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Table 1 Sixteen domains in AMSTAR 2

From: AMSTAR 2 appraisal of systematic reviews and meta-analyses in the field of heart failure from high-impact journals

Domain number

Critical or non-critical

Content of the domain

Yes or partial yes (%)

No (%)

1

Non-critical domain

Did the research questions and inclusion criteria for the review include the components of PICOa?

65

35

2

Critical domain

Did the report of the review contain an explicit statement that the review methods were established prior to the conduct of the review and did the report justify any significant deviations from the protocol?

5

95

3

Non-critical domain

Did the review authors explain their selection of the study designs for inclusion in the review?

15

85

4

Critical domain

Did the review authors use a comprehensive literature search strategy?

86

14

5

Non-critical domain

Did the review authors perform study selection in duplicate?

68

32

6

Non-critical domain

Did the review authors perform data extraction in duplicate?

73

27

7

Critical domain

Did the review authors provide a list of excluded studies and justify the exclusions?

5

95

8

Non-critical domain

Did the review authors describe the included studies in adequate detail?

83

17

9

Critical domain

Did the review authors use a satisfactory technique for assessing the risk of bias in individual studies that were included in the review?

69

31

10

Non-critical domain

Did the review authors report on the sources of funding for the studies included in the review?

15

85

11

Critical domain

If meta-analysis was performed did the review authors use appropriate methods for statistical combination of results?

78

22

12

Non-critical domain

If meta-analysis was performed, did the review authors assess the potential impact of risk of bias in individual studies on the results of the meta-analysis or other evidence synthesis?

27

73

13

Critical domain

Did the review authors account for risk of bias in individual studies when interpreting/ discussing the results of the review?

88

12

14

Non-critical domain

Did the review authors provide a satisfactory explanation for, and discussion of, any heterogeneity observed in the results of the review?

85

15

15

Critical domain

If they performed quantitative synthesis did the review authors carry out an adequate investigation of publication bias (small study bias) and discuss its likely impact on the results of the review?

60

40

16

Non-critical domain

Did the review authors report any potential sources of conflict of interest, including any funding they received for conducting the review?

99

1

  1. aPICO Population, Intervention, Control, and Outcomes