records for 1998–2002

17,914,580

209,405

CD

Yes

No

Gunarathne, 2008 [45]

UK

1997–2005

Retrospective

Patients with a first-in-a-lifetime stroke admitted to Sandwell and West Birmingham Hospitals Trust during 1997–2005

2,405

420

Stroke/TIA

Yes

No

Gupta, 2002 [46]

Canada

01/1994–04-1999

Retrospective

Patients who had acute MI at one of two Toronto-area hospitals

1,106

553

AMI

Yes

No

Hadjinikolaou, 2009 [47]

UK

04/2002–09/2007

Retrospective

Patients undergoing isolated coronary bypass surgery

2,897

274

CAD

No

Yes

Harding, 2008 [48]

UK

1979–2003

Cross-sectional

People aged 30–69 years in England and Wales who died between 79–83, 89–93, and 99-03–

25,044,381

571,339

CAD

Yes

No

Hsu, 1999 [49]

UK

1996–1996

Prospective

Patients in 23 general practices with patients in Leicestershire, UK

199

69

Stroke/TIA

Yes

No

Jones, 2011 [50]

UK

01/2003–09/2008

Retrospective

Patients who underwent PCI in East London, UK

9,771

1,805

CAD

No

Yes

Jones, 2014 [51]

UK

01/2004–07/2011

Retrospective

Patients who underwent PCI

279,256

19,938

CAD

No

Yes

Kaila, 2014 [52]

Canada

01/1999–03/2012

Observational

Canadians admitted with an ACS

7,292

1,823

ACS

No

Yes

Khan, 2010 [53]

Canada

1994–2003

Retrospective

Routinely collected hospital administrative data from the provinces of British Columbia and Alberta, Canada

41,615

2,190

AMI

No

Yes

Khan, 2013 [54]

Canada

07/2003–03/2008

Retrospective

Clinical data from the Registry of the Canadian Stroke Network (RCSN)

1409a

43a

AIH, stroke/TIA

No

Yes

7588b

210b

Krishnamurthy, 2019 [55]

UK

01/2009–12/2011

Prospective

Patients undergoing PPCI for STEMI as part of the West Yorkshire PPCI Outcome Study

2,867

297

MI

No

Yes

Lane, 2005 [56]

UK

1979–1986

Observational

Patients part of the Birmingham Factory Screening Project

2,624

195

Various

Yes

Yes

Mackay, 2017 [57]

Canada

04/2001–10/2010

Prospective

Prospectively collected data from the Cardiac Services British Columbia Cardiac Registry

41,792

3,904

CAD

No

Yes

Muilwijk, 2019 [58]

UK

04/2007–12/2010

Prospective

UK Biobank participants who have type 2 diabetes mellitus

465,307

7,102

MI, stroke/TIA

Yes

Yes

Mukhtar, 1995 [59]

UK

07/1986–06/1987

Prospective

Patients who were admitted with chest pain to coronary care units of five hospitals in Birmingham, who had a confirmed MI, and who were discharged alive from the hospital

204

102

MI

Yes

Yes

Nijjar, 2010 [60]

Canada

04/1995–03/2002

Retrospective

Incident AMI patients in BC and Calgary, Canada, with diabetes or without diabetes

40,669

2,190

AMI

No

Yes

O’Neill, 2018 [61]

UK

01/2006–12/2016

Retrospective

Patients with de novo dual chamber and cardiac resynchronisation therapy pacemakers implantations

144

72

AF

No

Yes

Patel, 2021 [72]

UK

2006–2010

Prospective

UK Biobank participants

449,349

8,124

CHD, stroke/TIA

Yes

No

Pursani, 2020 [62]

USA

2006–2016

Retrospective

Participant who underwent a screening lipid panel and had no prior history of CHD

341,309

5,149

CHD

Yes

No

Quan, 2010 [63]

Canada

1995–2004

Prospective

Patients who underwent percutaneous coronary intervention and CABG, part of APPROACH and BCCR

81,848

3,031

CAD

Yes

No

Rafnsson, 2013 [64]

UK

1990–2007

Observational, cross-sectional

Mortality and population data from six EU countries — Denmark, England/Wales, France, the Netherlands, Scotland, and Sweden

368,707,201

3,167,341

CD, IHD, stroke/TIA

Yes

No

Raghavan, 2008 [65]

Canada

1995–2000

Retrospective

Patients admitted with ACS

130

65

ACS

No

Yes

Sheth 1999 [66]

Canada

1979–1993

Cross-sectional

Canadian Mortality Database

NA

NA

CHD, stroke/TIA, various

Yes

Yes

Sun, 2019 [67]

Canada

04/2010–03/2016

Retrospective

Patients hospitalised for AHR

82,125

1,662

AHF

No

Yes

Toor, 2011 [68]

UK

04/2002–12/2004

Observational

PCI procedures undertaken in Birmingham, UK

1,158

239

CAD

No

Yes

Vyas, 2021 [70]

UK

1988–1991

Prospective

Data from the SABRE cohort

801

396

Various

No

Yes

Vyas, 2021 [71]

Canada

2002–2008

Prospective

Patients with ischemic stroke in the Ontario Stroke Registry

31,923

NR

Stroke/TIA

No

Yes

Wilkinson, 1996 [69]

UK

12/1998–12/1992

Observational

Patients admitted to the coronary care unit with AMI

462

149

AMI

No

Yes

  1. Abbreviations: ACS acute coronary syndrome, AF atrial fibrillation, AHF acute heart failure, AIH acute ischaemic haemorrhage, AMI acute myocardial infarction, CABG coronary artery bypass graft, CAD coronary arterial disease, CD circulatory disease, CHD coronary heart disease, HF heart failure, IHD ischaemic heart disease, MI myocardial infarction, NR not reported, PCI percutaneous coronary intervention, TIA transient ischaemic attack, UK United Kingdom, USA United States of America
  2. aAcute ischaemic haemorrhage patients
  3. bStroke patients